Cerebral visual impairment

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15Active trials41Specialists8Treatment centers

Where are you in your journey?

UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Cerebral visual impairment (CVI), also sometimes called cortical visual impairment or cortical blindness, is the most common cause of visual impairment in children in developed countries. Unlike eye problems that affect the eye itself, CVI happens when the part of the brain responsible for processing what we see — mainly the back of the brain called the visual cortex — is damaged or does not develop properly. The eyes themselves may look and work normally, but the brain has trouble making sense of the visual information it receives. CVI can cause a wide range of vision problems, from mild difficulty recognizing faces or objects to very severe vision loss. Many children with CVI also have other neurological conditions such as cerebral palsy, epilepsy, or intellectual disability, because the same brain injury or developmental problem that caused CVI often affects other brain functions too. There is no cure for CVI, but early intervention and specialized vision therapy can make a significant difference. With the right support, many children learn to use their remaining vision more effectively and can improve their ability to function in daily life. Treatment focuses on understanding each child's unique visual profile and adapting their environment, learning materials, and daily routines to help them thrive.

Also known as:

Key symptoms:

Difficulty recognizing faces, even familiar onesTrouble seeing objects in a cluttered or busy visual environmentBetter vision in familiar or simple settingsPreference for looking at objects with bright colors or lightsDifficulty with depth perception and judging distancesTendency to look at objects from the side rather than straight onDelayed or absent visual response to objects or peopleDifficulty with reading or tracking moving objectsVisual field loss (not seeing things in certain areas of vision)Sensitivity to light (photophobia)Difficulty recognizing objects by sight aloneInconsistent vision — seeing better on some days than othersReaching past or missing objects when trying to grab them

Clinical phenotype terms (41)— hover any for plain English
Abnormal cerebral morphologyHP:0002060Unusual CNS infectionHP:0011450Exacerbated by head traumaHP:0025315NeurodegenerationHP:0002180Impaired visuospatial constructive cognitionHP:0010794Central nervous system degenerationHP:0007009Abnormality of refractionHP:0000539Increased cup-to-disc ratioHP:0012796Severely reduced visual acuityHP:0001141Visual fixation instabilityHP:0025405Impaired smooth pursuitHP:0007772
Inheritance

Variable

Can be inherited in different ways depending on the underlying gene

Age of Onset

Infantile

Begins in infancy, roughly 1 month to 2 years old

Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Jun 2026Remapping Text in Sentence and Word Tasks to Aid Reading With Central Vision Loss

University of Minnesota — NA

TrialNOT YET RECRUITING
Jun 2026Sensory Substitution and Brain Plasticity Following Vision Loss

Stanford University — NA

TrialNOT YET RECRUITING
Apr 2026Ameliorating Stroke-induced Hemianopia Via Multisensory Training

Wake Forest University Health Sciences — NA

TrialNOT YET RECRUITING
Apr 2026Retinopathy of Prematurity - Visual Function and Retinal Structure

Oslo University Hospital

TrialNOT YET RECRUITING
Mar 2026Robot-Assisted Gait Training vs Visual Feedback Balance Training in Stroke

Abant Izzet Baysal University — NA

TrialRECRUITING
Mar 2026Filter Lenses for the Prevention of Migraine Attacks

Rune Skovgaard Rasmussen — NA

TrialNOT YET RECRUITING
Mar 2026Visual Restoration Using Focused Ultrasound Stimulation and Immersive Virtual Reality After Stroke

Duke University — NA

TrialNOT YET RECRUITING
Mar 2026TMS for Improving Cognitive Function in Bipolar Disorder

First Affiliated Hospital of Zhejiang University — NA

TrialNOT YET RECRUITING
Jan 2026Differentiation of Human Body Balance Disorders

Military Institute od Medicine National Research Institute — NA

TrialACTIVE NOT RECRUITING
Jan 2026Valproate for the Treatment of Residual Amblyopia

Boston Children's Hospital — PHASE1, PHASE2

TrialNOT YET RECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Cerebral visual impairment.

15 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

15 recruitingView all trials with filters →
N/A9 trials
Re-Orchestration of Interregional Oscillatory Activity to Promote Visual Recovery
N/A
Active
· Sites: Geneva · Age: 1899 yrs
Effect of Visual Retraining After Stroke
N/A
Actively Recruiting
· Sites: Rochester, New York · Age: 2180 yrs
Improving Visual Field Deficits With Noninvasive Brain Stimulation
N/A
Actively Recruiting
PI: Lorella Battelli, PhD (Beth Israel Deaconess Medical Center) · Sites: Boston, Massachusetts · Age: 1880 yrs
Statistical Learning as a Novel Intervention for Cortical Blindness
N/A
Enrolling by Invitation
· Sites: Rochester, New York · Age: 2175 yrs
Viewing Strategy Training in Children With (Cerebral) Visual Impairment
N/A
Actively Recruiting
PI: Bianca Huurneman, PhD (Royal Dutch Visio) · Sites: Nijmegen · Age: 512 yrs
Hemianopsia Rehabilitation After Stroke or Brain Injury
N/A
Actively Recruiting
· Sites: Edmonton, Alberta · Age: 1899 yrs
Biofeedback for Hemianopia Vision Rehabilitation
N/A
Actively Recruiting
· Sites: Toronto, Ontario · Age: 1890 yrs
Visual Plasticity Following Brain Lesions
N/A
Actively Recruiting
· Sites: Washington D.C., District of Columbia · Age: 1899 yrs
In-person and Telehealth Visual Rehabilitation for Children With Low Vision
N/A
Actively Recruiting
· Sites: Taipei · Age: 012 yrs
Other6 trials
Anatomical and Functional Predictions of Blindsight Capabilities in Patients With Lateral Hemianopsia
Active
PI: Clémentine GARRIC (Integrative Neuroscience and Cognition Center) · Sites: Paris · Age: 1899 yrs
Validation of a Parental Questionnaire for Screening Children for Neurovisual Disorders
Actively Recruiting
· Sites: Louvain-la-Neuve · Age: 399 yrs
Early Visual Functions in Patients at Risk of Developing Cerebral Visual Impairment. A Pilot Study
Actively Recruiting
· Sites: Rome
Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates
Actively Recruiting
PI: Mohamed El-Dib, MD (Brigham and Women's Hospital) · Sites: Boston, Massachusetts
Mechanisms of Visual Restoration After Occipital Stroke
Actively Recruiting
· Sites: Rochester, New York · Age: 2180 yrs
Neurodevelopmental Outcomes in Cerebral Visual Impairment
Enrolling by Invitation
PI: Karen L Harpster, PhD, OTR/L (Cincinnati Childrens Hospital Medical Center) · Sites: Cincinnati, Ohio

Specialists

Showing 25 of 41View all specialists →
EP
Els Ortibus, MD PhD
Specialist
PI on 1 active trial
CG
Clémentine GARRIC
Specialist
PI on 1 active trial
AF
Alistair Laidlaw, MD FRCOphth
Specialist
PI on 1 active trial
AP
Alessandro Invernizzi, Prof.
Specialist
PI on 1 active trial
GM
Geordie P. Grant, MD
Specialist
PI on 1 active trial1 Cerebral visual impairment publication
JG
Jessica Galli
EAST NORTHPORT, NY
Specialist
2 Cerebral visual impairment publications
LM
Lotfi B Merabet
BOSTON, MA
Specialist
7 Cerebral visual impairment publications
CM
Claire E Manley
Specialist
5 Cerebral visual impairment publications
RB
Richard Bowman
Specialist
4 Cerebral visual impairment publications
SM
Serena Micheletti
Specialist
4 Cerebral visual impairment publications
CB
Corinna M Bauer
MC COOL JUNCTION, NE
Specialist
3 Cerebral visual impairment publications
EF
Elisa Fazzi
Specialist
2 Cerebral visual impairment publications
ZP
Zahide Pamir
Specialist
2 Cerebral visual impairment publications
PB
Peter J Bex
Specialist
2 Cerebral visual impairment publications
EF
Elisa M Fazzi
Specialist
2 Cerebral visual impairment publications
MC
Mustafa Cemali
Specialist
2 Cerebral visual impairment publications
LA
Louise Allen
CORDOVA,, TN
Specialist
2 Cerebral visual impairment publications
CW
Cathy Williams
Specialist
2 Cerebral visual impairment publications
HP
hatice adiguzel, PhD
Specialist
PI on 2 active trials
PP
Peter Stiegler, PhD
Specialist
PI on 2 active trials
MS
mustafa cemali, Phd. student
Specialist
PI on 1 active trial
AM
ARNAUD MARTEL
Specialist
PI on 1 active trial2 Cerebral visual impairment publications
FB
Frouke N Boonstra
Specialist
2 Cerebral visual impairment publications
AR
Andrea Rossi
Specialist
2 Cerebral visual impairment publications

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Cerebral visual impairment.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Cerebral visual impairment

Disease timeline:

New recruiting trial: Visual Plasticity Following Brain Lesions

A new clinical trial is recruiting patients for Cerebral visual impairment

New recruiting trial: Viewing Strategy Training in Children With (Cerebral) Visual Impairment

A new clinical trial is recruiting patients for Cerebral visual impairment

New recruiting trial: In-person and Telehealth Visual Rehabilitation for Children With Low Vision

A new clinical trial is recruiting patients for Cerebral visual impairment

New recruiting trial: Early Visual Functions in Patients at Risk of Developing Cerebral Visual Impairment. A Pilot Study

A new clinical trial is recruiting patients for Cerebral visual impairment

New recruiting trial: Effects of Exercise With Visual Feedback in Parkinson's Disease

A new clinical trial is recruiting patients for Cerebral visual impairment

New recruiting trial: Biofeedback for Hemianopia Vision Rehabilitation

A new clinical trial is recruiting patients for Cerebral visual impairment

New recruiting trial: Validation of a Parental Questionnaire for Screening Children for Neurovisual Disorders

A new clinical trial is recruiting patients for Cerebral visual impairment

New recruiting trial: Factors in Learning And Plasticity: Macular Degeneration

A new clinical trial is recruiting patients for Cerebral visual impairment

New recruiting trial: Rehabilitation of Visual Function After Brain Injury

A new clinical trial is recruiting patients for Cerebral visual impairment

New recruiting trial: Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates

A new clinical trial is recruiting patients for Cerebral visual impairment

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.What is causing my child's CVI, and can we find out if there is an underlying condition responsible?,What does my child's specific visual profile look like — what can they see well and what is most difficult for them?,What therapies or interventions do you recommend, and how often should we do them?,How should we adapt our home and my child's classroom to support their vision?,Is my child's vision likely to improve over time, and what factors affect that?,Are there any associated conditions we should be watching for, such as epilepsy?,What resources or support groups do you recommend for families dealing with CVI?

Common questions about Cerebral visual impairment

What is Cerebral visual impairment?

Cerebral visual impairment (CVI), also sometimes called cortical visual impairment or cortical blindness, is the most common cause of visual impairment in children in developed countries. Unlike eye problems that affect the eye itself, CVI happens when the part of the brain responsible for processing what we see — mainly the back of the brain called the visual cortex — is damaged or does not develop properly. The eyes themselves may look and work normally, but the brain has trouble making sense of the visual information it receives. CVI can cause a wide range of vision problems, from mild dif

At what age does Cerebral visual impairment typically begin?

Typical onset of Cerebral visual impairment is infantile. Age of onset can vary across affected individuals.

Are there clinical trials for Cerebral visual impairment?

Yes — 15 recruiting clinical trials are currently listed for Cerebral visual impairment on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Cerebral visual impairment?

25 specialists and care centers treating Cerebral visual impairment are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.