Overview
Subcutaneous tissue disease (Orphanet code 79382) is a broad classification category within Orphanet that encompasses a heterogeneous group of rare disorders primarily affecting the subcutaneous tissue — the layer of fat and connective tissue located beneath the skin (dermis). This grouping includes various conditions such as panniculitis variants, lipodystrophies, subcutaneous fat necrosis, and other rare disorders that involve inflammation, degeneration, or abnormal development of the subcutaneous fat and connective tissue compartment. Because this is a classification group rather than a single discrete disease entity, the clinical features, inheritance patterns, age of onset, and severity vary widely depending on the specific condition within this category. Affected individuals may experience subcutaneous nodules, skin induration, localized or generalized loss or redistribution of subcutaneous fat, pain, inflammation, or skin changes overlying affected areas. Some conditions within this group may also have systemic manifestations affecting metabolic function, particularly when lipodystrophy or widespread fat tissue abnormalities are present. Treatment approaches are highly dependent on the specific underlying diagnosis and may range from anti-inflammatory medications and immunosuppressive therapies for inflammatory panniculitis subtypes, to metabolic management and leptin replacement therapy for certain lipodystrophies. Patients suspected of having a rare subcutaneous tissue disorder should be evaluated by specialists in dermatology, endocrinology, or clinical genetics as appropriate to establish a precise diagnosis and individualized management plan.
Variable
Can be inherited in different ways depending on the underlying gene
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
10 eventsTerSera Therapeutics LLC — PHASE1
AstraZeneca
Suzhou Suncadia Biopharmaceuticals Co., Ltd. — PHASE1
Eli Lilly and Company — PHASE1
Mayo Clinic — NA
Zhimin Shao — PHASE2
MoonLake Immunotherapeutics AG — PHASE3
BrightGene Bio-Medical Technology Co., Ltd. — PHASE1
Atridia Pty Ltd. — PHASE1
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University — NA
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Subcutaneous tissue disease.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for Subcutaneous tissue disease at this time.
New trials open frequently. Follow this disease to get notified.
Rare Disease Specialist
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Subcutaneous tissue disease.
Community
No community posts yet. Be the first to share your experience with Subcutaneous tissue disease.
Start the conversation →Latest news about Subcutaneous tissue disease
Disease timeline:
New recruiting trial: An Open-label, Single-arm Study to Evaluate Pharmacokinetics and Safety of Subcutaneous Sonelokimab in Adolescents With Moderate to Severe Hidradenitis Suppurativa (VELA-TEEN)
A new clinical trial is recruiting patients for Subcutaneous tissue disease
New recruiting trial: Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)
A new clinical trial is recruiting patients for Subcutaneous tissue disease
New recruiting trial: Effectiveness of a Zinc Oxide Adhesive Securement Device in the Fixation of Midline and Peripherally Inserted Central Catheters in Hospitalized Adult Patients
A new clinical trial is recruiting patients for Subcutaneous tissue disease
New recruiting trial: Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors
A new clinical trial is recruiting patients for Subcutaneous tissue disease
New recruiting trial: A Phase I Study of Single Subcutaneous Dose of SHR-1894 in Healthy Subjects
A new clinical trial is recruiting patients for Subcutaneous tissue disease
New recruiting trial: Radiomics of Intra-abdominal and Subcutaneous Adipose Tissue Predict the Efficacy of Bariatric Surgery (RISABS)
A new clinical trial is recruiting patients for Subcutaneous tissue disease
New recruiting trial: An Open-label, Time-lagged, Dose-escalation Study to Evalaute the Safety and Efficacy of Subcutaneous Siplizumab in the Treatment of Hidradenitis Suppurativa.
A new clinical trial is recruiting patients for Subcutaneous tissue disease
New recruiting trial: A RWS of SC MTX in Chinese RA Patients
A new clinical trial is recruiting patients for Subcutaneous tissue disease
New recruiting trial: Efficacy of Neoadjuvant Subcutaneous Trastuzumab-Pertuzumab in Algerian Women With Locally Advanced HER2 Positive Breast Cancer
A new clinical trial is recruiting patients for Subcutaneous tissue disease
New recruiting trial: A Phase I Study to Assess LBL-047 in Healthy Adults and Patients With Systemic Lupus Erythematosus
A new clinical trial is recruiting patients for Subcutaneous tissue disease
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Common questions about Subcutaneous tissue disease
What is Subcutaneous tissue disease?
Subcutaneous tissue disease (Orphanet code 79382) is a broad classification category within Orphanet that encompasses a heterogeneous group of rare disorders primarily affecting the subcutaneous tissue — the layer of fat and connective tissue located beneath the skin (dermis). This grouping includes various conditions such as panniculitis variants, lipodystrophies, subcutaneous fat necrosis, and other rare disorders that involve inflammation, degeneration, or abnormal development of the subcutaneous fat and connective tissue compartment. Because this is a classification group rather than a si
Which specialists treat Subcutaneous tissue disease?
19 specialists and care centers treating Subcutaneous tissue disease are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.