Pulmonary arterial hypertension

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ORPHA:182090
Who is this for?
Show terms as
20FDA treatments1Active trials27Specialists8Treatment centers25Financial resources

Where are you in your journey?

UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Pulmonary Arterial Hypertension is treated with 19 medications in our database, including Ambrisentan, EPOPROSTENOL, BYQLOVI, Sterile Diluent for Treprostinil, Treprostinil, bosentan, and 14 more. 12 of these have manufacturer assistance programs available to help reduce out-of-pocket costs. Medications are manufactured by Gilead, GlaxoSmithKline, Laurus, United Therapeutics, Actelion and others. Patients and caregivers can find copay cards, patient assistance programs, and travel grants for Pulmonary Arterial Hypertension treatment below.

Also known as:

Inheritance

Variable

Can be inherited in different ways depending on the underlying gene

Age of Onset

Variable

Can begin at different ages, from infancy through adulthood

Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Apr 2026

BOSENTAN: New indication approved

FDAcompleted
Apr 2026

BOSENTAN: New indication approved

FDAcompleted
Apr 2026TYVASO: New indication approved
FDAcompleted
Apr 2026

BOSENTAN: New indication approved

FDAcompleted
Mar 2026WINREVAIR: New indication approved
FDAcompleted
Mar 2026

BOSENTAN: New indication approved

FDAcompleted
Mar 2026

BOSENTAN: New indication approved

FDAcompleted
Mar 2026TRACLEER: New indication approved
FDAcompleted
Mar 2026TRACLEER: New indication approved
FDAcompleted
Mar 2026

BOSENTAN: New indication approved

FDAcompleted

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

20 available

WINREVAIR

SOTATERCEPT-CSRK· Merck Sharp & Dohme LLC
indicated for the treatment of adults with pulmonary arterial hypertension (PAH, Group 1 pulmonary hypertension) to improve exercise capacity and World Health Organization (WHO) functional class (FC),

indicated for the treatment of adults with pulmonary arterial hypertension (PAH, Group 1 pulmonary hypertension) to improve exercise capacity and World Health Organization (WHO) functional class (FC), and reduce the risk of clinical worsening events including hospitalization for PAH, lung transplantation and death

Flolan

EPOPROSTENOL SODIUM· GlaxoSmithKline LLC

FLOLAN is indicated for the treatment of pulmonary arterial hypertension (PAH) (WHO Group I) to improve exercise capacity

Sildenafil

SILDENAFIL POWDER,· Camber Pharmaceuticals, Inc.

indicated for the treatment of pulmonary arterial hypertension (PAH) (World Health Organization [WHO] Group I) in adults to improve exercise ability and delay clinical worsening

Sildenafil

SILDENAFIL CITRATE· ANI Pharmaceuticals, Inc.

indicated for the treatment of pulmonary arterial hypertension (PAH) (World Health Organization [WHO] Group I) in adults to improve exercise ability and delay clinical worsening

Sildenafil

SILDENAFIL· Asclemed USA, Inc.

indicated for the treatment of pulmonary arterial hypertension (WHO Group I) in adults to improve exercise ability and delay clinical worsening

Epoprostenol

EPOPROSTENOL· Mylan Institutional LLC

indicated for the treatment of pulmonary arterial hypertension (PAH) (WHO Group 1) to improve exercise capacity

Opsynvi

MACITENTAN AND TADALAFIL· Actelion Pharmaceuticals US, Inc.■ Boxed WarningOrphan Drug

chronic treatment of adults with pulmonary arterial hypertension (PAH, WHO Group I and WHO Functional Class (FC) II-III)

Tyvaso DPI

treprostinil inhalation powder· United Therapeutics CorporationOrphan Drug

Treatment of pulmonary arterial hypertension (PAH; WHO Group 1) to improve exercise ability

Uptravi

selexipag· JanssenOrphan Drug

Indicated for PAH to delay disease progression and reduce hospitalization risk.

Opsumit

macitentan· Janssen■ Boxed WarningOrphan Drug

Indicated for PAH to delay disease progression. Dual endothelin receptor antagonist.

Tyvaso

treprostinil· United TherapeuticsOrphan Drug

Indicated to improve exercise ability in PAH patients. Prostacyclin analog.

Tadalafil

TADALAFIL· Northwind Health Company, LLCOrphan Drug

Treatment of pulmonary arterial hypertension (WHO Group I) to improve exercise ability

Ambrisentan

AMBRISENTAN· Cipla USA Inc.■ Boxed WarningOrphan Drug

Treatment of pulmonary arterial hypertension (WHO group I) in patients with WHO class II or III symptoms to improve exercise capacity and delay clinical worsening

Ventavis

Iloprost inhalation solution· CoTherix, Inc.Orphan Drug

Treatment of pulmonary arterial hypertension (WHO Group I) in patients with NYHA Class III or IV symptoms

Bosentan

BOSENTAN· Actavis Pharma, Inc.■ Boxed WarningOrphan Drug

Treatment of pulmonary arterial hypertension.

BYQLOVI

clobetasol propionate· ANI Pharmaceuticals

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program fo

Treprostinil, DILUENT

· United Therapeutics

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program fo

Revonto

dantrolene sodium· US WorldMeds

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program fo

Oxygen/Nitrogen 38/62

Oxygen/Nitrogen 38/62· Airgas

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program fo

Sterile Diluent for Treprostinil, Treprostinil

· United Therapeutics

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program fo

Clinical Trials

1 recruitingView all trials with filters →
N/A1 trial
Cognitive Alterations in Pulmonary Arterial Hypertension (PAH)
N/A
Active
· Sites: Milan, Italy · Age: 1899 yrs

Specialists

Showing 25 of 27View all specialists →
CM
Corey E Ventetuolo, MD, MS
RIVERSIDE, RI
Specialist
PI on 1 active trial
ER
Ester A Faried, Resident
Specialist
PI on 1 active trial
FP
F.A. Klok, MD PhD
Specialist
PI on 2 active trials
LP
Liang Zhong, PhD
Specialist
PI on 1 active trial
GM
G. Ganesh Konduri, MD
Specialist
PI on 2 active trials1 Pulmonary arterial hypertension publication
AM
Andrew Boyle, MD
Specialist
PI on 1 active trial1 Pulmonary arterial hypertension publication
KP
Kenneth W Rundell, Ph.D.
Specialist
PI on 1 active trial
EF
Elizabeth Orchard, MA, MBBS, FRCP
LOMA LINDA, CA
Specialist
PI on 1 active trial
JM
Joan albert Barbera, MD
Specialist
PI on 1 active trial
TD
Talant M Sooronbaev, Prof. Dr.
Specialist
PI on 4 active trials
LD
Lu Hua, Dr.
Specialist
PI on 1 active trial
DM
David F Lobach, MD, PhD, MS
DURHAM, NC
Specialist
PI on 1 active trial
SP
Steeve Provencher
Quebec City, QC
Specialist

Cardiology / Pulmonary Hypertension

SR
Sudarshan Rajagopal
Durham, NC
Specialist

Cardiology / Pulmonary Vascular Disease

RS
Rajan Saggar
Los Angeles, CA
Specialist

Pulmonology / Pulmonary Vascular Disease

NH
Nicholas S Hill
Boston, MA
Specialist

Pulmonology / Pulmonary Hypertension

AF
Adaani E Frost
Houston, TX
Specialist

Pulmonology / Pulmonary Vascular Disease

RO
Ronald J Oudiz
Torrance, CA
Specialist

Cardiology / Pulmonary Hypertension

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Financial Resources

19 resources
WINREVAIR(SOTATERCEPT-CSRK)Merck Sharp & Dohme LLC
Flolan(EPOPROSTENOL SODIUM)GlaxoSmithKline LLC
Sildenafil(SILDENAFIL POWDER,)Camber Pharmaceuticals, Inc.
Sildenafil(SILDENAFIL CITRATE)ANI Pharmaceuticals, Inc.
Sildenafil(SILDENAFIL)Asclemed USA, Inc.
Epoprostenol(EPOPROSTENOL)Mylan Institutional LLC
Opsynvi(MACITENTAN AND TADALAFIL)Actelion Pharmaceuticals US, Inc.
Tyvaso DPI(treprostinil inhalation powder)United Therapeutics Corporation
Tyvaso(treprostinil)United Therapeutics
Tadalafil(TADALAFIL)Northwind Health Company, LLC
Ambrisentan(AMBRISENTAN)Cipla USA Inc.
Bosentan(BOSENTAN)Actavis Pharma, Inc.

PAN Foundation — Pulmonary arterial hypertension

PAN Foundation

Pulmonary arterial hypertension

Verified 3d ago
Foundation Grant
foundation grant
Accepting applications

NORD Patient Assistance — Pulmonary arterial hypertension

NORD Patient Assistance

Pulmonary arterial hypertension

Verified 3d ago
Foundation Grant
foundation grant
Accepting applications

Good Days — Pulmonary arterial hypertension

Good Days

Pulmonary arterial hypertension

Verified 3d ago
Foundation Grant
foundation grant
Accepting applications

HealthWell Foundation — Pulmonary arterial hypertension

HealthWell Foundation

Pulmonary arterial hypertension

Verified 3d ago
Foundation Grant
foundation grant
Accepting applications

The Assistance Fund — Pulmonary arterial hypertension

The Assistance Fund

Pulmonary arterial hypertension

Verified 3d ago
Foundation Grant
foundation grant
Accepting applications

Patient Advocate Foundation — Pulmonary arterial hypertension

Patient Advocate Foundation

Pulmonary arterial hypertension

Verified 3d ago
Foundation Grant
foundation grant
Accepting applications

Patient Services Inc — Pulmonary arterial hypertension

Patient Services Inc

Pulmonary arterial hypertension

Verified 3d ago
Foundation Grant
foundation grant
Accepting applications

6 travel grants are also available for Pulmonary arterial hypertension patients — see Travel Grants below ↓

Travel Grants

6 grants

PAN Foundation Pulmonary Hypertension Copay Grant

PAN Foundation

Applicants must be receiving treatment for pulmonary hypertension in the United States and have health insurance that covers their qualifying prescribed medication. Eligibility also requires a household income at or below 500% of the Federal Poverty Level.

Apply ↗Up to $13,500

ONWARD Patient Support Program

UCB

The ONWARD program is available to patients aged 2 years and older who are prescribed FINTEPLA for Dravet syndrome or Lennox-Gastaut syndrome. It provides access to financial support resources, clinical education, and dedicated care coordination to assist with insurance and treatment navigation.

Apply ↗

QuickRx Specialty Pharmacy Tyvaso Copay Assistance

QuickRx Specialty Pharmacy

Eligibility is based on having a valid prescription for FDA-approved PAH treatment and varies by insurance type, including commercial, Medicare/Medicaid, or uninsured status. Requirements typically include US residency, age 18 or older, and demonstrated financial need for specific foundation or manufacturer assistance.

Apply ↗

Tyvaso Patient Assistance Program

Eligibility generally requires patients to be uninsured or underinsured, reside in the U.S., and demonstrate financial hardship. Specific programs mention income limits up to 500% of the Federal Poverty Level, though many evaluate applications on a case-by-case basis.

Apply ↗

GSK for You Patient Assistance Program

GSK

Eligibility is determined by pharmaceutical manufacturers based on income limits, insurance status, and financial need, with specific thresholds like 300% FPL mentioned for certain medications. Programs typically require patients to be either commercially insured for co-pay assistance or uninsured/underinsured for free medication through patient assistance foundations.

Apply ↗

Opsumit Patient Assistance Enrollment Form

Apply ↗

Community

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Latest news about Pulmonary arterial hypertension

4 articles
ResearchRSSApr 22, 2026
RUNX1 gene may serve as biomarker for right heart failure in PAH
Scientists found that a gene called RUNX1 might help doctors predict when patients with pulmonary arterial hypertension (PAH) — a serious lung disease that make
NewsRSSApr 22, 2026
Test Your Knowledge About Riociguat for the Treatment of PAH
This article is a quiz that tests what you know about riociguat, a medication used to treat pulmonary arterial hypertension (PAH). PAH is a rare condition where
Clinical trialRSSApr 22, 2026
First patient enrolled in Phase 3 trial of PAH treatment IKT-001
A new clinical trial has started testing a drug called IKT-001 in people with pulmonary arterial hypertension (PAH), a rare condition where blood vessels in the
NewsRSSApr 22, 2026
Orenitram (oral treprostinil) for pulmonary arterial hypertension
Orenitram is a pill form of a medicine called treprostinil that helps people with pulmonary arterial hypertension (a serious lung condition where blood vessels
See all news about Pulmonary arterial hypertension

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Pulmonary arterial hypertension

What is Pulmonary arterial hypertension?

Pulmonary Arterial Hypertension is treated with 19 medications in our database, including Ambrisentan, EPOPROSTENOL, BYQLOVI, Sterile Diluent for Treprostinil, Treprostinil, bosentan, and 14 more. 12 of these have manufacturer assistance programs available to help reduce out-of-pocket costs. Medications are manufactured by Gilead, GlaxoSmithKline, Laurus, United Therapeutics, Actelion and others. Patients and caregivers can find copay cards, patient assistance programs, and travel grants for Pulmonary Arterial Hypertension treatment below.

Are there clinical trials for Pulmonary arterial hypertension?

Yes — 1 recruiting clinical trial is currently listed for Pulmonary arterial hypertension on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Pulmonary arterial hypertension?

25 specialists and care centers treating Pulmonary arterial hypertension are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.

What treatment and support options exist for Pulmonary arterial hypertension?

16 FDA-approved treatments and 20 patient support programs are currently tracked on UniteRare for Pulmonary arterial hypertension. See the treatments and support programs sections for copay assistance, eligibility, and contact details.