Chronic graft versus host disease

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At a Glance

Live from database

Regulatory Watchboard

10 events
Nov 2026Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine

VA Office of Research and Development — PHASE3

TrialNOT YET RECRUITING
May 2026A Mechanistic Study on the Effect of HTD1801 Versus Placebo on Kidney Function in Patients With Type 2 Diabetes and Chronic Kidney Disease.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences — PHASE2

TrialNOT YET RECRUITING
May 2026Shock Wave Therapy as a Treatment Intervention for Frozen Shoulder

University of Stirling — NA

TrialNOT YET RECRUITING
Apr 2026A Study to Investigate Safety of Belumosudil in Participants Aged 12 Years and Above, With Chronic Graft-versus-host Disease (cGVHD)

Sanofi — PHASE4

TrialNOT YET RECRUITING
Mar 2026A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)

Incyte Corporation — PHASE2

TrialRECRUITING
Mar 2026Mobile Health Self-Management Intervention for Patient With Chronic Obstructive Pulmonary Disease

Universitas Katolik Widya Mandala Surabaya — NA

TrialNOT YET RECRUITING
Mar 2026Validation of a Virtual Reality Timed Up and Go Test in Adults With Chronic Non-Specific Low Back Pain

Selcuk University

TrialNOT YET RECRUITING
Mar 2026Assessing and Improving Misuse of Inhalers in COPD Outpatients

Hôpital Fribourgeois — NA

TrialNOT YET RECRUITING
Feb 2026Evaluation of Belumosudil Whole Tablets vs. Crushed Tablets Pharmacokinetics in Patients Suffering From Chronic GvHD

M.D. Anderson Cancer Center

TrialRECRUITING
Feb 2026A Phase 3 Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults at High Risk of Delayed Graft Function (DGF) Following Kidney Allograft Transplantation

Apellis Pharmaceuticals, Inc. — PHASE3

TrialRECRUITING

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

2 programs

FINANCIAL LANDSCAPE SUMMARY

2

Total programs

2

Open now

1

Copay cards

Copay Assistance1

NIKTIMVO

Incyte

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Patient Assistance Programs1

Orencia

Bristol-Myers Squibb Co.

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Approved Treatments

4 FDA-approved

Niktimvo

(axatilimab-csfr)Orphan drug

Incyte Corporation

Colony Stimulating Factor-1 Receptor Blocker [EPC]

12.1 Mechanism of Action Axatilimab-csfr is a monoclonal antibody that binds to colony stimulating factor-1 receptors (CSF-1R) expressed on monocytes ...

Approved Aug 2024FDA label ↗

IMBRUVICA

(ibrutinib)Orphan drugstandard

Pharmacyclics, LLC

Kinase Inhibitor [EPC]

12.1 Mechanism of Action Ibrutinib is a small-molecule inhibitor of Bruton’s tyrosine kinase (BTK). Ibrutinib forms a covalent bond with a cysteine re...

FDA label ↗

Rezurock

(belumosudil)Orphan drugstandard

Kadmon Pharmaceuticals, LLC

12.1 Mechanism of Action Belumosudil is an inhibitor of rho-associated, coiled-coil containing protein kinase (ROCK) which inhibits ROCK2 and ROCK1 wi...

FDA label ↗

JAKAFI

(RUXOLITINIB)Orphan drugstandard

Incyte Corporation

FDA label ↗

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Clinical Trial Landscape

32 active trials
3Phase 3
1Phase 4
14Phase 2
4Phase 1
4N/A
2Unknown
4PHASE1, PHASE2
32Total recruiting
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Recent News & Research

6 articles
Expert opinion on biological therapyApr 22, 2026

Emerging strategies for the prevention and management of chronic graft-versus-host disease.

Chronic graft-versus-host disease remains a major cause of late morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Conventional prevention and management strategies, hea...

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Stem cell reviews and reportsApr 20, 2026

Evolving Paradigms in Chronic Graft-Versus-Host Disease: From Global Immunosuppression to Precision Targeted and Cell-Based Therapies.

Evolving Paradigms in Chronic Graft-Versus-Host Disease: From Global Immunosuppression to Precision Targeted and Cell-Based Therapies.

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Transplantation and cellular therapyApr 8, 2026

Belumosudil for Chronic Graft-Versus-Host Disease: A Systematic Review and Meta-Analysis.

Chronic graft-versus-host disease (cGvHD) is a debilitating complication following allogeneic hematopoietic stem cell transplantation, often refractory to standard therapies. Belumosudil, a selective ...

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Transplantation and cellular therapyApr 8, 2026

Toward Better and More Effective Clinical Trials for Chronic Graft-Versus-Host Disease.

While the incidence of chronic Graft-versus-Host Disease (chronic GVHD) is declining due to advances in prophylaxis and survival is improving due to better supportive care, first-line treatment of chr...

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Bone marrow transplantationApr 7, 2026

Chronic graft-versus-host disease: Current situation and unmet needs - A European position statement.

Chronic graft-versus-host disease (cGVHD) remains the leading cause of late morbidity and non-relapse mortality after allogeneic hematopoietic cell transplantation, despite major advances in transplan...

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Arthritis & rheumatology (Hoboken, N.J.)Apr 7, 2026

Linezolid-mediated Prevention of Fibroblast Activation and Tissue Fibrosis via Mitochondrial Translation Inhibition.

Beyond its role as a ribosome-targeting antibiotic, linezolid was recently shown to modulate immune responses by inhibiting mitochondrial translation. Because mitochondrial dysfunction is implicated i...

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Specialist Network

Top 6 by expertise

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