Pleural empyema

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9Active trials45Specialists8Treatment centers

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Pleural empyema, also known as empyema thoracis or pyothorax, is a serious condition where pus collects in the space between the lung and the inner wall of the chest (called the pleural space). This is not a genetic disease — it is an infectious condition that usually develops as a complication of pneumonia (lung infection), chest surgery, or chest trauma. Bacteria are the most common cause, though fungi can sometimes be responsible. When pus builds up in the pleural space, it puts pressure on the lung and makes it hard to breathe. Common symptoms include fever, chest pain (especially when breathing deeply), shortness of breath, cough, and feeling generally unwell. Patients often experience night sweats, fatigue, and weight loss. If left untreated, the infection can become life-threatening. Treatment typically involves draining the infected fluid from the chest, usually with a chest tube, and giving strong antibiotics through an IV (intravenous line). In more advanced cases, surgery may be needed to remove the infected tissue and allow the lung to re-expand. Early diagnosis and treatment are very important for a good outcome. Most patients recover well with proper care, but delayed treatment can lead to long-term lung problems. Pleural empyema can affect people of any age but is more common in older adults, young children, and people with weakened immune systems.

Key symptoms:

Fever and chillsChest pain that worsens with breathingShortness of breathPersistent coughNight sweatsFatigue and weaknessUnintentional weight lossFeeling generally unwellRapid breathingReduced breath sounds on one side of the chestLoss of appetiteFoul-smelling sputum if the empyema ruptures into the airway

Inheritance

Sporadic

Usually appears on its own, not inherited from a parent

Age of Onset

Variable

Can begin at different ages, from infancy through adulthood

Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Jan 2026Diagnostic Utility of Pleural Infection-specific Multiplex PCR Panel

Chinese University of Hong Kong

TrialNOT YET RECRUITING
Sep 2025Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema

University of North Carolina, Chapel Hill — PHASE4

TrialNOT YET RECRUITING
Jul 2025Fungal Empyema Thoracis

University of Health Sciences Lahore — NA

TrialRECRUITING
Mar 2025Pleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema/Complicated Parapneumonic Effusion

Mayo Clinic — NA

TrialRECRUITING
Nov 2024Comparative Study Between Outcome of ICT Drainage and VATS in Management of Second Stage Empyema

Sohag University — NA

TrialNOT YET RECRUITING
Jun 2024Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas

Vanderbilt University Medical Center — NA

TrialRECRUITING
May 2024Complicated Pneumonia (CP) in Children in South-East Europe

Aleksandar Sovtic

TrialRECRUITING
May 2024Evaluation of Efficacy and Safety Parameters of Different Antibiotics Regimens for Management of Empyema

Fayoum University — NA

TrialRECRUITING
Apr 2024Pediatric Video Assisted Thoracoscopic Surgery (VATS) in Management of Empyema

Assiut University — NA

TrialRECRUITING
Apr 2024Effectiveness and Safety of Sodium Bicarbonate Pleural Lavage in the Treatment of Complex Pleural Effusion

First Affiliated Hospital of Ningbo University — NA

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Pleural empyema.

9 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

9 recruitingView all trials with filters →
N/A7 trials
Pediatric Video Assisted Thoracoscopic Surgery (VATS) in Management of Empyema
N/A
Actively Recruiting
PI: Mohamed Ayyad, prof. (professor) · Sites: Asyut · Age: 118 yrs
Effectiveness and Safety of Sodium Bicarbonate Pleural Lavage in the Treatment of Complex Pleural Effusion
N/A
Actively Recruiting
· Sites: Ningbo, Zhejiang · Age: 1880 yrs
Pleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema/Complicated Parapneumonic Effusion
N/A
Actively Recruiting
PI: Dagny Anderson, MD (Mayo Clinic) · Sites: Rochester, Minnesota · Age: 1899 yrs
Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas
N/A
Actively Recruiting
PI: Jennifer D Duke, MD (Vanderbilt University) · Sites: Sterling Heights, Michigan; Omaha, Nebraska +3 more · Age: 1899 yrs
Evaluation of Efficacy and Safety Parameters of Different Antibiotics Regimens for Management of Empyema
N/A
Actively Recruiting
PI: Raghda Roshdy Hussein, Assistant professor (Faculty of pharmacy Beni suef University) · Sites: Al Fayyum, Faiyum Governorate
VATS Surgery Compared to Drainage in the Treatment of Pleural Empyema
N/A
Actively Recruiting
PI: Christian B Laursen, MD, PhD (Odense University Hospital) · Sites: Aarhus, Aarhus; Copenhagen +1 more · Age: 1899 yrs
Fungal Empyema Thoracis
N/A
Actively Recruiting
PI: Muhammad Shoaib Nabi, FCPS (Saglik Bilimleri Universitesi) · Sites: Lahore, Punjab Province
Other2 trials
Complicated Pneumonia (CP) in Children in South-East Europe
Actively Recruiting
· Sites: Belgrade · Age: 018 yrs
UNC Pleural Fluid Registry
Actively Recruiting
PI: Jason Akulian (UNC Lineberger Comprehensive Cancer Center) · Sites: Chapel Hill, North Carolina · Age: 1899 yrs

Specialists

Showing 25 of 45View all specialists →
EM
Eyal Cohen, MD, MSc
Specialist
PI on 1 active trial
NP
Niels Katballe, MD, PhD
Specialist
PI on 1 active trial
AA
Ali H Abdelaal
HARRISON, AR
Specialist
PI on 1 active trial4 Pleural empyema publications
AD
Adam Jaffe, Dr
Specialist
PI on 1 active trial
YL
Yassmin Mohamed Medany, Lecturer
Specialist
PI on 1 active trial
MP
Marwa Kamal Tolba, Assistant professor
Specialist
PI on 1 active trial1 Pleural empyema publication
AA
Abdelrahman Ahmed Mohamed, Teaching assistant
Specialist
PI on 1 active trial
JA
Jason Akulian
BALTIMORE, MD
Specialist
PI on 1 active trial
MP
Mona Ibrahim Ahmed, Assistant professor
Specialist
PI on 1 active trial1 Pleural empyema publication
JM
Jennifer D Duke, MD
Specialist
PI on 1 active trial
TH
Taeho Hong
Specialist
PI on 1 active trial22 Pleural empyema publications
FM
Fayez Kheir, MD, MSc
BOSTON, MA
Specialist
PI on 1 active trial
SM
Sorin Edu, MD,FCS
Specialist
PI on 1 active trial
MM
Mostafa M Elsayed, MD
WOODBRIDGE, VA
Specialist
PI on 1 active trial
BM
Bradley W Thomas, MD
Specialist
PI on 1 active trial
MH
Mohamed Faisal Abdul Hamid
LYNDHURST, OH
Specialist
PI on 1 active trial70 Pleural empyema publications
JM
Jed Gorden, MD
SEATTLE, WA
Specialist
PI on 1 active trial
DM
David Shitrit, MD
Specialist
PI on 3 active trials
MS
Muhammad Shoaib Nabi, Professor of Thoracic Surgery
Specialist
PI on 2 active trials13 Pleural empyema publications
KM
Ka Pang Chan, MBChB
Specialist
PI on 2 active trials
DM
Damien BASILLE, MD
Specialist
PI on 1 active trial
DM
Dagny Anderson, MD
ROCHESTER, MN
Specialist
PI on 1 active trial
BM
Babu Naidu, MBBS
Specialist
PI on 1 active trial
PM
Paul De Leyn, PhD; MD
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Pleural empyema.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Pleural empyema

Disease timeline:

New recruiting trial: Evaluation of Efficacy and Safety Parameters of Different Antibiotics Regimens for Management of Empyema

A new clinical trial is recruiting patients for Pleural empyema

New recruiting trial: Fungal Empyema Thoracis

A new clinical trial is recruiting patients for Pleural empyema

New recruiting trial: UNC Pleural Fluid Registry

A new clinical trial is recruiting patients for Pleural empyema

New recruiting trial: Pediatric Video Assisted Thoracoscopic Surgery (VATS) in Management of Empyema

A new clinical trial is recruiting patients for Pleural empyema

New recruiting trial: Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas

A new clinical trial is recruiting patients for Pleural empyema

New recruiting trial: Complicated Pneumonia (CP) in Children in South-East Europe

A new clinical trial is recruiting patients for Pleural empyema

New recruiting trial: Effectiveness and Safety of Sodium Bicarbonate Pleural Lavage in the Treatment of Complex Pleural Effusion

A new clinical trial is recruiting patients for Pleural empyema

New recruiting trial: VATS Surgery Compared to Drainage in the Treatment of Pleural Empyema

A new clinical trial is recruiting patients for Pleural empyema

New recruiting trial: Pleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema/Complicated Parapneumonic Effusion

A new clinical trial is recruiting patients for Pleural empyema

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.What caused my empyema, and is the underlying infection under control?,Will I need a chest tube, and how long will it need to stay in?,Is surgery likely to be needed in my case?,How long will I need to take antibiotics, and are there side effects I should watch for?,What signs should I watch for that would mean I need to come back to the hospital?,How long will my recovery take, and when can I return to work or school?,Will this cause any long-term damage to my lungs?

Common questions about Pleural empyema

What is Pleural empyema?

Pleural empyema, also known as empyema thoracis or pyothorax, is a serious condition where pus collects in the space between the lung and the inner wall of the chest (called the pleural space). This is not a genetic disease — it is an infectious condition that usually develops as a complication of pneumonia (lung infection), chest surgery, or chest trauma. Bacteria are the most common cause, though fungi can sometimes be responsible. When pus builds up in the pleural space, it puts pressure on the lung and makes it hard to breathe. Common symptoms include fever, chest pain (especially when br

How is Pleural empyema inherited?

Pleural empyema follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

Are there clinical trials for Pleural empyema?

Yes — 9 recruiting clinical trials are currently listed for Pleural empyema on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Pleural empyema?

25 specialists and care centers treating Pleural empyema are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.