Gastrointestinal stromal tumor

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ORPHA:44890OMIM:175510C26.9
Who is this for?
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4FDA treatments47Active trials144Specialists8Treatment centers2Financial resources

Where are you in your journey?

UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Also known as:

Clinical phenotype terms— hover any for plain English:

Intestinal obstructionHP:0005214Neoplasm of the stomachHP:0006753Neoplasm of the gastrointestinal tractHP:0007378SarcomaHP:0100242Neoplasm of the colonHP:0100273Gastrointestinal stroma tumorHP:0100723Neoplasm of the rectumHP:0100743Esophageal neoplasmHP:0100751Neoplasm of the small intestineHP:0100833
Orphanet ↗OMIM ↗NORD ↗

FDA & Trial Timeline

10 events
Jun 2026PH 2 Pemigatinib in SDH-deficient GIST

Dana-Farber Cancer Institute — PHASE2

TrialNOT YET RECRUITING
Jun 2026Neoadjuvant Imatinib and Fampridine in KIT Mutant Gastrointestinal Stromal Tumor

University of California, San Diego — PHASE1

TrialRECRUITING
Apr 2026A Multicenter, Open-label Clinical Study to Evaluate the Efficacy and Safety of NB003 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)

Ningbo Newbay Technology Development Co., Ltd — PHASE2, PHASE3

TrialNOT YET RECRUITING
Apr 2026KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting

Kumquat Biosciences Inc. — PHASE2

TrialNOT YET RECRUITING
Mar 2026Liposomal Irinotecan in Combination With Temozolomide and Bevacizumab in Patients With Advanced STS

Second Affiliated Hospital, School of Medicine, Zhejiang University — PHASE2

TrialNOT YET RECRUITING
Feb 2026Development of a Multimodal AI System for GIST Management

Qun Zhao

TrialNOT YET RECRUITING
Feb 2026Safety of Robotic Surgery for GISTs at Special Anatomic Sites

The First Affiliated Hospital with Nanjing Medical University — NA

TrialRECRUITING
Jan 2026A Comprehensive, Multinational GIST Registry

Universität Duisburg-Essen

TrialNOT YET RECRUITING
Dec 2025A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy

GlaxoSmithKline — PHASE3

TrialRECRUITING
Sep 2025Lenvatinib After Progression on Imatinib, Sunitinib, and Regorafenib for GIST Patients

Asan Medical Center — PHASE1, PHASE2

TrialNOT YET RECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

4 available

Imatinib Mesylate

IMATINIB MESYLATE· Apotex Corp

Patients with Kit (CD117) positive unresectable and/or metastatic malignant gastrointestinal stromal tumors (GIST)

Stivarga

regorafenib· Bayer HealthCare Pharmaceuticals, Inc.■ Boxed Warning
indicated for the treatment of adult patients with locally advanced, unresectable or metastatic gastrointestinal stromal tumor (GIST) who have been previously treated with imatinib mesylate and suniti

indicated for the treatment of adult patients with locally advanced, unresectable or metastatic gastrointestinal stromal tumor (GIST) who have been previously treated with imatinib mesylate and sunitinib malate

Ayvakit

avapritinib· Blueprint Medicines CorporationOrphan Drug

Treatment of adults with unresectable or metastatic GIST harboring a platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutation, including PDGFRA D842V mutations

Imatinib Mesylate

IMATINIB· Mylan Institutional IncOrphan Drug

Treatment of patients with Kit (CD117) positive unresectable and/or metastatic malignant gastrointestinal stromal tumors (GIST)

Clinical Trials

20 recruitingView all trials with filters →
Phase 36 trials
A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib
Phase 3
Active
· Sites: Scottsdale, Arizona; La Jolla, California +119 more · Age: 1899 yrs
(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors
Phase 3
Active
· Sites: Scottsdale, Arizona; Tucson, Arizona +108 more · Age: 1899 yrs
A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib
Phase 3
Active
PI: Clinical Team (Deciphera Pharmaceuticals, LLC) · Sites: La Jolla, California; New Haven, Connecticut +68 more · Age: 1899 yrs
Three Versus Five Years of Adjuvant Imatinib as Treatment of Patients With Operable GIST
Phase 3
Active
PI: Heikki Joensuu (Helsinki University Central Hospital) · Sites: Helsinki · Age: 18100 yrs
A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy
Phase 3
Actively Recruiting
· Sites: Boston, Massachusetts; Omaha, Nebraska +18 more · Age: 1899 yrs
A Study of Olverembatinib in SDH-deficient GIST.
Phase 3
Actively Recruiting
PI: Ruihua Xu, M.D., Ph.D. (Sun Yat-sen University) · Sites: Guangzhou, Guangdong · Age: 1299 yrs
Phase 41 trial
Study to Allow Access to Imatinib for Patients Who Are on Imatinib Treatment in a Novartis-sponsored Study and Are Benefiting From the Treatment as Judged by the Investigator
Phase 4
Active
PI: Novartis Pharmaceuticals (Novartis Pharmaceuticals) · Sites: Los Angeles, California; Chicago, Illinois +27 more · Age: 0100 yrs
Phase 21 trial
A Prospective, Randomized, Multicenter, Comparative Study of the Efficacy of Imatinib Resumption Combined With Atezolizumab Versus Imatinib Resumption Alone in Patients With Unresectable Advanced Gastrointestinal Stromal Tumors (GIST) After Failure of Standard Treatments
Phase 2
Actively Recruiting
PI: Mehdi BRAHMI, MD (Centre Leon Berard) · Sites: Lyon, Rhône; Bordeaux +11 more · Age: 1899 yrs
Other12 trials
Prediction of Postoperative Treatment Efficacy and Recurrence Risk of High-risk GIST Based on Liquid Biopsy MRD
Actively Recruiting
PI: Yingjiang Ye (Peking University People's Hospital) · Sites: Beijing, Beijing Municipality
Comparison of Tumor Efficacy Safety in Laparoscopic Resection of Gastrointestinal Stromal Tumors Between Favorable and Unfavorable Site
Actively Recruiting
· Sites: Fuzhou, Fujian · Age: 1875 yrs
Second-line Pharmacotherapy Patterns and Outcomes of Advanced Gastrointestinal Stromal Tumor: A Real-world Study
Actively Recruiting
PI: zhang xinhua, PhD (First affiliated hosptial,Sun Yat-sen university) · Sites: Chongqing, Chongqing Municipality; Guangzhou, Guangdong +6 more · Age: 1899 yrs
Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma
Actively Recruiting
PI: James M Ford (Stanford University) · Sites: Stanford, California · Age: 1899 yrs
A Multicenter Study of Avapritinib Efficacy and Safety of Metastatic or Unresectable Gastrointestinal Stromal Tumors
Actively Recruiting
PI: Xinhua Zhang, PhD (First affiliated hosptial,Sun Yat-sen university) · Sites: Guangzhou · Age: 1899 yrs
Avapritinib in the Treatment of Unresectable or Recurrent Metastatic GIST Non-exon18 Mutations of PDGFRA
Actively Recruiting
PI: Xinhua Zhang, PhD (First affiliated hosptial,Sun Yat-sen university) · Sites: Guangzhou · Age: 1899 yrs
The Australia and New Zealand Multicentre Upper Gastrointestinal Endoscopic Tissue Resection Study
Actively Recruiting
PI: Michael Bourke (WSLHD) · Sites: Sydney, New South Wales · Age: 1899 yrs
Oncogenetic Panel and Integrated Clinical Data Registry Study for Wild Type Gastrointestinal Stromal Tumor Patients
Active
PI: Hui-Jen Tsai, M.D. (National Health Research Institutes, Taiwan) · Sites: Kaohsiung City; Kaohsiung City +9 more · Age: 2099 yrs
The Correlation Between Ripretinib Exposure and the Efficacy and Safety in Patients with Advanced GISTs
Actively Recruiting
· Sites: Guangzhou · Age: 1899 yrs
Observational Registry Data on GIST Patients
Actively Recruiting
PI: Tsang-Wu Liu, M.D (Taiwan Cooperation Organization Group,NHRI,Taiwan) · Sites: Taipei · Age: 2099 yrs
Clinical Research of Drug Holiday Based on MRD Detection in GIST Patients at High Risk of Recurrence
Actively Recruiting
PI: Zhidong Gao, MD (Peking University People's Hospital) · Sites: Beijing, Beijing Municipality · Age: 1875 yrs
A Cohort Study on the Safety of Laparoscopic Resection of 5cm or Larger Gastric Gastrointestinal Stromal Tumors
Actively Recruiting
· Sites: Fuzhou, Fujian · Age: 1875 yrs

Specialists

Showing 25 of 144View all specialists →
PM
Paolo G. Casali, MD
Specialist
PI on 2 active trials
JP
Jonathan Trent, MD, PhD
Specialist
PI on 3 active trials
RD
Ronald DeMatteo
PHILADELPHIA, PA
Specialist
PI on 2 active trials3 Gastrointestinal stromal tumor publications
SO
Scott Okuno
ROCHESTER, MN
Specialist
PI on 3 active trials4 Gastrointestinal stromal tumor publications
JP
Jean Yves Blay, PR
Specialist
PI on 2 active trials
ZP
zhang xinhua, PhD
Specialist
PI on 1 active trial
CM
Christopher W Teshima, MD,FRCPC
Specialist
PI on 1 active trial
SK
Srinadh Komanduri
CHICAGO, IL
Specialist
PI on 1 active trial
TL
Teri A Longacre
STANFORD, CA
Specialist
PI on 1 active trial1 Gastrointestinal stromal tumor publication
GL
Global Clinical Leader
Specialist
PI on 44 active trials4 Gastrointestinal stromal tumor publications
NS
Neeta Somaiah
HOUSTON, TX
Specialist
PI on 3 active trials
AI
Antoine Italiano
Bordeaux, NY
Specialist

Rare Disease Specialist

PI on 6 active trials
KM
Kristen Ganjoo, MD
STANFORD, CA
Specialist
PI on 3 active trials
GM
George D. Demetri, MD
BOSTON, MA
Specialist
PI on 4 active trials1 Gastrointestinal stromal tumor publication
AM
Arun Singh, MD
Specialist
PI on 1 active trial1 Gastrointestinal stromal tumor publication
BM
Brigitte C Widemann, M.D.
Bethesda, Maryland
Specialist

Rare Disease Specialist

PI on 18 active trials
SD
Sandra D'Angelo
SPRINGFIELD, MO
Specialist
PI on 2 active trials4 Gastrointestinal stromal tumor publications
UD
Urielle Desalbres
Specialist
PI on 21 active trials1 Gastrointestinal stromal tumor publication
RP
Rachael Easton, MD, PhD
TROY, MI
Specialist
PI on 3 active trials
JY
Jiren Yu
Specialist
PI on 3 active trials385 Gastrointestinal stromal tumor publications
DH
David S Hong
Specialist
PI on 7 active trials37 Gastrointestinal stromal tumor publications
MM
Margaret von Mehren, MD
Specialist
PI on 7 active trials
SG
Suzanne George
Specialist
PI on 2 active trials60 Gastrointestinal stromal tumor publications
YP
Yoon-Koo Kang, PhD
Specialist
PI on 2 active trials

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Financial Resources

2 resources
Stivarga(regorafenib)Bayer HealthCare Pharmaceuticals, Inc.
Ayvakit(avapritinib)Blueprint Medicines Corporation

Travel Grants

No travel grants are currently matched to Gastrointestinal stromal tumor.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Gastrointestinal stromal tumor

Disease timeline:

New recruiting trial: The Australia and New Zealand Multicentre Upper Gastrointestinal Endoscopic Tissue Resection Study

A new clinical trial is recruiting patients for Gastrointestinal stromal tumor

New recruiting trial: Graded Insulin Suppression Test P&F

A new clinical trial is recruiting patients for Gastrointestinal stromal tumor

New recruiting trial: iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation

A new clinical trial is recruiting patients for Gastrointestinal stromal tumor

New recruiting trial: Apatinib Mesylate Versus Standard Second-line TKI in the Treatment of Advanced GIST

A new clinical trial is recruiting patients for Gastrointestinal stromal tumor

New recruiting trial: Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma

A new clinical trial is recruiting patients for Gastrointestinal stromal tumor

New recruiting trial: Safety of Robotic Surgery for GISTs at Special Anatomic Sites

A new clinical trial is recruiting patients for Gastrointestinal stromal tumor

New recruiting trial: 5 Years of Adjuvant Imatinib in Patients With Gastrointestinal Stromal Tumor With a High Risk

A new clinical trial is recruiting patients for Gastrointestinal stromal tumor

New recruiting trial: Clinical Research of Drug Holiday Based on MRD Detection in GIST Patients at High Risk of Recurrence

A new clinical trial is recruiting patients for Gastrointestinal stromal tumor

New recruiting trial: Prediction of Postoperative Treatment Efficacy and Recurrence Risk of High-risk GIST Based on Liquid Biopsy MRD

A new clinical trial is recruiting patients for Gastrointestinal stromal tumor

New recruiting trial: Observational Registry Data on GIST Patients

A new clinical trial is recruiting patients for Gastrointestinal stromal tumor

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Gastrointestinal stromal tumor

Are there clinical trials for Gastrointestinal stromal tumor?

Yes — 20 recruiting clinical trials are currently listed for Gastrointestinal stromal tumor on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Gastrointestinal stromal tumor?

25 specialists and care centers treating Gastrointestinal stromal tumor are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.

What treatment and support options exist for Gastrointestinal stromal tumor?

1 patient support program are currently tracked on UniteRare for Gastrointestinal stromal tumor. See the treatments and support programs sections for copay assistance, eligibility, and contact details.