FDA-Approved Treatments

Drugs with orphan designation or indications for rare diseases — 955 total

Treatment data is sourced from FDA drug labels, DailyMed, and openFDA.
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Drug information is sourced from FDA labels and prescribing information. Always verify current prescribing information with your pharmacist or prescriber before starting, stopping, or changing any medication.

Orphan

Nulibry

fosdenopterin

Origin Biosciences, Inc.

1 INDICATIONS AND USAGE NULIBRY is indicated to reduce the risk of mortality in patients with molybdenum cofactor deficiency (MoCD) Type A. NULIBRY is

Sulfite oxidase deficiency due to molybdenum cofactor deficiency type C
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FOSFOMYCIN TROMETHAMINE

FOSFOMYCIN TROMETHAMINE

Aucta Pharmaceuticals, Inc.

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Orphan⚠️ Black Box

Cerebyx

Fosphenytoin

Warner-Lambert Company

1 INDICATIONS AND USAGE CEREBYX is indicated for the treatment of generalized tonic-clonic status epilepticus and prevention and treatment of seizures

Febrile infection-related epilepsy syndromeView details →
Orphan

Lytgobi

futibatinib

Taiho Oncology, Inc.

Treatment of adult patients with previously treated, unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma harboring fibroblast

Combined hepatocellular carcinoma and cholangiocarcinoma
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Orphan

Gralise

gabapentin

Golf Acquiror LLC

1 INDICATIONS AND USAGE GRALISE is indicated for the management of postherpetic neuralgia. GRALISE is not substitutable with other gabapentin products

NON RARE IN EUROPE: Post-herpetic neuralgia
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Orphan

Horizant

gabapentin enacarbil

Arbor Pharmaceuticals, LLC

1 INDICATIONS AND USAGE HORIZANT is indicated for: treatment of moderate-to-severe primary Restless Legs Syndrome (RLS) in adults. ( 1.1 ) management

NON RARE IN EUROPE: Post-herpetic neuralgiaX-linked severe syndromic thoracic aortic aneurysm and dissection
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Orphan

NETSPOT

Gallium [Ga-68]-N-[(4,7,10-Tricarboxymethyl-1,4,7,10-tetraazacyclododec-1-yl)acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophanyl-L-lysyl-L-threoninyl-L-cysteinyl-L-threonine-cyclic(2-7)disulfide

Advanced Accelerator Applications, USA

1 INDICATIONS AND USAGE NETSPOT, after radiolabeling with gallium-68, is indicated for use with positron emission tomography (PET) for localization of

Classic neuroendocrine tumor of appendixSerotonin-producing neuroendocrine tumor of pancreas
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Orphan

Ganite

Gallium nitrate injection

Solopak Pharmaceutical Co.

Transient hypogammaglobulinemia of infancyView details →
Orphan⚠️ Black Box

NAGLAZYME

GALSULFASE

BioMarin Pharmaceutical Inc.

1 INDICATIONS AND USAGE NAGLAZYME is indicated for patients with Mucopolysaccharidosis VI (MPS VI, Maroteaux-Lamy syndrome). NAGLAZYME has been shown

Mucopolysaccharidosis type 6, rapidly progressing
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Orphan

Ztalmy

ganaxolone

Marinus Pharmaceuticals

1 INDICATIONS AND USAGE ZTALMY is indicated for the treatment of seizures associated with cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (

CDKL5-deficiency disorder
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Orphan

Zirgan

ganciclovir

Sirion Therapeutics, Inc.

1 INDICATIONS AND USAGE ZIRGAN is indicated for the treatment of acute herpetic keratitis (dendritic ulcers) in adults and pediatric patients aged 2 y

Transient infantile hypertriglyceridemia and hepatosteatosisOBSOLETE: Herpes simplex virus keratitis
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Orphan

Vitrasert Implant

Ganciclovir intravitreal implant

Bausch & Lomb Surgical, Chiron Vision Products

Treatment of CMV retinitis in patients with acquired immunodeficiency syndrome.

Fetal cytomegalovirus syndromeUveitis
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Orphan⚠️ Black Box

Cytovene

Ganciclovir sodium

Syntex (USA), Inc.

1 INDICATIONS AND USAGE Ganciclovir Injection Ganciclovir Injection is a deoxynucleoside analogue cytomegalovirus (CMV) DNA polymerase inhibitor indic

Adenovirus infection in immunocompromised patientsView details →
Orphan

ANDEMBRY

GARADACIMAB

CSL

1 INDICATIONS AND USAGE ANDEMBRY is indicated for prophylaxis to prevent attacks of hereditary angioedema (HAE) in adult and pediatric patients aged 1

Hereditary angioedema
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Orphan

Iressa

gefitinib

AstraZeneca Pharmaceuticals LP

1 INDICATIONS AND USAGE IRESSA is indicated for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors h

NON RARE IN EUROPE: Non-small cell lung cancer
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Orphan⚠️ Black Box

Mylotarg

Gemtuzumab ozogamicin

Wyeth Pharmaceuticals, Inc., a Pfizer Company

1 INDICATIONS AND USAGE MYLOTARG is a CD33-directed antibody and cytotoxic drug conjugate indicated for: • treatment of newly-diagnosed CD33-positive

Acute myeloid leukemiaInherited acute myeloid leukemiaUnclassified acute myeloid leukemia
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Orphan⚠️ Black Box

XOSPATA

gilteritinib

Astellas Pharma US, Inc.

1 INDICATIONS AND USAGE XOSPATA is a kinase inhibitor indicated for the treatment of adult patients who have relapsed or refractory acute myeloid leuk

Acute megakaryoblastic leukemiaAcute myeloid leukemia with NPM1 somatic mutations
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Orphan

DUVYZAT

GIVINOSTAT

Italfarmaco SPA

1 INDICATIONS AND USAGE DUVYZAT is indicated for the treatment of Duchenne muscular dystrophy (DMD) in patients 6 years of age and older. DUVYZAT is a

Duchenne and Becker muscular dystrophyDuchenne muscular dystrophy
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Orphan

GIVLAARI

givosiran

Alnylam Pharmaceuticals, Inc.

1 INDICATIONS AND USAGE GIVLAARI is indicated for the treatment of adults with acute hepatic porphyria (AHP). GIVLAARI is an aminolevulinate synthase

Acute hepatic porphyria
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Orphan⚠️ Black Box

DAURISMO

Glasdegib

Pfizer, Inc.

1 INDICATIONS AND USAGE DAURISMO is indicated, in combination with low-dose cytarabine, for the treatment of newly-diagnosed acute myeloid leukemia (A

Acute megakaryoblastic leukemia
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Orphan⚠️ Black Box

Copaxone

glatiramer acetate

Teva Pharmaceuticals USA

1 INDICATIONS AND USAGE COPAXONE is indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome

Pediatric multiple sclerosisNON RARE IN EUROPE: Multiple sclerosisNicolau syndrome
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Orphan⚠️ Black Box

MAVYRET

glecaprevir and pibrentasvir

AbbVie, Inc.

1 INDICATIONS AND USAGE MAVYRET is indicated for the treatment of adult and pediatric patients 3 years and older with acute or chronic hepatitis C vir

Pediatric acute respiratory distress syndromeBartonella bacilliformis infectionHepatitis B reinfection following liver transplantationRecurrent hepatitis C virus induced liver disease in liver transplant recipientsIdiopathic copper-associated cirrhosisPost 5-alpha-reductase inhibitors treatment syndrome
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GLIPIZIDE

GLIPIZIDE

Actavis Pharma, Inc.

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Orphan

Voraxaze

glucarpidase

BTG International Inc.

1 INDICATIONS AND USAGE VORAXAZE is indicated to reduce toxic plasma methotrexate concentration (greater than 1 micromole per liter) in adult and pedi

Methotrexate toxicity46,XY difference of sex development due to impaired androgen production
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Orphan

Endari

GLUTAMINE

Emmaus Medical, Inc.

1 INDICATIONS AND USAGE Endari is indicated to reduce the acute complications of sickle cell disease in adult and pediatric patients 5 years of age an

Sickle cell disease
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GLYCEROL PHENYLBUTYRATE

GLYCEROL PHENYLBUTYRATE

Teva Pharmaceuticals, Inc.

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GLYCEROL PHENYLBUTYRATE

GLYCEROL PHENYLBUTYRATE

Novadoz Pharmaceuticals LLC

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GLYCEROL PHENYLBUTYRATE

GLYCEROL PHENYLBUTYRATE

Novadoz Pharmaceuticals LLC

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GLYCEROL PHENYLBUTYRATE

GLYCEROL PHENYLBUTYRATE

Aurobindo Pharma Limited

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GLYCEROL PHENYLBUTYRATE

GLYCEROL PHENYLBUTYRATE

Novadoz Pharmaceuticals LLC

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