Semantic dementia

Last reviewed March 21, 2026

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ORPHA:100069OMIM:172700G31.0

Who is this for?

Show terms as

2Active trials 23Specialists 8Treatment centers

Where are you in your journey?

ℹ

UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.

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Overview

Also known as:

Semantic primary progressive aphasia Semantic variant PPA

Clinical phenotype terms— hover any for plain English:

Visual agnosiaHP:0030222Anomic aphasiaHP:0030784DyslexiaHP:0010522AlexiaHP:0010523DysgraphiaHP:0010526AbuliaHP:0012671

Orphanet ↗OMIM ↗NORD ↗

FDA & Trial Timeline

4 events

Feb 2025Revealing Engagement Dynamics Among Semantic Dementia Patients

Power Life Sciences Inc.

TrialNOT YET RECRUITING

Oct 2024Assessing Cognitive Decline at Home

Stanford University — NA

TrialRECRUITING

Dec 2022Semantic Recognition Task (SRT) in Alzheimer Disease

Istanbul University — NA

TrialRECRUITING

Apr 2022Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology

Peter Ljubenkov, MD — PHASE1

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Semantic dementia.

2 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

2 recruitingView all trials with filters →

Phase 11 trial

Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology

Phase 1

Actively Recruiting

PI: Peter Ljubenkov, MD (University of California, San Francisco) · Sites: San Francisco, California; Chicago, Illinois +3 more · Age: 18–85 yrs

N/A1 trial

Assessing Cognitive Decline at Home

N/A

Actively Recruiting

PI: Ehsan Adeli, PhD (Stanford University) · Sites: Palo Alto, California · Age: 65–99 yrs

Specialists

23 foundView all specialists →

AM

Alberto Benussi, MD

Trieste, Trieste

Specialist

Rare Disease Specialist

Amyotrophic lateral sclerosis Ataxia-oculomotor apraxia type 1 Autosomal recessive cerebellar ataxia+14 more

PI on 5 active trials

Active trials Directions Travel grants

FM

Forbes D Porter, M.D.

Bethesda, Maryland

Specialist

Rare Disease Specialist

Batten Disease CHILD syndrome Chronic visceral acid sphingomyelinase deficiency+25 more

PI on 14 active trials

Active trials Directions Travel grants

MM

Mitchell S Cairo, MD

HAWTHORNE, NY

Specialist

Acute adrenal insufficiency Acute myelomonocytic leukemia Adrenomyeloneuropathy+42 more

PI on 12 active trials

Active trials Directions Travel grants

DP

Darby Morhardt, PhD

CHICAGO, IL

Specialist

Frontotemporal dementia Primary progressive aphasia Primary progressive apraxia of speech

PI on 1 active trial

Active trials Directions Travel grants

JP

Jennifer Whitwell, PhD

Specialist

Classic progressive supranuclear palsy syndrome Frontotemporal dementia Logopenic progressive aphasia+4 more

PI on 3 active trials

Active trials Directions Travel grants

JM

Justin Y Kwan, M.D.

NILES, IL

Specialist

Corticobasal syndrome Frontotemporal dementia Frontotemporal dementia with motor neuron disease+5 more

PI on 4 active trials

Active trials Directions Travel grants

DM

Doreen Görß, MD

Specialist

Frontotemporal dementia Primary progressive aphasia Primary progressive apraxia of speech

PI on 1 active trial

Active trials Directions Travel grants

BM

Barbara Borroni, MD

Specialist

Amyotrophic lateral sclerosis Ataxia-oculomotor apraxia type 1 Autosomal recessive cerebellar ataxia+15 more

PI on 7 active trials

Active trials Directions Travel grants

MM

Maria C Tartaglia, M.D.

Specialist

Corticobasal syndrome Frontotemporal dementia Frontotemporal dementia with motor neuron disease+8 more

PI on 3 active trials

Active trials Directions Travel grants

RM

Robert B Innis, M.D.

Bethesda, Maryland

Specialist

Rare Disease Specialist

Amyloidosis Dementia pugilistica Encephalitis+8 more

PI on 8 active trials

Active trials Directions Travel grants

MP

Mark W Albers, MD, PhD

Specialist

Frontotemporal dementia Frontotemporal dementia with motor neuron disease Primary progressive aphasia+1 more

PI on 1 active trial

Active trials Directions Travel grants

JP

Janine Diehl-Schmid, Prof.

Specialist

Frontotemporal dementia Primary progressive aphasia Primary progressive apraxia of speech

PI on 1 active trial

Active trials Directions Travel grants

RP

Reinhold Schmidt, Professor

Specialist

Disorder of peptide metabolism Early-onset autosomal dominant Alzheimer disease Frontotemporal dementia+2 more

PI on 2 active trials2 Semantic dementia publications

Active trials Directions Travel grants

MM

Michael W. Weiner, MD

Specialist

Amyloidosis Frontotemporal dementia Primary progressive aphasia+1 more

PI on 3 active trials

Active trials Directions Travel grants

IP

Ilya Nasrallah, MD, PhD

PHILADELPHIA, PA

Specialist

Frontotemporal dementia Primary progressive aphasia Primary progressive apraxia of speech

PI on 1 active trial

Active trials Directions Travel grants

YP

Yaakov Stern, PhD

NEW YORK, NY

Specialist

Frontotemporal dementia Primary progressive aphasia Primary progressive apraxia of speech

PI on 1 active trial

Active trials Directions Travel grants

RM

Reisa Sperling, MD

BOSTON, MA

Specialist

Frontotemporal dementia Primary progressive aphasia Primary progressive apraxia of speech

PI on 1 active trial

Active trials Directions Travel grants

PM

Paul S. Aisen, MD

SAN DIEGO, CA

Specialist

Primary progressive aphasia Primary progressive apraxia of speech

PI on 1 active trial

Active trials Directions Travel grants

AP

Arndt Rolfs, Prof.

Specialist

ATTRV122I amyloidosis Frontotemporal dementia Langerhans cell histiocytosis+3 more

PI on 2 active trials

Active trials Directions Travel grants

RP

Ronald Petersen, MD, PhD

Specialist

Primary progressive aphasia Primary progressive apraxia of speech

PI on 1 active trial

Active trials Directions Travel grants

AM

Ariel Gildengers, MD

PITTSBURGH, PA

Specialist

Frontotemporal dementia Primary progressive aphasia Primary progressive apraxia of speech

PI on 1 active trial

Active trials Directions Travel grants

EP

Ehsan Adeli, PhD

Palo Alto, California

Specialist

Rare Disease Specialist

Directions Travel grants

DC

David G Clark

Specialist

PI on 1 active trial

Active trials Directions Travel grants

Treatment Centers

8 centers

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

UCLA Rare Disease Day Program ↗

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Semantic dementia.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Semantic dementia

Disease timeline:

New recruiting trial: Semantic Recognition Task (SRT) in Alzheimer Disease

A new clinical trial is recruiting patients for Semantic dementia

New trial: Assessing Cognitive Decline at Home

Phase NA trial recruiting.

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Semantic dementia

Are there clinical trials for Semantic dementia?

Yes — 2 recruiting clinical trials are currently listed for Semantic dementia on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Semantic dementia?

23 specialists and care centers treating Semantic dementia are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.