Anterior uveitis

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1FDA treatments11Active trials71Specialists8Treatment centers1Financial resources

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Anterior uveitis is an inflammatory condition that affects the front part of the eye, specifically the iris and the area just behind it called the ciliary body. It is the most common form of uveitis and is sometimes called iritis or iridocyclitis. When the immune system mistakenly attacks the tissues inside the eye, it causes redness, pain, light sensitivity, and blurred vision. The condition can occur in one or both eyes and may happen as a single episode or come back repeatedly over time. Anterior uveitis can occur on its own or be linked to other conditions such as autoimmune diseases (like ankylosing spondylitis, juvenile idiopathic arthritis, or sarcoidosis), infections, or trauma. In many cases, no specific cause is found, and it is called idiopathic anterior uveitis. The condition is considered relatively common compared to other forms of uveitis but can still be challenging to manage when it becomes chronic or recurrent. Treatment typically involves corticosteroid eye drops to reduce inflammation and dilating drops (cycloplegics) to relieve pain and prevent the iris from sticking to the lens. In more severe or chronic cases, doctors may prescribe oral corticosteroids, immunosuppressive medications, or biologic therapies. Early diagnosis and treatment are important to prevent complications such as glaucoma, cataracts, or permanent vision loss.

Also known as:

Key symptoms:

Eye rednessEye pain or achingSensitivity to light (photophobia)Blurred visionTearing or watery eyesSmall or irregularly shaped pupilFloaters in visionHeadache around the affected eyeFeeling of pressure in the eyeDecreased visionEye discomfort that worsens with focusing

Inheritance

Multifactorial

Caused by a mix of several genes and environmental factors

Age of Onset

Variable

Can begin at different ages, from infancy through adulthood

Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Sep 2026Clinical, Laboratory, and Therapeutic Analysis of Behçet's Disease in Assiut

Assiut University

TrialNOT YET RECRUITING
May 2026Impact Of Upadacitinib On The Frequency Of Acute Recurrent Anterior Uveitis In Patients With Axial Spondyloarthritis

CARE ARTHRITIS LTD. — PHASE4

TrialNOT YET RECRUITING
Mar 2026Tacrolimus Ophthalmic Solution for the Treatment of Non-infectious Anterior Uveitis

Novaliq GmbH — PHASE2

TrialNOT YET RECRUITING
Mar 2026Efficacy and Tolerance of Baricitinib, a JAK Inhibitor, in the Treatment of Refractory Non-infectious Non-anterior Uveitis

University Hospital, Rouen — PHASE3

TrialNOT YET RECRUITING
Jan 2026Clinical, Biochemical and Epigenetic Profile of Pediatric Behçet Disease

Meyer Children's Hospital IRCCS — NA

TrialRECRUITING
Dec 2025A Study of REGN7041 for Active Noninfectious Uveitis in Adult Participants

Regeneron Pharmaceuticals — PHASE1, PHASE2

TrialRECRUITING
Nov 2025Targeting Immunosuppressive Treatment for Non-infectious Uveitis Using Aqueous Humor Cytokine Profiles

University of Milan — NA

TrialACTIVE NOT RECRUITING
Oct 2025Cranial Nerve Functions in Behçet's Disease and Their Relationship With Clinical Parameters

Marmara University

TrialNOT YET RECRUITING
Oct 2025A Phase 3 Study of VVN461 Ophthalmic Solution for Noninfectious Anterior Uveitis

VivaVision Biotech, Inc — PHASE3

TrialNOT YET RECRUITING
Sep 2025Ustekinumab in BEhçet's Syndrome STudy

Groupe français d'étude des Maladies Inflammatoires de loeil

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

1 available

TOBRADEX ST

TOBRAMYCIN / DEXAMETHASONE· Harrow Eye, LLC

They are also indicated in chronic anterior uveitis and corneal injury from chemical, radiation or thermal burns, or penetration of foreign bodies.

Clinical Trials

11 recruitingView all trials with filters →
Phase 33 trials
A Study of Brepocitinib in Adults With Active, Non-Infectious, Non-Anterior Uveitis
Phase 3
Active
· Sites: Phoenix, Arizona; Phoenix, Arizona +105 more · Age: 1875 yrs
A Study of Baricitinib (LY3009104) in Participants From 2 Years to Less Than 18 Years Old With Active JIA-Associated Uveitis or Chronic Anterior Antinuclear Antibody-Positive Uveitis
Phase 3
Active
PI: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) (Eli Lilly and Company) · Sites: Le Kremlin-Bicêtre; Paris +18 more · Age: 217 yrs
The Use of Two YUTIQ Versus Sham for Treatment of Chronic Non Infectious Intraocular Inflammation Affecting the Posterior Segment
Phase 3
Actively Recruiting
· Sites: Plano, Texas · Age: 1899 yrs
N/A2 trials
Targeting Immunosuppressive Treatment for Non-infectious Uveitis Using Aqueous Humor Cytokine Profiles
N/A
Active
PI: Alessandro Invernizzi, MD (University of Milan) · Sites: Milan; Milan +1 more · Age: 1899 yrs
Ocular Pathogen and Transcriptome Investigation Using Comprehensive Sequencing
N/A
Actively Recruiting
PI: Thuy Doan, MD, PhD (University of California, San Francisco) · Sites: San Francisco, California · Age: 1899 yrs
Other5 trials
Quantification & Classification of Inflammatory Cells in Uveitis Using OCT
Actively Recruiting
PI: Yan Li, PhD (Oregon Health and Science University) · Sites: Portland, Oregon · Age: 585 yrs
Analysis of Anterior Chamber Inflammation by Optical Coherence Tomography
Actively Recruiting
PI: Sunil K Srivastva, MD (The Cleveland Clinic) · Sites: Cleveland, Ohio
AutoInflammatory Disease Alliance Registry (AIDA)
Actively Recruiting
· Sites: Algiers; Boumerdas +110 more
German Spondyloarthritis Inception Cohort
Actively Recruiting
PI: Joachim Sieper, Prof. Dr. (Charite University, Berlin, Germany) · Sites: Berlin
Observational Prospective Turkish Inception Cohort of Uveitis and Spondyloarthritis
Actively Recruiting
· Sites: Istanbul, Maltepe · Age: 1875 yrs

Specialists

Showing 25 of 71View all specialists →
YM
Young Hee Yoon, MD
Specialist
PI on 2 active trials
CM
Christoph Tappeiner, MD
Specialist
PI on 1 active trial
SP
Shigeaki Ohno, PhD
Specialist
PI on 1 active trial
JX
Jim S Xie
KANSAS CITY, MO
Specialist
2 Anterior uveitis publications
JR
Judith Rademacher
Specialist
2 Anterior uveitis publications
IP
Ikhwanuliman Putera
Specialist
2 Anterior uveitis publications
JR
James T Rosenbaum
SARASOTA, FL
Specialist
2 Anterior uveitis publications
MW
Mark Westcott
ENDICOTT, NY
Specialist
2 Anterior uveitis publications
RN
Rina La Distia Nora
Specialist
2 Anterior uveitis publications
RA
Rupesh Agrawal
Specialist
2 Anterior uveitis publications
AK
Ankush Kawali
Specialist
2 Anterior uveitis publications
KK
Koju Kamoi
Specialist
1 Anterior uveitis publication
KB
Karoline Baquet-Walscheid
Specialist
2 Anterior uveitis publications
UP
Uwe Pleyer
Specialist
3 Anterior uveitis publications
VG
Vishali Gupta
Specialist
2 Anterior uveitis publications
AK
Alexander J Kaplan
Specialist
2 Anterior uveitis publications
AM
Arnd Heiligenhaus, MD
Specialist
PI on 3 active trials1 Anterior uveitis publication
TM
Thomas Ciulla, MD
CARMEL, IN
Specialist
PI on 8 active trials
TM
Thomas Cuilla, MD, MBA
Specialist
PI on 1 active trial
EM
Emily Y Chew, M.D.
BETHESDA, MD
Specialist
PI on 8 active trials
HM
Hatice N Sen, M.D.
RIVERSIDE, CA
Specialist
PI on 8 active trials
PM
Peter C Grayson, M.D.
BOSTON, MA
Specialist
PI on 2 active trials
SC
Soon P Chee
Specialist
PI on 1 active trial7 Anterior uveitis publications

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Financial Resources

1 resources

DIFLUPREDNATE

Harrow

Anterior Uveitis

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Travel Grants

No travel grants are currently matched to Anterior uveitis.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Anterior uveitis

1 articles
NewsFDA
FDA Approves TOBRADEX ST
TOBRADEX ST (DEXAMETHASONE) received FDA approval.
See all news about Anterior uveitis

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.Is my anterior uveitis linked to an underlying condition like ankylosing spondylitis or another autoimmune disease?,Should I be tested for HLA-B27, and what would a positive result mean for me?,How often will I need follow-up eye exams, and what complications should I watch for?,What are the risks of long-term corticosteroid eye drop use, and are there alternatives?,What should I do if I notice symptoms of a flare-up — should I restart drops on my own or come in first?,Would I benefit from a systemic immunosuppressive medication or biologic therapy?,Are there lifestyle changes or triggers I should be aware of that might reduce flare-ups?

Common questions about Anterior uveitis

What is Anterior uveitis?

Anterior uveitis is an inflammatory condition that affects the front part of the eye, specifically the iris and the area just behind it called the ciliary body. It is the most common form of uveitis and is sometimes called iritis or iridocyclitis. When the immune system mistakenly attacks the tissues inside the eye, it causes redness, pain, light sensitivity, and blurred vision. The condition can occur in one or both eyes and may happen as a single episode or come back repeatedly over time. Anterior uveitis can occur on its own or be linked to other conditions such as autoimmune diseases (lik

How is Anterior uveitis inherited?

Anterior uveitis follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

Are there clinical trials for Anterior uveitis?

Yes — 11 recruiting clinical trials are currently listed for Anterior uveitis on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Anterior uveitis?

25 specialists and care centers treating Anterior uveitis are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.

What treatment and support options exist for Anterior uveitis?

1 patient support program are currently tracked on UniteRare for Anterior uveitis. See the treatments and support programs sections for copay assistance, eligibility, and contact details.