Overview
Pleural empyema, also known as empyema thoracis or pyothorax, is a serious condition where pus collects in the space between the lung and the inner wall of the chest (called the pleural space). This is not a genetic disease — it is an infectious condition that usually develops as a complication of pneumonia (lung infection), chest surgery, or chest trauma. Bacteria are the most common cause, though fungi can sometimes be responsible. When pus builds up in the pleural space, it puts pressure on the lung and makes it hard to breathe. Common symptoms include fever, chest pain (especially when breathing deeply), shortness of breath, cough, and feeling generally unwell. Patients often experience night sweats, fatigue, and weight loss. If left untreated, the infection can become life-threatening. Treatment typically involves draining the infected fluid from the chest, usually with a chest tube, and giving strong antibiotics through an IV (intravenous line). In more advanced cases, surgery may be needed to remove the infected tissue and allow the lung to re-expand. Early diagnosis and treatment are very important for a good outcome. Most patients recover well with proper care, but delayed treatment can lead to long-term lung problems. Pleural empyema can affect people of any age but is more common in older adults, young children, and people with weakened immune systems.
Key symptoms:
Fever and chillsChest pain that worsens with breathingShortness of breathPersistent coughNight sweatsFatigue and weaknessUnintentional weight lossFeeling generally unwellRapid breathingReduced breath sounds on one side of the chestLoss of appetiteFoul-smelling sputum if the empyema ruptures into the airway
Sporadic
Usually appears on its own, not inherited from a parent
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
10 eventsChinese University of Hong Kong
University of North Carolina, Chapel Hill — PHASE4
Mayo Clinic — NA
Sohag University — NA
Vanderbilt University Medical Center — NA
Fayoum University — NA
Assiut University — NA
First Affiliated Hospital of Ningbo University — NA
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Pleural empyema.
9 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Pleural empyema.
Community
No community posts yet. Be the first to share your experience with Pleural empyema.
Start the conversation →Latest news about Pleural empyema
Disease timeline:
New recruiting trial: Evaluation of Efficacy and Safety Parameters of Different Antibiotics Regimens for Management of Empyema
A new clinical trial is recruiting patients for Pleural empyema
New recruiting trial: Fungal Empyema Thoracis
A new clinical trial is recruiting patients for Pleural empyema
New recruiting trial: UNC Pleural Fluid Registry
A new clinical trial is recruiting patients for Pleural empyema
New recruiting trial: Pediatric Video Assisted Thoracoscopic Surgery (VATS) in Management of Empyema
A new clinical trial is recruiting patients for Pleural empyema
New recruiting trial: Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas
A new clinical trial is recruiting patients for Pleural empyema
New recruiting trial: Complicated Pneumonia (CP) in Children in South-East Europe
A new clinical trial is recruiting patients for Pleural empyema
New recruiting trial: Effectiveness and Safety of Sodium Bicarbonate Pleural Lavage in the Treatment of Complex Pleural Effusion
A new clinical trial is recruiting patients for Pleural empyema
New recruiting trial: VATS Surgery Compared to Drainage in the Treatment of Pleural Empyema
A new clinical trial is recruiting patients for Pleural empyema
New recruiting trial: Pleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema/Complicated Parapneumonic Effusion
A new clinical trial is recruiting patients for Pleural empyema
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What caused my empyema, and is the underlying infection under control?,Will I need a chest tube, and how long will it need to stay in?,Is surgery likely to be needed in my case?,How long will I need to take antibiotics, and are there side effects I should watch for?,What signs should I watch for that would mean I need to come back to the hospital?,How long will my recovery take, and when can I return to work or school?,Will this cause any long-term damage to my lungs?
Common questions about Pleural empyema
What is Pleural empyema?
Pleural empyema, also known as empyema thoracis or pyothorax, is a serious condition where pus collects in the space between the lung and the inner wall of the chest (called the pleural space). This is not a genetic disease — it is an infectious condition that usually develops as a complication of pneumonia (lung infection), chest surgery, or chest trauma. Bacteria are the most common cause, though fungi can sometimes be responsible. When pus builds up in the pleural space, it puts pressure on the lung and makes it hard to breathe. Common symptoms include fever, chest pain (especially when br
How is Pleural empyema inherited?
Pleural empyema follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
Are there clinical trials for Pleural empyema?
Yes — 9 recruiting clinical trials are currently listed for Pleural empyema on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Pleural empyema?
25 specialists and care centers treating Pleural empyema are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.