FDA-Approved Treatments

Drugs with orphan designation or indications for rare diseases — 968 total

Treatment data is sourced from FDA drug labels, DailyMed, and openFDA.
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Drug information is sourced from FDA labels and prescribing information. Always verify current prescribing information with your pharmacist or prescriber before starting, stopping, or changing any medication.

Orphan⚠️ Black Box

Arikayce

liposomal amikacin

Insmed Incorporated

1 INDICATIONS AND USAGE LIMITED POPULATION: ARIKAYCE ® is indicated in adults, who have limited or no alternative treatment options, for the treatment

Pulmonary non-tuberculous mycobacterial infection
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Orphan

AmBisome

Liposomal amphotericin B

Fujisawa USA, Inc.

INDICATIONS AND USAGE Am B isome is indicated for the following: • Empirical therapy for presumed fungal infection in febrile, neutropenic patients. •

Diffuse leptomeningeal melanocytosisPneumococcal meningitisLegionella infectionListeriosisFetal parvovirus syndromeCryptosporidiosis
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⚠️ Black Box

LISDEXAMFETAMINE DIMESYLATE

LISDEXAMFETAMINE DIMESYLATE

Camber Pharmaceuticals, Inc.

1 INDICATIONS AND USAGE Lisdexamfetamine dimesylate capsules are indicated for the treatment of: Attention Deficit Hyperactivity Disorder (ADHD) in ad

Rare genetic hyperkinetic movement disorderImprinting disorders
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Orphan⚠️ Black Box

Breyanzi

lisocabtagene maraleucel

Juno Therapeutics, Inc.

1 INDICATIONS AND USAGE BREYANZI is a CD19-directed genetically modified autologous T cell immunotherapy indicated for the treatment of: • adult patie

Primary mediastinal large B-cell lymphomaEpstein-Barr virus-positive diffuse large B-cell lymphoma
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Orphan

Alomide Ophthalmic Solution

Lodoxamide tromethamine

Alcon Laboratories, Inc.

Treatment of ocular disorders referred to by the terms vernal keratoconjunctivitis, vernal conjunctivitis, vernal keratitis.

Vernal keratoconjunctivitis
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Orphan⚠️ Black Box

Juxtapid

lomitapide

Chiesi Farmaceutici S.p.A.

1 INDICATIONS AND USAGE JUXTAPID is indicated as an adjunct to a low-fat diet and exercise and other low density lipoprotein cholesterol (LDL-C) thera

Homozygous familial hypercholesterolemia
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Orphan

Zokinvy

LONAFARNIB

Sentynl Therapeutics, Inc.

1 INDICATIONS AND USAGE ZOKINVY is indicated in patients 12 months of age and older with a body surface area (BSA) of 0.39 m 2 and above: To reduce th

Hutchinson-Gilford progeria syndrome
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Orphan

Skytrofa

lonapegsomatropin-tcgd

Ascendis Pharma Endocrinology Division A/S

1 INDICATIONS AND USAGE SKYTROFA (lonapegsomatropin-tcgd) is a human growth hormone indicated for the: Treatment of pediatric patients 1 year and olde

Non-acquired isolated growth hormone deficiencyRare disorder due to inadequate sharing of the placenta
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Orphan

Zynlonta

loncastuximab tesirine-lpyl

ADC Therapeutics SA

1 INDICATIONS AND USAGE ZYNLONTA is indicated for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more

Diffuse large B-cell lymphomaEpstein-Barr virus-positive diffuse large B-cell lymphomaALK-positive large B-cell lymphoma
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Orphan

LORBRENA

Lorlatinib

Pfizer, Inc.

1 INDICATIONS AND USAGE LORBRENA ® is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors ar

NON RARE IN EUROPE: Non-small cell lung cancer
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LOSARTAN POTASSIUM

LOSARTAN POTASSIUM

Micro Labs Limited

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Orphan⚠️ Black Box

Lyfgenia

LOVOTIBEGLOGENE AUTOTEMCEL

Genetix Biotherapeutics Inc.

1 INDICATIONS AND USAGE LYFGENIA is indicated for the treatment of patients 12 years of age or older with sickle cell disease and a history of vaso-oc

Sickle cell disease
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Orphan

ORKAMBI

LUMACAFTOR AND IVACAFTOR

Vertex Pharmaceuticals Incorporated

1 INDICATIONS AND USAGE ORKAMBI is indicated for the treatment of cystic fibrosis (CF) in patients aged 1 year and older who are homozygous for the F5

Cystic fibrosis
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Orphan

Oxlumo

LUMASIRAN

Alnylam Pharmaceuticals, Inc.

1 INDICATIONS AND USAGE OXLUMO is indicated for the treatment of primary hyperoxaluria type 1 (PH1) to lower urinary and plasma oxalate levels in pedi

Primary hyperoxaluria type 1
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CAPLYTA

LUMATEPERONE

Intra-Cellular Therapies, Inc

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LURASIDONE HYDROCHLORIDE

LURASIDONE HYDROCHLORIDE

Torrent Pharmaceuticals Limited

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Orphan

Zepzelca

lurbinectedin

Jazz Pharmaceuticals Ireland Limited

1 INDICATIONS AND USAGE ZEPZELCA is an alkylating drug indicated: • in combination with atezolizumab or atezolizumab and hyaluronidase-tqjs, for the m

Small cell lung cancer
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Orphan

Reblozyl

LUSPATERCEPT

Celgene Corporation

1 INDICATIONS AND USAGE REBLOZYL is an erythroid maturation agent indicated for the treatment of: • Anemia in adult patients with beta thalassemia who

Beta-thalassemiaAcute myeloid leukemia and myelodysplastic syndromes related to radiationMyelodysplastic neoplasm with low blastsMyelodysplastic neoplasm with increased blasts type 2
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Orphan

Lutathera

lutetium Lu 177 dotatate

Advanced Accelerator Applications

1 INDICATIONS AND USAGE LUTATHERA is indicated for the treatment of adult and pediatric patients 12 years and older with somatostatin receptor-positiv

Gastroenteropancreatic neuroendocrine neoplasm
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PLUVICTO

LUTETIUM LU 177 VIPIVOTIDE TETRAXETAN

Novartis Pharmaceuticals Corporation

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Orphan

Macrelin

macimorelin acetate

Aeterna Zentaris GmbH

1 INDICATIONS AND USAGE MACRILEN is indicated for the diagnosis of adult growth hormone deficiency (AGHD). MACRILEN is a growth hormone (GH) secretago

Isolated growth hormone deficiency type IIINon-acquired isolated growth hormone deficiency
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Orphan⚠️ Black Box

Opsumit

macitentan

Janssen

1 INDICATIONS AND USAGE OPSUMIT is an endothelin receptor antagonist (ERA) indicated for the treatment of pulmonary arterial hypertension (PAH, WHO Gr

Pulmonary arterial hypertension
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Orphan⚠️ Black Box

Opsynvi

MACITENTAN AND TADALAFIL

Actelion Pharmaceuticals US, Inc.

1 INDICATIONS AND USAGE OPSYNVI is a combination of macitentan, an endothelin receptor antagonist (ERA), and tadalafil, a phosphodiesterase 5 (PDE5) i

Pulmonary arterial hypertension
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Orphan

Sulfamylon solution

Mafenide acetate solution

Mylan Laboratories, Inc.

Susceptibility to viral and mycobacterial infections due to STAT1 deficiencyView details →
Orphan

Bronchitol

mannitol

Pharmaxis Europe Limited

1 INDICATIONS AND USAGE OSMITROL is indicated for: • The reduction of intracranial pressure and treatment of cerebral edema; • The reduction of elevat

OBSOLETE: Poliomyelitis in patients with immunodeficiencies deemed at riskView details →
Orphan

Livmarli

MARALIXIBAT CHLORIDE

Mirum Pharmaceuticals Inc.

1 INDICATIONS AND USAGE LIVMARLI is an ileal bile acid transporter (IBAT) inhibitor indicated for: • the treatment of cholestatic pruritus in patients

Cholestatic pruritus in patients with Alagille syndrome (ALGS)
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Orphan⚠️ Black Box

Bupivilog Kit

MARCAINE, KENALOG, POVIDONE IODINE

Advanced Rx of Tennessee, LLC

1 INDICATIONS AND USAGE Bupivacaine Hydrochloride Injection is indicated in adults for the production of local or regional anesthesia or analgesia for

OBSOLETE: Occupational allergic alveolitisView details →
Orphan⚠️ Black Box

Mlk Kit F2

MARCAINE, LIDOCAINE, KENALOG, POVIDONE IODINE

Asclemed USA, Inc.

1 INDICATIONS AND USAGE Bupivacaine Hydrochloride Injection is indicated in adults for the production of local or regional anesthesia or analgesia for

View details →
Orphan

Livtencity

maribavir

Takeda Pharmaceuticals U.S.A., Inc.

1 INDICATIONS AND USAGE LIVTENCITY ® is indicated for the treatment of adults and pediatric patients (12 years of age and older and weighing at least

Severe disseminated cytomegalovirus infection in immunocompetent patientsOff-periods in Parkinson disease not responding to oral treatment
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Orphan

HYMPAVZI

MARSTACIMAB-HNCQ

Pfizer Laboratories Div Pfizer Inc

1 INDICATIONS AND USAGE HYMPAVZI is indicated for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric p

Czeizel-Losonci syndromeHemophilia AHereditary angioedema with normal C1Inh
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