Adult T-cell leukemia/lymphoma

Last reviewed

🖨 Print for my doctorAdvocacy Hub →
ORPHA:86875C91.5
Who is this for?
Show terms as
16Active trials139Specialists8Treatment centers

Where are you in your journey?

ℹ
UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
Report missing data

Overview

Also known as:

ATLL
Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Jun 2026Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LL)

Children's Oncology Group — PHASE2, PHASE3

TrialNOT YET RECRUITING
Jun 2026U69-CART-Cells For R/R T-ALL

The First Affiliated Hospital of Soochow University — PHASE1

TrialRECRUITING
Jun 2026A Clinical Study of Humanized CD19 CAR-T Cells With TLR2 for the Treatment of Adult Patients With Naive B-Cell Acute Lymphoblastic Leukemia/Lymphoma Who Are Intolerant to Intensive Chemotherapy

Zhujiang Hospital — EARLY_PHASE1

TrialNOT YET RECRUITING
Mar 2026Azacitidine and Abatacept in Relapsed or Refractory T-Cell Lymphoma

National Cancer Institute (NCI) — PHASE1

TrialRECRUITING
Dec 2025Daratumumab for T Cell ALL With MRD-positive After Standard Chemotherapy

Institute of Hematology & Blood Diseases Hospital, China — PHASE2

TrialNOT YET RECRUITING
Sep 2025Clinical Study of LV009 Injection for the Treatment of Relapsed/Refractory CD19-Positive Hematologic and Lymphoid Malignancies

PersonGen BioTherapeutics (Suzhou) Co., Ltd. — EARLY_PHASE1

TrialRECRUITING
Sep 2025Venetoclax Combined With Azacitidine, Chidamide, Vindesine, and Dexamethasone in Newly Diagnosed ETP-ALL Like Patients

The First Affiliated Hospital of Soochow University — PHASE2

TrialRECRUITING
Jun 2025uCD7 CART for Relapsed or Refractory CD7 Positive Hematologic Malignancies

Institute of Hematology & Blood Diseases Hospital, China — PHASE1

TrialRECRUITING
Jun 2025SupCD7 CART for Relapsed or Refractory CD7 Positive Hematologic Malignancies

Institute of Hematology & Blood Diseases Hospital, China — PHASE1, PHASE2

TrialRECRUITING
Jun 2025A Phase I Dose Finding Study of MB-CART2219.1

University Hospital Tuebingen — PHASE1

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Adult T-cell leukemia/lymphoma.

16 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

16 recruitingView all trials with filters →
Phase 24 trials
Venetoclax Combined With Azacitidine, Chidamide, Vindesine, and Dexamethasone in Newly Diagnosed ETP-ALL Like Patients
Phase 2
Actively Recruiting
· Sites: Suzhou, Jiangsu · Age: 14–65 yrs
View on ClinicalTrials.gov ↗I'm interested →
Valemetostat Tosylate (DS-3201b), an Enhancer of Zeste Homolog (EZH) 1/2 Dual Inhibitor, for Relapsed/Refractory Peripheral T-Cell Lymphoma (VALENTINE-PTCL01)
Phase 2
Active
PI: Global Clinical Leader (Daiichi Sankyo) · Sites: Duarte, California; Palo Alto, California +58 more · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Brentuximab Vedotin and Combination Chemotherapy in Treating Patients With CD30-Positive Peripheral T-cell Lymphoma
Phase 2
Active
PI: Alex F Herrera (City of Hope Comprehensive Cancer Center) · Sites: Duarte, California; Hackensack, New Jersey +3 more · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
A Study of Mogamulizumab to Prevent Adult T-cell Leukemia/Lymphoma in People With HTLV-1
Phase 2
Actively Recruiting
PI: Steven Horwitz, MD (Memorial Sloan Kettering Cancer Center) · Sites: Basking Ridge, New Jersey; Middletown, New Jersey +5 more · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Phase 17 trials
Carmustine, Etoposide, Cyclophosphamide, and Stem Cell Transplant in Treating Patients With HIV-Associated Lymphoma
Phase 1
Active
PI: Amrita Y. Krishnan, MD (City of Hope Medical Center) · Sites: Duarte, California · Age: 10–60 yrs
View on ClinicalTrials.gov ↗I'm interested →
Azacitidine and Abatacept in Relapsed or Refractory T-Cell Lymphoma
Phase 1
Actively Recruiting
PI: Max J Gordon, M.D. (National Cancer Institute (NCI)) · Sites: Bethesda, Maryland · Age: 18–120 yrs
View on ClinicalTrials.gov ↗I'm interested →
CD19-specific CAR T Cells With a Fully Human Binding Domain for CD19+ Leukemia or Lymphoma
Phase 1
Active
PI: Colleen Annesley, MD (Seattle Children's Hospital) · Sites: Los Angeles, California; Seattle, Washington · Age: 1–30 yrs
View on ClinicalTrials.gov ↗I'm interested →
Third-Party Natural Killer Cells and Mogamulizumab for the Treatment of Relapsed or Refractory Cutaneous T-cell Lymphomas or Adult T-Cell Leukemia/Lymphoma
Phase 1
Actively Recruiting
PI: John C Reneau, MD, PhD (Ohio State University Comprehensive Cancer Center) · Sites: Columbus, Ohio · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
A Feasibility and Safety Study of Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy for CD19+CD22+ Leukemia
Phase 1
Active
PI: Colleen Annesley, MD (Seattle Children's Hospital) · Sites: Los Angeles, California; Washington D.C., District of Columbia +3 more · Age: 0–30 yrs
View on ClinicalTrials.gov ↗I'm interested →
A Phase I Dose Finding Study of MB-CART2219.1
Phase 1
Actively Recruiting
· Sites: Tübingen, Baden-Wurttemberg; Tübingen, Baden-Wurttemberg · Age: 12–75 yrs
View on ClinicalTrials.gov ↗I'm interested →
CD22-CAR T Cells in Children and Young Adults With B Cell Malignancies
Phase 1
Active
PI: Liora Schultz, MD (Stanford University) · Sites: Stanford, California · Age: 1–30 yrs
View on ClinicalTrials.gov ↗I'm interested →
Other3 trials
Clinico-biological Characterization and Survival of Patients With Adult T-cell Leukemia / Lymphoma (ATL) and Patients Chronically Infected With the HTLV-1 Virus (HTLV-OBS)
Active
PI: Ambroise MARCAIS, MD (Assistance Publique-Hôpitaux Paris) · Sites: Paris · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
A Registry for People With T-cell Lymphoma
Actively Recruiting
PI: Steven Horwitz, MD (Memorial Sloan Kettering Cancer Center) · Sites: Duarte, California; San Diego, California +24 more
View on ClinicalTrials.gov ↗I'm interested →
Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution
Actively Recruiting
PI: Lauren Pommert, MD (Children's Hospital Medical Center, Cincinnati) · Sites: Aurora, Colorado; Cincinnati, Ohio +3 more · Age: 0–38 yrs
View on ClinicalTrials.gov ↗I'm interested →

Specialists

Showing 25 of 139View all specialists →
CE
Charles Erlichman
ROCHESTER, MN
Specialist
PI on 2 active trials
LR
Lee Ratner
ALBANY, NY
Specialist
PI on 3 active trials3 Adult T-cell leukemia/lymphoma publications
KS
Kotaro Shide
Specialist
4 Adult T-cell leukemia/lymphoma publications
MY
Makoto Yoshimitsu
Specialist
6 Adult T-cell leukemia/lymphoma publications
KN
Kisato Nosaka
Specialist
5 Adult T-cell leukemia/lymphoma publications
YK
Yasunori Kogure
Specialist
3 Adult T-cell leukemia/lymphoma publications
TH
Tomonori Hidaka
Specialist
5 Adult T-cell leukemia/lymphoma publications
YK
Yoko Kubuki
Specialist
4 Adult T-cell leukemia/lymphoma publications
YM
Yasushi Miyazaki
Specialist
4 Adult T-cell leukemia/lymphoma publications
MS
Masaaki Sekine
Specialist
4 Adult T-cell leukemia/lymphoma publications
JK
Junji Koya
Specialist
3 Adult T-cell leukemia/lymphoma publications
KA
Keiichi Akizuki
Specialist
4 Adult T-cell leukemia/lymphoma publications
TK
Takuro Kameda
Specialist
4 Adult T-cell leukemia/lymphoma publications
KI
Kenji Ishitsuka
Specialist
4 Adult T-cell leukemia/lymphoma publications
AU
Atae Utsunomiya
Specialist
4 Adult T-cell leukemia/lymphoma publications
AK
Ayako Kamiunten
Specialist
4 Adult T-cell leukemia/lymphoma publications
YI
Yoshitaka Imaizumi
Specialist
4 Adult T-cell leukemia/lymphoma publications
HM
Hagop Kantarjian, MD
HOUSTON, TX
Specialist
PI on 7 active trials
HM
He Huang, MD
Hanzhou, Zhejiang
Specialist

Rare Disease Specialist

PI on 11 active trials
GL
Global Clinical Leader
Specialist
PI on 44 active trials4 Adult T-cell leukemia/lymphoma publications
FR
Farhad Ravandi-Kashani
HOUSTON, TX
Specialist
PI on 7 active trials2 Adult T-cell leukemia/lymphoma publications
PS
Prof. Dr. Michael Schmitt
Specialist
PI on 1 active trial
DM
David Maloney
Specialist
PI on 11 active trials
MM
Mitchell Cairo, MD
HAWTHORNE, NY
Specialist
PI on 11 active trials
AG
Ajay Gopal
SEATTLE, WA
Specialist
PI on 14 active trials

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program ↗

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Adult T-cell leukemia/lymphoma.

Search all travel grants →NORD Financial Assistance ↗

Community

Open Adult T-cell leukemia/lymphomaForum →

No community posts yet. Be the first to share your experience with Adult T-cell leukemia/lymphoma.

Start the conversation →

Latest news about Adult T-cell leukemia/lymphoma

Disease timeline:

New recruiting trial: Prevention of GvHD in Participants With Hematological Malignancies Undergoing Hematopoietic Stem Cell Transplant (HSCT)

A new clinical trial is recruiting patients for Adult T-cell leukemia/lymphoma

New recruiting trial: Targeting CD5 CAR-T Cells in the Treatment of r/r CD5+ T-ALL

A new clinical trial is recruiting patients for Adult T-cell leukemia/lymphoma

New recruiting trial: Nanobody-Based Anti-CD5 CAR-T for Relapsed/Refractory T-ALL/LBL

A new clinical trial is recruiting patients for Adult T-cell leukemia/lymphoma

New recruiting trial: A Study of Mogamulizumab to Prevent Adult T-cell Leukemia/Lymphoma in People With HTLV-1

A new clinical trial is recruiting patients for Adult T-cell leukemia/lymphoma

New recruiting trial: A Registry for People With T-cell Lymphoma

A new clinical trial is recruiting patients for Adult T-cell leukemia/lymphoma

New recruiting trial: Safety and Efficacy of GYA01 (CART84) in Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) and Acute Lymphoblastic T Leukemia Patients (T-ALL).

A new clinical trial is recruiting patients for Adult T-cell leukemia/lymphoma

New recruiting trial: Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)

A new clinical trial is recruiting patients for Adult T-cell leukemia/lymphoma

New recruiting trial: Isatuximab in Adult Patients With Cytologic or Molecular Relapsed/Refractory CD38 Positive T-cell Acute Lymphoblastic Leukemia

A new clinical trial is recruiting patients for Adult T-cell leukemia/lymphoma

New recruiting trial: Third-Party Natural Killer Cells and Mogamulizumab for the Treatment of Relapsed or Refractory Cutaneous T-cell Lymphomas or Adult T-Cell Leukemia/Lymphoma

A new clinical trial is recruiting patients for Adult T-cell leukemia/lymphoma

New recruiting trial: A Phase 2 Study to Evaluate Efficacy of Calaspargase Pegol-mknl and Decitabine Combined With Venetoclax in Pediatric, Adolescent, and Young Adult Patients With Relapsed/Refractory T-cell Acute Lymphoblastic Leukemia (T-ALL) and T- Cell Lymphoblastic Lymphoma (T-LLy)

A new clinical trial is recruiting patients for Adult T-cell leukemia/lymphoma

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Adult T-cell leukemia/lymphoma

Are there clinical trials for Adult T-cell leukemia/lymphoma?

Yes — 16 recruiting clinical trials are currently listed for Adult T-cell leukemia/lymphoma on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Adult T-cell leukemia/lymphoma?

25 specialists and care centers treating Adult T-cell leukemia/lymphoma are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.