Overview
Tumor of endocrine glands (Orphanet code 182130) is a broad classification category encompassing neoplasms that arise within the endocrine system, which includes hormone-producing glands such as the thyroid, parathyroid, adrenal glands, pituitary gland, and the endocrine pancreas. These tumors may be benign (adenomas) or malignant (carcinomas) and can be functioning (hormone-secreting) or non-functioning. When functioning, they may cause clinical syndromes related to hormone overproduction, such as hyperthyroidism, Cushing syndrome, hyperaldosteronism, hyperparathyroidism, acromegaly, or hypoglycemia, depending on the gland and cell type involved. Endocrine gland tumors can occur sporadically or as part of hereditary tumor syndromes such as Multiple Endocrine Neoplasia (MEN) types 1, 2A, and 2B, Von Hippel-Lindau syndrome, or Carney complex. Symptoms vary widely depending on the specific gland affected and whether the tumor produces excess hormones. Common presentations include a palpable mass, hormonal imbalance symptoms, fatigue, weight changes, and metabolic disturbances. Some tumors are discovered incidentally on imaging studies performed for other reasons. Treatment approaches depend on the tumor type, location, size, and whether it is benign or malignant. Options include surgical resection, which remains the primary treatment for most endocrine tumors, as well as targeted therapies, radioactive iodine therapy (for thyroid cancers), hormone-suppressive medications, chemotherapy, and radiation therapy. Surveillance and monitoring of hormone levels are important components of long-term management. Genetic counseling and testing are recommended when a hereditary syndrome is suspected.
Variable
Can be inherited in different ways depending on the underlying gene
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
10 eventsWashington University School of Medicine — PHASE2
Natera, Inc. — NA
FutureGen Biopharmaceutical (Beijing) Co., Ltd — PHASE3
Astellas Pharma Global Development, Inc. — PHASE3
TME Pharma AG — PHASE2
Xerient Pharma — PHASE1, PHASE2
Alpha Tau Medical LTD. — NA
Insel Gruppe AG, University Hospital Bern — NA
RenJi Hospital
PanTher Therapeutics — PHASE1
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Tumor of endocrine glands.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for Tumor of endocrine glands at this time.
New trials open frequently. Follow this disease to get notified.
Rare Disease Specialist
Rare Disease Specialist
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Tumor of endocrine glands.
Community
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Start the conversation →Latest news about Tumor of endocrine glands
Disease timeline:
New recruiting trial: Multicenter Study of Circulating Tumor DNA in Patients With Pancreatic Cancer Using a Personalized Panel
A new clinical trial is recruiting patients for Tumor of endocrine glands
New recruiting trial: Safety & Feasibility of Ultrasound-assisted Non-invasive Measurement of Compressibility of the Thyroid Gland in Patients Scheduled for Surgical Removal
A new clinical trial is recruiting patients for Tumor of endocrine glands
New recruiting trial: Intraoperative Hypotension in Pancreatoduodenectomy: A Randomized Trial of General Versus Combined Anesthesia
A new clinical trial is recruiting patients for Tumor of endocrine glands
New recruiting trial: Evaluate the Safety and Efficacy of BGT007H Cell Therapy in Patients With Relapsed/Refractory Pancreatic Cancer
A new clinical trial is recruiting patients for Tumor of endocrine glands
New recruiting trial: A Phase I Clinical Study of IX001 TCR-T Injection in the Treatment of Advanced Pancreatic Cancer Patients With KRAS G12V Mutation
A new clinical trial is recruiting patients for Tumor of endocrine glands
New recruiting trial: Preoperative Hemogram Parameters and BRAF Molecular Test Detected by Bethesda 3 Cytology.
A new clinical trial is recruiting patients for Tumor of endocrine glands
New recruiting trial: Echo-endoscopy Biopsy Impact on the Circulating Tumor Cell Level
A new clinical trial is recruiting patients for Tumor of endocrine glands
New recruiting trial: A Study Evaluating Anvumetostat in Combination With Other Therapies in Participants With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion (MTAPESTRY 103)
A new clinical trial is recruiting patients for Tumor of endocrine glands
New recruiting trial: PTM-101 in Pancreatic Ductal Adenocarcinoma (PDAC)
A new clinical trial is recruiting patients for Tumor of endocrine glands
New recruiting trial: PACAREG: a Multicenter Registry Trial in Pancreatic Ductal Adencarcinoma
A new clinical trial is recruiting patients for Tumor of endocrine glands
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Common questions about Tumor of endocrine glands
What is Tumor of endocrine glands?
Tumor of endocrine glands (Orphanet code 182130) is a broad classification category encompassing neoplasms that arise within the endocrine system, which includes hormone-producing glands such as the thyroid, parathyroid, adrenal glands, pituitary gland, and the endocrine pancreas. These tumors may be benign (adenomas) or malignant (carcinomas) and can be functioning (hormone-secreting) or non-functioning. When functioning, they may cause clinical syndromes related to hormone overproduction, such as hyperthyroidism, Cushing syndrome, hyperaldosteronism, hyperparathyroidism, acromegaly, or hypog
Which specialists treat Tumor of endocrine glands?
25 specialists and care centers treating Tumor of endocrine glands are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.