Overview
Vernal keratoconjunctivitis (VKC) is a long-term, recurring inflammatory condition that affects the outer surface of the eye — specifically the conjunctiva (the clear tissue lining the eyelids and covering the white of the eye) and the cornea (the clear front surface of the eye). The name 'vernal' comes from the Latin word for spring, because symptoms often get worse during warmer months, though many people experience problems year-round. VKC is sometimes called 'spring catarrh' or 'warm-weather conjunctivitis,' though these older terms are less commonly used today. VKC is driven by an overactive immune response, similar to severe allergies. The immune system mistakenly attacks the eye's surface, causing intense inflammation. This leads to the hallmark symptoms: severe itching, thick mucus discharge, sensitivity to light, and a feeling like something is stuck in the eye. In more serious cases, the cornea can be damaged, which may affect vision. Raised, cobblestone-like bumps can form on the inside of the upper eyelid, and a white ring called a Horner-Trantas dot may appear at the edge of the cornea. Treatment focuses on controlling inflammation and protecting the eye from damage. Options include antihistamine eye drops, mast cell stabilizers, anti-inflammatory drops (including corticosteroids and cyclosporine), and in some cases, newer biologic medications. With proper management, most people can protect their vision and live comfortably, though the condition often requires ongoing care throughout childhood and adolescence.
Also known as:
Key symptoms:
Intense eye itching, often described as unbearableThick, ropy or stringy mucus discharge from the eyeSensitivity to light (photophobia)A feeling that something is stuck in the eye (foreign body sensation)Redness of the eyesExcessive tearing or watery eyesSwollen or drooping eyelidsCobblestone-like bumps on the inside of the upper eyelidBlurred visionEye pain or discomfortWhite or grayish spots at the edge of the cornea (Horner-Trantas dots)Corneal ulcers or scarring in severe casesWorsening symptoms in warm, sunny, or windy weather
Clinical phenotype terms (23)— hover any for plain English
Multifactorial
Caused by a mix of several genes and environmental factors
Childhood
Begins in childhood, roughly ages 1 to 12
FDA & Trial Timeline
10 eventsLaboratoires Thea — PHASE2
The University of Hong Kong — PHASE3
Sohag University — NA
Superior University
Mohsen Pourazizi — PHASE1
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
3 availableVerkazia
Treatment of vernal keratoconjunctivitis (VKC) in children and adults
Alomide Ophthalmic Solution
Treatment of ocular disorders referred to by the terms vernal keratoconjunctivitis, vernal conjunctivitis, vernal keratitis.
Opticrom 4% ophthalmic solution
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Financial Resources
1 resourcesTravel Grants
No travel grants are currently matched to Vernal keratoconjunctivitis.
Community
No community posts yet. Be the first to share your experience with Vernal keratoconjunctivitis.
Start the conversation →Latest news about Vernal keratoconjunctivitis
No recent news articles for Vernal keratoconjunctivitis.
Follow this condition to be notified when news becomes available.
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.How severe is my child's VKC, and is there any corneal damage already present?,Which eye drops do you recommend, and how do we use them safely long-term without steroid side effects?,How often should we come in for check-ups, and what signs should prompt an urgent visit?,Are there any known triggers we should try to avoid to reduce flare-ups?,Will my child's VKC likely improve as they get older, and what is the expected outlook for their vision?,Are there any newer treatments, such as biologic therapies, that might be appropriate for my child?,What should we do if symptoms suddenly get much worse or vision changes?
Common questions about Vernal keratoconjunctivitis
What is Vernal keratoconjunctivitis?
Vernal keratoconjunctivitis (VKC) is a long-term, recurring inflammatory condition that affects the outer surface of the eye — specifically the conjunctiva (the clear tissue lining the eyelids and covering the white of the eye) and the cornea (the clear front surface of the eye). The name 'vernal' comes from the Latin word for spring, because symptoms often get worse during warmer months, though many people experience problems year-round. VKC is sometimes called 'spring catarrh' or 'warm-weather conjunctivitis,' though these older terms are less commonly used today. VKC is driven by an overac
How is Vernal keratoconjunctivitis inherited?
Vernal keratoconjunctivitis follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Vernal keratoconjunctivitis typically begin?
Typical onset of Vernal keratoconjunctivitis is childhood. Age of onset can vary across affected individuals.
Are there clinical trials for Vernal keratoconjunctivitis?
Yes — 1 recruiting clinical trial is currently listed for Vernal keratoconjunctivitis on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Vernal keratoconjunctivitis?
25 specialists and care centers treating Vernal keratoconjunctivitis are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.
What treatment and support options exist for Vernal keratoconjunctivitis?
4 patient support programs are currently tracked on UniteRare for Vernal keratoconjunctivitis. See the treatments and support programs sections for copay assistance, eligibility, and contact details.