Systemic sclerosis

Last reviewed

🖨 Print for my doctorAdvocacy Hub →
ORPHA:90291OMIM:181750M34.0M34.1M34.2
Who is this for?
Show terms as
15Active trials39Specialists8Treatment centers

Where are you in your journey?

ℹ
UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
Report missing data

Overview

Also known as:

Progressive systemic sclerosisSclerodermaSScSystemic scleroderma

Clinical phenotype terms— hover any for plain English:

Raynaud phenomenonHP:0030880Cutaneous sclerotic plaqueHP:0031359TelangiectasiaHP:0001009Nail bed telangiectasiaHP:0001232Abnormal esophagus morphologyHP:0002031Spotty hypopigmentationHP:0005590Acral ulcerationHP:0006121Abnormal phalangeal joint morphology of the handHP:0006261Abnormal pulmonary interstitial morphologyHP:0006530
Orphanet ↗OMIM ↗NORD ↗

FDA & Trial Timeline

10 events
Mar 2026Systemic Sclerosis DIet for GastrointESTinal Symptoms

University of Michigan — NA

TrialRECRUITING
Jan 2026Safety, Efficacy and Cellular Metabolic Dynamics of CT1195E in Patients With Refractory / Progressive SSC

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology — EARLY_PHASE1

TrialRECRUITING
Jan 2026Efficacy and Safety of Allogenic Cultured Adipose-derived Mesenchymal Stromal Cell Injections on MoUth Fibrosis and Handicap in Patients With Systemic sclEroderma

University Hospital, Toulouse — PHASE2

TrialNOT YET RECRUITING
Dec 2025Safety and Efficacy of Adipose-Derived Regenerative Cells (ADRCs) for Improving Hand Dysfunction in Systemic Sclerosis

Cytori Therapeutics — NA

TrialRECRUITING
Oct 2025Quantification of Calcinosis Cutis Disease Burden Using Computed Tomography Images

Yale University

TrialRECRUITING
Oct 2025A Study of OL-CD19-GDT in Relapsed/ Refractory Autoimmune Diseases

Beijing GoBroad Hospital — PHASE1

TrialRECRUITING
Sep 2025A Study of Cizutamig in Systemic Sclerosis

Ruijin Hospital — EARLY_PHASE1

TrialNOT YET RECRUITING
Sep 2025A Study of GB261 in Systemic Sclerosis

Ruijin Hospital — EARLY_PHASE1

TrialNOT YET RECRUITING
Aug 2025GC012F in Patients With Autoimmune Diseases

Qiong Fu — EARLY_PHASE1

TrialNOT YET RECRUITING
Jul 2025PPI Refractory - GERD Mechanisms in Systemic Sclerosis

Hospital Universitari Vall d'Hebron Research Institute

TrialNOT YET RECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Systemic sclerosis.

15 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

15 recruitingView all trials with filters →
Phase 21 trial
A Study to Assess the Efficacy and Safety of Efgartigimod PH20 SC in Adults With Systemic Sclerosis
Phase 2
Actively Recruiting
· Sites: Phoenix, Arizona; Los Angeles, California +67 more · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Phase 12 trials
Clinical Study of CD19 CAR-T in the Treatment of Refractory Systemic Sclerosis
Phase 1
Actively Recruiting
· Sites: Hangzhou, Zhejiang; Hangzhou, Zhejiang · Age: 5–18 yrs
View on ClinicalTrials.gov ↗I'm interested →
A Study of OL-CD19-GDT in Relapsed/ Refractory Autoimmune Diseases
Phase 1
Actively Recruiting
· Sites: Beijing · Age: 18–65 yrs
View on ClinicalTrials.gov ↗I'm interested →
N/A3 trials
Systemic Sclerosis DIet for GastrointESTinal Symptoms
N/A
Actively Recruiting
PI: Dinesh Khanna, MD, MSc (University of Michigan) · Sites: Ann Arbor, Michigan · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
The Apollo Device in Systemic Sclerosis for the Management of fatiguE, Raynaud Phenomenon and qualiTy of Life
N/A
Actively Recruiting
PI: Robyn T Domsic, MD (University of Pittsburgh) · Sites: New Orleans, Louisiana; Ann Arbor, Michigan +2 more · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Safety and Efficacy of Adipose-Derived Regenerative Cells (ADRCs) for Improving Hand Dysfunction in Systemic Sclerosis
N/A
Actively Recruiting
· Sites: Guangzhou, Guangdong; Shanghai · Age: 18–70 yrs
View on ClinicalTrials.gov ↗I'm interested →
Other5 trials
DERMATOMICS: Identifying Regulators of Skin Homeostasis
Actively Recruiting
· Sites: Leeds; London · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Functional Performance and Biopsychosocial Characteristics in Individuals with Systemic Sclerosis
Actively Recruiting
· Sites: Ankara, Altındağ · Age: 18–65 yrs
View on ClinicalTrials.gov ↗I'm interested →
Quantification of Calcinosis Cutis Disease Burden Using Computed Tomography Images
Actively Recruiting
PI: Monique Hinchcliff, MD, MS (Yale University) · Sites: New Haven, Connecticut · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Home-Based Clinical Management of Cardiac Complications in Systemic Sclerosis
Actively Recruiting
PI: Anna-Maria Hoffmann-Vold, MD, PhD (Oslo University Hospital) · Sites: Oslo · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Hand Disability In Systemic Sclerosis - Digital Ulcers
Enrolling by Invitation
· Sites: Denizli, Malatya; Malatya, Malatya · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →

Specialists

Showing 25 of 39View all specialists →
CD
Christopher P Denton
Specialist
3 Systemic sclerosis publications
EV
Elizabeth R Volkmann
LOS ANGELES, CA
Specialist
2 Systemic sclerosis publications
VC
Veronica Codullo
Specialist
3 Systemic sclerosis publications
MB
Marco Di Battista
Specialist
3 Systemic sclerosis publications
GL
Gemma Lepri
Specialist
3 Systemic sclerosis publications
FG
Francesco Del Galdo
Specialist
3 Systemic sclerosis publications
TK
Thomas Krieg
Specialist
2 Systemic sclerosis publications
AR
Alessandra Della Rossa
Specialist
3 Systemic sclerosis publications
SG
Serena Guiducci
Specialist
3 Systemic sclerosis publications
JS
Julia Spierings
Specialist
PI on 1 active trial
EM
Elena Pope, MD
SANTA FE, NM
Specialist
PI on 4 active trials
SM
Scott D Lifchez, MD
BALTIMORE, MD
Specialist
PI on 1 active trial
HT
Hussein A Tawbi
HOUSTON, TX
Specialist
PI on 2 active trials
ZM
Zsuzsanna McMahan, MD, MHS
HOUSTON, TX
Specialist
PI on 1 active trial
NM
Neha Bhanusali, MD
ORLANDO, FL
Specialist
PI on 1 active trial
AD
Ayse Ayan, Dr
Specialist
PI on 2 active trials
DP
David KLATZMANN, MD, PhD
Specialist
PI on 2 active trials
LC
Lorinda S Chung
PALO ALTO, CA
Specialist
PI on 2 active trials11 Systemic sclerosis publications
LP
Luc Mouthon, MD, PhD
Specialist
PI on 6 active trials
HX
Hu ji Xu
Specialist
PI on 1 active trial374 Systemic sclerosis publications
PP
Philippe GUILPAIN, MD, PhD
Specialist
PI on 2 active trials
JM
Janet E Pope, MD MPH
HAMPTON, VA
Specialist
PI on 1 active trial
AM
Arunabh Talwar, MD
NEW HYDE PARK, NY
Specialist
PI on 3 active trials
AP
Ariane Herrick, MD, phD
Specialist
PI on 1 active trial
AF
Ariane E Herrick, MD, FRCP
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program ↗

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Systemic sclerosis.

Search all travel grants →NORD Financial Assistance ↗

Community

Open Systemic sclerosisForum →

No community posts yet. Be the first to share your experience with Systemic sclerosis.

Start the conversation →

Latest news about Systemic sclerosis

1 articles
Clinical trialCLINICALTRIALSApr 3, 2026
Trial Now Recruiting: Understanding of Rare Inflammatory Arthritis in Comparison to Classical Inflammatory Arthritis : Tissular Observations and Immune Infiltrate Characterization : the UTOPIC Project (NCT07302074)
Researchers are looking for 100 people with rare types of joint inflammation to better understand how these conditions develop and damage joints. Some of these …
See all news about Systemic sclerosis →

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Systemic sclerosis

Are there clinical trials for Systemic sclerosis?

Yes — 15 recruiting clinical trials are currently listed for Systemic sclerosis on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Systemic sclerosis?

25 specialists and care centers treating Systemic sclerosis are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.