Acute biphenotypic leukemia

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ORPHA:98837
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13Active trials59Specialists8Treatment centers

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Jan 2026A Study of Revumenib and Mezigdomide in People With Leukemia

Memorial Sloan Kettering Cancer Center — PHASE1, PHASE2

TrialRECRUITING
Dec 2025Trial of Orca-T Following Reduced Intensity or Nonmyeloablative Conditioning in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

Orca Biosystems, Inc. — PHASE2

TrialRECRUITING
Aug 2024A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies

Ossium Health, Inc. — PHASE1, PHASE2

TrialRECRUITING
Jul 2024Preventing of GVHD with Post-transplantation Cyclophosphamide, Abatacept, Vedolizumab and Ruxolitinib At Children and Young Adults with Hemoblastosis

Federal Research Institute of Pediatric Hematology, Oncology and Immunology — PHASE2, PHASE3

TrialRECRUITING
May 2024Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial

Imperial College London — PHASE2

TrialRECRUITING
Apr 2024SENTI-202: Off-the-shelf Logic Gated CAR NK Cell Therapy in Adults With CD33 and/or FLT3 Blood Cancers Including AML/MDS

Senti Biosciences — PHASE1

TrialACTIVE NOT RECRUITING
Apr 2024Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

St. Jude Children's Research Hospital — PHASE1

TrialRECRUITING
May 2023MCW Alpha/Beta T-Cell and B-Cell Depletion With Targeted ATG Dosing

Medical College of Wisconsin — NA

TrialRECRUITING
Mar 2023Venetoclax Basket Trial for High Risk Hematologic Malignancies

Andrew E. Place, MD — PHASE1

TrialRECRUITING
May 2022Infusion of Expanded Cord Blood Cells in Addition to Single Cord Blood Transplant in Treating Patients With Acute Leukemia, Chronic Myeloid Leukemia, or Myelodysplastic Syndromes

Fred Hutchinson Cancer Center — PHASE2

TrialACTIVE NOT RECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Acute biphenotypic leukemia.

13 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

13 recruitingView all trials with filters →
Phase 27 trials
Infusion of Expanded Cord Blood Cells in Addition to Single Cord Blood Transplant in Treating Patients With Acute Leukemia, Chronic Myeloid Leukemia, or Myelodysplastic Syndromes
Phase 2
Active
PI: Filippo Milano (Fred Hutch/University of Washington Cancer Consort) · Sites: Seattle, Washington · Age: 10–65 yrs
View on ClinicalTrials.gov ↗I'm interested →
Enasidenib and Azacitidine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia and IDH2 Gene Mutation
Phase 2
Actively Recruiting
PI: Courtney DiNardo (M.D. Anderson Cancer Center) · Sites: Houston, Texas · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Cladribine, Idarubicin, Cytarabine, and Venetoclax in Treating Patients With Acute Myeloid Leukemia, High-Risk Myelodysplastic Syndrome, or Blastic Phase Chronic Myeloid Leukemia
Phase 2
Actively Recruiting
PI: Tapan M Kadia (M.D. Anderson Cancer Center) · Sites: Houston, Texas · Age: 18–65 yrs
View on ClinicalTrials.gov ↗I'm interested →
Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant
Phase 2
Actively Recruiting
PI: Marie Bleakley (Fred Hutch/University of Washington Cancer Consort) · Sites: Los Angeles, California; Washington D.C., District of Columbia +8 more · Age: 0–26 yrs
View on ClinicalTrials.gov ↗I'm interested →
Venetoclax and Azacitidine for the Treatment of Acute Myeloid Leukemia in the Post-Transplant Setting
Phase 2
Active
PI: Betul Oran (M.D. Anderson Cancer Center) · Sites: Houston, Texas · Age: 18–75 yrs
View on ClinicalTrials.gov ↗I'm interested →
Personalized NK Cell Therapy in CBT
Phase 2
Actively Recruiting
PI: Amanda Olson, MD (M.D. Anderson Cancer Center) · Sites: Houston, Texas · Age: 15–80 yrs
View on ClinicalTrials.gov ↗I'm interested →
Venetoclax in Combination With Decitabine and Cedazuridine for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia
Phase 2
Active
PI: Abhishek Maiti (M.D. Anderson Cancer Center) · Sites: Houston, Texas · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Phase 11 trial
Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed/Refractory Acute Myeloid Leukemia and Persistent/Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm
Phase 1
Active
PI: Lihua E. Budde (City of Hope Medical Center) · Sites: Duarte, California · Age: 12–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
N/A1 trial
MCW Alpha/Beta T-Cell and B-Cell Depletion With Targeted ATG Dosing
N/A
Actively Recruiting
· Sites: Milwaukee, Wisconsin · Age: 0–25 yrs
View on ClinicalTrials.gov ↗I'm interested →

Specialists

Showing 25 of 59View all specialists →
WC
Wan-Ru Chao
Specialist
1 Acute biphenotypic leukemia publication
YL
Yen-Ting Lai
Specialist
1 Acute biphenotypic leukemia publication
YC
Yu-Wei Chang
HERSHEY, PA
Specialist
1 Acute biphenotypic leukemia publication
FF
Frank Sheng Fan
Specialist
1 Acute biphenotypic leukemia publication
ZM
Zachariah DeFilipp, MD
ATLANTA, GA
Specialist
PI on 5 active trials
OM
Olivier Hermine, MD
Specialist
PI on 3 active trials
BM
Brigitte C. Widemann, MD
BETHESDA, MD
Specialist
PI on 6 active trials
TK
Tapan M Kadia
Houston, Texas
Specialist

Rare Disease Specialist

PI on 9 active trials
KM
Kyoo H. Lee, MD
Specialist
PI on 8 active trials
MB
Marie Bleakley
SEATTLE, WA
Specialist
PI on 4 active trials
EJ
Elias Jabbour
HOUSTON, TX
Specialist
PI on 9 active trials
JM
Jennifer L McNeer
CHICAGO, IL
Specialist
PI on 1 active trial
HS
Heather J Symons
BALTIMORE, MD
Specialist
PI on 1 active trial
CD
Courtney DiNardo
HOUSTON, TX
Specialist
PI on 3 active trials
RW
Roland Walter
SEATTLE, WA
Specialist
PI on 9 active trials
AM
Ashkan Emadi, MD
MORGANTOWN, WV
Specialist
PI on 1 active trial
SM
Steven Devine, MD
LA CROSSE, WI
Specialist
PI on 4 active trials
AD
Ann Dahlberg
MILWAUKEE, WI
Specialist
PI on 2 active trials
JP
Jiri Pavlu
Specialist
PI on 1 active trial
YL
Yue-jun Liu
Specialist
PI on 1 active trial
FM
Filippo Milano
SEATTLE, WA
Specialist
PI on 7 active trials2 Acute biphenotypic leukemia publications
BO
Betul Oran
HOUSTON, TX
Specialist
PI on 1 active trial
MK
Mark Kirschbaum
HERSHEY, PA
Specialist
PI on 4 active trials2 Acute biphenotypic leukemia publications
NR
Nancy Wells, DNSc, RN
Specialist
PI on 2 active trials
EM
Elizabeth Fox, MD
Specialist
PI on 5 active trials

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program ↗

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Acute biphenotypic leukemia.

Search all travel grants →NORD Financial Assistance ↗

Community

Open Acute biphenotypic leukemiaForum →

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Latest news about Acute biphenotypic leukemia

Disease timeline:

New recruiting trial: Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

A new clinical trial is recruiting patients for Acute biphenotypic leukemia

New recruiting trial: Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT)

A new clinical trial is recruiting patients for Acute biphenotypic leukemia

New recruiting trial: Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant

A new clinical trial is recruiting patients for Acute biphenotypic leukemia

New recruiting trial: Pharmacokinetic and Safety Study of MRX-2843 in Adolescents and Adults With Relapsed/Refractory AML, ALL, or MPAL

A new clinical trial is recruiting patients for Acute biphenotypic leukemia

New recruiting trial: Combination Chemotherapy (FLAG-Ida) Followed Immediately by Reduced-Intensity Total Body Radiation Therapy and Donor Hematopoietic Cell Transplant for the Treatment of Adults Age 60 and Older With Newly Diagnosed Adverse-Risk Acute Myeloid Leukemia or Other High-Grade Myeloid Cancer

A new clinical trial is recruiting patients for Acute biphenotypic leukemia

New recruiting trial: A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies

A new clinical trial is recruiting patients for Acute biphenotypic leukemia

New recruiting trial: Phase I Trial for Patients w/ Advanced Hematologic Malignancies Undergoing Allogeneic HCT

A new clinical trial is recruiting patients for Acute biphenotypic leukemia

New recruiting trial: Revumenib for the Treatment of Acute Leukemia in Patients Post-Allogeneic Stem Cell Transplant

A new clinical trial is recruiting patients for Acute biphenotypic leukemia

New recruiting trial: Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma

A new clinical trial is recruiting patients for Acute biphenotypic leukemia

New recruiting trial: Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial

A new clinical trial is recruiting patients for Acute biphenotypic leukemia

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Acute biphenotypic leukemia

Are there clinical trials for Acute biphenotypic leukemia?

Yes — 13 recruiting clinical trials are currently listed for Acute biphenotypic leukemia on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Acute biphenotypic leukemia?

25 specialists and care centers treating Acute biphenotypic leukemia are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.