Overview
Toxic dermatosis is a broad term used to describe skin conditions that develop as a reaction to toxic substances. These substances can include medications, chemicals, environmental toxins, or other agents that trigger harmful reactions in the skin. The condition can range from mild rashes and redness to severe blistering, peeling, and widespread skin damage. Symptoms often include skin redness, itching, burning, swelling, blistering, and in severe cases, large areas of skin may peel away. The severity depends on the type of toxic agent involved, the amount of exposure, and the individual's sensitivity. Toxic dermatoses can affect people of any age and may appear suddenly after exposure to the offending substance. Some forms, such as drug-induced toxic skin reactions, can be life-threatening and require urgent medical attention. Treatment focuses on identifying and removing the causative agent, managing symptoms with topical or systemic medications, and providing supportive care. In severe cases, hospitalization may be needed for wound care, fluid management, and prevention of infection. Early recognition and prompt treatment are essential for the best outcomes. The treatment landscape includes corticosteroids, antihistamines, immunosuppressive agents, and supportive wound care depending on the severity and type of reaction.
Key symptoms:
Skin redness or rashItching or burning sensation on the skinBlistering of the skinPeeling or shedding of skinSwelling of affected areasPain or tenderness of the skinSkin discolorationOpen sores or ulcers on the skinFeverFeeling generally unwell or fatiguedSensitivity to touch on affected skinDry or cracked skinOozing or weeping from skin lesions
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
10 eventsM.D. Anderson Cancer Center — PHASE1
Region Jönköping County
Poitiers University Hospital — PHASE4
Sligo General Hospital — NA
SOLTI Breast Cancer Research Group — PHASE2
Dena h. Al-Tameemi — NA
Shiraz University of Medical Sciences — PHASE4
Haiphong University of Medicine and Pharmacy — PHASE4
Universidad de Granada — NA
Institut Claudius Regaud — PHASE4
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Toxic dermatosis.
3 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Treatment Centers
8 centersErasmus Medical Center
📍 Rotterdam
👤 Robert Rissmann, Professor
Leiden University Medical Center
📍 Leiden
👤 Robert Rissmann, Professor
Stanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
Travel Grants
No travel grants are currently matched to Toxic dermatosis.
Community
No community posts yet. Be the first to share your experience with Toxic dermatosis.
Start the conversation →Latest news about Toxic dermatosis
Disease timeline:
New recruiting trial: Pilot Study of a MIND Diet Intervention in Women Undergoing Active Treatment for Breast Cancer
A new clinical trial is recruiting patients for Toxic dermatosis
New recruiting trial: Ultra-hypofractioNated Adjuvant Radiotherapy ± sImultaneous Integrated Boost for Low-risk Breast Cancer Patients
A new clinical trial is recruiting patients for Toxic dermatosis
New recruiting trial: Oncologic Outcomes and Toxicities of Salvage Treatment in Patients With Locoregionally Recurrent Breast Cancer
A new clinical trial is recruiting patients for Toxic dermatosis
New recruiting trial: Statins for Reduction of Cardiac Toxicity in Patients Receiving HER2 Targeted
A new clinical trial is recruiting patients for Toxic dermatosis
New recruiting trial: IMmune checkPoint Inhibitor Related gonAdal toxiCiTy in Premenopausal Women and Men With Melanoma
A new clinical trial is recruiting patients for Toxic dermatosis
New recruiting trial: Ultra Hypo-fractionated Adjuvant Whole Breast Radiation Therapy With Simultaneous Integrated Boost for Early-Stage Breast Cancer (H-ASSIST)
A new clinical trial is recruiting patients for Toxic dermatosis
New recruiting trial: Investigating Paclitaxel Toxicity in Breast Cancer: the Roles of Physical Activity and Body Composition.
A new clinical trial is recruiting patients for Toxic dermatosis
New recruiting trial: Sacubitril/Valsartan in PriMAry preventIoN of the Cardiotoxicity of Systematic breaST canceR trEAtMent (MAINSTREAM)
A new clinical trial is recruiting patients for Toxic dermatosis
New recruiting trial: Retrospective Observational Study of the Safety and Toxicity Management of Abemaciclib in Combination with Adjuvant Hormone Therapy in Patients with RH+ ,HER2-nonoveramplified Breast Cancer, Real-life Data (MONARCHE29)
A new clinical trial is recruiting patients for Toxic dermatosis
New recruiting trial: Predictive Toxicity Test Linked to Radiotherapy After Mastectomy and Immediate Implant Reconstruction
A new clinical trial is recruiting patients for Toxic dermatosis
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What is the most likely cause of my skin reaction?,How can we confirm which substance triggered this reaction?,What treatments are available for my level of severity?,Are there medications or substances I need to avoid in the future?,What warning signs should prompt me to seek emergency care?,Will my skin fully recover, or should I expect lasting changes?,Should I carry a medical alert card or bracelet listing my trigger?
Common questions about Toxic dermatosis
What is Toxic dermatosis?
Toxic dermatosis is a broad term used to describe skin conditions that develop as a reaction to toxic substances. These substances can include medications, chemicals, environmental toxins, or other agents that trigger harmful reactions in the skin. The condition can range from mild rashes and redness to severe blistering, peeling, and widespread skin damage. Symptoms often include skin redness, itching, burning, swelling, blistering, and in severe cases, large areas of skin may peel away. The severity depends on the type of toxic agent involved, the amount of exposure, and the individual's sen
Are there clinical trials for Toxic dermatosis?
Yes — 3 recruiting clinical trials are currently listed for Toxic dermatosis on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Toxic dermatosis?
25 specialists and care centers treating Toxic dermatosis are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.