Cancer of unknown primary site | UniteRare Disease Library

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

Phase 3

Actively Recruiting

PI: Siddharth Sheth (Alliance for Clinical Trials in Oncology) · Sites: Little Rock, Arkansas; Marysville, California +173 more · Age: 18–99 yrs

Phase 26 trials

Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic

Phase 2

Active

PI: Aung Naing (M.D. Anderson Cancer Center) · Sites: Houston, Texas · Age: 18–99 yrs

Pembrolizumab in Patients With Poor-Prognosis Carcinoma of Unknown Primary Site (CUP)

Phase 2

Active

PI: Jose Monzon, MD (Arthur J.E. Child Comprehensive Cancer Centre) · Sites: Calgary, Alberta; Edmonton, Alberta +1 more · Age: 18–99 yrs

Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study

Phase 2

Actively Recruiting

PI: Scott C. Lester, M.D. (Mayo Clinic in Rochester) · Sites: Phoenix, Arizona; Scottsdale, Arizona +7 more · Age: 18–99 yrs

Olanzapine for Managing Anorexia in Head and Neck Cancer Patients Undergoing Chemoradiation, MACRO Trial

Phase 2

Actively Recruiting

PI: Anurag K Singh (Roswell Park Cancer Institute) · Sites: Buffalo, New York · Age: 18–99 yrs

Lovastatin and Pembrolizumab for the Treatment of Patients With Recurrent or Metastatic Head and Neck Cancer, LAPP Trial

Phase 2

Actively Recruiting

PI: Nicole C Schmitt, D, FACS (Emory University Hospital/Winship Cancer Institute) · Sites: Atlanta, Georgia; Atlanta, Georgia · Age: 18–99 yrs

Cemiplimab, Low-Dose Paclitaxel and Carboplatin for the Treatment of Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck

Phase 2

Active

PI: Marcelo R Bonomi, MD (Ohio State University Comprehensive Cancer Center) · Sites: Columbus, Ohio · Age: 18–99 yrs

Phase 14 trials

Testing the Addition of M6620 (VX-970, Berzosertib) to Usual Chemotherapy and Radiation for Head and Neck Cancer

Phase 1

Active

PI: Taofeek K Owonikoko (JHU Sidney Kimmel Comprehensive Cancer Center LAO) · Sites: Duarte, California; Sacramento, California +17 more · Age: 18–99 yrs

Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer

Phase 1

Actively Recruiting

PI: Malcolm D Mattes (University Health Network Princess Margaret Cancer) · Sites: Tampa, Florida; Chicago, Illinois +16 more · Age: 18–99 yrs

TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer

Phase 1

Actively Recruiting

PI: Dong M. Shin, MD, FACP, FAAAS (Emory University) · Sites: Atlanta, Georgia; Atlanta, Georgia · Age: 18–99 yrs

Combining Immunotherapy Salvage Surgery & IORT Tx Persistent/Recurrent Head & Neck Cancer

Phase 1

Actively Recruiting

PI: Dukagjin M Blakaj, MD, PhD (Ohio State University Comprehensive Cancer Center) · Sites: Columbus, Ohio · Age: 18–99 yrs

N/A5 trials

[18F]F-FAPI PET-CT to Identify Carcinoma of Unknown Primary Origin

N/A

Actively Recruiting

PI: Sophie Veldhuijzen van Zanten (Erasmus Medical Center) · Sites: Amsterdam; Groningen +4 more · Age: 18–99 yrs

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

N/A

Actively Recruiting

PI: Gabriel A. Brooks, MD, MPH (Alliance for Clinical Trials in Oncology) · Sites: Phoenix, Arizona; Fort Smith, Arkansas +269 more · Age: 18–99 yrs

Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation

N/A

Actively Recruiting

PI: Nicole C Schmitt, MD, FACS (Emory University Hospital/Winship Cancer Institute) · Sites: Atlanta, Georgia · Age: 18–99 yrs

Cancer Genetic Testing in Ethnic Populations

N/A

Actively Recruiting

PI: Jewel Samadder, M.D. (Mayo Clinic) · Sites: Scottsdale, Arizona; Jacksonville, Florida · Age: 18–99 yrs

TCF-001 TRACK (Target Rare Cancer Knowledge) Study

N/A

Actively Recruiting

PI: Razelle Kurzrock, M.D. (Medical College of Wisconsin) · Sites: Cambridge, Massachusetts · Age: 18–99 yrs

Other1 trial

Blood Tests and Questionnaires in Studying Adherence to Preventative Swallowing Exercises in Participants With Metastatic Head and Neck Cancer

Actively Recruiting

PI: Eileen H Shinn (M.D. Anderson Cancer Center) · Sites: Houston, Texas · Age: 18–99 yrs

Specialists

Showing 25 of 80View all specialists →

Kanwal Raghav

HOUSTON, TX

Specialist

PI on 1 active trial

Active trials Directions Travel grants

Jose Monzon, MD

SPRINGFIELD, MA

Specialist

PI on 1 active trial

Active trials Directions Travel grants

Sally Clive, MBChB

Specialist

PI on 1 active trial

Active trials Directions Travel grants

Daniel J. Ma, M.D.

Specialist

PI on 1 active trial

Active trials Directions Travel grants

Michele Bibas

Specialist

1 Cancer of unknown primary site publication

Directions Travel grants

Dongmei Li

EL PASO, TX

Specialist

1 Cancer of unknown primary site publication

Directions Travel grants

Maria Fransisca Ham

Specialist

1 Cancer of unknown primary site publication

Directions Travel grants

Tadeusz Dorobisz

Specialist

2 Cancer of unknown primary site publications

Directions Travel grants

Karolina Dorobisz

Specialist

2 Cancer of unknown primary site publications

Directions Travel grants

Indrati Suroyo

Specialist

1 Cancer of unknown primary site publication

Directions Travel grants

Alvita Dewi Siswoyo

Specialist

1 Cancer of unknown primary site publication

Directions Travel grants

Joseph A Bellanti

ANNANDALE, VA

Specialist

1 Cancer of unknown primary site publication

Directions Travel grants

João Neif Antonio Junior

Specialist

1 Cancer of unknown primary site publication

Directions Travel grants

Renaningtyas Tambun

Specialist

1 Cancer of unknown primary site publication

Directions Travel grants

Lie Rebecca Yen Hwei

Specialist

1 Cancer of unknown primary site publication

Directions Travel grants

Erwin Danil Yulian

Specialist

1 Cancer of unknown primary site publication

Directions Travel grants

Daniel D 'Almeida Preto

Specialist

1 Cancer of unknown primary site publication

Directions Travel grants

Katarzyna Pazdro-Zastawny

Specialist

2 Cancer of unknown primary site publications

Directions Travel grants

Rubén Cuesta-Barriuso, PhD

Specialist

Chronic graft versus host disease Congenital deformities of limbs Hemophilia+4 more

PI on 19 active trials

Active trials Directions Travel grants

John D. Hainsworth, MD

NASHVILLE, TN

Specialist

Acquired cystic disease-associated renal cell carcinoma B-cell chronic lymphocytic leukemia B-cell non-Hodgkin lymphoma+3 more

PI on 11 active trials

Active trials Directions Travel grants

Lillian Siu, MD

Specialist

Adenocarcinoma of the cervix uteri Bannayan-Riley-Ruvalcaba syndrome Genetic head and neck malformation+18 more

PI on 13 active trials

Active trials Directions Travel grants

Athanassios (Ethan) Argiris

Mobile, Alabama

Specialist

Rare Disease Specialist

Lymphoid interstitial pneumonia NON RARE IN EUROPE: Non-small cell lung cancer

PI on 2 active trials

Active trials Directions Travel grants

Sunil Sharma, MD

Specialist

Adenocarcinoma of the cervix uteri Chromophobe renal cell carcinoma Congenital cystic eye+10 more

PI on 5 active trials

Active trials Directions Travel grants

Niloy J Samadder

SCOTTSDALE, AZ

Specialist

Attenuated familial adenomatous polyposis Familial adenomatous polyposis Genetic intestinal polyposis+3 more

PI on 4 active trials3 Cancer of unknown primary site publications

Active trials Directions Travel grants

Stanislaw R. Burzynski, MD, PhD

HOUSTON, TX

Specialist

Adamantinoma Adenoma of pancreas Adrenocortical carcinoma+32 more

PI on 29 active trials

Active trials Directions Travel grants

Treatment Centers

8 centers

⚗️ Trial Site

Banner University Medical Center - Tucson

📍 Tucson, Arizona

⚗️ Trial Site

University of Alabama at Birmingham Cancer Center

📍 Birmingham, Alabama

⚗️ Trial Site

University of Arkansas for Medical Sciences

📍 Little Rock, Arkansas

⚗️ Trial Site

PCR Oncology

📍 Arroyo Grande, California

⚗️ Trial Site

University of Arizona Cancer Center-North Campus

📍 Tucson, Arizona

⚗️ Trial Site

Mercy Hospital Fort Smith

📍 Fort Smith, Arkansas

⚗️ Trial Site

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

📍 Jonesboro, Arkansas

⚗️ Trial Site

Fairbanks Memorial Hospital

📍 Fairbanks, Alaska

Travel Grants

No travel grants are currently matched to Cancer of unknown primary site.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Cancer of unknown primary site

Disease timeline:

New recruiting trial: Effectiveness and Tolerability of Eptinezumab

A new clinical trial is recruiting patients for Cancer of unknown primary site

New recruiting trial: RimegepAnt effectIvenesS and tolErability as Migraine Preventive Treatment

A new clinical trial is recruiting patients for Cancer of unknown primary site

New recruiting trial: Stereotactic Ablative Radiotherapy (SABR) for the Treatment of Patients With Metastatic Cancer, ID-COMET Trial

A new clinical trial is recruiting patients for Cancer of unknown primary site

New recruiting trial: A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

A new clinical trial is recruiting patients for Cancer of unknown primary site

New recruiting trial: Gepant treAtments: EffectIveNess and tolERability (GAINER)

A new clinical trial is recruiting patients for Cancer of unknown primary site

New recruiting trial: A Randomized Controlled Study Evaluating Modified Cup Anteversion Placement in Prevention of Postoperative Dislocation in Patients Undergoing Acetabular Tumor Resection and Reconstruction

A new clinical trial is recruiting patients for Cancer of unknown primary site

New recruiting trial: Effect of Lithotomy Position on Optic Nerve Sheath Diameter

A new clinical trial is recruiting patients for Cancer of unknown primary site

New recruiting trial: Dual-mobility Cups Compared to Unipolar Cups on Dislocation and Cost-effectiveness After Primary Total Hip Arthroplasty.

A new clinical trial is recruiting patients for Cancer of unknown primary site

New recruiting trial: Observational Study to Evaluate Long-Term Outcome in Hip Arthroplasty

A new clinical trial is recruiting patients for Cancer of unknown primary site

New recruiting trial: Effectiveness and Acceptability of Insertable Devices for Obstetric Fistula Management

A new clinical trial is recruiting patients for Cancer of unknown primary site

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Cancer of unknown primary site

Are there clinical trials for Cancer of unknown primary site?

Yes — 19 recruiting clinical trials are currently listed for Cancer of unknown primary site on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Cancer of unknown primary site?

25 specialists and care centers treating Cancer of unknown primary site are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.