Primary progressive aphasia

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ORPHA:95432
Who is this for?
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18Active trials23Specialists8Treatment centers

Where are you in your journey?

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Also known as:

Mesulam syndromePPA
Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Jan 2026Post-Market Clinical Follow-Up of S.M.A.R.T. Family of Stents in Treating Iliac and Femoropopliteal Artery Disease

Cordis US Corp.

TrialNOT YET RECRUITING
Jan 2026Intervention for Communication Quality of Life in Primary Progressive Aphasia

University of Texas at Austin — NA

TrialRECRUITING
Jan 2026Remotely-supervised Neuromodulation in PPA

University of Texas at Austin — NA

TrialRECRUITING
Nov 2025Tegoprazan Plus Amoxicillin BID vs TID Regimens for H. Pylori Eradication（Frequency Adjusted Same-dose Therapy for H. Pylori）

First People's Hospital of Hangzhou — PHASE4

TrialNOT YET RECRUITING
Sep 2025Long Term Effect of Brain Stimulation in PPA

Hospital San Carlos, Madrid — NA

TrialRECRUITING
Aug 2025Clinical Study of Neflamapimod in Patients With Primary Progressive Aphasia

EIP Pharma Inc — PHASE2

TrialRECRUITING
Jul 2025Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive Aphasia

IRCCS San Raffaele — NA

TrialNOT YET RECRUITING
Apr 2025Development of a Cough Control Questionnaire (CCQ)

King's College Hospital NHS Trust

TrialRECRUITING
Sep 2024Speech and Language Interventions for Italian People With PPA

Istituti Clinici Scientifici Maugeri SpA

TrialRECRUITING
Aug 2024Communication Bridge 3 Study

University of Chicago — PHASE2

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Primary progressive aphasia.

18 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

18 recruitingView all trials with filters →
Phase 23 trials
Clinical Study of Neflamapimod in Patients With Primary Progressive Aphasia
Phase 2
Actively Recruiting
· Sites: Rochester, Minnesota; Columbus, Ohio +1 more · Age: 40–85 yrs
View on ClinicalTrials.gov ↗I'm interested →
Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia
Phase 2
Actively Recruiting
PI: Kyrana Tsapkini, PhD. (Johns Hopkins University) · Sites: Baltimore, Maryland; Philadelphia, Pennsylvania +1 more · Age: 50–90 yrs
View on ClinicalTrials.gov ↗I'm interested →
Communication Bridge 3 Study
Phase 2
Actively Recruiting
PI: Emily Roglaski, PhD (Professor of Neurology) · Sites: Chicago, Illinois · Age: 18–100 yrs
View on ClinicalTrials.gov ↗I'm interested →
N/A13 trials
Remotely-supervised Neuromodulation in PPA
N/A
Actively Recruiting
PI: Maya L Henry, PhD (University of Texas at Austin) · Sites: San Francisco, California; Austin, Texas · Age: 40–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
N/A
Actively Recruiting
PI: Stephanie M Grasso, Ph.D (University of Texas at Austin) · Sites: Austin, Texas; Barcelona +1 more · Age: 40–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Treating Primary Progressive Aphasia and Apraxia of Speech Using Non-invasive Brain Stimulation
N/A
Active
PI: John Hart, MD (The University of Texas at Dallas) · Sites: Dallas, Texas · Age: 18–85 yrs
View on ClinicalTrials.gov ↗I'm interested →
Treatment for Speech and Language in Primary Progressive Aphasia
N/A
Active
PI: Maya L Henry, PhD (University of Texas at Austin) · Sites: San Francisco, California; Austin, Texas
View on ClinicalTrials.gov ↗I'm interested →
Enhancing Language Function in Primary Progressive Aphasia
N/A
Actively Recruiting
PI: Aneta Kielar, PhD (University of Arizona) · Sites: Tucson, Arizona · Age: 45–80 yrs
View on ClinicalTrials.gov ↗I'm interested →
Enhancing Language Function in Aphasia
N/A
Actively Recruiting
PI: Aneta Kielar, PhD (University of Arizona) · Sites: Tucson, Arizona · Age: 21–80 yrs
View on ClinicalTrials.gov ↗I'm interested →
A Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia, MAINSTREAM ID:3430931
N/A
Actively Recruiting
PI: Maria Cotelli (IRCCS Istituto Centro San Giovanni di Dio- Fateben) · Sites: Brescia, BS; Milan, MI +2 more · Age: 40–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Speech-Language Treatment With Remotely Supervised Transcranial Direct Current Stimulation in Primary Progressive Aphasia
N/A
Enrolling by Invitation
PI: Maya Henry, PhD (University of Texas at Austin) · Sites: San Francisco, California; Austin, Texas
View on ClinicalTrials.gov ↗I'm interested →
Semantic Rehabilitation for Patients With Primary Progressive Semantic Aphasia
N/A
Actively Recruiting
PI: Jérémie PARIENTE, MD PhD (University Hospital, Toulouse) · Sites: Toulouse · Age: 18–100 yrs
View on ClinicalTrials.gov ↗I'm interested →
Communication Bridge Pilot Study
N/A
Active
PI: Emily Roglaski, PhD (Professor of Neurology) · Sites: Chicago, Illinois · Age: 18–100 yrs
View on ClinicalTrials.gov ↗I'm interested →
Intervention for Communication Quality of Life in Primary Progressive Aphasia
N/A
Actively Recruiting
PI: Maya L Henry, PhD (University of Texas at Austin) · Sites: Austin, Texas · Age: 40–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Primary Progressive Aphasia Multicomponent Language Treatment Study
N/A
Enrolling by Invitation
PI: Maya L Henry, PhD (University of Texas at Austin) · Sites: Austin, Texas
View on ClinicalTrials.gov ↗I'm interested →
Long Term Effect of Brain Stimulation in PPA
N/A
Actively Recruiting
· Sites: Madrid · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Other2 trials
Speech and Language Interventions for Italian People With PPA
Actively Recruiting
· Sites: Bari; Milan · Age: 40–85 yrs
View on ClinicalTrials.gov ↗I'm interested →
Language in Primary Progressive Aphasia
Actively Recruiting
PI: Marsel Mesulam, MD (Northwestern University Feinberg School of Medicin) · Sites: Chicago, Illinois
View on ClinicalTrials.gov ↗I'm interested →

Specialists

23 foundView all specialists →
AM
Alberto Benussi, MD
Trieste, Trieste
Specialist

Rare Disease Specialist

PI on 5 active trials
FM
Forbes D Porter, M.D.
Bethesda, Maryland
Specialist

Rare Disease Specialist

PI on 14 active trials
MM
Mitchell S Cairo, MD
HAWTHORNE, NY
Specialist
PI on 12 active trials
DP
Darby Morhardt, PhD
CHICAGO, IL
Specialist
PI on 1 active trial
JP
Jennifer Whitwell, PhD
Specialist
PI on 3 active trials
JM
Justin Y Kwan, M.D.
NILES, IL
Specialist
PI on 4 active trials
DM
Doreen Görß, MD
Specialist
PI on 1 active trial
BM
Barbara Borroni, MD
Specialist
PI on 7 active trials
MM
Maria C Tartaglia, M.D.
Specialist
PI on 3 active trials
RM
Robert B Innis, M.D.
Bethesda, Maryland
Specialist

Rare Disease Specialist

PI on 8 active trials
MP
Mark W Albers, MD, PhD
Specialist
PI on 1 active trial
JP
Janine Diehl-Schmid, Prof.
Specialist
PI on 1 active trial
RP
Reinhold Schmidt, Professor
Specialist
PI on 2 active trials2 Primary progressive aphasia publications
MM
Michael W. Weiner, MD
Specialist
PI on 3 active trials
YP
Yaakov Stern, PhD
NEW YORK, NY
Specialist
PI on 1 active trial
IP
Ilya Nasrallah, MD, PhD
PHILADELPHIA, PA
Specialist
PI on 1 active trial
RM
Reisa Sperling, MD
BOSTON, MA
Specialist
PI on 1 active trial
AP
Arndt Rolfs, Prof.
Specialist
PI on 2 active trials
PM
Paul S. Aisen, MD
SAN DIEGO, CA
Specialist
PI on 1 active trial
WM
William Gray, MD
Specialist
PI on 4 active trials
GM
Gary Ansel, MD
COLUMBUS, OH
Specialist
PI on 2 active trials
RP
Ronald Petersen, MD, PhD
Specialist
PI on 1 active trial
AM
Ariel Gildengers, MD
PITTSBURGH, PA
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program ↗

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Primary progressive aphasia.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Primary progressive aphasia

Disease timeline:

New recruiting trial: A Non-pharmacological Cough Control Therapy

A new clinical trial is recruiting patients for Primary progressive aphasia

New recruiting trial: Development of a Cough Control Questionnaire (CCQ)

A new clinical trial is recruiting patients for Primary progressive aphasia

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Primary progressive aphasia

Are there clinical trials for Primary progressive aphasia?

Yes — 18 recruiting clinical trials are currently listed for Primary progressive aphasia on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Primary progressive aphasia?

23 specialists and care centers treating Primary progressive aphasia are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.