Overview
Chondrosarcoma is a type of bone cancer that starts in cartilage cells — the tough, flexible tissue that cushions your joints and makes up parts of your skeleton. It is the second most common primary bone cancer in adults. Unlike some other bone cancers, chondrosarcoma tends to grow slowly, but it can spread to other parts of the body if not treated. The tumor most often forms in the bones of the pelvis, thigh (femur), upper arm (humerus), ribs, and shoulder blade, though it can appear in almost any bone. Most people with chondrosarcoma notice a slowly growing lump or swelling near a bone, along with dull, aching pain that may get worse at night or with activity. Because the tumor grows slowly, symptoms can be present for months or even years before a diagnosis is made. There are several subtypes of chondrosarcoma, including conventional (the most common), dedifferentiated, mesenchymal, and clear cell, each with different behaviors and outlooks. Treatment depends on the grade and location of the tumor. Surgery to remove the tumor is the main treatment and is often the only effective option, since chondrosarcoma does not respond well to standard chemotherapy or radiation. For low-grade tumors caught early, surgery can be curative. Higher-grade or advanced tumors are harder to treat, and research into new therapies is ongoing. A team of specialists works together to plan the best approach for each person.
Key symptoms:
Dull, aching pain near a bone that may worsen at night or with activityA slowly growing lump or swelling on or near a boneSwelling or tenderness around a jointLimited range of motion in a nearby jointFeeling of pressure or fullness in the affected areaBone pain that does not go away with restUnexplained fracture of a bone (pathological fracture)Fatigue or general tiredness in advanced casesUnintended weight loss in advanced casesNumbness or tingling if the tumor presses on nearby nerves
Variable
Can be inherited in different ways depending on the underlying gene
Adult
Begins in adulthood (age 18 or older)
FDA & Trial Timeline
10 eventsMedical University of Graz
Quantum Surgical — NA
Istituto Ortopedico Rizzoli — NA
St. Anne's University Hospital Brno, Czech Republic
Var2 Pharmaceuticals — EARLY_PHASE1
Power Life Sciences Inc.
Servier Bio-Innovation LLC — PHASE3
Costantino Errani
National Cancer Institute (NCI) — PHASE2
Ricoh USA, Inc. — NA
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Chondrosarcoma.
20 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Rare Disease Specialist
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Chondrosarcoma.
Community
No community posts yet. Be the first to share your experience with Chondrosarcoma.
Start the conversation →Latest news about Chondrosarcoma
Disease timeline:
New recruiting trial: Adherence to a Personalized Home Exercise Program in Patients With Bone Tumor Undergoing Lower Extremity Salvage Surgery
A new clinical trial is recruiting patients for Chondrosarcoma
New recruiting trial: PET-imaging of Two Vartumabs in Patients With Solid Tumors
A new clinical trial is recruiting patients for Chondrosarcoma
New recruiting trial: Diagnostic and Therapeutic Targets in Cartilaginous Tumours
A new clinical trial is recruiting patients for Chondrosarcoma
New recruiting trial: Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone
A new clinical trial is recruiting patients for Chondrosarcoma
New recruiting trial: Assessment of Healing and Function After Reconstruction Surgery for Bone Sarcomas
A new clinical trial is recruiting patients for Chondrosarcoma
New recruiting trial: A Study of Anlotinib Combined With or Without PD-1 Antibody on Unresectable High-grade Chondrosarcoma
A new clinical trial is recruiting patients for Chondrosarcoma
New recruiting trial: A Study of AdAPT-001 in Subjects With Sarcoma and Refractory Solid Tumors
A new clinical trial is recruiting patients for Chondrosarcoma
New recruiting trial: Hypofractionated Protontherapy in Chordomas and Chondrosarcomas of the Skull Base
A new clinical trial is recruiting patients for Chondrosarcoma
New recruiting trial: Proton or Photon RT for Retroperitoneal Sarcomas
A new clinical trial is recruiting patients for Chondrosarcoma
New recruiting trial: Study on Trabectedin in Advanced Rearranged Mesenchymal Chondrosarcoma
A new clinical trial is recruiting patients for Chondrosarcoma
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What grade and stage is my chondrosarcoma, and what does that mean for my outlook?,Is surgery possible, and can you preserve my limb or joint?,Are there any clinical trials I might be eligible for?,Should I have genetic testing to see if my cancer is related to a hereditary condition?,How often will I need follow-up scans, and what are we watching for?,What are the risks of the surgery, and what will my recovery look like?,Are there any targeted therapies or newer treatments that might work for my specific tumor type?
Common questions about Chondrosarcoma
What is Chondrosarcoma?
Chondrosarcoma is a type of bone cancer that starts in cartilage cells — the tough, flexible tissue that cushions your joints and makes up parts of your skeleton. It is the second most common primary bone cancer in adults. Unlike some other bone cancers, chondrosarcoma tends to grow slowly, but it can spread to other parts of the body if not treated. The tumor most often forms in the bones of the pelvis, thigh (femur), upper arm (humerus), ribs, and shoulder blade, though it can appear in almost any bone. Most people with chondrosarcoma notice a slowly growing lump or swelling near a bone, al
At what age does Chondrosarcoma typically begin?
Typical onset of Chondrosarcoma is adult. Age of onset can vary across affected individuals.
Are there clinical trials for Chondrosarcoma?
Yes — 20 recruiting clinical trials are currently listed for Chondrosarcoma on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Chondrosarcoma?
25 specialists and care centers treating Chondrosarcoma are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.