Chondrosarcoma

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ORPHA:55880OMIM:215300C49.9
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24Active trials56Specialists8Treatment centers

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Chondrosarcoma is a type of bone cancer that starts in cartilage cells — the tough, flexible tissue that cushions your joints and makes up parts of your skeleton. It is the second most common primary bone cancer in adults. Unlike some other bone cancers, chondrosarcoma tends to grow slowly, but it can spread to other parts of the body if not treated. The tumor most often forms in the bones of the pelvis, thigh (femur), upper arm (humerus), ribs, and shoulder blade, though it can appear in almost any bone. Most people with chondrosarcoma notice a slowly growing lump or swelling near a bone, along with dull, aching pain that may get worse at night or with activity. Because the tumor grows slowly, symptoms can be present for months or even years before a diagnosis is made. There are several subtypes of chondrosarcoma, including conventional (the most common), dedifferentiated, mesenchymal, and clear cell, each with different behaviors and outlooks. Treatment depends on the grade and location of the tumor. Surgery to remove the tumor is the main treatment and is often the only effective option, since chondrosarcoma does not respond well to standard chemotherapy or radiation. For low-grade tumors caught early, surgery can be curative. Higher-grade or advanced tumors are harder to treat, and research into new therapies is ongoing. A team of specialists works together to plan the best approach for each person.

Key symptoms:

Dull, aching pain near a bone that may worsen at night or with activityA slowly growing lump or swelling on or near a boneSwelling or tenderness around a jointLimited range of motion in a nearby jointFeeling of pressure or fullness in the affected areaBone pain that does not go away with restUnexplained fracture of a bone (pathological fracture)Fatigue or general tiredness in advanced casesUnintended weight loss in advanced casesNumbness or tingling if the tumor presses on nearby nerves

Inheritance

Variable

Can be inherited in different ways depending on the underlying gene

Age of Onset

Adult

Begins in adulthood (age 18 or older)

Orphanet ↗OMIM ↗NORD ↗

FDA & Trial Timeline

10 events
Jun 2026Clinical Applicability of Liquid Biopsy in Chondrosarcoma

Medical University of Graz

TrialNOT YET RECRUITING
Mar 2026U.S. Prospective Evaluation of EPIONE Device for Percutaneous MSK Procedures

Quantum Surgical — NA

TrialNOT YET RECRUITING
Sep 2025Clear Cell Chondrosarcoma in Italy

Istituto Ortopedico Rizzoli — NA

TrialACTIVE NOT RECRUITING
May 2025Diagnostic and Therapeutic Targets in Cartilaginous Tumours

St. Anne's University Hospital Brno, Czech Republic

TrialRECRUITING
Dec 2024PET-imaging of Two Vartumabs in Patients With Solid Tumors

Var2 Pharmaceuticals — EARLY_PHASE1

TrialRECRUITING
Oct 2024Understanding Engagement Trends in Chondrosarcoma Clinical Trials

Power Life Sciences Inc.

TrialNOT YET RECRUITING
Jul 2024Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen

Servier Bio-Innovation LLC — PHASE3

TrialRECRUITING
Apr 2024Proximal Femur Reconstruction Following Resection of Primary Bone Tumors: Analysis of the Clinical and Radiographic Results

Costantino Errani

TrialRECRUITING
Mar 2024Enasidenib in IDH2-Mutated Malignant Sinonasal and Skull Base Tumors

National Cancer Institute (NCI) — PHASE2

TrialRECRUITING
Mar 2024A Study to Evaluate the Utilization of 3D Printed Models in Pre-Operative Planning

Ricoh USA, Inc. — NA

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Chondrosarcoma.

20 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

20 recruitingView all trials with filters →
Phase 31 trial
Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen
Phase 3
Actively Recruiting
· Sites: Los Angeles, California; Santa Monica, California +112 more · Age: 1899 yrs
Phase 212 trials
A Study of AdAPT-001 in Subjects With Sarcoma and Refractory Solid Tumors
Phase 2
Actively Recruiting
PI: Bryan Oronsky, MD PhD (EpicentRx, Inc.) · Sites: Duarte, California; San Marcos, California +4 more · Age: 1899 yrs
Vismodegib in Treating Patients With Advanced Chondrosarcomas
Phase 2
Active
PI: Antoine Italiano (Institut Bergonie Cancer Center) · Sites: Bordeaux; Lille +4 more · Age: 1899 yrs
Testing Ipilimumab and Nivolumab Combination With or Without Cabozantinib in People >= 18 Years Old With Advanced Soft Tissue Sarcoma
Phase 2
Active
PI: A P Chen (National Cancer Institute LAO) · Sites: Duarte, California; Irvine, California +25 more · Age: 1899 yrs
Enasidenib in IDH2-Mutated Malignant Sinonasal and Skull Base Tumors
Phase 2
Actively Recruiting
PI: Charalampos Floudas, M.D. (National Cancer Institute (NCI)) · Sites: Bethesda, Maryland · Age: 18120 yrs
Proton Beam Therapy for Chondrosarcoma
Phase 2
Active
PI: David Grosshans, MD,PHD (M.D. Anderson Cancer Center) · Sites: Houston, Texas
Study on Trabectedin in Advanced Rearranged Mesenchymal Chondrosarcoma
Phase 2
Actively Recruiting
PI: Silvia Stacchiotti, MD (Fondazione IRCCS Istituto Nazionale dei Tumori di ) · Sites: Prato, Firenze; Roma, RM +5 more · Age: 1699 yrs
Testing the Combination of Belinostat and SGI-110 (Guadecitabine) or ASTX727 for the Treatment of Unresectable and Metastatic Conventional Chondrosarcoma
Phase 2
Active
PI: Mia Weiss (Yale University Cancer Center LAO) · Sites: Phoenix, Arizona; Duarte, California +37 more · Age: 1899 yrs
Study of INBRX-109 in Conventional Chondrosarcoma
Phase 2
Active
PI: Clinical Lead (Inhibrx Biosciences, Inc) · Sites: Phoenix, Arizona; Beverly Hills, California +66 more · Age: 1885 yrs
AG-120 in People With IDH1 Mutant Chondrosarcoma
Phase 2
Active
PI: Ciara M Kelly, MBBCh, BAO (Memorial Sloan Kettering Cancer Center) · Sites: Baltimore, Maryland; New York, New York +3 more · Age: 1899 yrs
Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration
Phase 2
Actively Recruiting
PI: John Charlson, MD (Medical College of Wisconsin) · Sites: Jacksonville, Florida; Iowa City, Iowa +2 more · Age: 1899 yrs
A Study of Anlotinib Combined With or Without PD-1 Antibody on Unresectable High-grade Chondrosarcoma
Phase 2
Actively Recruiting
PI: Binghao Li, Medical PhD (Second Affiliated Hospital of Zhejiang University ) · Sites: Hangzhou, Zhejiang · Age: 18100 yrs
Testing Atezolizumab in People 2-17 Years Old With Clear Cell Sarcoma or Advanced Chondrosarcoma
Phase 2
Active
PI: A P Chen (National Cancer Institute LAO) · Sites: Los Angeles, California; Gainesville, Florida +13 more · Age: 299 yrs
Phase 11 trial
Anti-Osteoclast Therapy as Neoadjuvant in Treatment of Chondrosarcoma - Phase 1b Trial
Phase 1
Active
PI: Mohammed Milhem, MBBS (University of Iowa) · Sites: Iowa City, Iowa · Age: 1899 yrs
N/A1 trial
Hypofractionated Protontherapy in Chordomas and Chondrosarcomas of the Skull Base
N/A
Actively Recruiting
· Sites: Madrid, Madrid · Age: 1899 yrs
Other5 trials
Proximal Femur Reconstruction Following Resection of Primary Bone Tumors: Analysis of the Clinical and Radiographic Results
Actively Recruiting
· Sites: Bologna, BO · Age: 1890 yrs
Assessment of Healing and Function After Reconstruction Surgery for Bone Sarcomas
Actively Recruiting
PI: Daniel Prince, MD (Memorial Sloan Kettering Cancer Center) · Sites: Middletown, New Jersey; Harrison, New York +1 more · Age: 499 yrs
Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone
Actively Recruiting
PI: Bradford S. Hoppe, MD, MPH (Mayo Clinic) · Sites: Scottsdale, Arizona; Jacksonville, Florida +1 more · Age: 1599 yrs
Diagnostic and Therapeutic Targets in Cartilaginous Tumours
Actively Recruiting
PI: Tomáš Tomáš, Assoc.Prof., M.D., Ph.D. (Faculty of Medicine, Masaryk University, Brno, 602) · Sites: Brno, South Moravian
Adherence to a Personalized Home Exercise Program in Patients With Bone Tumor Undergoing Lower Extremity Salvage Surgery
Actively Recruiting
PI: alida abbruzzese (ufficio ricerca professioni sanitarie) · Sites: Bologna · Age: 1290 yrs

Specialists

Showing 25 of 56View all specialists →
TP
Tomáš Tomáš, Assoc.Prof., M.D., Ph.D.
Specialist
PI on 1 active trial
AA
alida abbruzzese
Specialist
PI on 1 active trial
MP
Michal Mahdal, M.D., Ph.D.
Specialist
PI on 1 active trial
FP
Florence DUFFAUD, MD PhD
Specialist
PI on 1 active trial
AI
Antoine Italiano
Bordeaux, NY
Specialist

Rare Disease Specialist

PI on 6 active trials
TM
Thomas F. DeLaney, MD
Specialist
PI on 2 active trials
HP
Hans Gelderblom, Prof
Specialist
PI on 1 active trial
RP
Robert Maki, MD, PhD
PHILADELPHIA, PA
Specialist
PI on 8 active trials
SM
Silvia Stacchiotti, MD
Specialist
PI on 4 active trials
MW
Mia Weiss
SAINT LOUIS, MO
Specialist
PI on 1 active trial
DM
David Grosshans, MD,PHD
HOUSTON, TX
Specialist
PI on 1 active trial
BP
Bryan Oronsky, MD PhD
JACKSONVILLE, FL
Specialist
PI on 1 active trial
WP
William Petty
Specialist
PI on 1 active trial
MM
Mary L. Keohan, MD
NEW YORK, NY
Specialist
PI on 1 active trial
RC
Rashmi Chugh
ANN ARBOR, MI
Specialist
PI on 1 active trial12 Chondrosarcoma publications
GG
Giovanni Grignani
Specialist
PI on 2 active trials4 Chondrosarcoma publications
JC
Josefina Cruz
PHILADELPHIA, PA
Specialist
PI on 1 active trial23 Chondrosarcoma publications
AR
Andrés Redondo
Specialist
PI on 2 active trials5 Chondrosarcoma publications
SM
Scot C. Remick, MD
SCARBOROUGH, ME
Specialist
PI on 9 active trials
JB
Javier Martín Broto
Specialist
PI on 2 active trials
DM
Daniel Prince, MD
Specialist
PI on 1 active trial
DP
David M Loeb, MD, PhD
JACKSONVILLE, FL
Specialist
PI on 1 active trial
SS
Silvia Stacchiotti
Specialist
PI on 2 active trials9 Chondrosarcoma publications

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Chondrosarcoma.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Chondrosarcoma

Disease timeline:

New recruiting trial: Adherence to a Personalized Home Exercise Program in Patients With Bone Tumor Undergoing Lower Extremity Salvage Surgery

A new clinical trial is recruiting patients for Chondrosarcoma

New recruiting trial: PET-imaging of Two Vartumabs in Patients With Solid Tumors

A new clinical trial is recruiting patients for Chondrosarcoma

New recruiting trial: Diagnostic and Therapeutic Targets in Cartilaginous Tumours

A new clinical trial is recruiting patients for Chondrosarcoma

New recruiting trial: Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone

A new clinical trial is recruiting patients for Chondrosarcoma

New recruiting trial: Assessment of Healing and Function After Reconstruction Surgery for Bone Sarcomas

A new clinical trial is recruiting patients for Chondrosarcoma

New recruiting trial: A Study of Anlotinib Combined With or Without PD-1 Antibody on Unresectable High-grade Chondrosarcoma

A new clinical trial is recruiting patients for Chondrosarcoma

New recruiting trial: A Study of AdAPT-001 in Subjects With Sarcoma and Refractory Solid Tumors

A new clinical trial is recruiting patients for Chondrosarcoma

New recruiting trial: Hypofractionated Protontherapy in Chordomas and Chondrosarcomas of the Skull Base

A new clinical trial is recruiting patients for Chondrosarcoma

New recruiting trial: Proton or Photon RT for Retroperitoneal Sarcomas

A new clinical trial is recruiting patients for Chondrosarcoma

New recruiting trial: Study on Trabectedin in Advanced Rearranged Mesenchymal Chondrosarcoma

A new clinical trial is recruiting patients for Chondrosarcoma

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.What grade and stage is my chondrosarcoma, and what does that mean for my outlook?,Is surgery possible, and can you preserve my limb or joint?,Are there any clinical trials I might be eligible for?,Should I have genetic testing to see if my cancer is related to a hereditary condition?,How often will I need follow-up scans, and what are we watching for?,What are the risks of the surgery, and what will my recovery look like?,Are there any targeted therapies or newer treatments that might work for my specific tumor type?

Common questions about Chondrosarcoma

What is Chondrosarcoma?

Chondrosarcoma is a type of bone cancer that starts in cartilage cells — the tough, flexible tissue that cushions your joints and makes up parts of your skeleton. It is the second most common primary bone cancer in adults. Unlike some other bone cancers, chondrosarcoma tends to grow slowly, but it can spread to other parts of the body if not treated. The tumor most often forms in the bones of the pelvis, thigh (femur), upper arm (humerus), ribs, and shoulder blade, though it can appear in almost any bone. Most people with chondrosarcoma notice a slowly growing lump or swelling near a bone, al

At what age does Chondrosarcoma typically begin?

Typical onset of Chondrosarcoma is adult. Age of onset can vary across affected individuals.

Are there clinical trials for Chondrosarcoma?

Yes — 20 recruiting clinical trials are currently listed for Chondrosarcoma on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Chondrosarcoma?

25 specialists and care centers treating Chondrosarcoma are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.