NON RARE IN EUROPE: Non-small cell lung cancer

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26FDA treatments68Active trials123Specialists8Treatment centers20Financial resources

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Also known as:

Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Mar 2026TILs Therapy for Multiple Primary Early-Stage NSCLC

Tianjin Medical University General Hospital — EARLY_PHASE1

TrialNOT YET RECRUITING
Mar 2026MEKINIST: New indication approved
FDAcompleted
Mar 2026MEKINIST: New indication approved
FDAcompleted
Mar 2026Anesthesia Comparison in Early-stage Small NSCLC: A Multicenter RCT

Tang-Du Hospital — NA

TrialNOT YET RECRUITING
Mar 2026Study on the Efficacy and Safety of JSKN016 as Neoadjuvant Therapy in Resectable Stage II-III Non-small Cell Lung Cancer Patients

Shanghai Pulmonary Hospital, Shanghai, China — PHASE2

TrialNOT YET RECRUITING
Feb 2026BRAFTOVI: New indication approved
FDAcompleted
Jan 2026Toripalimab Combined With Platinum-based Chemotherapy With or Without H1 Receptor Antagonist in the Perioperative Treatment of Resectable Non-small Cell Lung Cancer

Tianjin Medical University Cancer Institute and Hospital — PHASE2

TrialNOT YET RECRUITING
Jan 2026LORBRENA: New indication approved
FDAcompleted
Jan 2026Post-operative Radiotherapy After Neodjuvant Chemo-immunotherapy and Surgery in Stage III NSCLC

Centre hospitalier de l'Université de Montréal (CHUM) — PHASE2

TrialRECRUITING
Jan 2026Lidocaine Decreases Postoperative Lung Cancer Reoccurance and Metatasis Risk

First Affiliated Hospital of Ningbo University — NA

TrialNOT YET RECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

26 available

Lumakras

sotorasib· Amgen Inc.Accelerated Approval
As a single agent, for the treatment of adult patients with KRAS G12C-mutated locally advanced or metastatic NSCLC, as determined by an FDA-approved test, who have received at least one prior systemic

As a single agent, for the treatment of adult patients with KRAS G12C-mutated locally advanced or metastatic NSCLC, as determined by an FDA-approved test, who have received at least one prior systemic therapy.

Avastin

bevacizumab· Genentech, Inc.

Unresectable, locally advanced, recurrent or metastatic non-squamous non-small cell lung cancer, in combination with carboplatin and paclitaxel for first-line treatment.

TAFINLAR

dabrafenib· Novartis Pharmaceuticals Corp.

TAFINLAR is indicated, in combination with trametinib, for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation as detected by an FDA-approved test.

IMFINZI

durvalumab· AstraZeneca Pharmaceuticals LP
in combination with platinum-containing chemotherapy as neoadjuvant treatment, followed by IMFINZI continued as a single agent as adjuvant treatment after surgery, for the treatment of adult patients

in combination with platinum-containing chemotherapy as neoadjuvant treatment, followed by IMFINZI continued as a single agent as adjuvant treatment after surgery, for the treatment of adult patients with resectable (tumors ≥ 4 cm and/or node positive) non-small cell lung cancer (NSCLC) and no known epidermal growth factor receptor (EGFR) mutations or anaplastic lymphoma kinase (ALK) rearrangements

Photofrin

porfimer· Axcan Scandipharm Inc.

Treatment of microinvasive endobronchial non-small-cell lung cancer (NSCLC) in patients for whom surgery and radiotherapy are not indicated

GAVRETO�

pralsetinib· Rigel Pharmaceuticals, Inc.■ Boxed Warning

GAVRETO is indicated for the treatment of adult patients with metastatic RET fusion-positive non-small cell lung cancer (NSCLC) as detected by an FDA approved test.

Alimta

pemetrexed disodium· Eli Lilly and Company
in combination with pembrolizumab and platinum chemotherapy, for the initial treatment of patients with metastatic non-squamous non-small cell lung cancer (NSCLC), with no EGFR or ALK genomic tumor ab

in combination with pembrolizumab and platinum chemotherapy, for the initial treatment of patients with metastatic non-squamous non-small cell lung cancer (NSCLC), with no EGFR or ALK genomic tumor aberrations

Bizengri

zenocutuzumab-zbco· Partner Therapeutics, Inc.■ Boxed WarningAccelerated Approval

Adults with advanced, unresectable or metastatic non-small cell lung cancer (NSCLC) harboring a neuregulin 1 (NRG1) gene fusion with disease progression on or after prior systemic therapy

Alunbrig

brigatinib· Takeda Development Center Americas, Inc.

ALUNBRIG is indicated for the treatment of adult patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) as detected by an FDA-approved test

ROZLYTREK

entrectinib· Genentech, Inc.

ROZLYTREK is indicated for the treatment of adult patients with ROS1-positive metastatic non-small cell lung cancer (NSCLC), as detected by an FDA-approved test.

KEYTRUDA

pembrolizumab· MSD International Business GmbH

in combination with pemetrexed and platinum chemotherapy, as first-line treatment of adult patients with metastatic nonsquamous NSCLC, with no EGFR or ALK genomic tumor aberrations

Yervoy

ipilimumab· Bristol-Myers Squibb Company
Treatment of adult patients with metastatic or recurrent non-small cell lung cancer with no EGFR or ALK genomic tumor aberrations as first-line treatment, in combination with nivolumab and 2 cycles of

Treatment of adult patients with metastatic or recurrent non-small cell lung cancer with no EGFR or ALK genomic tumor aberrations as first-line treatment, in combination with nivolumab and 2 cycles of platinum-doublet chemotherapy

RETEVMO

selpercatinib· Loxo Oncology Inc., a wholly owned subsidiary of Eli Lilly and Company
RETEVMO is indicated for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with a rearranged during transfection (RET) gene fusion, as detected by

RETEVMO is indicated for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with a rearranged during transfection (RET) gene fusion, as detected by an FDA-approved test

Xalkori

crizotinib· Pfizer, Inc.
XALKORI is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK) or ROS1-positive as detected by an FDA-app

XALKORI is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK) or ROS1-positive as detected by an FDA-approved test

Ibtrozi

taletrectinib· Nuvation Bio Inc.Orphan Drug

treatment of adult patients with locally advanced or metastatic ROS1-positive non-small cell lung cancer (NSCLC)

Augtyro

repotrectinib· Bristol Myers Squibb CompanyOrphan Drug

treatment of adult patients with locally advanced or metastatic ROS1-positive non-small cell lung cancer (NSCLC)

Braftovi

encorafenib· Array BioPharma Inc. (a wholly owned subsidiary of Pfizer Inc.)Orphan Drug

in combination with binimetinib, for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) with a BRAF V600E mutation, as detected by an FDA-approved test

Tepmetko

tepotinib· EMD Serono, Inc.Orphan Drug

treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) harboring mesenchymal-epithelial transition (MET) exon 14 skipping alterations

LORBRENA

Lorlatinib· Pfizer, Inc.Orphan Drug
LORBRENA� is indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) whose disease has progressed on crizotinib and at le

LORBRENA� is indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) whose disease has progressed on crizotinib and at least one other ALK inhibitor for metastatic disease; or alectinib as the first ALK inhibitor therapy for metastatic disease; or ceritinib as the first ALK inhibitor therapy for metastatic disease.

VIZIMPRO

dacomitinib· Pfizer, Inc.Orphan Drug

For the first-line treatment of patients with metastatic non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 19 deletion or exon 21 L858R

Gilotrif

afatinib· Boehringer Ingelheim Pharmaceuticals, Inc.Orphan Drug
GILOTRIF is indicated for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have non-resistant epidermal growth factor receptor (EGFR) mutations as d

GILOTRIF is indicated for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have non-resistant epidermal growth factor receptor (EGFR) mutations as detected by an FDA-approved test.

Alecensa

alectinib· Hoffmann-La Roche, Inc. (c/o Genentech, Inc.)Orphan Drug

ALECENSA is indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive, metastatic non-small cell lung cancer (NSCLC) as detected by an FDA-approved test.

MEKINIST

trametinib· Novartis Pharmaceuticals Corp.Orphan Drug

Mekinist in combination with dabrafenib, for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation as detected by an FDA-approved test.

ZYKADIA

ceritinib· Novartis Pharmaceuticals Corp.Orphan Drug

Treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK)-positive as detected by an FDA-approved test

Tagrisso

osimertinib· AstraZeneca Pharmaceuticals LPOrphan Drug
For treatment of patients with metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive non-small cell lung cancer (NSCLC), as detected by an FDA-approved test, who have progressed o

For treatment of patients with metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive non-small cell lung cancer (NSCLC), as detected by an FDA-approved test, who have progressed on or after EGFR TKI therapy

Iressa

gefitinib· AstraZeneca Pharmaceuticals LPOrphan Drug
For the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution

For the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations as detected by an FDA-approved test

Clinical Trials

20 recruitingView all trials with filters →
Phase 33 trials
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)
Phase 3
Actively Recruiting
· Sites: Birmingham, Alabama; Long Beach, California +127 more · Age: 1899 yrs
Effect of Infusion Timing on Pathologic Response to Neoadjuvant Immunotherapy in Resectable Non-Small Cell Lung Cancer
Phase 3
Actively Recruiting
· Sites: Changsha, Hunan; Changsha, Hunan · Age: 1875 yrs
To Assess the Efficacy and Safety of Furmonertinib Versus Placebo, in Patients With Epidermal Growth Factor Receptor Mutation Positive Stage II-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy
Phase 3
Actively Recruiting
PI: Jianxing He, PHD (The First Affiliated Hospital of Guangzhou Medical) · Sites: Suzhou, Jiangsu · Age: 1875 yrs
Phase 41 trial
Firmonertinib Combined With Intrathecal Injection for the Treatment of EGFR Mutant NSCLC With Leptomeningeal Metastases
Phase 4
Actively Recruiting
PI: Xiaorong Dong, Dr (Union Hospital, Tongji Medical College, Huazhong U) · Sites: Wuhan, Hubei · Age: 1899 yrs
Other16 trials
Impact of Smoking Cessation Duration on Postoperative Complications in Lung Cancer Surgery
Active
· Sites: Samsun, Samsun · Age: 1880 yrs
Molecular Landscape Analysis and Clinical Implications for NSCLC Patients With Rare Mutations
Actively Recruiting
PI: Xiaomin Niu (Shanghai Chest Hospital) · Sites: Shanghai, Shanghai Municipality; Shanghai, Shanghai Municipality · Age: 1899 yrs
Chemotherapy With or Without Immune Checkpoint Inhibitors for Lung Cancer
Actively Recruiting
PI: Yongchang Zhang, MD (Hunan Cancer Hospital) · Sites: Changsha, Hunan · Age: 1899 yrs
The Efficacy and Safety of Adjuvant Immunotherapy After Pathological Complete Response Following Neoadjuvant Chemoimmunotherapy in Patients with Resectable NSCLC
Active
· Sites: Changsha, Hunan · Age: 1880 yrs
Clinical Effectiveness and Safety of Trastuzumab Deruxtecan (T-DXd) in Chinese Patients With HER2m NSCLC (RERUN)
Actively Recruiting
PI: Project Manager (Daiichi Sankyo Co., Ltd.) · Sites: Beijing; Beijing +21 more · Age: 1899 yrs
The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors
Actively Recruiting
· Sites: Elizabethtown, Kentucky · Age: 1899 yrs
Observational Lung Trial to Collect Tissue to Train and Validate a Live Tumor Diagnostic Platform
Actively Recruiting
PI: Fred Hausheer, MD, FACP (Elephas) · Sites: Los Angeles, California; Frederick, Maryland +5 more · Age: 1899 yrs
Analysis of RATS, VATS and Open Lung Resections After Neoadjuvant Chemo-immunotherapy in Patients Performed in Five Referred Centers
Actively Recruiting
· Sites: Miami, Florida; New York, New York +4 more · Age: 1899 yrs
A Real-world Study on the Treatment of Non-small Cell Lung Cancer With Leptomeningeal Metastasis in China
Actively Recruiting
· Sites: Guangzhou, Guangdong; Guangzhou, Guangdong
A Post Approval Commitment Study on Tabrecta® (Capmatinib) in South Korea
Actively Recruiting
PI: Novartis Pharmaceuticals (Novartis Pharmaceuticals) · Sites: Daegu, Dalseo Gu; Suwon, Gyeonggi-do +10 more · Age: 18100 yrs
Nintedanib for the Prevention of Radiation Pneumonia in Unresectable NSCLC
Actively Recruiting
PI: Gang Jin, Dr. (Second Hospital of Shanxi Medical University) · Sites: Jincheng, Shanxi; Jinzhong, Shanxi +5 more · Age: 1899 yrs
OSIREAL - Osimertinib RWE on EGFRm NSCLC in Spain
Actively Recruiting
· Sites: Alicante; Barcelona +23 more · Age: 1899 yrs
Palliative Thoracic ImmunoRT
Active
· Sites: Toronto, Ontario · Age: 1899 yrs
Feasibility Study to Investigate Rectal Mucus in Aero-Digestive Tract Cancer.
Actively Recruiting
PI: Mr F McDermott, FRCS (Chief Investigator) · Sites: Exeter · Age: 1899 yrs
Detection of Circulating Tumour Cells, Spread Through Air Space in Patients With Lung Cancer
Actively Recruiting
PI: Pietro Bertoglio, MD (IRCCS Azienda Ospedaliero-Universitaria di Bologna) · Sites: Bologna, Emilia-Romagna · Age: 1899 yrs
Early Rebiopsy to Identify Biomarkers of Tumor Cell Survival Following EGFR, ALK, ROS1 or BRAF TKI Therapy
Actively Recruiting
PI: Erin Schenk (University of Colorado, Denver) · Sites: Aurora, Colorado · Age: 1885 yrs

Specialists

Showing 25 of 123View all specialists →
DT
Daniel SW Tan
Specialist
PI on 2 active trials
AA
Athanassios (Ethan) Argiris
Mobile, Alabama
Specialist

Rare Disease Specialist

PI on 2 active trials
NM
Neal Flomenberg, MD
PHILADELPHIA, PA
Specialist
PI on 5 active trials
SM
Si-Yu Wang, MD
Specialist
PI on 3 active trials
CP
Charles Theuer, MD, PhD
SAN DIEGO, CA
Specialist
PI on 3 active trials
GL
Global Team Leader
Specialist
PI on 6 active trials
FF
Fred Hausheer, MD, FACP
Specialist
PI on 2 active trials
NM
Nasser Hanna, MD
INDIANAPOLIS, IN
Specialist
PI on 4 active trials
PM
Project Manager
Ancona, Ancona
Specialist

Rare Disease Specialist

PI on 2 active trials7 NON RARE IN EUROPE: Non-small cell lung cancer publications
MK
Marianna Koczywas
DUARTE, CA
Specialist
PI on 2 active trials
SL
Shun Lu
HACIENDA HEIGHTS, CA
Specialist
PI on 2 active trials
TS
Tess Schmalbach
Specialist
PI on 2 active trials
WH
Waël c Hanna
Specialist
PI on 1 active trial
YW
Yi-Long Wu
Specialist
PI on 2 active trials
VL
Victor Lee
Specialist
PI on 2 active trials
YD
Yiping Zhang, Dr.
Specialist
PI on 1 active trial
YZ
Yongchang Zhang
Specialist
PI on 2 active trials
LC
Lucio Crinò
Specialist
PI on 1 active trial
RG
Rasim Gucalp
BRONX, NY
Specialist
PI on 1 active trial
DM
David Morris
Specialist
PI on 1 active trial
HC
Hannah Chen
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Financial Resources

20 resources
Lumakras(sotorasib)Amgen Inc.
Avastin(bevacizumab)Genentech, Inc.
TAFINLAR(dabrafenib)Novartis Pharmaceuticals Corp.
IMFINZI(durvalumab)AstraZeneca Pharmaceuticals LP
Alimta(pemetrexed disodium)Eli Lilly and Company
Alunbrig(brigatinib)Takeda Development Center Americas, Inc.
ROZLYTREK(entrectinib)Genentech, Inc.
Yervoy(ipilimumab)Bristol-Myers Squibb Company
RETEVMO(selpercatinib)Loxo Oncology Inc., a wholly owned subsidiary of Eli Lilly and Company
Xalkori(crizotinib)Pfizer, Inc.
Braftovi(encorafenib)Array BioPharma Inc. (a wholly owned subsidiary of Pfizer Inc.)
Tepmetko(tepotinib)EMD Serono, Inc.
LORBRENA(Lorlatinib)Pfizer, Inc.
VIZIMPRO(dacomitinib)Pfizer, Inc.
Gilotrif(afatinib)Boehringer Ingelheim Pharmaceuticals, Inc.
Alecensa(alectinib)Hoffmann-La Roche, Inc. (c/o Genentech, Inc.)
MEKINIST(trametinib)Novartis Pharmaceuticals Corp.
ZYKADIA(ceritinib)Novartis Pharmaceuticals Corp.
Tagrisso(osimertinib)AstraZeneca Pharmaceuticals LP
Iressa(gefitinib)AstraZeneca Pharmaceuticals LP

Travel Grants

No travel grants are currently matched to NON RARE IN EUROPE: Non-small cell lung cancer.

Search all travel grants →NORD Financial Assistance ↗

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Latest news about NON RARE IN EUROPE: Non-small cell lung cancer

2 articles
Clinical trialCLINICALTRIALSApr 1, 2026
Trial Now Recruiting: Dabrafenib and/or Trametinib Rollover Study (NCT03340506)
This is a continuation study for patients who are already taking the cancer drugs dabrafenib and/or trametinib and have done well on them. If your doctor thinks
ResearchPUBMEDMar 26, 2026
Evaluation of mixed response in tumor size and survival in patients with rare cancers treated with dual checkpoint inhibitor therapy (DART SWOG S1609).
Researchers studied how cancer tumors respond differently to a two-drug immunotherapy treatment (ipilimumab plus nivolumab) in patients with rare cancers. Some
See all news about NON RARE IN EUROPE: Non-small cell lung cancer

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about NON RARE IN EUROPE: Non-small cell lung cancer

Are there clinical trials for NON RARE IN EUROPE: Non-small cell lung cancer?

Yes — 20 recruiting clinical trials are currently listed for NON RARE IN EUROPE: Non-small cell lung cancer on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat NON RARE IN EUROPE: Non-small cell lung cancer?

25 specialists and care centers treating NON RARE IN EUROPE: Non-small cell lung cancer are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.

What treatment and support options exist for NON RARE IN EUROPE: Non-small cell lung cancer?

15 patient support programs are currently tracked on UniteRare for NON RARE IN EUROPE: Non-small cell lung cancer. See the treatments and support programs sections for copay assistance, eligibility, and contact details.