Dementia pugilistica

Last reviewed March 21, 2026

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ORPHA:97353F01.8

Who is this for?

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5Active trials 19Specialists 8Treatment centers

Where are you in your journey?

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.

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Overview

Also known as:

Boxer's dementia Chronic traumatic encephalopathy Punch-drunk syndrome

Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events

Jan 2028Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury

Healing Hope International

TrialNOT YET RECRUITING

Jun 2026Allopregnanolone in Chronic Complex Traumatic Brain Injury

VA Office of Research and Development — PHASE2

TrialNOT YET RECRUITING

Jun 2026Comparing Approaches to Helping People With Chronic Traumatic Brain Injury Manage Their Health Care

Indiana University — NA

TrialNOT YET RECRUITING

May 2026Treating Traumatic Brain Injury With Transcranial Direct Current Stimulation

Johns Hopkins University — NA

TrialNOT YET RECRUITING

Apr 2026Goal-oriented Telehealth Rehabilitation of Executive Functioning for Veterans With Chronic TBI

VA Office of Research and Development — NA

TrialNOT YET RECRUITING

Mar 2026fNIRS for Disorders of Consciousness

University of California, Los Angeles

TrialNOT YET RECRUITING

Mar 2026Promoting Recovery After Brain Injury Using Focused Ultrasound

Massachusetts General Hospital — NA

TrialRECRUITING

Feb 2026Chronic Pain After Combat-Related Traumatic Brain Injury (cTBI-Pain Study) A Prospective Cohort Study of Pain Chronification After Combat-Related Traumatic Brain Injury

Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)

TrialNOT YET RECRUITING

Nov 2025Effects of Moderate/Severe Traumatic Brain Injury in the Subacute or Chronic Phase on Locomotor Strategies Involved in Navigation in Complex Virtual Environments

Pôle Saint Hélier — NA

TrialRECRUITING

Oct 2025Using Non-invasive Brain Stimulation to Treat Word Finding Difficulty in Chronic Traumatic Brain Injury

Beth Israel Deaconess Medical Center — NA

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Dementia pugilistica.

5 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

5 recruitingView all trials with filters →

Phase 31 trial

Visualizing Brain Proteinopathies Using [F-18]Flornaptitril-PET in the Prediction of Clinical Progression of Mild Cognitive Impairment With Either Suspected Chronic Traumatic Encephalopathy or Alzheimer's Disease

Phase 3

Actively Recruiting

PI: Chad Yucus, MD (Endeavor Health System) · Sites: Evanston, Illinois · Age: 45–99 yrs

Other4 trials

The DIAGNOSE CTE Research Project-II

Enrolling by Invitation

PI: Michael Alosco, PhD (Boston University Alzheimer's Disease and CTE Cent) · Sites: Phoenix, Arizona; San Francisco, California +3 more · Age: 50–99 yrs

Pilot Study Evaluating brainQuant's Ability to Detect Alterations in White Matter in Diffusion MRI, Indicative of Post-traumatic Lesions

Actively Recruiting

· Sites: Strasbourg · Age: 32–60 yrs

Post-Concussion Syndrome in Professional Athletes: A Multidisciplinary Study

Actively Recruiting

PI: Maria Carmela Tartaglia, M.D (Toronto Western Hopsital,UHN;Tanz CRND) · Sites: Toronto, Ontario · Age: 25–85 yrs

Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)

Actively Recruiting

PI: Katherine Turk, MD (VA Boston Healthcare System Jamaica Plain Campus, ) · Sites: Boston, Massachusetts · Age: 30–90 yrs

Specialists

19 foundView all specialists →

KP

Kyrana Tsapkini, PhD.

Specialist

Logopenic progressive aphasia Progressive non-fluent aphasia

PI on 2 active trials

Active trials Directions Travel grants

RM

Robert B Innis, M.D.

Bethesda, Maryland

Specialist

Rare Disease Specialist

Amyloidosis Encephalitis Fragile X syndrome+8 more

PI on 8 active trials

Active trials Directions Travel grants

FM

Flora Hammond, MD

INDIANAPOLIS, IN

Specialist

Best vitelliform macular dystrophy Moderate and severe traumatic brain injury

PI on 3 active trials

Active trials Directions Travel grants

JP

Jeanne M Hoffman, PhD

Specialist

Moderate and severe traumatic brain injury

PI on 3 active trials

Active trials Directions Travel grants

ME

Merz Medical Expert

Specialist

Alopecia Cutis laxa Focal, segmental or multifocal dystonia+1 more

PI on 9 active trials

Active trials Directions Travel grants

DP

Daniel C Lu, MD, PhD

Specialist

Neuromuscular disease Saethre-Chotzen syndrome Spinal cord injury

PI on 4 active trials

Active trials Directions Travel grants

DP

David L Brody, MD, PhD

Bethesda, Maryland

Specialist

Rare Disease Specialist

PI on 2 active trials

Active trials Directions Travel grants

RD

Ramon Diaz-Arrastia

PHILADELPHIA, PA

Specialist

PI on 1 active trial

Active trials Directions Travel grants

MA

Michael Alosco

BOSTON, MA

Specialist

PI on 1 active trial

Active trials Directions Travel grants

AR

Ashley RIDLEY

Specialist

PI on 1 active trial

Active trials Directions Travel grants

PL

Ping Lei

Specialist

PI on 1 active trial

Active trials Directions Travel grants

RM

Rowena Mobbs

Specialist

PI on 1 active trial

Active trials Directions Travel grants

SJ

Sheldon Jordan

SANTA MONICA, CA

Specialist

PI on 2 active trials

Active trials Directions Travel grants

HL

Helen Lavretsky

LOS ANGELES, CA

Specialist

PI on 1 active trial

Active trials Directions Travel grants

CY

Chad Yucus

GLENVIEW, IL

Specialist

PI on 1 active trial

Active trials Directions Travel grants

MS

Martha E. Shenton

BROCKTON, MA

Specialist

PI on 1 active trial

Active trials Directions Travel grants

JO

Jaap Oosterlaan

Specialist

PI on 1 active trial

Active trials Directions Travel grants

RS

Robert A Stern

Specialist

PI on 1 active trial

Active trials Directions Travel grants

MM

Maria Carmela Tartaglia, M.D

Specialist

PI on 1 active trial

Active trials Directions Travel grants

Treatment Centers

8 centers

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

UCLA Rare Disease Day Program ↗

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Dementia pugilistica.

Search all travel grants →NORD Financial Assistance ↗

Community

Open Dementia pugilisticaForum →

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Latest news about Dementia pugilistica

Disease timeline:

New recruiting trial: Using Non-invasive Brain Stimulation to Treat Word Finding Difficulty in Chronic Traumatic Brain Injury

A new clinical trial is recruiting patients for Dementia pugilistica

New recruiting trial: Personalized Brain Stimulation to Treat Chronic Concussive Symptoms

A new clinical trial is recruiting patients for Dementia pugilistica

New recruiting trial: Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU

A new clinical trial is recruiting patients for Dementia pugilistica

New recruiting trial: The FBRI VTC Neuromotor Research Clinic

A new clinical trial is recruiting patients for Dementia pugilistica

New recruiting trial: Ultrasound Stimulation for Patients in a Disorder of Consciousness

A new clinical trial is recruiting patients for Dementia pugilistica

New recruiting trial: Multimodal, Enriched Environment for Rehabilitation in Chronic Traumatic Brain Injury

A new clinical trial is recruiting patients for Dementia pugilistica

New recruiting trial: Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function

A new clinical trial is recruiting patients for Dementia pugilistica

New recruiting trial: Post-Concussion Syndrome in Professional Athletes: A Multidisciplinary Study

A new clinical trial is recruiting patients for Dementia pugilistica

New recruiting trial: Multimodal Neuroprognostication in Disorders of Consciousness

A new clinical trial is recruiting patients for Dementia pugilistica

New recruiting trial: Online Memory Intervention for Individuals with Traumatic Brain Injury

A new clinical trial is recruiting patients for Dementia pugilistica

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Dementia pugilistica

Are there clinical trials for Dementia pugilistica?

Yes — 5 recruiting clinical trials are currently listed for Dementia pugilistica on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Dementia pugilistica?

19 specialists and care centers treating Dementia pugilistica are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.