Acute liver failure

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13Active trials84Specialists8Treatment centers1Financial resources

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Also known as:

Acute hepatic failureFulminant hepatic failure

Clinical phenotype terms— hover any for plain English:

Hepatocellular necrosisHP:0001404Adrenal insufficiencyHP:0000846Hepatic necrosisHP:0002605Hepatic periportal necrosisHP:0002614
Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Jan 2028National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III Trial

Institute of Liver and Biliary Sciences, India — PHASE3

TrialNOT YET RECRUITING
Jan 2027National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial

Institute of Liver and Biliary Sciences, India — PHASE2

TrialNOT YET RECRUITING
May 2026Double Plasma Separation and Adsorption in Acute-on-Chronic Liver Failure (DPMAS-ACLF Trial)

Institute of Liver and Biliary Sciences, India — NA

TrialNOT YET RECRUITING
Apr 2026Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial

Institute of Liver and Biliary Sciences, India — NA

TrialNOT YET RECRUITING
Mar 2026Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome

Yale University — PHASE2

TrialRECRUITING
Mar 2026Evaluation of Fibroscan® Performance in Diagnosing Acute Heart Failure in Patients Presenting to the Emergency Department

Assistance Publique - Hôpitaux de Paris — NA

TrialNOT YET RECRUITING
Feb 2026Efficacy and Safety of Early Initiation of Midodrine for Control and Prevention of Ascites and Its Related Complications in Acute-on-chronic Liver Failure.

Institute of Liver and Biliary Sciences, India — NA

TrialNOT YET RECRUITING
Feb 2026EGEN-5784 Porcine Liver With the Metra® ELC Device

eGenesis, INC — PHASE1

TrialNOT YET RECRUITING
Feb 2026A Novel Extracorporeal Liver Support Therapy In ALCF and to Evaluate the Efficacy of DIALIVE 2.0, a Liver Dialysis Device.

Yaqrit Ltd — PHASE3

TrialNOT YET RECRUITING
Jan 2026PT-MSCs Exosome Injection in the Treatment of Chronic-to-acute Liver Failure

Third Affiliated Hospital, Sun Yat-Sen University — EARLY_PHASE1

TrialACTIVE NOT RECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Acute liver failure.

13 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

13 recruitingView all trials with filters →
Phase 22 trials
TReatment for ImmUne Mediated PathopHysiology
Phase 2
Actively Recruiting
PI: Estella M Alonso, MD (Ann & Robert H Lurie Children's Hospital of Chicag) · Sites: Los Angeles, California; Palo Alto, California +22 more · Age: 1–18 yrs
View on ClinicalTrials.gov ↗I'm interested →
F573 for Injection for the Treatment of Liver Injury/Failure
Phase 2
Actively Recruiting
· Sites: Beijing, Beijing Municipality; Qingyuan, Guangdong +8 more · Age: 18–60 yrs
View on ClinicalTrials.gov ↗I'm interested →
N/A5 trials
Standard Volume vs. High Volume Plasma Exchange in Pediatric Acute Liver Failure
N/A
Actively Recruiting
· Sites: New Delhi, National Capital Territory of Delhi · Age: 3–18 yrs
View on ClinicalTrials.gov ↗I'm interested →
ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Function of Vital Organs in ALF or ACLF
N/A
Actively Recruiting
· Sites: Prague · Age: 18–75 yrs
View on ClinicalTrials.gov ↗I'm interested →
Role of N-Acetylcysteine in Non-Acetaminophen-Induced Acute Liver Failure
N/A
Active
PI: Muhammad Irfan Jamil (Lahore General Hospital, Lahore) · Sites: Lahore, Punjab Province · Age: 18–60 yrs
View on ClinicalTrials.gov ↗I'm interested →
Fecal Microbiota Transplantation for Liver Failure
N/A
Actively Recruiting
· Sites: Ningbo, Zhejiang · Age: 18–65 yrs
View on ClinicalTrials.gov ↗I'm interested →
Continuous Renal Replacement Therapy Intensity in Hyperammonemia
N/A
Enrolling by Invitation
· Sites: Porto Alegre, Rio Grande do Sul · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Other4 trials
Efficacy and Safety of Citrate Anticoagulation in CRRT for Patients With Liver Failure/DysfuncTION, the CAUTION Trial! A Retrospective Study on Etiology of Liver Failure and Their Complications
Actively Recruiting
PI: Rita Jacobs, Dr. (Antwerp Univesity Hospital) · Sites: Edegem, Antwerp · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Evaluation of Cardiac Function in Acutely Decompensated Cirrhosis
Active
· Sites: Bucharest · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Clinical Study of Pediatric Acute Liver Failure
Enrolling by Invitation
· Sites: Guangzhou, Guangdong · Age: 0–18 yrs
View on ClinicalTrials.gov ↗I'm interested →
Biomarkers in Liver Failure
Active
· Age: 16–80 yrs
View on ClinicalTrials.gov ↗I'm interested →

Specialists

Showing 25 of 84View all specialists →
DD
Dr Rakhi Maiwall, DM
Specialist
PI on 1 active trial
BD
Bingliang Lin, Doctor
Specialist
PI on 1 active trial
RW
Robert J Wong
Specialist
1 Acute liver failure publication
SA
Saleh Alqahtani
WASHINGTON, DC
Specialist
1 Acute liver failure publication
FS
Faouzi Saliba
Specialist
2 Acute liver failure publications
RS
R Todd Stravitz
RICHMOND, VA
Specialist
2 Acute liver failure publications
AL
Anne M Larson
Specialist
1 Acute liver failure publication
AK
Anand V Kulkarni
SOMERSET, NJ
Specialist
2 Acute liver failure publications
RF
Rilu Feng
Specialist
2 Acute liver failure publications
JW
Jamilé Wakim-Fleming
Specialist
1 Acute liver failure publication
RL
Roman Liebe
Specialist
2 Acute liver failure publications
WB
William Bernal
Specialist
3 Acute liver failure publications
AS
Alexandra Shingina
ANN ARBOR, MI
Specialist
1 Acute liver failure publication
ST
Shannan Tujios
DALLAS, TX
Specialist
2 Acute liver failure publications
WL
William M Lee
Specialist
2 Acute liver failure publications
GL
Global Clinical Leader
Specialist
PI on 44 active trials4 Acute liver failure publications
YM
Yu Chen, MD
Specialist
PI on 3 active trials
WM
William M Lee, MD
Specialist
PI on 3 active trials1 Acute liver failure publication
AM
Anna S Lok, MD
ANN ARBOR, MI
Specialist
PI on 1 active trial1 Acute liver failure publication
DD
Dr Madhumita Premkumar, DM
Specialist
PI on 2 active trials
LD
Liang Peng, Doctor
HOUSTON, TX
Specialist
PI on 8 active trials
HP
Helle Kieler, MD, PhD, Assoc Prof
Specialist
PI on 1 active trial
HP
hatice adiguzel, PhD
Specialist
PI on 2 active trials
KM
Krzysztof Jaworski, MD
Specialist
PI on 1 active trial
NM
Nizar Mukhtar
SEATTLE, WA
Specialist
1 Acute liver failure publication

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program ↗

UCLA Health

📍 Los Angeles, CA

Financial Resources

1 resources

Corlanor

Amgen

Systolic Heart Failure

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Copay CardPatient Assistance
Accepting applications

Travel Grants

No travel grants are currently matched to Acute liver failure.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Acute liver failure

Disease timeline:

New recruiting trial: Single-center Prospective Study of Non-invasive Methods for the Diagnosis of Postoperative Complications in Liver Transplant Recipients

A new clinical trial is recruiting patients for Acute liver failure

New recruiting trial: The Effects of Double Plasma Molecular Adsorption System in Acute on Chronic Liver Failure Patients

A new clinical trial is recruiting patients for Acute liver failure

New recruiting trial: Validation of New Prognostic Biomarkers in Patients With Decompensated Cirrhosis

A new clinical trial is recruiting patients for Acute liver failure

New recruiting trial: Study About Hepatic Toxins Kinetic and Evaluation of Organ Damage in Acute on Chronic Liver Failure (ACLF) Patients

A new clinical trial is recruiting patients for Acute liver failure

New recruiting trial: Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF

A new clinical trial is recruiting patients for Acute liver failure

New recruiting trial: Skeletal Muscle Parameters of Liver Cirrhosis in Non-invasive Imaging and Outcome

A new clinical trial is recruiting patients for Acute liver failure

New recruiting trial: ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Function of Vital Organs in ALF or ACLF

A new clinical trial is recruiting patients for Acute liver failure

New recruiting trial: Comparison of Blood Products Required Using Two Different ROTEM Cut-offs Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure (ACLF) Patients With Severe Coagulopathy

A new clinical trial is recruiting patients for Acute liver failure

New recruiting trial: SSM Predicts Outcomes of CLD Inpatients With Acute Liver Injury

A new clinical trial is recruiting patients for Acute liver failure

New recruiting trial: TReatment for ImmUne Mediated PathopHysiology

A new clinical trial is recruiting patients for Acute liver failure

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Acute liver failure

Are there clinical trials for Acute liver failure?

Yes — 13 recruiting clinical trials are currently listed for Acute liver failure on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Acute liver failure?

25 specialists and care centers treating Acute liver failure are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.

What treatment and support options exist for Acute liver failure?

1 patient support program are currently tracked on UniteRare for Acute liver failure. See the treatments and support programs sections for copay assistance, eligibility, and contact details.