Squamous cell carcinoma of pancreas

Squamous cell carcinoma of the pancreas is a very rare type of pancreatic cancer. Most pancreatic cancers are a type called adenocarcinoma, which starts in gland cells. Squamous cell carcinoma, by contrast, starts in flat, scale-like cells that are not normally found in the pancreas — making this an unusual and poorly understood cancer. It may also be called pancreatic squamous cell carcinoma or primary squamous cell carcinoma of the pancreas. Because it is so rare, it is sometimes grouped under the broader term 'rare exocrine pancreatic tumors.' The pancreas sits deep in the abdomen and plays two main roles: helping digestion and controlling blood sugar. When a tumor grows in the pancreas, it can block nearby structures like the bile duct or digestive tract, causing a range of symptoms. Common symptoms include yellowing of the skin and eyes (jaundice), belly or back pain, unexplained weight loss, poor appetite, nausea, and new-onset diabetes. Because the pancreas is located deep inside the body, symptoms often appear late, when the cancer has already grown or spread. Treatment options are similar to other pancreatic cancers and may include surgery to remove the tumor (if caught early enough), chemotherapy, and radiation therapy. However, because squamous cell carcinoma of the pancreas is so rare, there are no treatment guidelines specifically designed for it, and most care is based on what works for other pancreatic cancers. The outlook is generally poor, especially when the cancer is found at an advanced stage.

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Bring these to your next appointment

• Q1.Has the cancer spread beyond the pancreas, and what does that mean for my treatment options?,Is surgery possible in my case, and what are the risks and benefits?,Which chemotherapy regimen do you recommend for me, and what side effects should I expect?,Are there any clinical trials I might be eligible for given how rare this cancer type is?,Should I get a second opinion at a major cancer center that specializes in pancreatic cancer?,What palliative care or supportive services are available to help manage my symptoms?,How will we monitor whether the treatment is working?

Common questions about Squamous cell carcinoma of pancreas