Overview
Malignant germ cell tumor of the cervix uteri is an extremely rare neoplasm in which germ cell-derived malignant cells arise within the uterine cervix. Germ cell tumors more commonly occur in the ovaries or extragonadal sites, making cervical localization exceptionally unusual. Histological subtypes that have been reported at this site include yolk sac tumor (endodermal sinus tumor), choriocarcinoma, embryonal carcinoma, and mixed germ cell tumors. These tumors primarily affect the reproductive system and may present with abnormal vaginal bleeding, a cervical mass, pelvic pain, or vaginal discharge. Due to the rarity of this condition, patients may initially be misdiagnosed with more common cervical malignancies such as squamous cell carcinoma or adenocarcinoma. The disease predominantly affects younger women, including adolescents and women of reproductive age, which is consistent with the general age distribution of germ cell tumors. Diagnosis typically requires histopathological examination with immunohistochemical staining, and serum tumor markers such as alpha-fetoprotein (AFP) and beta-human chorionic gonadotropin (beta-hCG) may be elevated depending on the histological subtype. Imaging studies including MRI and CT scans are used for staging and to assess the extent of disease. Treatment approaches are largely extrapolated from experience with ovarian germ cell tumors and other cervical malignancies, given the lack of large clinical series. Management generally involves a combination of surgery and platinum-based chemotherapy (such as BEP: bleomycin, etoposide, and cisplatin). Radiation therapy may also be considered in certain cases. Prognosis varies depending on the stage at diagnosis, histological subtype, and response to treatment, but germ cell tumors in general tend to be chemosensitive, offering potential for favorable outcomes when diagnosed and treated early.
Also known as:
Sporadic
Usually appears on its own, not inherited from a parent
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
10 eventsSwansea Bay University Health Board
Petrov, Andrey — PHASE1
The Netherlands Cancer Institute — PHASE2, PHASE3
Case Comprehensive Cancer Center — NA
Charite University, Berlin, Germany — PHASE2
Ipsen — PHASE1, PHASE2
M.D. Anderson Cancer Center — PHASE1, PHASE2
N.N. Petrov National Medical Research Center of Oncology
TILT Biotherapeutics Ltd. — PHASE1
Amgen — PHASE1, PHASE2
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
1 availableLynparza
for the adjuvant treatment of adult patients with deleterious or suspected deleterious germline BRCA-mutated, HER2-negative high risk early breast cancer who have been treated with neoadjuvant or adju…
for the adjuvant treatment of adult patients with deleterious or suspected deleterious germline BRCA-mutated, HER2-negative high risk early breast cancer who have been treated with neoadjuvant or adjuvant chemotherapy
Clinical Trials
View all trials with filters →No actively recruiting trials found for Malignant germ cell tumor of the cervix uteri at this time.
New trials open frequently. Follow this disease to get notified.
Rare Disease Specialist
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Financial Resources
2 resourcesExkivity
Takeda Development Center Americas, Inc.
Travel Grants
No travel grants are currently matched to Malignant germ cell tumor of the cervix uteri.
Community
No community posts yet. Be the first to share your experience with Malignant germ cell tumor of the cervix uteri.
Start the conversation →Latest news about Malignant germ cell tumor of the cervix uteri
Disease timeline:
New recruiting trial: Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer
A new clinical trial is recruiting patients for Malignant germ cell tumor of the cervix uteri
New recruiting trial: GB1211 and Pembrolizumab Versus Pembrolizumab and Placebo in Patients With Metastatic Melanoma and Head and Neck Squamous Cell Carcinoma
A new clinical trial is recruiting patients for Malignant germ cell tumor of the cervix uteri
New recruiting trial: EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.
A new clinical trial is recruiting patients for Malignant germ cell tumor of the cervix uteri
New recruiting trial: A Study to Assess IPN01194 When Administered Alone in Adults With Advanced Solid Tumours
A new clinical trial is recruiting patients for Malignant germ cell tumor of the cervix uteri
New recruiting trial: Contrast-enhanced Ultrasound for Sentinel Node Detection
A new clinical trial is recruiting patients for Malignant germ cell tumor of the cervix uteri
New recruiting trial: Clinico-biological Database in Patients Treated With Metabolic Radiotherapy in the Nuclear Medicine Department
A new clinical trial is recruiting patients for Malignant germ cell tumor of the cervix uteri
New recruiting trial: Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE)
A new clinical trial is recruiting patients for Malignant germ cell tumor of the cervix uteri
New recruiting trial: Validation of ICG-99mTc-nanoscan as Hybrid Tracer for Sentinel Node Biopsy
A new clinical trial is recruiting patients for Malignant germ cell tumor of the cervix uteri
New recruiting trial: [212Pb]VMT-Alpha-NET in Metastatic or Inoperable Somatostatin-Receptor Positive Gastrointestinal Neuroendocrine Tumors, Pheochromocytoma/Paragangliomas, Small Cell Lung, Renal Cell, and Head and Neck Cancers
A new clinical trial is recruiting patients for Malignant germ cell tumor of the cervix uteri
New recruiting trial: A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors
A new clinical trial is recruiting patients for Malignant germ cell tumor of the cervix uteri
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Common questions about Malignant germ cell tumor of the cervix uteri
What is Malignant germ cell tumor of the cervix uteri?
Malignant germ cell tumor of the cervix uteri is an extremely rare neoplasm in which germ cell-derived malignant cells arise within the uterine cervix. Germ cell tumors more commonly occur in the ovaries or extragonadal sites, making cervical localization exceptionally unusual. Histological subtypes that have been reported at this site include yolk sac tumor (endodermal sinus tumor), choriocarcinoma, embryonal carcinoma, and mixed germ cell tumors. These tumors primarily affect the reproductive system and may present with abnormal vaginal bleeding, a cervical mass, pelvic pain, or vaginal disc
How is Malignant germ cell tumor of the cervix uteri inherited?
Malignant germ cell tumor of the cervix uteri follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
Which specialists treat Malignant germ cell tumor of the cervix uteri?
8 specialists and care centers treating Malignant germ cell tumor of the cervix uteri are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.
What treatment and support options exist for Malignant germ cell tumor of the cervix uteri?
1 patient support program are currently tracked on UniteRare for Malignant germ cell tumor of the cervix uteri. See the treatments and support programs sections for copay assistance, eligibility, and contact details.