Neuroendocrine carcinoma of pancreas

Neuroendocrine carcinoma of the pancreas (also called pancreatic neuroendocrine carcinoma, or NEC of the pancreas) is a rare and aggressive type of cancer that starts in the hormone-producing cells of the pancreas. The pancreas has two main jobs: helping with digestion and making hormones like insulin that control blood sugar. Neuroendocrine carcinomas arise from the cells that make these hormones, but unlike the more common and slower-growing pancreatic neuroendocrine tumors (PNETs), neuroendocrine carcinomas grow and spread quickly. They are considered high-grade, meaning the cancer cells look very abnormal and divide rapidly. This cancer can cause a wide range of symptoms depending on whether it releases hormones into the bloodstream. Some tumors are 'functional' and produce hormones that cause noticeable symptoms like low blood sugar or diarrhea. Others are 'non-functional' and may not cause symptoms until the tumor grows large or spreads. Common symptoms include abdominal pain, unexplained weight loss, nausea, and fatigue. Treatment usually involves a combination of surgery (when possible), chemotherapy, and sometimes targeted therapies. Because this cancer is aggressive and often diagnosed at a late stage, treatment focuses on controlling the disease and improving quality of life. A team of specialists works together to create a personalized plan for each patient.

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Bring these to your next appointment

• Q1.What stage is my cancer, and has it spread to other organs?,Is surgery an option for me, and what would that involve?,What chemotherapy regimen do you recommend, and what side effects should I expect?,Should I have genetic testing to see if a hereditary syndrome might be involved?,Are there any clinical trials I might be eligible for?,How will we know if the treatment is working, and how often will I be monitored?,What palliative care or supportive services are available to help manage my symptoms and quality of life?

Common questions about Neuroendocrine carcinoma of pancreas