Overview
Orphanet code 98006 corresponds to the broad category of rare neurologic diseases, which encompasses a wide and heterogeneous group of disorders affecting the central and/or peripheral nervous system. These conditions may involve the brain, spinal cord, peripheral nerves, neuromuscular junction, or muscles, and can manifest with a diverse range of symptoms including movement abnormalities, cognitive impairment, seizures, sensory deficits, weakness, and autonomic dysfunction. Because this code represents a grouping category rather than a single specific disease entity, the clinical features, inheritance patterns, age of onset, and prognosis vary enormously depending on the individual condition within this classification. Rare neurologic diseases collectively affect a significant number of individuals worldwide, though each individual condition may be extremely uncommon. Many of these disorders have a genetic basis, while others may be autoimmune, metabolic, degenerative, or of unknown etiology. Diagnosis often requires specialized neurological evaluation, advanced neuroimaging, electrophysiological studies, genetic testing, and sometimes tissue biopsy. Treatment approaches range from symptomatic and supportive care to targeted therapies, including enzyme replacement therapy, gene therapy, immunomodulatory treatments, and disease-modifying agents, depending on the specific underlying condition. Research into rare neurologic diseases has accelerated in recent years, with numerous clinical trials and emerging therapies offering hope for improved outcomes in many of these conditions.
Also known as:
Variable
Can be inherited in different ways depending on the underlying gene
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
10 eventsSt. Jude Children's Research Hospital
Assistance Publique - Hôpitaux de Paris
National Cancer Institute (NCI) — NA
UNC Lineberger Comprehensive Cancer Center — NA
Assistance Publique - Hôpitaux de Paris
Cancer Research UK — PHASE2, PHASE3
Solid Biosciences Inc. — PHASE1
Myositis International Health & Research Collaborative Alliance Foundation
Yongguo Yu — EARLY_PHASE1
Third Military Medical University — NA
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Rare neurologic disease.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for Rare neurologic disease at this time.
New trials open frequently. Follow this disease to get notified.
Rare Disease Specialist
Rare Disease Specialist
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Rare neurologic disease.
Community
No community posts yet. Be the first to share your experience with Rare neurologic disease.
Start the conversation →Latest news about Rare neurologic disease
Disease timeline:
New recruiting trial: The ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis
A new clinical trial is recruiting patients for Rare neurologic disease
New recruiting trial: Clinical Study To Further Evaluate The Efficacy Of Dabrafenib Plus Trametinib In Patients With Rare BRAF V600E Mutation-Positive Unresectable or Metastatic Solid Tumors
A new clinical trial is recruiting patients for Rare neurologic disease
New recruiting trial: Stakeholders of Rare Diseases Informing Values In Neuroethics
A new clinical trial is recruiting patients for Rare neurologic disease
New recruiting trial: Caregiving Networks Across Disease Context and the Life Course
A new clinical trial is recruiting patients for Rare neurologic disease
New recruiting trial: Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study
A new clinical trial is recruiting patients for Rare neurologic disease
New recruiting trial: Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure
A new clinical trial is recruiting patients for Rare neurologic disease
New recruiting trial: Epilepsy Learning Healthcare System (ELHS)
A new clinical trial is recruiting patients for Rare neurologic disease
New recruiting trial: Establishing Walking-related Digital Biomarkers in Rare Childhood Onset Progressive Neuromuscular Disorders
A new clinical trial is recruiting patients for Rare neurologic disease
New recruiting trial: Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies
A new clinical trial is recruiting patients for Rare neurologic disease
New recruiting trial: Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial
A new clinical trial is recruiting patients for Rare neurologic disease
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Common questions about Rare neurologic disease
What is Rare neurologic disease?
Orphanet code 98006 corresponds to the broad category of rare neurologic diseases, which encompasses a wide and heterogeneous group of disorders affecting the central and/or peripheral nervous system. These conditions may involve the brain, spinal cord, peripheral nerves, neuromuscular junction, or muscles, and can manifest with a diverse range of symptoms including movement abnormalities, cognitive impairment, seizures, sensory deficits, weakness, and autonomic dysfunction. Because this code represents a grouping category rather than a single specific disease entity, the clinical features, in
Which specialists treat Rare neurologic disease?
25 specialists and care centers treating Rare neurologic disease are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.