Dedifferentiated liposarcoma

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ORPHA:99970C49.9
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11Active trials36Specialists8Treatment centers

Where are you in your journey?

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Also known as:

DDLS
Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Mar 2026Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma

National Cancer Institute (NCI) — PHASE1, PHASE2

TrialRECRUITING
Mar 2025Safety and Preliminary Efficacy of SA53-OS in Patients With Locally Advanced or Metastatic Solid Tumors

Lamassu Bio Inc — PHASE1, PHASE2

TrialRECRUITING
Dec 2024First-line Treatment of Advanced/unresectable DDLPS

Fudan University — PHASE2

TrialNOT YET RECRUITING
Sep 2024Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

National Cancer Institute (NCI) — PHASE3

TrialRECRUITING
Jun 2024A Phase 2, Open Label Study of PEmigatinib and REtifanlimab in Advanced Dedifferentiated LIposarcoma (PERELI)

Lund University Hospital — PHASE2

TrialRECRUITING
Feb 2024Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma

National Cancer Institute (NCI) — PHASE1

TrialRECRUITING
Jun 2023Testing the Addition of Cemiplimab to Palbociclib for the Treatment of Advanced Dedifferentiated Liposarcoma

Alliance for Clinical Trials in Oncology — PHASE2

TrialACTIVE NOT RECRUITING
May 2023A Study of Etrumadenant and Zimberelimab in People With Dedifferentiated Liposarcoma

Memorial Sloan Kettering Cancer Center — PHASE2

TrialACTIVE NOT RECRUITING
Nov 2022A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, or Dedifferentiated Liposarcoma

Memorial Sloan Kettering Cancer Center — PHASE1

TrialRECRUITING
Nov 2021SARC041: Study of Abemaciclib Versus Placebo in Patients with Advanced Dedifferentiated Liposarcoma

Sarcoma Alliance for Research through Collaboration — PHASE3

TrialACTIVE NOT RECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Dedifferentiated liposarcoma.

11 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

11 recruitingView all trials with filters →
Phase 32 trials
Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas
Phase 3
Actively Recruiting
PI: Seth M Pollack (ECOG-ACRIN Cancer Research Group) · Sites: Phoenix, Arizona; Tucson, Arizona +245 more · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
SARC041: Study of Abemaciclib Versus Placebo in Patients with Advanced Dedifferentiated Liposarcoma
Phase 3
Active
PI: Mark Dickson, MD (Memorial Sloan Kettering Cancer Center) · Sites: Aurora, Colorado; Jacksonville, Florida +7 more · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Phase 25 trials
Testing the Addition of Cemiplimab to Palbociclib for the Treatment of Advanced Dedifferentiated Liposarcoma
Phase 2
Active
· Sites: Birmingham, Alabama; Phoenix, Arizona +192 more · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
A Phase 2, Open Label Study of PEmigatinib and REtifanlimab in Advanced Dedifferentiated LIposarcoma (PERELI)
Phase 2
Actively Recruiting
· Sites: Oslo; Gothenburg +2 more · Age: 18–100 yrs
View on ClinicalTrials.gov ↗I'm interested →
A Study of Etrumadenant and Zimberelimab in People With Dedifferentiated Liposarcoma
Phase 2
Active
PI: Sandra D'Angelo, MD (Memorial Sloan Kettering Cancer Center) · Sites: Basking Ridge, New Jersey; Middletown, New Jersey +5 more · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Study of Abemaciclib in Dedifferentiated Liposarcoma
Phase 2
Active
PI: Mark Dickson, MD (Memorial Sloan Kettering Cancer Center) · Sites: New York, New York · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)
Phase 2
Active
PI: Margaret von Mehren, MD (Fox Chase Cancer Center) · Sites: Boston, Massachusetts; Philadelphia, Pennsylvania · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Phase 13 trials
Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma
Phase 1
Actively Recruiting
PI: Candace L Haddox (Dana-Farber - Harvard Cancer Center LAO) · Sites: Los Angeles, California; Los Angeles, California +14 more · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma
Phase 1
Active
PI: Vishruth Reddy, MD, PhD (UCLA / Jonsson Comprehensive Cancer Center) · Sites: Los Angeles, California · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, or Dedifferentiated Liposarcoma
Phase 1
Actively Recruiting
PI: Alexander Shoushtari, MD (Memorial Sloan Kettering Cancer Center) · Sites: Harrison, New York; New York, New York · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →

Specialists

Showing 25 of 36View all specialists →
SD
Sandra P D'Angelo
SPRINGFIELD, MO
Specialist
PI on 1 active trial
MM
Mark Dickson, MD
Specialist
PI on 3 active trials
PM
Paolo G. Casali, MD
Specialist
PI on 2 active trials
OM
Olayode Babatunde, MD
NEW YORK, NY
Specialist
PI on 1 active trial
LM
Larry Hayward, MD
WEATHERFORD, TX
Specialist
PI on 1 active trial
HL
Heather Lin
ATLANTA, GA
Specialist
2 Dedifferentiated liposarcoma publications
LQ
Li-Xuan Qin
Specialist
3 Dedifferentiated liposarcoma publications
SS
Samuel Singer
Specialist
3 Dedifferentiated liposarcoma publications
WW
Wei-Lien Wang
Specialist
2 Dedifferentiated liposarcoma publications
RR
Ravin Ratan
HOUSTON, TX
Specialist
2 Dedifferentiated liposarcoma publications
DA
Dejka Araujo
HOUSTON, TX
Specialist
2 Dedifferentiated liposarcoma publications
SP
Shreyaskumar Patel
HOUSTON, TX
Specialist
2 Dedifferentiated liposarcoma publications
AC
Anthony P Conley
HOUSTON, TX
Specialist
2 Dedifferentiated liposarcoma publications
VR
Vinod Ravi
HOUSTON, TX
Specialist
2 Dedifferentiated liposarcoma publications
RT
Raymond S Traweek
TEMPLE, TX
Specialist
2 Dedifferentiated liposarcoma publications
XZ
Xiao Zhou
Specialist
2 Dedifferentiated liposarcoma publications
RG
Rodrigo Gularte-Mérida
Specialist
2 Dedifferentiated liposarcoma publications
ES
Evan Seffar
Specialist
2 Dedifferentiated liposarcoma publications
MB
Martina Bradic
Specialist
2 Dedifferentiated liposarcoma publications
EK
Emily Z Keung
HOUSTON, TX
Specialist
3 Dedifferentiated liposarcoma publications
NS
Neeta Somaiah
HOUSTON, TX
Specialist
PI on 3 active trials
CR
Christina L Roland
WESTAMPTON, NJ
Specialist
PI on 2 active trials2 Dedifferentiated liposarcoma publications
AI
Antoine Italiano
Bordeaux, NY
Specialist

Rare Disease Specialist

PI on 6 active trials
SP
Seth M Pollack
CHICAGO, IL
Specialist
PI on 1 active trial
HP
Hans Gelderblom, Prof
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program ↗

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Dedifferentiated liposarcoma.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Dedifferentiated liposarcoma

Disease timeline:

New recruiting trial: Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma

A new clinical trial is recruiting patients for Dedifferentiated liposarcoma

New recruiting trial: Safety and Preliminary Efficacy of SA53-OS in Patients With Locally Advanced or Metastatic Solid Tumors

A new clinical trial is recruiting patients for Dedifferentiated liposarcoma

New recruiting trial: A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, or Dedifferentiated Liposarcoma

A new clinical trial is recruiting patients for Dedifferentiated liposarcoma

New recruiting trial: A Phase 2, Open Label Study of PEmigatinib and REtifanlimab in Advanced Dedifferentiated LIposarcoma (PERELI)

A new clinical trial is recruiting patients for Dedifferentiated liposarcoma

New recruiting trial: Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma

A new clinical trial is recruiting patients for Dedifferentiated liposarcoma

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Dedifferentiated liposarcoma

Are there clinical trials for Dedifferentiated liposarcoma?

Yes — 11 recruiting clinical trials are currently listed for Dedifferentiated liposarcoma on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Dedifferentiated liposarcoma?

25 specialists and care centers treating Dedifferentiated liposarcoma are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.