Overview
Complications in hemodialysis refer to the various medical problems that can happen during or after hemodialysis treatment. Hemodialysis is a life-sustaining procedure used when the kidneys can no longer filter waste and excess fluid from the blood effectively, most commonly due to end-stage kidney disease. During hemodialysis, blood is drawn from the body, passed through a special filter called a dialyzer (artificial kidney), and then returned to the body. Complications can occur at any point during or between dialysis sessions. The most common problems include low blood pressure (hypotension), muscle cramps, nausea, vomiting, headaches, and chest pain during treatment. More serious complications can include infections at the vascular access site, blood clots in the access, air embolism (air entering the bloodstream), irregular heartbeat, and allergic reactions to the dialysis membrane or tubing. Over time, patients may also develop problems related to long-term dialysis such as amyloidosis (protein buildup in organs), cardiovascular disease, bone mineral disorders, and anemia. Treatment focuses on preventing and managing these complications through careful monitoring during dialysis sessions, adjusting dialysis prescriptions, medications to control blood pressure and other symptoms, proper care of the vascular access site, and maintaining appropriate fluid and dietary restrictions between sessions. Advances in dialysis technology and protocols have significantly reduced the frequency and severity of many complications, but they remain an important concern for the millions of people worldwide who depend on hemodialysis.
Key symptoms:
Low blood pressure during dialysisMuscle crampsNausea and vomitingHeadachesChest painDizziness or lightheadednessItchy skinFatigue and weakness after treatmentFever or chills (sign of infection)Swelling, redness, or pain at the access siteShortness of breathIrregular or fast heartbeatNumbness or tingling in hands and feetDifficulty sleepingRestless legs during or after treatment
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
10 eventsSuzhou Municipal Hospital of Anhui Province — NA
Imperial College London — NA
University Hospitals of Derby and Burton NHS Foundation Trust — NA
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
The University of Queensland — NA
Universitas Muhammadiyah Surakarta — NA
Inonu University — NA
University of Pennsylvania — NA
Central Hospital, Nancy, France
Badr University — PHASE3
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
1 availableAcetylcysteine
adjuvant therapy for patients with abnormal, viscid, or inspissated mucous secretions in use during anesthesia
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Complication in hemodialysis.
Community
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Start the conversation →Latest news about Complication in hemodialysis
Disease timeline:
New recruiting trial: Chronic Pain in Patients in Hemodialysis
A new clinical trial is recruiting patients for Complication in hemodialysis
New recruiting trial: Intravascular Ultrasound in Patients With End-stage Renal Disease on Dialysis
A new clinical trial is recruiting patients for Complication in hemodialysis
New recruiting trial: Canagliflozin in Advanced Renal Disease With MRI Endpoints
A new clinical trial is recruiting patients for Complication in hemodialysis
New recruiting trial: A Study to Evaluate the Safety and Effectiveness of the InnAVasc Arteriovenous Graft for Hemodialysis Access in Patients With End-Stage Renal Disease
A new clinical trial is recruiting patients for Complication in hemodialysis
New recruiting trial: Study of Markers of Iron Metabolism and Their Relationship With Phosphocalcic and Hepatic Metabolism and Inflammation in Hemodialysis Patients
A new clinical trial is recruiting patients for Complication in hemodialysis
New recruiting trial: Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultrafiltration Compared to Conventional Hemodialysis
A new clinical trial is recruiting patients for Complication in hemodialysis
New recruiting trial: Single-Needle Distal Return for Long-Term Arteriovenous Fistula Care
A new clinical trial is recruiting patients for Complication in hemodialysis
New recruiting trial: Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients
A new clinical trial is recruiting patients for Complication in hemodialysis
New recruiting trial: Kinesiophobia, Pain, Balance, Quality of Life and Mental Status in Hemodialysis Patients
A new clinical trial is recruiting patients for Complication in hemodialysis
New recruiting trial: Effect of a Structured Physical Exercise Program on Arteriovenous Fistula Maturation for Hemodialysis in Chronic Kidney Disease Patients
A new clinical trial is recruiting patients for Complication in hemodialysis
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What type of vascular access is best for me, and how do I care for it?,What are the warning signs of a serious complication I should watch for?,How can we adjust my dialysis prescription to reduce side effects like low blood pressure and cramps?,Am I a candidate for a kidney transplant, and what steps should I take?,What dietary and fluid restrictions should I follow, and can I see a renal dietitian?,Are there any newer dialysis options, such as home hemodialysis or peritoneal dialysis, that might work for me?,What medications am I taking, and what are their side effects?
Common questions about Complication in hemodialysis
What is Complication in hemodialysis?
Complications in hemodialysis refer to the various medical problems that can happen during or after hemodialysis treatment. Hemodialysis is a life-sustaining procedure used when the kidneys can no longer filter waste and excess fluid from the blood effectively, most commonly due to end-stage kidney disease. During hemodialysis, blood is drawn from the body, passed through a special filter called a dialyzer (artificial kidney), and then returned to the body. Complications can occur at any point during or between dialysis sessions. The most common problems include low blood pressure (hypotensio
Are there clinical trials for Complication in hemodialysis?
Yes — 18 recruiting clinical trials are currently listed for Complication in hemodialysis on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Complication in hemodialysis?
25 specialists and care centers treating Complication in hemodialysis are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.