Moderate and severe traumatic brain injury

Last reviewed

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ORPHA:90056S06.4S06.5S06.6
Who is this for?
Show terms as
5Active trials48Specialists8Treatment centers

Where are you in your journey?

UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
May 2026Valproic AcId for Traumatic BRAin INjury Trial

Northwestern University — PHASE2, PHASE3

TrialNOT YET RECRUITING
Apr 2026Effects of Recombinant Human Growth Hormone in Elderly Patients With Moderate to Severe Acute Brain Injury (GH-ABI-RCT)

Anhui Provincial Hospital — PHASE4

TrialNOT YET RECRUITING
Feb 2026FFP In Traumatic BRAin INjury (FIT-BRAIN) Trial

Northwestern University — PHASE2, PHASE3

TrialRECRUITING
Oct 2025Methylprednisolone for Moderate to Severe Traumatic Brain Injury

Zhangjiagang First People's Hospital — PHASE4

TrialNOT YET RECRUITING
Sep 2025An Exploration of Sleep Disturbance and Outcomes in TBI (SLEEP-TBI)

University of Nottingham

TrialNOT YET RECRUITING
Apr 2025Seizure Prevention in Traumatic Brain Injury With Levetiracetam and Lacosamide

Wake Forest University Health Sciences — PHASE4

TrialRECRUITING
Jan 2025Dopaminergic Disruption Induced by Traumatic Coma: Dopaminergic Pathways Abnormalities and Biomarkers of Recovery Using MRI and 18F-LBT-999 PET

Institut National de la Santé Et de la Recherche Médicale, France — PHASE2

TrialRECRUITING
Oct 2024Safety and Efficacy of Enhanced Recovery After Surgery in Neurocritical Care

Shanghai 6th People's Hospital — NA

TrialRECRUITING
May 2024Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury

University of Arizona — PHASE1, PHASE2

TrialRECRUITING
Sep 2023Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury

University of Texas Southwestern Medical Center — NA

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Moderate and severe traumatic brain injury.

5 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

5 recruitingView all trials with filters →
Phase 41 trial
Seizure Prevention in Traumatic Brain Injury With Levetiracetam and Lacosamide
Phase 4
Actively Recruiting
PI: Rita Brintzenhoff, MD (Atrium Health Carolina Medical Center) · Sites: Winston-Salem, North Carolina · Age: 1899 yrs
Phase 11 trial
Combinatory Rehabilitation Used for Substantially Helping Individuals With Traumatic Brain Injury
Phase 1
Actively Recruiting
PI: Nancy D Chiaravalloti, PhD (Kessler Foundation) · Sites: West Orange, New Jersey · Age: 1865 yrs
N/A2 trials
Intervention to Change Affect Recognition and Empathy
N/A
Active
PI: Flora Hammond, MD (Indiana University) · Sites: Indianapolis, Indiana · Age: 1899 yrs
Safety and Efficacy of Enhanced Recovery After Surgery in Neurocritical Care
N/A
Actively Recruiting
PI: Hao Chen, M.D., Ph.D. (Shanghai 6th Peoples' Hospital) · Sites: Shanghai · Age: 1875 yrs

Specialists

Showing 25 of 48View all specialists →
HM
Hasan Alam, MD
CHICAGO, IL
Specialist
PI on 2 active trials
EM
Erich Schmutzhard, Prof. MD
Specialist
PI on 1 active trial
FD
Frank Tegtmeier, Dr.
Specialist
PI on 1 active trial
RM
Rita Brintzenhoff, MD
Specialist
PI on 1 active trial
AM
Arthur L Kellermann, MD, MPH
BETHESDA, MD
Specialist
PI on 1 active trial
MP
Miguel A Martinez-Gonzalez, MD, MPH, PhD
Specialist
PI on 1 active trial
RM
Rémy BERNARD, MD
Specialist
PI on 1 active trial
BP
Brenda Bartnik-Olson, PhD
Specialist
PI on 1 active trial
AD
Angela Sinner, DO
SAINT PAUL, MN
Specialist
PI on 1 active trial
DM
Duc Tran, MD
Specialist
PI on 1 active trial
LM
Linda Krach, MD
SAINT PAUL, MN
Specialist
PI on 1 active trial
BM
Bellal Joseph, MD
DETROIT, MI
Specialist
PI on 2 active trials
FM
Flora Hammond, MD
INDIANAPOLIS, IN
Specialist
PI on 3 active trials
LP
Luiz E Mello, MD, PhD
Specialist
PI on 1 active trial
EP
Eliana Garzon, MD, PhD
Specialist
PI on 1 active trial
AP
Asso. Professor Bandit - Thinkhamrop, M.P.H., Ph.D
Specialist
PI on 1 active trial
PM
Professor Nakornchai - Phuenpathom, B.Sc., M.D.
Specialist
PI on 1 active trial
WM
Warawut - Kittiwattanagul, M.D.
Specialist
PI on 1 active trial
PM
Professor Pisake - Lumbiganon, M.D.,M.S.
Specialist
PI on 1 active trial
PM
Parnumas - Piyavechvirat, M.D.
Specialist
PI on 1 active trial
LK
Leslie Kempthorne
Specialist
PI on 1 active trial
JP
Jeanne M Hoffman, PhD
Specialist
PI on 3 active trials
AP
Amanda Rabinowitz, PhD
LAKE WORTH, FL
Specialist
PI on 2 active trials
MP
Marie SABIA, PhD
Specialist
PI on 1 active trial
KM
Kan Ding, MD
Dallas, Texas
Specialist

Rare Disease Specialist

PI on 1 active trial

Treatment Centers

8 centers
⚗️ Trial Site

UT Southwestern Medical Center

📍 Dallas, Texas

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

Travel Grants

No travel grants are currently matched to Moderate and severe traumatic brain injury.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Moderate and severe traumatic brain injury

Disease timeline:

New recruiting trial: Combinatory Rehabilitation Used for Substantially Helping Individuals With Traumatic Brain Injury

A new clinical trial is recruiting patients for Moderate and severe traumatic brain injury

New recruiting trial: Safety and Efficacy of Enhanced Recovery After Surgery in Neurocritical Care

A new clinical trial is recruiting patients for Moderate and severe traumatic brain injury

New recruiting trial: Seizure Prevention in Traumatic Brain Injury With Levetiracetam and Lacosamide

A new clinical trial is recruiting patients for Moderate and severe traumatic brain injury

New recruiting trial: Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury

A new clinical trial is recruiting patients for Moderate and severe traumatic brain injury

New recruiting trial: Biperiden Trial for Epilepsy Prevention

A new clinical trial is recruiting patients for Moderate and severe traumatic brain injury

New recruiting trial: Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury

A new clinical trial is recruiting patients for Moderate and severe traumatic brain injury

New recruiting trial: Dopaminergic Disruption Induced by Traumatic Coma: Dopaminergic Pathways Abnormalities and Biomarkers of Recovery Using MRI and 18F-LBT-999 PET

A new clinical trial is recruiting patients for Moderate and severe traumatic brain injury

New recruiting trial: PRECISION-TBI - An Observational Study of Patients With Moderate to Severe Traumatic Brain Injury

A new clinical trial is recruiting patients for Moderate and severe traumatic brain injury

New recruiting trial: FFP In Traumatic BRAin INjury (FIT-BRAIN) Trial

A new clinical trial is recruiting patients for Moderate and severe traumatic brain injury

New trial: Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury

Phase NA trial recruiting.

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Moderate and severe traumatic brain injury

Are there clinical trials for Moderate and severe traumatic brain injury?

Yes — 5 recruiting clinical trials are currently listed for Moderate and severe traumatic brain injury on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Moderate and severe traumatic brain injury?

25 specialists and care centers treating Moderate and severe traumatic brain injury are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.