FDA-Approved Treatments

Drugs with orphan designation or indications for rare diseases — 968 total

Treatment data is sourced from FDA drug labels, DailyMed, and openFDA.
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Drug information is sourced from FDA labels and prescribing information. Always verify current prescribing information with your pharmacist or prescriber before starting, stopping, or changing any medication.

Orphan

Amatine

Midodrine HCl

Takeda Development Center Americas, Inc.

Treatment of symptomatic orthostatic hypotension.

Pure autonomic failure
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Orphan⚠️ Black Box

Korlym

mifepristone

Corcept Therapeutics, Inc.

1 INDICATIONS AND USAGE KORLYM (mifepristone) is a cortisol receptor blocker indicated to control hyperglycemia secondary to hypercortisolism in adult

Endogenous Cushing syndrome
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Orphan

Galafold

MIGALASTAT HYDROCHLORIDE

Amicus Therapeutics US, LLC

1 INDICATIONS AND USAGE GALAFOLD is indicated for the treatment of adults with a confirmed diagnosis of Fabry disease and an amenable galactosidase al

Fabry disease
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Orphan

OPFOLDA

MIGLUSTAT

AMICUS THERAPEUTICS US, LLC

1 INDICATIONS AND USAGE OPFOLDA is indicated, in combination with Pombiliti, for the treatment of adult patients with late-onset Pompe disease (lysoso

Gaucher diseaseView details →

MILNACIPRAN HYDROCHLORIDE

MILNACIPRAN HYDROCHLORIDE

Breckenridge Pharmaceutical, Inc.

View details →
Orphan⚠️ Black Box

IMPAVIDO

miltefosine

Knight Therapeutics (USA)

1 INDICATIONS AND USAGE IMPAVIDO (miltefosine) capsules are indicated in adults and adolescents ≥12 years of age weighing ≥ 30 kg for the treatment of

LeishmaniasisCutaneous small vessel vasculitisWound botulismPrimary hypomagnesemia with secondary hypocalcemiaNeonatal intrahepatic cholestasis due to citrin deficiency
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Orphan

KYNAMRO

mipomersen

Kastle Therapeutics, LLC

Adjunct to lipid-lowering medications and diet to reduce low density lipoprotein-cholesterol (LDL-C), apolipoprotein B (apo B), total cholesterol (TC)

Homozygous familial hypercholesterolemia
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Orphan

Gomekli

mirdametinib

SpringWorks Therapeutics (EMD Serono / Merck KGaA)

1 INDICATIONS AND USAGE GOMEKLI is indicated for the treatment of adult and pediatric patients 2 years of age and older with neurofibromatosis type 1

Neurofibromatosis type 1
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Orphan⚠️ Black Box

Elahere

mirvetuximab soravtansine-gynx

ImmunoGen, Inc.

1 INDICATIONS AND USAGE ELAHERE ® is indicated for the treatment of adult patients with folate receptor-alpha (FRα) positive, platinum-resistant epith

Rare ovarian cancerPrimary peritoneal carcinoma
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Orphan⚠️ Black Box

AQVESME

MITAPIVAT

Agios Pharmaceuticals, Inc.

1 INDICATIONS AND USAGE AQVESME is indicated for the treatment of anemia in adults with alpha- or beta-thalassemia. AQVESME is a pyruvate kinase activ

Beta-thalassemiaHemoglobin H disease
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Orphan

Jelmyto

mitomycin

UroGen Pharma, Ltd.

1 INDICATIONS AND USAGE JELMYTO ® is indicated for the treatment of adult patients with low-grade Upper Tract Urothelial Cancer (LG-UTUC). JELMYTO is

Upper tract urothelial carcinoma
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Orphan

Mitosol

mitomycin-C

Glaukos Corporation

1 INDICATIONS AND USAGE Mitosol ® is an antimetabolite indicated for use as an adjunct to ab externo glaucoma surgery. Mitosol ® is an antimetabolite

Congenital malformation of the eye with glaucoma as a major feature
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Orphan⚠️ Black Box

Novantrone

Mitoxantrone

Serono, Inc.

INDICATIONS AND USAGE Mitoxantrone injection, USP (concentrate) is indicated for reducing neurologic disability and/or the frequency of clinical relap

NON RARE IN EUROPE: Multiple sclerosisPediatric multiple sclerosisRare respiratory tumorAcute lymphoblastic leukemia
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Orphan

Exkivity

mobocertinib

Takeda Development Center Americas, Inc.

Treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 2

Malignant germ cell tumor of the cervix uteriView details →
Orphan

Provigil

Modafinil

Cephalon, Inc.

1 INDICATIONS AND USAGE PROVIGIL is indicated to improve wakefulness in adult patients with excessive sleepiness associated with narcolepsy, obstructi

Idiopathic hypersomniaOBSOLETE: Primary pigmented nodular adrenocortical diseaseNijmegen breakage syndrome-like disorder
View details →
Orphan

POTELIGEO

mogamulizumab

Kyowa Kirin Pharmaceutical Development Inc.

1 INDICATIONS AND USAGE POTELIGEO is indicated for the treatment of adult patients with relapsed or refractory mycosis fungoides (MF) or Sézary syndro

Indolent primary cutaneous T-cell lymphomaMycosis fungoides and variantsEEC syndrome and related disorders
View details →
Orphan

Ojjaara

MOMELOTINIB

GlaxoSmithKline LLC

1 INDICATIONS AND USAGE OJJAARA is indicated for the treatment of intermediate or high-risk myelofibrosis (MF), including primary MF or secondary MF [

Primary myelofibrosis
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Orphan

Moctanin

Monooctanoin

Ethitek Pharmaceuticals, Inc.

Chromosome Y microdeletion syndromeView details →
Orphan⚠️ Black Box

Infumorph

Morphine sulfate concentrate (preservative free)

Elkins-Sinn, Inc.

1 INDICATIONS AND USAGE INFUMORPH is for use in continuous microinfusion devices and indicated only for intrathecal or epidural infusion in the manage

Hypertension due to gain-of-function mutations in the mineralocorticoid receptor
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Orphan⚠️ Black Box

Lunsumio

mosunetuzumab-axgb

Genentech, Inc.

1 INDICATIONS AND USAGE LUNSUMIO is a bispecific CD20-directed CD3 T-cell engager indicated for the treatment of adult patients with relapsed or refra

Follicular lymphoma
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Orphan

Aphexda

motixafortide

Ayrmid Pharma Ltd.

1 INDICATIONS AND USAGE APHEXDA is indicated in combination with filgrastim (G-CSF) to mobilize hematopoietic stem cells to the peripheral blood for c

Complications after hematopoietic stem cell transplantationMultiple myeloma
View details →
Orphan

LUMOXITI

moxetumomab pasudotox-tdfk

AstraZeneca Pharmaceuticals LP

LUMOXITI is indicated for the treatment of adult patients with relapsed or refractory hairy cell leukemia (HCL) who received at least two prior system

Classic hairy cell leukemia
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Orphan

M.V.I.-12

multi-vitamin infusion without vitamin K

Mayne Pharma (USA) Inc.

Prevention of vitamin deficiency and thrombormbolic complications in people receiving home parenteral nutrition who also receive warfarin-type anticoa

Chromomycosis
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⚠️ Black Box

MYCOPHENOLATE MOFETIL

MYCOPHENOLATE MOFETIL

Aurobindo Pharma Limited

1 INDICATIONS AND USAGE Mycophenolate mofetil (MMF) is indicated for the prophylaxis of organ rejection, in adult and pediatric recipients 3 months of

Mycophenolate mofetil embryopathyView details →
Orphan

Synarel Nasal Solution

Nafarelin acetate

Syntex (USA), Inc.

INDICATIONS AND USAGE FOR CENTRAL PRECOCIOUS PUBERTY (For Endometriosis, See Reverse Side ) SYNAREL is indicated for treatment of central precocious p

Rare central precocious pubertyExtrapelvic endometriosis
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REZENOPY

NALOXONE HCL

Scienture LLC

View details →
Orphan

Trexan

Naltrexone HCl

DuPont Pharmaceuticals

OBSOLETE: Congenital absence of upper arm and forearm with hand present, bilateral
View details →
Orphan

Yartemlea

narsoplimab-wuug

Omeros Corporation

1 INDICATIONS AND USAGE YARTEMLEA is indicated for the treatment of adult and pediatric patients 2 years of age and older with hematopoietic stem cell

Complications after hematopoietic stem cell transplantation
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Orphan

Yuviwel

navepegritide

Ascendis Pharma Growth Disorders A/S

to increase linear growth in pediatric patients 2 years of age and older with achondroplasia with open epiphyses

AchondroplasiaView details →
Orphan

DANYELZA

naxitamab-gqgk

Y-mAbs Therapeutics, Inc.

in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), for the treatment of pediatric patients 1 year of age and older and adu

Neuroblastoma
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