Overview
Anterior uveitis is an inflammatory condition that affects the front part of the eye, specifically the iris and the area just behind it called the ciliary body. It is the most common form of uveitis and is sometimes called iritis or iridocyclitis. When the immune system mistakenly attacks the tissues inside the eye, it causes redness, pain, light sensitivity, and blurred vision. The condition can occur in one or both eyes and may happen as a single episode or come back repeatedly over time. Anterior uveitis can occur on its own or be linked to other conditions such as autoimmune diseases (like ankylosing spondylitis, juvenile idiopathic arthritis, or sarcoidosis), infections, or trauma. In many cases, no specific cause is found, and it is called idiopathic anterior uveitis. The condition is considered relatively common compared to other forms of uveitis but can still be challenging to manage when it becomes chronic or recurrent. Treatment typically involves corticosteroid eye drops to reduce inflammation and dilating drops (cycloplegics) to relieve pain and prevent the iris from sticking to the lens. In more severe or chronic cases, doctors may prescribe oral corticosteroids, immunosuppressive medications, or biologic therapies. Early diagnosis and treatment are important to prevent complications such as glaucoma, cataracts, or permanent vision loss.
Also known as:
Key symptoms:
Eye rednessEye pain or achingSensitivity to light (photophobia)Blurred visionTearing or watery eyesSmall or irregularly shaped pupilFloaters in visionHeadache around the affected eyeFeeling of pressure in the eyeDecreased visionEye discomfort that worsens with focusing
Multifactorial
Caused by a mix of several genes and environmental factors
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
10 eventsAssiut University
CARE ARTHRITIS LTD. — PHASE4
Novaliq GmbH — PHASE2
University Hospital, Rouen — PHASE3
Meyer Children's Hospital IRCCS — NA
Regeneron Pharmaceuticals — PHASE1, PHASE2
University of Milan — NA
Marmara University
VivaVision Biotech, Inc — PHASE3
Groupe français d'étude des Maladies Inflammatoires de loeil
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
1 availableTOBRADEX ST
They are also indicated in chronic anterior uveitis and corneal injury from chemical, radiation or thermal burns, or penetration of foreign bodies.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Financial Resources
1 resourcesDIFLUPREDNATE
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Anterior Uveitis
Travel Grants
No travel grants are currently matched to Anterior uveitis.
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1 articlesCaregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
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Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Is my anterior uveitis linked to an underlying condition like ankylosing spondylitis or another autoimmune disease?,Should I be tested for HLA-B27, and what would a positive result mean for me?,How often will I need follow-up eye exams, and what complications should I watch for?,What are the risks of long-term corticosteroid eye drop use, and are there alternatives?,What should I do if I notice symptoms of a flare-up — should I restart drops on my own or come in first?,Would I benefit from a systemic immunosuppressive medication or biologic therapy?,Are there lifestyle changes or triggers I should be aware of that might reduce flare-ups?
Common questions about Anterior uveitis
What is Anterior uveitis?
Anterior uveitis is an inflammatory condition that affects the front part of the eye, specifically the iris and the area just behind it called the ciliary body. It is the most common form of uveitis and is sometimes called iritis or iridocyclitis. When the immune system mistakenly attacks the tissues inside the eye, it causes redness, pain, light sensitivity, and blurred vision. The condition can occur in one or both eyes and may happen as a single episode or come back repeatedly over time. Anterior uveitis can occur on its own or be linked to other conditions such as autoimmune diseases (lik
How is Anterior uveitis inherited?
Anterior uveitis follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
Are there clinical trials for Anterior uveitis?
Yes — 11 recruiting clinical trials are currently listed for Anterior uveitis on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Anterior uveitis?
25 specialists and care centers treating Anterior uveitis are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.
What treatment and support options exist for Anterior uveitis?
1 patient support program are currently tracked on UniteRare for Anterior uveitis. See the treatments and support programs sections for copay assistance, eligibility, and contact details.