Overview
Cerebral visual impairment (CVI), also sometimes called cortical visual impairment or cortical blindness, is the most common cause of visual impairment in children in developed countries. Unlike eye problems that affect the eye itself, CVI happens when the part of the brain responsible for processing what we see — mainly the back of the brain called the visual cortex — is damaged or does not develop properly. The eyes themselves may look and work normally, but the brain has trouble making sense of the visual information it receives. CVI can cause a wide range of vision problems, from mild difficulty recognizing faces or objects to very severe vision loss. Many children with CVI also have other neurological conditions such as cerebral palsy, epilepsy, or intellectual disability, because the same brain injury or developmental problem that caused CVI often affects other brain functions too. There is no cure for CVI, but early intervention and specialized vision therapy can make a significant difference. With the right support, many children learn to use their remaining vision more effectively and can improve their ability to function in daily life. Treatment focuses on understanding each child's unique visual profile and adapting their environment, learning materials, and daily routines to help them thrive.
Also known as:
Key symptoms:
Difficulty recognizing faces, even familiar onesTrouble seeing objects in a cluttered or busy visual environmentBetter vision in familiar or simple settingsPreference for looking at objects with bright colors or lightsDifficulty with depth perception and judging distancesTendency to look at objects from the side rather than straight onDelayed or absent visual response to objects or peopleDifficulty with reading or tracking moving objectsVisual field loss (not seeing things in certain areas of vision)Sensitivity to light (photophobia)Difficulty recognizing objects by sight aloneInconsistent vision — seeing better on some days than othersReaching past or missing objects when trying to grab them
Clinical phenotype terms (41)— hover any for plain English
Variable
Can be inherited in different ways depending on the underlying gene
Infantile
Begins in infancy, roughly 1 month to 2 years old
FDA & Trial Timeline
10 eventsUniversity of Minnesota — NA
Stanford University — NA
Wake Forest University Health Sciences — NA
Oslo University Hospital
Abant Izzet Baysal University — NA
Rune Skovgaard Rasmussen — NA
Duke University — NA
First Affiliated Hospital of Zhejiang University — NA
Military Institute od Medicine National Research Institute — NA
Boston Children's Hospital — PHASE1, PHASE2
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Cerebral visual impairment.
15 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Cerebral visual impairment.
Community
No community posts yet. Be the first to share your experience with Cerebral visual impairment.
Start the conversation →Latest news about Cerebral visual impairment
Disease timeline:
New recruiting trial: Visual Plasticity Following Brain Lesions
A new clinical trial is recruiting patients for Cerebral visual impairment
New recruiting trial: Viewing Strategy Training in Children With (Cerebral) Visual Impairment
A new clinical trial is recruiting patients for Cerebral visual impairment
New recruiting trial: In-person and Telehealth Visual Rehabilitation for Children With Low Vision
A new clinical trial is recruiting patients for Cerebral visual impairment
New recruiting trial: Early Visual Functions in Patients at Risk of Developing Cerebral Visual Impairment. A Pilot Study
A new clinical trial is recruiting patients for Cerebral visual impairment
New recruiting trial: Effects of Exercise With Visual Feedback in Parkinson's Disease
A new clinical trial is recruiting patients for Cerebral visual impairment
New recruiting trial: Biofeedback for Hemianopia Vision Rehabilitation
A new clinical trial is recruiting patients for Cerebral visual impairment
New recruiting trial: Validation of a Parental Questionnaire for Screening Children for Neurovisual Disorders
A new clinical trial is recruiting patients for Cerebral visual impairment
New recruiting trial: Factors in Learning And Plasticity: Macular Degeneration
A new clinical trial is recruiting patients for Cerebral visual impairment
New recruiting trial: Rehabilitation of Visual Function After Brain Injury
A new clinical trial is recruiting patients for Cerebral visual impairment
New recruiting trial: Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates
A new clinical trial is recruiting patients for Cerebral visual impairment
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What is causing my child's CVI, and can we find out if there is an underlying condition responsible?,What does my child's specific visual profile look like — what can they see well and what is most difficult for them?,What therapies or interventions do you recommend, and how often should we do them?,How should we adapt our home and my child's classroom to support their vision?,Is my child's vision likely to improve over time, and what factors affect that?,Are there any associated conditions we should be watching for, such as epilepsy?,What resources or support groups do you recommend for families dealing with CVI?
Common questions about Cerebral visual impairment
What is Cerebral visual impairment?
Cerebral visual impairment (CVI), also sometimes called cortical visual impairment or cortical blindness, is the most common cause of visual impairment in children in developed countries. Unlike eye problems that affect the eye itself, CVI happens when the part of the brain responsible for processing what we see — mainly the back of the brain called the visual cortex — is damaged or does not develop properly. The eyes themselves may look and work normally, but the brain has trouble making sense of the visual information it receives. CVI can cause a wide range of vision problems, from mild dif
At what age does Cerebral visual impairment typically begin?
Typical onset of Cerebral visual impairment is infantile. Age of onset can vary across affected individuals.
Are there clinical trials for Cerebral visual impairment?
Yes — 15 recruiting clinical trials are currently listed for Cerebral visual impairment on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Cerebral visual impairment?
25 specialists and care centers treating Cerebral visual impairment are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.