Chronic graft versus host disease

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4FDA treatments32Active trials54Specialists8Treatment centers3Financial resources

Where are you in your journey?

UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Clinical phenotype terms— hover any for plain English:

Intermittent generalized erythematous papular rashHP:0007432Recurrent corneal erosionsHP:0000495OnycholysisHP:0001806Food intoleranceHP:0012537Abnormal vagina morphologyHP:0000142
Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Nov 2026Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine

VA Office of Research and Development — PHASE3

TrialNOT YET RECRUITING
May 2026Shock Wave Therapy as a Treatment Intervention for Frozen Shoulder

University of Stirling — NA

TrialNOT YET RECRUITING
May 2026A Mechanistic Study on the Effect of HTD1801 Versus Placebo on Kidney Function in Patients With Type 2 Diabetes and Chronic Kidney Disease.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences — PHASE2

TrialNOT YET RECRUITING
Apr 2026A Study to Investigate Safety of Belumosudil in Participants Aged 12 Years and Above, With Chronic Graft-versus-host Disease (cGVHD)

Sanofi — PHASE4

TrialNOT YET RECRUITING
Mar 2026A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)

Incyte Corporation — PHASE2

TrialRECRUITING
Mar 2026Mobile Health Self-Management Intervention for Patient With Chronic Obstructive Pulmonary Disease

Universitas Katolik Widya Mandala Surabaya — NA

TrialNOT YET RECRUITING
Mar 2026Validation of a Virtual Reality Timed Up and Go Test in Adults With Chronic Non-Specific Low Back Pain

Selcuk University

TrialNOT YET RECRUITING
Mar 2026Assessing and Improving Misuse of Inhalers in COPD Outpatients

Hôpital Fribourgeois — NA

TrialNOT YET RECRUITING
Feb 2026Evaluation of Belumosudil Whole Tablets vs. Crushed Tablets Pharmacokinetics in Patients Suffering From Chronic GvHD

M.D. Anderson Cancer Center

TrialRECRUITING
Feb 2026A Phase 3 Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults at High Risk of Delayed Graft Function (DGF) Following Kidney Allograft Transplantation

Apellis Pharmaceuticals, Inc. — PHASE3

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

4 available

IMBRUVICA

ibrutinib· Pharmacyclics, LLC

IMBRUVICA is indicated for the treatment of adult and pediatric patients age 1 year and older with chronic graft-versus-host disease (cGVHD) after failure of one or more lines of systemic therapy.

Rezurock

belumosudil· Kadmon Pharmaceuticals, LLC
REZUROCK is indicated for the treatment of adult and pediatric patients 12 years and older with chronic graft-versus-host disease (chronic GVHD) after failure of at least two prior lines of systemic t

REZUROCK is indicated for the treatment of adult and pediatric patients 12 years and older with chronic graft-versus-host disease (chronic GVHD) after failure of at least two prior lines of systemic therapy.

JAKAFI

RUXOLITINIB· Incyte Corporation

treatment of chronic graft-versus-host disease after failure of one or two lines of systemic therapy in adult and pediatric patients 12 years and older

Niktimvo

axatilimab-csfr· Incyte CorporationOrphan Drug

treatment of chronic graft-versus-host disease (cGVHD) after failure of at least two prior lines of systemic therapy in adult and pediatric patients weighing at least 40 kg

Clinical Trials

20 recruitingView all trials with filters →
Phase 33 trials
A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease
Phase 3
Actively Recruiting
PI: Albert Assad, MD (Incyte Corporation) · Sites: Birmingham, Alabama; La Jolla, California +113 more · Age: 1299 yrs
A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.
Phase 3
Active
· Sites: Little Rock, Arkansas; Duarte, California +149 more · Age: 1299 yrs
A Study to Evaluate Axatilimab Versus Best Available Therapy in Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy
Phase 3
Active
PI: Incyte Medical Monitor (Incyte Corporation) · Sites: Graz; Innsbruck +128 more · Age: 1299 yrs
Phase 41 trial
A Clinical Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Belumosudil in Chinese Adolescents With cGVHD Who Have Had an Inadequate Response to Glucocorticoids or Other Systemic Therapies
Phase 4
Active
PI: Clinical Sciences & Operations (Sanofi) · Sites: Beijing; Shanghai · Age: 1217 yrs
Phase 214 trials
A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)
Phase 2
Active
PI: Vedran Radojcic, M.D. (Syndax Pharmaceuticals) · Sites: Birmingham, Alabama; Birmingham, Alabama +119 more · Age: 299 yrs
Belumosudil for the Pre-emptive Treatment of Patients With Chronic Graft Versus Host Disease
Phase 2
Actively Recruiting
PI: Stephanie Lee, MD, MPH (Fred Hutch/University of Washington Cancer Consort) · Sites: Tampa, Florida; Boston, Massachusetts +2 more · Age: 1899 yrs
Therapeutic Effects of Hydrogen on Steroid-refractory/or Steroid-dependent cGVHD
Phase 2
Actively Recruiting
PI: Liren Qian, M.D. (Navy General Hospital, Beijing) · Sites: Beijing, Beijing Municipality · Age: 065 yrs
Daily IL-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease
Phase 2
Active
PI: John Koreth, MBBS, DPhil (Dana-Farber Cancer Institute) · Sites: Boston, Massachusetts; Boston, Massachusetts +1 more · Age: 1899 yrs
Belumosudil and Rituximab for Primary Treatment of Chronic Graft-Versus-Host-Disease
Phase 2
Actively Recruiting
PI: Scott Solomon, MD (BMTGA/Northside Hospital) · Sites: Atlanta, Georgia · Age: 1899 yrs
A Study to Evaluate the Safety and Efficacy of Axatilimab in Combination With Ruxolitinib in Participants With Newly Diagnosed Chronic Graft-Versus-Host Disease
Phase 2
Actively Recruiting
PI: Incyte Medical Monitor (Incyte Corporation) · Sites: Phoenix, Arizona; Duarte, California +68 more · Age: 1299 yrs
A Study of Belumosudil in Children With Chronic Graft Versus Host Disease (schoolROCK)
Phase 2
Actively Recruiting
· Sites: New York, New York; Houston, Texas +21 more · Age: 118 yrs
A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)
Phase 2
Actively Recruiting
PI: Incyte Medical Monitor (Incyte Corporation) · Sites: Duarte, California; Stanford, California +36 more · Age: 217 yrs
A Clinical Trial of TQ05105 Tablets in the Treatment of Chronic Graft-versus-host Disease
Phase 2
Actively Recruiting
· Sites: Hefei, Anhui; Lanzhou, Gansu +10 more · Age: 1870 yrs
Axatilimab in Combination With Extracorporeal Photopheresis (ECP) in Chronic Graft-versus-Host Disease
Phase 2
Actively Recruiting
PI: Trent P Wang, DO (University of Miami) · Sites: Miami, Florida · Age: 1299 yrs
Ruxolitinib vs Prednisone as First-line Therapy for cGVHD Needing Systemic Therapy
Phase 2
Actively Recruiting
PI: Farhad Khimani, MD (Moffitt Cancer Center) · Sites: Miami, Florida; Tampa, Florida +2 more · Age: 1899 yrs
Axatilimab for Sclerotic Chronic Graft-versus-Host Disease
Phase 2
Actively Recruiting
PI: Stephanie J. Lee, MD, MPH (Fred Hutch/University of Washington Cancer Consort) · Sites: Tampa, Florida; Boston, Massachusetts +1 more · Age: 1899 yrs
Ibrutinib for the Prevention of Chronic Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplant
Phase 2
Actively Recruiting
PI: Mohamed A. Kharfan Dabaja, MD, MBA (Mayo Clinic) · Sites: Jacksonville, Florida · Age: 1899 yrs
A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)
Phase 2
Actively Recruiting
PI: Clinical Team (Deciphera Pharmaceuticals, LLC) · Sites: Duarte, California; Los Angeles, California +24 more · Age: 1899 yrs
Other2 trials
Improving Outcomes Assessment in Chronic GVHD
Active
PI: Stephanie J Lee, MD MPH (Fred Hutchinson Cancer Center) · Sites: Stanford, California; Tampa, Florida +7 more · Age: 299 yrs
Evaluation of Belumosudil Whole Tablets vs. Crushed Tablets Pharmacokinetics in Patients Suffering From Chronic GvHD
Actively Recruiting
PI: Amin Alousi, MD (M.D. Anderson Cancer Center) · Sites: Houston, Texas · Age: 1899 yrs

Specialists

Showing 25 of 54View all specialists →
RP
Rubén Cuesta-Barriuso, PhD
Specialist
PI on 19 active trials
KM
Kenneth Peters, MD
Specialist
PI on 8 active trials
AP
Andrew Zelenetz, MD, PhD
NEW YORK, NY
Specialist
PI on 3 active trials
SM
Satish R Raj, MD MSCI
Nashville, Tennessee
Specialist

Rare Disease Specialist

PI on 17 active trials
DM
David S Schrump, M.D.
BETHESDA, MD
Specialist
PI on 19 active trials
FP
Franck DURIF, Pr
Specialist
PI on 2 active trials
JP
James L. Rubenstein, MD, PhD
Specialist
PI on 2 active trials
SD
Silvia Ulrich Somaini, Prof. Dr.
Specialist
PI on 2 active trials
NS
Neha Sharma
Specialist
PI on 1 active trial
DP
Don Kellerman, PharmD
Specialist
PI on 1 active trial
JP
Jennifer B Brown, MD, PhD
Specialist
PI on 1 active trial
PP
Piercarlo Sarzi-Puttini, MD, Professor
Specialist
PI on 1 active trial
LP
Lorys Castelli, Professor
Specialist
PI on 1 active trial
FP
Federica Galli, Professor
Specialist
PI on 1 active trial
CD
Cristina Iannuccelli, Dr
Specialist
PI on 1 active trial
SP
Sara Bottiroli, Professor
Specialist
PI on 1 active trial
HM
Hye Won Song, MD
Specialist
PI on 1 active trial
JM
Joan albert Barbera, MD
Specialist
PI on 1 active trial
FP
François-Xavier MAHON, Pr
Specialist
PI on 1 active trial
DM
David M Spiegel, MD
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Financial Resources

3 resources
JAKAFI(RUXOLITINIB)Incyte Corporation
Niktimvo(axatilimab-csfr)Incyte Corporation

Orencia

Bristol-Myers Squibb Co.

Orencia Patient Support (BMS Access Support)

Patient Assistance
Manufacturer Program
Accepting applications

Travel Grants

No travel grants are currently matched to Chronic graft versus host disease.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Chronic graft versus host disease

5 articles
NewsEXPERT OPINION ON BIOLOGICAL THERAPYApr 22, 2026
Emerging strategies for the prevention and management of chronic graft-versus-host disease.
Chronic graft-versus-host disease remains a major cause of late morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Conventional p
NewsSTEM CELL REVIEWS AND REPORTSApr 20, 2026
Evolving Paradigms in Chronic Graft-Versus-Host Disease: From Global Immunosuppression to Precision Targeted and Cell-Based Therapies.
Evolving Paradigms in Chronic Graft-Versus-Host Disease: From Global Immunosuppression to Precision Targeted and Cell-Based Therapies.
NewsTRANSPLANTATION AND CELLULAR THERAPYApr 8, 2026
Belumosudil for Chronic Graft-Versus-Host Disease: A Systematic Review and Meta-Analysis.
Chronic graft-versus-host disease (cGvHD) is a debilitating complication following allogeneic hematopoietic stem cell transplantation, often refractory to stand
NewsTRANSPLANTATION AND CELLULAR THERAPYApr 8, 2026
Toward Better and More Effective Clinical Trials for Chronic Graft-Versus-Host Disease.
While the incidence of chronic Graft-versus-Host Disease (chronic GVHD) is declining due to advances in prophylaxis and survival is improving due to better supp
NewsBONE MARROW TRANSPLANTATIONApr 7, 2026
Chronic graft-versus-host disease: Current situation and unmet needs - A European position statement.
Chronic graft-versus-host disease (cGVHD) remains the leading cause of late morbidity and non-relapse mortality after allogeneic hematopoietic cell transplantat
See all news about Chronic graft versus host disease

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Chronic graft versus host disease

Are there clinical trials for Chronic graft versus host disease?

Yes — 20 recruiting clinical trials are currently listed for Chronic graft versus host disease on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Chronic graft versus host disease?

25 specialists and care centers treating Chronic graft versus host disease are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.

What treatment and support options exist for Chronic graft versus host disease?

2 patient support programs are currently tracked on UniteRare for Chronic graft versus host disease. See the treatments and support programs sections for copay assistance, eligibility, and contact details.