Complication in hemodialysis

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1FDA treatments18Active trials65Specialists8Treatment centers

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Overview

Complications in hemodialysis refer to the various medical problems that can happen during or after hemodialysis treatment. Hemodialysis is a life-sustaining procedure used when the kidneys can no longer filter waste and excess fluid from the blood effectively, most commonly due to end-stage kidney disease. During hemodialysis, blood is drawn from the body, passed through a special filter called a dialyzer (artificial kidney), and then returned to the body. Complications can occur at any point during or between dialysis sessions. The most common problems include low blood pressure (hypotension), muscle cramps, nausea, vomiting, headaches, and chest pain during treatment. More serious complications can include infections at the vascular access site, blood clots in the access, air embolism (air entering the bloodstream), irregular heartbeat, and allergic reactions to the dialysis membrane or tubing. Over time, patients may also develop problems related to long-term dialysis such as amyloidosis (protein buildup in organs), cardiovascular disease, bone mineral disorders, and anemia. Treatment focuses on preventing and managing these complications through careful monitoring during dialysis sessions, adjusting dialysis prescriptions, medications to control blood pressure and other symptoms, proper care of the vascular access site, and maintaining appropriate fluid and dietary restrictions between sessions. Advances in dialysis technology and protocols have significantly reduced the frequency and severity of many complications, but they remain an important concern for the millions of people worldwide who depend on hemodialysis.

Key symptoms:

Low blood pressure during dialysisMuscle crampsNausea and vomitingHeadachesChest painDizziness or lightheadednessItchy skinFatigue and weakness after treatmentFever or chills (sign of infection)Swelling, redness, or pain at the access siteShortness of breathIrregular or fast heartbeatNumbness or tingling in hands and feetDifficulty sleepingRestless legs during or after treatment

Age of Onset

Variable

Can begin at different ages, from infancy through adulthood

Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Dec 2026Single-Needle Distal Return for Long-Term Arteriovenous Fistula Care

Suzhou Municipal Hospital of Anhui Province — NA

TrialRECRUITING
Apr 2026A Multi-centre Trial to Assess the Efficacy and Safety of the Omnipod 5 System in People With Type 2 Diabetes Undergoing Haemodialysis

Imperial College London — NA

TrialNOT YET RECRUITING
Apr 2026Dialysate Cooling for the Preservation of Cognitive Function in People Receiving Haemodialysis

University Hospitals of Derby and Burton NHS Foundation Trust — NA

TrialNOT YET RECRUITING
Apr 2026Outcomes of Renal Replacement in Mexico

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

TrialNOT YET RECRUITING
Mar 2026Chlorhexidine Caps for CLABSI Prevention in Hemodialysis: a Pilot Randomized Controlled Trial

The University of Queensland — NA

TrialNOT YET RECRUITING
Mar 2026Autogenic Relaxation and Murottal Therapy in Hemodialysis Patients

Universitas Muhammadiyah Surakarta — NA

TrialNOT YET RECRUITING
Jan 2026The Effectiveness of Education in Diabetic Hemodialysis Patients

Inonu University — NA

TrialRECRUITING
Jan 2026Virtual Reality in End Stage Kidney Disease

University of Pennsylvania — NA

TrialNOT YET RECRUITING
Dec 2025Copeptin Concentration Measured in Plasma Samples and Intradialytic Blood Pressure Variation

Central Hospital, Nancy, France

TrialACTIVE NOT RECRUITING
Dec 2025Probiotics Against Erythropoietin Resistance in Chronic Kidney Disease Patients.

Badr University — PHASE3

TrialNOT YET RECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

1 available

Acetylcysteine

ACETYLCYSTEINE· Hospira, Inc.

adjuvant therapy for patients with abnormal, viscid, or inspissated mucous secretions in use during anesthesia

Clinical Trials

18 recruitingView all trials with filters →
Phase 31 trial
Alpha Lipoic Acid in Pediatrics on Hemodialysis
Phase 3
Enrolling by Invitation
PI: Mahmoud Mohsen, Pharmacist (Misr University for Science and Technology) · Sites: Cairo, El Weili · Age: 816 yrs
Phase 42 trials
PRevEnting FracturEs in REnal Disease - 1
Phase 4
Active
PI: Kristin K Clemens, MD, MSc (St. Joseph's Health Care London) · Sites: Kingston, Ontario; London, Ontario +4 more · Age: 4099 yrs
Amino Acids Supplementation and Exercise Intervention in Hemodialysis Patients
Phase 4
Active
· Sites: Al Mansurah · Age: 1860 yrs
N/A8 trials
Twice vs Thrice Weekly Incident Hemodialysis in Elderly Patients
N/A
Actively Recruiting
PI: Soon Hyo Kwon, MD (Soonchunhyang University Hospital) · Sites: Bucheon-si; Chuncheon +5 more · Age: 6099 yrs
Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients
N/A
Actively Recruiting
PI: Peter Noel Van Buren, MD (VA North Texas Health Care System Dallas VA Medica) · Sites: Dallas, Texas · Age: 1899 yrs
The Arteriovenous Vascular (AV) ACCESS Trial
N/A
Active
PI: Mariana Murea, MD (Wake Forest Health Sciences) · Sites: Birmingham, Alabama; Los Angeles, California +5 more · Age: 6099 yrs
Exercise Therapy on Rheological Functions of Erythrocyte in Hemodialysis
N/A
Actively Recruiting
PI: Jong-Shyan Wang, PhD (Chang Gung Memorial Hospital) · Sites: Taoyuan District · Age: 2080 yrs
A Study of Real-world Events of Vericiguat in Patients With Chronic Kidney Disease and Heart Failure
N/A
Actively Recruiting
PI: Shuangxin Liu (Guangdong Provincial People's Hospital) · Sites: Guangzhou, Guangdong · Age: 1880 yrs
A Study to Evaluate the Safety and Effectiveness of the InnAVasc Arteriovenous Graft for Hemodialysis Access in Patients With End-Stage Renal Disease
N/A
Actively Recruiting
PI: John Ross, MD (MUSC Health Dialysis Access Institute) · Sites: Phoenix, Arizona; Sarasota, Florida +19 more · Age: 1890 yrs
Plasma Biomarkers of Muscle Metabolism During Exercise to the Assessment of Insulin Resistance in CKD Dialysis Patients
N/A
Actively Recruiting
PI: GRILLET Pierre-Edouard, Pharma D. PhD (University Hospital, Montpellier) · Sites: Montpellier; Montpellier · Age: 4075 yrs
Intradialysis Exercise Functional Capacity, Body Composition and Survival in Hemodialysis Patients
N/A
Enrolling by Invitation
· Sites: León, Guanajuato · Age: 1850 yrs
Other7 trials
Kinesiophobia, Pain, Balance, Quality of Life and Mental Status in Hemodialysis Patients
Actively Recruiting
PI: Yusuf Topal (Kirsehir Ahi Evran University) · Sites: Kırşehir · Age: 1899 yrs
Cardiac Tissue Sodium Assessment in CKD Patients Using Sodium MRI
Actively Recruiting
PI: Christopher W McIntyre, MD/PhD (London Health Sciences Centre - Victoria Hospital) · Sites: London, Ontario · Age: 1899 yrs
Copeptin Concentration Measured in Plasma Samples and Intradialytic Blood Pressure Variation
Active
· Sites: Vandœuvre-lès-Nancy · Age: 1899 yrs
Predictive Value of Carotid Ultrasonography for Intradialytic Hypotension
Actively Recruiting
· Sites: Wuhu, Outside of the US · Age: 1880 yrs
Safely Disconnect From the Dialysis Machine in an Emergency Situation
Active
PI: Nurten Ozen, Assoc.Prof. (Istanbul University) · Sites: Istanbul · Age: 1899 yrs
This Study is to Estimate the Efficacy of Hemodialysis Alone for Uric Acid Clearance in Patients on Hemodialysis. In Order to Evaluate the Need of Adjuvant Uric Acid Lowering Therapy
Actively Recruiting
· Sites: Sohag · Age: 1899 yrs
Study of Markers of Iron Metabolism and Their Relationship With Phosphocalcic and Hepatic Metabolism and Inflammation in Hemodialysis Patients
Actively Recruiting
· Sites: Quincy-sous-Sénart · Age: 1899 yrs

Specialists

Showing 25 of 65View all specialists →
BM
Bo Shen, MD
CLEVELAND, OH
Specialist
PI on 3 active trials
PP
Patrice P Rioux, MD, PhD
Specialist
PI on 2 active trials
UC
Use Central Contact
Specialist
PI on 28 active trials
MF
Marietta Franco
Specialist
PI on 2 active trials21 Complication in hemodialysis publications
PM
Peter Kotanko, MD
NEW YORK, NY
Specialist
PI on 4 active trials
MP
Michael Dean, Ph.D.
Specialist
PI on 3 active trials
JA
Jens Rikardt Andersen
Specialist
PI on 2 active trials46 Complication in hemodialysis publications
SS
Shamik Shamik
Specialist
PI on 1 active trial
LY
Li Yuan
VANCOUVER, WA
Specialist
PI on 1 active trial
YX
Yi Xu
Specialist
PI on 1 active trial
HK
Hiromichi Kumagai
Specialist
PI on 1 active trial
MT
Maxime Touzot
Specialist
PI on 1 active trial
SL
Shuangxin Liu
Specialist
PI on 2 active trials
NL
Nathan W. Levin
LOS ANGELES, CA
Specialist
PI on 1 active trial
PD
Pedro Ponce, Dr
Specialist
PI on 1 active trial
CL
Chen-Hua Liu
Specialist
PI on 1 active trial
GB
Georg Bjarnason
Specialist
PI on 1 active trial
LM
Loubna MAZZI
Specialist
PI on 1 active trial
KT
Khajohn Tiranathanagul
Specialist
PI on 1 active trial
MB
Mark Boiskin
LA JOLLA, CA
Specialist
PI on 1 active trial
ME
Mohamed E Elrggal
Specialist
PI on 1 active trial
JT
James Tollitt
Specialist
PI on 1 active trial
EM
Ercan Ok, M.D
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Complication in hemodialysis.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Complication in hemodialysis

Disease timeline:

New recruiting trial: Chronic Pain in Patients in Hemodialysis

A new clinical trial is recruiting patients for Complication in hemodialysis

New recruiting trial: Intravascular Ultrasound in Patients With End-stage Renal Disease on Dialysis

A new clinical trial is recruiting patients for Complication in hemodialysis

New recruiting trial: Canagliflozin in Advanced Renal Disease With MRI Endpoints

A new clinical trial is recruiting patients for Complication in hemodialysis

New recruiting trial: A Study to Evaluate the Safety and Effectiveness of the InnAVasc Arteriovenous Graft for Hemodialysis Access in Patients With End-Stage Renal Disease

A new clinical trial is recruiting patients for Complication in hemodialysis

New recruiting trial: Study of Markers of Iron Metabolism and Their Relationship With Phosphocalcic and Hepatic Metabolism and Inflammation in Hemodialysis Patients

A new clinical trial is recruiting patients for Complication in hemodialysis

New recruiting trial: Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultrafiltration Compared to Conventional Hemodialysis

A new clinical trial is recruiting patients for Complication in hemodialysis

New recruiting trial: Single-Needle Distal Return for Long-Term Arteriovenous Fistula Care

A new clinical trial is recruiting patients for Complication in hemodialysis

New recruiting trial: Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients

A new clinical trial is recruiting patients for Complication in hemodialysis

New recruiting trial: Kinesiophobia, Pain, Balance, Quality of Life and Mental Status in Hemodialysis Patients

A new clinical trial is recruiting patients for Complication in hemodialysis

New recruiting trial: Effect of a Structured Physical Exercise Program on Arteriovenous Fistula Maturation for Hemodialysis in Chronic Kidney Disease Patients

A new clinical trial is recruiting patients for Complication in hemodialysis

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.What type of vascular access is best for me, and how do I care for it?,What are the warning signs of a serious complication I should watch for?,How can we adjust my dialysis prescription to reduce side effects like low blood pressure and cramps?,Am I a candidate for a kidney transplant, and what steps should I take?,What dietary and fluid restrictions should I follow, and can I see a renal dietitian?,Are there any newer dialysis options, such as home hemodialysis or peritoneal dialysis, that might work for me?,What medications am I taking, and what are their side effects?

Common questions about Complication in hemodialysis

What is Complication in hemodialysis?

Complications in hemodialysis refer to the various medical problems that can happen during or after hemodialysis treatment. Hemodialysis is a life-sustaining procedure used when the kidneys can no longer filter waste and excess fluid from the blood effectively, most commonly due to end-stage kidney disease. During hemodialysis, blood is drawn from the body, passed through a special filter called a dialyzer (artificial kidney), and then returned to the body. Complications can occur at any point during or between dialysis sessions. The most common problems include low blood pressure (hypotensio

Are there clinical trials for Complication in hemodialysis?

Yes — 18 recruiting clinical trials are currently listed for Complication in hemodialysis on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Complication in hemodialysis?

25 specialists and care centers treating Complication in hemodialysis are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.