Systemic lupus erythematosus

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ORPHA:536OMIM:301080M32.0M32.1M32.8
Who is this for?
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6FDA treatments148Active trials211Specialists8Treatment centers6Financial resources

Where are you in your journey?

UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Systemic Lupus Erythematosus is treated with 8 medications in our database, including prednisone, Dexamethasone Sodium Phosphate, Hydroxychloroquine sulfate, HYDROXYCHLOROQUINE SULFATE, Hydroxychloroquine Sulfate, and 3 more. 7 of these have manufacturer assistance programs available to help reduce out-of-pocket costs. Medications are manufactured by Pfizer, Merck, Sanofi, Hikma. Patients and caregivers can find copay cards, patient assistance programs, and travel grants for Systemic Lupus Erythematosus treatment below.

Also known as:

Clinical phenotype terms— hover any for plain English:

Lupus nephritisHP:0033726Anti-ribosome Po antibody positivityHP:0034076Anti-complement component C1q antibody positivityHP:0034077Decreased circulating complement C4 concentrationHP:0045042Anti-titin antibody positivityHP:5000038MalaiseHP:0033834Antineutrophil antibody positivityHP:0003453Decreased circulating complement C3 concentrationHP:0005421
Inheritance

Multifactorial

Caused by a mix of several genes and environmental factors

Age of Onset

Variable

Can begin at different ages, from infancy through adulthood

Orphanet ↗OMIM ↗NORD ↗

FDA & Trial Timeline

10 events
Nov 2026Cardiac Imaging in Systemic Disorders: the ORACLES Registry

Assistance Publique - Hôpitaux de Paris

TrialNOT YET RECRUITING
Oct 2026The Relation Between Serum Zinc and Lupus Nephritis

Assiut University

TrialNOT YET RECRUITING
Sep 2026Safety and Efficacy of ONT01 in Lupus

Hospital for Special Surgery, New York — EARLY_PHASE1

TrialRECRUITING
Aug 2026Associating Gastric Infection With Autoimmune Flare Severity in an Egyptians

Assiut University

TrialNOT YET RECRUITING
Jul 2026Therapeutic Drug Monitoring of Mycophenolate Mofetil in Lupus Nephritis

Federal University of Maranhao — NA

TrialNOT YET RECRUITING
Jul 2026Omega-3 Supplementation in Systemic Lupus Erythematosus

University of Sao Paulo — NA

TrialNOT YET RECRUITING
May 20262-HOBA in Systemic Lupus Erythematosus

Vanderbilt University Medical Center — PHASE2

TrialNOT YET RECRUITING
Apr 2026Identification of Modifiable Sleep-related Factors in Patients With Systemic Lupus Erythematosus.

Investigación en Hemofilia y Fisioterapia

TrialNOT YET RECRUITING
Mar 2026A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease

EMD Serono Research & Development Institute, Inc. — PHASE3

TrialNOT YET RECRUITING
Mar 2026Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA CAR-NK Cell Injection for the Treatment of Refractory Pediatric Rheumatic Diseases

The Children's Hospital of Zhejiang University School of Medicine — EARLY_PHASE1

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

6 available

HYDROXYCHLOROQUINE SULFATE

Hydroxychloroquine Sulfate· Sanofi

* Patient Copay Amount: Not Publicly Available * Maximum Annual Benefit Limit: Not Publicly Available * Core Eligibility Restrictions: Not Publicly Available * RxBIN, PCN, and Group numbers: Not Publi

Prednisone

prednisone· Bryant Ranch Prepack

* Patient Copay Amount: Not Publicly Available * Maximum Annual Benefit Limit: Not Publicly Available * Core Eligibility Restrictions: Not Publicly Available * RxBIN, PCN, and Group numbers: Not Publi

Plaquenil

Hydroxychloroquine Sulfate· Sanofi

* Patient Copay Amount: Not Publicly Available * Maximum Annual Benefit Limit: Not Publicly Available * Core Eligibility Restrictions: Must be a U.S. resident. * RxBIN, PCN, and Group numbers: Not Pub

DEXAMETHASONE SODIUM PHOSPHATE

DEXAMETHASONE SODIUM PHOSPHATE· Merck

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program fo

Dexamethasone 1.5 mg

Dexamethasone 1.5 mg· Unknown

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program fo

Dexamethasone Intensol, Dexamethasone

· Hikma

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program fo

Clinical Trials

20 recruitingView all trials with filters →
Other20 trials
Clinical Assessment for Rheumatologic Disease - Research and Advancement in Safety and Efficacy
Actively Recruiting
· Sites: Bonn, North Rhine-Westphalia · Age: 1899 yrs
Swiss Pediatric Inflammatory Brain Disease Registry (Swiss-Ped-IBrainD)
Actively Recruiting
PI: Sandra Bigi, PD MD (ISPM, University of Bern, Bern; Kinderspital Zentr) · Sites: Aarau, Canton of Aargau; Sankt Gallen, Canton of St. Gallen +11 more · Age: 036 yrs
Systemic Lupus Erythematosus and Chlordecone Impregnation in Martinique
Actively Recruiting
PI: Benoît SUZON, PhD (University Hospital Center of Martinique) · Sites: Fort-de-France · Age: 1899 yrs
High Quality Evidence of Guangzhou Lupus Nephritis Cohort (HOPE Cohort)
Actively Recruiting
PI: Wei Chen, MD PHD (First Affiliated Hospital, Sun Yat-Sen University) · Sites: Guangzhou, Guangdong · Age: 1499 yrs
National Systemic Lupus Erythematosus Prospective Cohort, Saudi Arabia
Actively Recruiting
· Sites: Riyadh, Central Province · Age: 1999 yrs
Achievement of LLDAS5 in Patients With Systemic Lupus Erythematosus Treated With Anifrolumab.
Actively Recruiting
· Sites: Monserrato, CA; Cona, Ferrara +17 more
Rheumatology Diet Study
Actively Recruiting
PI: Neha Bhanusali, MD (University of Central Florida) · Sites: Orlando, Florida · Age: 1865 yrs
Adjunctive Yu-Tone Music Therapy for Systemic Lupus Erythematosus: a Prospective Cohort Study
Active
· Sites: Hangzhou
Repository of Novel Analytes Leading to Autoimmune, Inflammatory and Diabetic Nephropathies (RENAL AID)
Actively Recruiting
PI: Alan S Perlman, M.D. (The Rogosin Institute) · Sites: New York, New York · Age: 1899 yrs
CorEvitas Systemic Lupus Erythematosus (SLE) Drug Safety and Effectiveness Registry
Actively Recruiting
· Sites: Waltham, Massachusetts · Age: 1899 yrs
A Study of Clinical Characteristics ,Risk Factors and Outcome of Lupus Nephritis Among Children With Systemic Lupus Erthromatousus in Sohag Univeristy Hospital
Actively Recruiting
· Sites: Sohag · Age: 018 yrs
Development of a Therapeutic Endpoint in Pediatric Rheumatologic Conditions
Actively Recruiting
· Sites: Washington D.C., District of Columbia · Age: 521 yrs
Safety and Efficacy of Telitacicept in the Treatment of Systemic Lupus Erythematosus (SLE)
Actively Recruiting
PI: Dong Lingli, MD (Tongji Hospital) · Sites: Wuhan, Hubei · Age: 1870 yrs
Systemic Immune Inflammatory Index in Systemic Lupus Erythematosus
Actively Recruiting
· Sites: Sohag, Sohag Governorate · Age: 1699 yrs
Neutrophil Extracellular Traps in Different Forms of Systemic Sclerosis
Actively Recruiting
· Sites: Reims · Age: 1899 yrs
Study of Neonatal IgG Fc Receptor Expression in Natural Killer T Cells Expressing an Invariant T Receptor : Implication in the Pathophysiology of Systemic Lupus
Actively Recruiting
PI: Yanis RAMDANI (CHRU de Tours) · Sites: Tours · Age: 1899 yrs
The Anifrolumab PRIM Program
Actively Recruiting
PI: Syd Philips (PPD Miami, US) · Sites: Södertälje
A Comparative Study of the Efficacy and Safety of Telitacicept and Belimumab in the Treatment of Systemic Lupus Erythematosus Involving Multiple Units, Based on Previous Data.
Active
· Sites: Jinan, Shandong · Age: 1865 yrs
" TREX1 Gene Mutations and Their Role in Systemic Lupus Erythematosus
Actively Recruiting
PI: Eisa Mohammed Hegazy, Professor (Dermatology, Venereology and Andrology. Faculty of) · Sites: Qina, South Valley · Age: 1860 yrs
Lupus Landmark Study: A Prospective Registry and Biorepository
Actively Recruiting
PI: Sam Lim, MD, MPH (Emory University) · Sites: Birmingham, Alabama; Tucson, Arizona +19 more · Age: 18110 yrs

Specialists

Showing 25 of 211View all specialists →
GM
Gian Marco Ghiggeri, MD
Specialist
PI on 3 active trials1 Systemic lupus erythematosus publication
EP
Eisa Mohammed Hegazy, professor
Specialist
PI on 2 active trials
ZL
Zhanguo Li
Specialist
PI on 7 active trials819 Systemic lupus erythematosus publications
GL
Global Clinical Leader
Specialist
PI on 44 active trials4 Systemic lupus erythematosus publications
DM
Doruk Erkan, MD
NEW YORK, NY
Specialist
PI on 4 active trials
NM
Nicolino Ruperto, MD, MPH
Specialist
PI on 2 active trials
RM
Ronald G Crystal, MD
NEW YORK, NY
Specialist
PI on 12 active trials
UC
Use Central Contact
Specialist
PI on 28 active trials
QL
Qianjin Lu
Specialist
PI on 5 active trials110 Systemic lupus erythematosus publications
CM
Chadwick Prodromos, MD
GLENVIEW, IL
Specialist
PI on 11 active trials
CP
Ching-Mao Chang, M.D., Ph.D.
Specialist
PI on 2 active trials
AL
Ali Ismail, lecturer
Dokki, Giza Governorate
Specialist

Rare Disease Specialist

PI on 4 active trials1 Systemic lupus erythematosus publication
AP
Austin T Robinson, PhD
Bloomington, Indiana
Specialist

Rare Disease Specialist

PI on 2 active trials
FZ
Fengchun Zhang
Specialist
PI on 4 active trials
ZD
Zahi Touma, Dr
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

6 grants

PAN Foundation Systemic Lupus Erythematosus Fund

PAN Foundation

Applicants must be receiving treatment for systemic lupus erythematosus in the United States and possess health insurance that covers their specific medication. Additionally, household income must be at or below 500% of the Federal Poverty Level.

Apply ↗Up to $4,200

HealthWell Foundation Systemic Lupus Erythematosus Fund

HealthWell Foundation

Applicants must be receiving treatment for Systemic Lupus Erythematosus in the United States and have health insurance that covers their medication. Household income must generally be at or below 500% of the Federal Poverty Level, adjusted for family size and cost of living.

Apply ↗Up to $15,000

Sanofi Patient Assistance Program

Sanofi

Apply ↗

CreakyJoints Co-pay Cards and Financial Assistance

CreakyJoints

This directory provides information on various co-pay assistance cards, pharmaceutical programs, and nonprofit foundations for arthritis patients. Eligibility typically requires patients to have commercial or private insurance and not be covered by government programs such as Medicare or Medicaid.

Apply ↗

Sanofi Patient Connection

Sanofi

Apply ↗

SAPHNELO Co-pay Savings Program

Eligible patients must be adults with moderate to severe systemic lupus erythematosus (SLE) currently receiving other lupus medicines. The co-pay savings program is specifically for US consumers with commercial or private insurance.

Apply ↗

Community

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Latest news about Systemic lupus erythematosus

Disease timeline:

New recruiting trial: A Study of Anti-CD19/BCMA Universal CAR-T Cell Therapy RD06-05 in Patients With Autoimmune Diseases.

A new clinical trial is recruiting patients for Systemic lupus erythematosus

New recruiting trial: Milk Fat Globule Membrane-Enhanced RUTF for Children With Severe Acute Malnutrition

A new clinical trial is recruiting patients for Systemic lupus erythematosus

New recruiting trial: Clinical Study on Targeted CD19/BCMA CAR-T Therapy for Autoimmune Diseases

A new clinical trial is recruiting patients for Systemic lupus erythematosus

New recruiting trial: CAR T-cell Therapy Targeting CD19 and BCMA in Patients With B Cell Mediated Autoimmune Disease

A new clinical trial is recruiting patients for Systemic lupus erythematosus

New recruiting trial: Cutaneous Lupus Registry

A new clinical trial is recruiting patients for Systemic lupus erythematosus

New recruiting trial: Cardiovascular Risk in Children With Chronic Conditions Study

A new clinical trial is recruiting patients for Systemic lupus erythematosus

New recruiting trial: Clinical Trial to Evaluate Safety, Tolerability, and Pharmacokinetics of SOF-SKN in Healthy Participants

A new clinical trial is recruiting patients for Systemic lupus erythematosus

New recruiting trial: Comparative Effectiveness of Online 8-session CBT vs. 1-Session Empowered Relief for Chronic Pain - The PROGRESS Study

A new clinical trial is recruiting patients for Systemic lupus erythematosus

New recruiting trial: Rare AutoImmune SElf-management Programme Development

A new clinical trial is recruiting patients for Systemic lupus erythematosus

New recruiting trial: Evaluation of the Cryocheck HexLA Integrated TCA for the Detection of Lupus Anticoagulant

A new clinical trial is recruiting patients for Systemic lupus erythematosus

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Systemic lupus erythematosus

What is Systemic lupus erythematosus?

Systemic Lupus Erythematosus is treated with 8 medications in our database, including prednisone, Dexamethasone Sodium Phosphate, Hydroxychloroquine sulfate, HYDROXYCHLOROQUINE SULFATE, Hydroxychloroquine Sulfate, and 3 more. 7 of these have manufacturer assistance programs available to help reduce out-of-pocket costs. Medications are manufactured by Pfizer, Merck, Sanofi, Hikma. Patients and caregivers can find copay cards, patient assistance programs, and travel grants for Systemic Lupus Erythematosus treatment below.

How is Systemic lupus erythematosus inherited?

Systemic lupus erythematosus follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

Are there clinical trials for Systemic lupus erythematosus?

Yes — 20 recruiting clinical trials are currently listed for Systemic lupus erythematosus on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Systemic lupus erythematosus?

25 specialists and care centers treating Systemic lupus erythematosus are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.

What treatment and support options exist for Systemic lupus erythematosus?

6 FDA-approved treatments are currently tracked on UniteRare for Systemic lupus erythematosus. See the treatments and support programs sections for copay assistance, eligibility, and contact details.