Autoimmune encephalitis

Last reviewed

🖨 Print for my doctorAdvocacy Hub →
ORPHA:622014
Who is this for?
Show terms as
17Active trials35Specialists8Treatment centers

Where are you in your journey?

ℹ
UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
Report missing data

Overview

Also known as:

AEAIE
Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Mar 2026Is [18F]-DPA-714 PET a Good Marker of Neuroinflammation in Autoimmune Encephalitis?

University Hospital, Toulouse — PHASE2

TrialNOT YET RECRUITING
Feb 2026A Study of C-CAR168 in the Treatment of Central Nervous System Autoimmune Diseases Refractory to Standard Therapy

Huashan Hospital — PHASE1

TrialNOT YET RECRUITING
Nov 2025Long-term Impact of NMDAR Encephalitis, Level 3

Hospices Civils de Lyon — NA

TrialRECRUITING
Nov 2025hUC-MSC-Exo Therapy for Autoimmune Encephalitis

Xuanwu Hospital, Beijing — PHASE1, PHASE2

TrialNOT YET RECRUITING
Aug 2025A Study in Participants With Anti-NMDAR Encephalitis and Anti-NMDAR Antibody-Associated Psychiatric Disease

Arialys Australia Pty Ltd — PHASE2

TrialNOT YET RECRUITING
Jul 2025Study of Pathogenic Mechanisms and Identification of Novel Autoantibodies in Autoimmune Encephalitis

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

TrialRECRUITING
Mar 2025Phase 1 Study of ART5803 Safety and PK After IVIG in Healthy Participants

Arialys Therapeutics — PHASE1

TrialACTIVE NOT RECRUITING
Mar 202518F-DPA-714 PET/MR in Dysfunctional Brain Diseases

Xijing Hospital — NA

TrialNOT YET RECRUITING
Feb 2025A Multicentric Cohort of Autoimmune Encephalitis

Xuanwu Hospital, Beijing

TrialNOT YET RECRUITING
Jan 2025Risk Prediction Model for Severe Autoimmune Encephalitis

Xuanwu Hospital, Beijing

TrialNOT YET RECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Autoimmune encephalitis.

17 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

17 recruitingView all trials with filters →
Phase 32 trials
Safety and Efficacy of Combined B Cell Depleting theRapy And Daratumumab In Autoimmune Encephalitis
Phase 3
Actively Recruiting
· Sites: Zhengzhou, Henan; Changzhou, Jiangsu · Age: 12–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Satralizumab in Participants With Anti-N-methyl-D-aspartic Acid Receptor (NMDAR) or Anti-leucine-rich Glioma-inactivated 1 (LGI1) Encephalitis
Phase 3
Actively Recruiting
PI: Clinical Trials (Hoffmann-La Roche) · Sites: Birmingham, Alabama; La Jolla, California +90 more · Age: 12–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Phase 23 trials
IVIG and Rituximab in Antibody-associated Psychosis - SINAPPS2
Phase 2
Actively Recruiting
PI: Alasdair Coles, PhD FRCP (University of Cambridge, UK) · Sites: Cambridge; Exeter +8 more · Age: 16–70 yrs
View on ClinicalTrials.gov ↗I'm interested →
Trial to Evaluate Efficacy and Safety of Bortezomib in Patients With Severe Autoimmune Encephalitis
Phase 2
Actively Recruiting
PI: Christian Geis, Prof. (University Hospital Jena) · Sites: München, Bavaria; Würzburg, Bavaria +15 more · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
The ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis
Phase 2
Actively Recruiting Prior treatment eligible
PI: Stacey L Clardy, MD, PhD (University of Utah) · Sites: Birmingham, Alabama; Phoenix, Arizona +18 more · Age: 12–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Phase 12 trials
Phase 1 Study of ART5803 Safety and PK After IVIG in Healthy Participants
Phase 1
Active
PI: Sankalp Gokhale, MD, MBA (Arialys Therapeutics) · Sites: Melbourne, Victoria · Age: 18–65 yrs
View on ClinicalTrials.gov ↗I'm interested →
Phase 1 Study of ART5803 in Healthy Participants
Phase 1
Active
PI: Sankalp Gokhale, MD, MBA (Arialys Therapeutics) · Sites: Melbourne, Victoria · Age: 18–65 yrs
View on ClinicalTrials.gov ↗I'm interested →
N/A3 trials
Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis Collection
N/A
Actively Recruiting
· Sites: Pointe à Pitre, Guadeloupe; Aix-en-Provence +60 more
View on ClinicalTrials.gov ↗I'm interested →
Efficacy and Safety of Calculus Bovis Sativus (CBS) for Adult Encephalitis (CBSinEncephalitis)
N/A
Actively Recruiting
· Sites: Wuhan, Hubei · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Long-term Impact of NMDAR Encephalitis, Level 3
N/A
Actively Recruiting
PI: Jérôme HONNORAT, Pr · Sites: Bron · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Other7 trials
A Prospective Study to Evaluate Clinical Outcomes in Anti-LGI1 Encephalitis
Actively Recruiting
PI: Chun-Hong Shen (2nd Affiliated Hospital, School of Medicine, Zheji) · Sites: Hangzhou, Zhejiang · Age: 18–100 yrs
View on ClinicalTrials.gov ↗I'm interested →
FDG-PET in the Diagnosis of Autoimmune Encephalitis
Actively Recruiting
PI: Simone Beretta, MD, PhD (University of Milano Bicocca) · Sites: Udine, Friuli Venezia Giulia; Genoa, Liguria +4 more
View on ClinicalTrials.gov ↗I'm interested →
Medium-term Effects of Treatments in Autoimmune Encephalitis
Actively Recruiting
· Sites: Bron
View on ClinicalTrials.gov ↗I'm interested →
Characterization of Immune-response in Autoimmune Encephalitis and Paraneoplastic Neurological Syndromes
Actively Recruiting
· Sites: Lyon · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Monitoring of Outcomes of Cellular and Exosome-based Therapies in Autoinflammatory and Post-infectious Neuroinflammatory Syndromes
Active
· Sites: Warsaw · Age: 6–70 yrs
View on ClinicalTrials.gov ↗I'm interested →
New Biomarkers in Auto-immune Encephalitis and Neurological Paraneoplastic Syndromes
Active
· Sites: Lyon
View on ClinicalTrials.gov ↗I'm interested →
Study of Pathogenic Mechanisms and Identification of Novel Autoantibodies in Autoimmune Encephalitis
Actively Recruiting
PI: Raffaele Iorio (Fondazione Policlinico Universitario A. Gemelli, I) · Sites: Rome, RM · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →

Specialists

Showing 25 of 35View all specialists →
RI
Raffaele Iorio
Specialist
PI on 5 active trials
AP
Anna Rostedt Punga, Professor
Specialist
PI on 1 active trial
JP
Joachim Burman, Assoc prof
Specialist
PI on 1 active trial
CP
Caroline Tilikete, Prof.
Specialist
PI on 1 active trial
JM
Jérôme HONNORAT, MD
Specialist
PI on 2 active trials
CS
Chunhong Shen
Specialist
PI on 2 active trials92 Autoimmune encephalitis publications
DM
Dai-shi Tian, MD
Specialist
PI on 2 active trials
SP
Stacey L Clardy, MD, PhD
Birmingham, Alabama
Specialist

Rare Disease Specialist

PI on 1 active trial
JM
Junwei Hao, MD
Specialist
PI on 3 active trials
SP
Soon Tae Lee, MD, Ph.D.
Specialist
PI on 1 active trial
KP
Kon Chu, MD, PhD
Specialist
PI on 3 active trials
DM
Daniel S Reich, M.D.
Specialist
PI on 3 active trials
RM
Raffaele Iorio, MD
Specialist
PI on 1 active trial
SA
Sara Ajina
Specialist
PI on 1 active trial1 Autoimmune encephalitis publication
SM
Sandra Bigi, PD MD
Specialist
PI on 1 active trial
JP
Jérôme HONNORAT, Pr
Bron
Specialist

Rare Disease Specialist

PI on 2 active trials
AM
Agnes Floeel, Prof. MD
Specialist
PI on 1 active trial1 Autoimmune encephalitis publication
RP
Rémi SALOMON, MD, PhD
Specialist
PI on 2 active trials
IM
Igor J Koralnik, MD
BOSTON, MA
Specialist
PI on 1 active trial
LM
Leslie J. Crofford, M.D.
NASHVILLE, TN
Specialist
PI on 1 active trial
VP
Vincent NAVARRO, Pr
Specialist
PI on 1 active trial
WM
William Wegener, PhD, MD
BROOMALL, PA
Specialist
PI on 1 active trial
KM
Kenneth D Laxer, M.D.
SAN FRANCISCO, CA
Specialist
PI on 1 active trial
PM
Pia Maly Sundgren, MD-PHD
Specialist
PI on 1 active trial
PP
Pia Maly Sundgren, MD, PHD
Specialist
PI on 1 active trial

Treatment Centers

8 centers
⚗️ Trial Site

Massachusetts General Hospital

📍 Boston, Massachusetts

👤 Matthew Frigault, MD

👤 Janssen Research & Development, LLC Clinical Trial

⚗️ Trial Site

Children's Hospital of Orange County

📍 Orange, California

👤 Richard Neibeger, MD

⚗️ Trial Site

University of Alabama at Birmingham

📍 Birmingham, Alabama

⚗️ Trial Site

Emory University

📍 Atlanta, Georgia

⚗️ Trial Site

University of Iowa

📍 Iowa City, Iowa

👤 Anthony A. Amato, MD

⚗️ Trial Site

Yale University

📍 New Haven, Connecticut

⚗️ Trial Site

Mayo Clinic in Arizona

📍 Scottsdale, Arizona

⚗️ Trial Site

University of Colorado

📍 Aurora, Colorado

Travel Grants

No travel grants are currently matched to Autoimmune encephalitis.

Search all travel grants →NORD Financial Assistance ↗

Community

Open Autoimmune encephalitisForum →

No community posts yet. Be the first to share your experience with Autoimmune encephalitis.

Start the conversation →

Latest news about Autoimmune encephalitis

Disease timeline:

New recruiting trial: FDG-PET in the Diagnosis of Autoimmune Encephalitis

A new clinical trial is recruiting patients for Autoimmune encephalitis

New recruiting trial: Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)

A new clinical trial is recruiting patients for Autoimmune encephalitis

New recruiting trial: Antibody-mediated LGI1 Encephalitis: Symptoms, Biomarkers, and Mechanisms of the Chronic Phase of the Disease

A new clinical trial is recruiting patients for Autoimmune encephalitis

New recruiting trial: Antibody-mediated NMDA Receptor Encephalitis: Symptoms, Biomarkers, and Mechanisms of the Prolonged Recovery Stage

A new clinical trial is recruiting patients for Autoimmune encephalitis

New recruiting trial: Study of Pathogenic Mechanisms and Identification of Novel Autoantibodies in Autoimmune Encephalitis

A new clinical trial is recruiting patients for Autoimmune encephalitis

New recruiting trial: Study of Pathophysiology of Status Epilepticus and Dysimmune Encephalitis

A new clinical trial is recruiting patients for Autoimmune encephalitis

New recruiting trial: Safety and Efficacy of Combined B Cell Depleting theRapy And Daratumumab In Autoimmune Encephalitis

A new clinical trial is recruiting patients for Autoimmune encephalitis

New recruiting trial: Lupus Landmark Study: A Prospective Registry and Biorepository

A new clinical trial is recruiting patients for Autoimmune encephalitis

New recruiting trial: Neural Autoantibody Prevalence in New-onset Focal Seizures of Unknown Etiology

A new clinical trial is recruiting patients for Autoimmune encephalitis

New recruiting trial: Efficacy and Safety of Taitacept in Treatment of Refractory or Recurrent Anti-NMDAR/anti-LGI1 Encephalitis

A new clinical trial is recruiting patients for Autoimmune encephalitis

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Autoimmune encephalitis

Are there clinical trials for Autoimmune encephalitis?

Yes — 17 recruiting clinical trials are currently listed for Autoimmune encephalitis on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Autoimmune encephalitis?

25 specialists and care centers treating Autoimmune encephalitis are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.