Overview
Avian influenza, commonly known as bird flu, is an infectious disease caused by influenza viruses that normally spread among birds but can sometimes infect humans. The most well-known strains that affect people include H5N1, H7N9, and H5N6, though other subtypes have also caused human infections. When the virus crosses from birds to humans, it can cause a wide range of illness, from mild eye infections and flu-like symptoms to severe pneumonia, acute respiratory distress syndrome (ARDS), organ failure, and even death. The disease primarily affects the lungs and respiratory system. After an incubation period of about 2 to 7 days, patients typically develop high fever, cough, sore throat, and muscle aches. In severe cases, the infection can rapidly progress to difficulty breathing, low oxygen levels, and multi-organ failure. Some patients also experience nausea, vomiting, and diarrhea. Children and people with weakened immune systems may be at higher risk for severe outcomes. Treatment mainly involves antiviral medications such as oseltamivir (Tamiflu) and supportive care including oxygen therapy and mechanical ventilation for severe cases. There is no widely available vaccine for the general public, though some countries have stockpiled vaccines for emergency use. The disease is considered rare in humans because it does not easily spread from person to person. Most human cases result from direct contact with infected poultry or contaminated environments. Early diagnosis and prompt antiviral treatment are critical for improving survival.
Key symptoms:
High feverSevere coughSore throatMuscle aches and body painDifficulty breathing or shortness of breathHeadacheFatigue and extreme tirednessRunny or stuffy noseNausea, vomiting, or diarrheaEye redness or conjunctivitisChest painConfusion or altered mental state in severe casesBluish discoloration of lips or face from low oxygen
Clinical phenotype terms (41)— hover any for plain English
Sporadic
Usually appears on its own, not inherited from a parent
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
8 eventsNational Institute of Allergy and Infectious Diseases (NIAID) — PHASE1
ModernaTX, Inc. — PHASE3
University Health Network, Toronto — PHASE3
Canadian Immunization Research Network — PHASE4
AstraZeneca — PHASE1, PHASE2
Butantan Institute — PHASE1, PHASE2
National Institute of Allergy and Infectious Diseases (NIAID) — PHASE1
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Avian influenza.
6 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Avian influenza.
Community
No community posts yet. Be the first to share your experience with Avian influenza.
Start the conversation →Latest news about Avian influenza
Disease timeline:
New recruiting trial: H5N1 Milk Detection Study
A new clinical trial is recruiting patients for Avian influenza
New recruiting trial: Safety and Immunogenicity of the Monovalent Influenza Vaccine A (H5N8) (Inactivated, Fragmented and Adjuvanted) in Adults and Older Adults
A new clinical trial is recruiting patients for Avian influenza
New recruiting trial: Pandemic Influenza Vaccine in Organ Transplantation (PIVOT Trial)
A new clinical trial is recruiting patients for Avian influenza
New recruiting trial: A Study of mRNA-1018-H5 Pandemic Influenza Vaccine in Healthy Adults
A new clinical trial is recruiting patients for Avian influenza
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What specific strain of avian influenza do I have, and what does that mean for my outlook?,How soon should I start antiviral treatment, and which medication is best for my case?,What warning signs should I watch for that would mean I need to go to the emergency room?,Can my family members or close contacts catch this from me, and should they take preventive medication?,How long will I need to be isolated, and when is it safe to be around others again?,Will I have any lasting effects on my lungs or other organs after recovery?,Should I be vaccinated against seasonal influenza, and is there a bird flu vaccine available for me?
Common questions about Avian influenza
What is Avian influenza?
Avian influenza, commonly known as bird flu, is an infectious disease caused by influenza viruses that normally spread among birds but can sometimes infect humans. The most well-known strains that affect people include H5N1, H7N9, and H5N6, though other subtypes have also caused human infections. When the virus crosses from birds to humans, it can cause a wide range of illness, from mild eye infections and flu-like symptoms to severe pneumonia, acute respiratory distress syndrome (ARDS), organ failure, and even death. The disease primarily affects the lungs and respiratory system. After an in
How is Avian influenza inherited?
Avian influenza follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
Are there clinical trials for Avian influenza?
Yes — 6 recruiting clinical trials are currently listed for Avian influenza on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Avian influenza?
25 specialists and care centers treating Avian influenza are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.