Overview
Genetic digestive tract tumor (Orphanet code 271835) is a broad classification category encompassing a group of rare tumors arising in the digestive tract that have a hereditary or genetic basis. This grouping includes various neoplasms of the gastrointestinal system — from the esophagus to the rectum, as well as associated organs such as the liver and pancreas — that occur in the context of inherited genetic predisposition syndromes. These tumors may present as part of well-characterized hereditary cancer syndromes or as isolated familial occurrences with identified germline mutations. The clinical presentation varies widely depending on the specific tumor type and location within the digestive tract. Symptoms may include abdominal pain, gastrointestinal bleeding, changes in bowel habits, weight loss, obstruction, or palpable abdominal masses. Some patients may be asymptomatic and identified through surveillance programs based on known family history or genetic testing. The age of onset, severity, and prognosis depend on the specific underlying genetic condition and tumor subtype. As this is a classification category rather than a single disease entity, treatment approaches are highly variable and depend on the specific tumor type. Management may include surgical resection, chemotherapy, targeted molecular therapies, immunotherapy, and endoscopic surveillance. Genetic counseling is an important component of care for affected individuals and their families, as identification of the underlying genetic cause can guide screening recommendations for at-risk relatives. Multidisciplinary care involving gastroenterologists, oncologists, surgeons, and clinical geneticists is typically recommended.
Variable
Can be inherited in different ways depending on the underlying gene
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
10 eventsArizona State University — NA
Yonsei University
Zedsen Limited
Seagen, a wholly owned subsidiary of Pfizer — PHASE1
Tampere University Hospital — NA
Avera McKennan Hospital & University Health Center
Institut Bergonié — NA
Seagen, a wholly owned subsidiary of Pfizer — PHASE2
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
National Cancer Institute (NCI)
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Genetic digestive tract tumor.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for Genetic digestive tract tumor at this time.
New trials open frequently. Follow this disease to get notified.
Rare Disease Specialist
Rare Disease Specialist
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Genetic digestive tract tumor.
Community
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Start the conversation →Latest news about Genetic digestive tract tumor
Disease timeline:
New recruiting trial: A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
A new clinical trial is recruiting patients for Genetic digestive tract tumor
New recruiting trial: Circulating DNA to Improve Outcome of Oncology PatiEnt. A Randomized Study
A new clinical trial is recruiting patients for Genetic digestive tract tumor
New recruiting trial: An Investigation Into Dielectric Assessment of Permittivity and Conductivity in Human Using a Novel Electrical Capacitance Tomography Scanner
A new clinical trial is recruiting patients for Genetic digestive tract tumor
New recruiting trial: Urothelial Cancer Screening in Individuals With Lynch Syndrome Using a Urine Tumor DNA Panel (LS-URO Study)
A new clinical trial is recruiting patients for Genetic digestive tract tumor
New recruiting trial: A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
A new clinical trial is recruiting patients for Genetic digestive tract tumor
New recruiting trial: The Danish Bladder Cancer Group 23 Study - A European Study on Cancer in the Upper Urinary Tract
A new clinical trial is recruiting patients for Genetic digestive tract tumor
New recruiting trial: Effect of a Fermented Dairy Protein With Prebiotic Fiber on GI Complaints
A new clinical trial is recruiting patients for Genetic digestive tract tumor
New recruiting trial: Diagnosis of Multiple Cancer and Monitoring of Minimal Residual Tumors After Treatment Using Blood and High-Sensitivity Genetic Analysis Techniques
A new clinical trial is recruiting patients for Genetic digestive tract tumor
New recruiting trial: Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining
A new clinical trial is recruiting patients for Genetic digestive tract tumor
New recruiting trial: Avera Cancer Sequencing and Analytics Protocol (ASAP)
A new clinical trial is recruiting patients for Genetic digestive tract tumor
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
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Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Common questions about Genetic digestive tract tumor
What is Genetic digestive tract tumor?
Genetic digestive tract tumor (Orphanet code 271835) is a broad classification category encompassing a group of rare tumors arising in the digestive tract that have a hereditary or genetic basis. This grouping includes various neoplasms of the gastrointestinal system — from the esophagus to the rectum, as well as associated organs such as the liver and pancreas — that occur in the context of inherited genetic predisposition syndromes. These tumors may present as part of well-characterized hereditary cancer syndromes or as isolated familial occurrences with identified germline mutations. The c
Which specialists treat Genetic digestive tract tumor?
10 specialists and care centers treating Genetic digestive tract tumor are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.