Avian influenza

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6Active trials56Specialists8Treatment centers

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Avian influenza, commonly known as bird flu, is an infectious disease caused by influenza viruses that normally spread among birds but can sometimes infect humans. The most well-known strains that affect people include H5N1, H7N9, and H5N6, though other subtypes have also caused human infections. When the virus crosses from birds to humans, it can cause a wide range of illness, from mild eye infections and flu-like symptoms to severe pneumonia, acute respiratory distress syndrome (ARDS), organ failure, and even death. The disease primarily affects the lungs and respiratory system. After an incubation period of about 2 to 7 days, patients typically develop high fever, cough, sore throat, and muscle aches. In severe cases, the infection can rapidly progress to difficulty breathing, low oxygen levels, and multi-organ failure. Some patients also experience nausea, vomiting, and diarrhea. Children and people with weakened immune systems may be at higher risk for severe outcomes. Treatment mainly involves antiviral medications such as oseltamivir (Tamiflu) and supportive care including oxygen therapy and mechanical ventilation for severe cases. There is no widely available vaccine for the general public, though some countries have stockpiled vaccines for emergency use. The disease is considered rare in humans because it does not easily spread from person to person. Most human cases result from direct contact with infected poultry or contaminated environments. Early diagnosis and prompt antiviral treatment are critical for improving survival.

Key symptoms:

High feverSevere coughSore throatMuscle aches and body painDifficulty breathing or shortness of breathHeadacheFatigue and extreme tirednessRunny or stuffy noseNausea, vomiting, or diarrheaEye redness or conjunctivitisChest painConfusion or altered mental state in severe casesBluish discoloration of lips or face from low oxygen

Clinical phenotype terms (41)— hover any for plain English
PharyngitisHP:0025439Ground-glass opacificationHP:0025179Nonproductive coughHP:0031246
Inheritance

Sporadic

Usually appears on its own, not inherited from a parent

Age of Onset

Variable

Can begin at different ages, from infancy through adulthood

Orphanet ↗NORD ↗

FDA & Trial Timeline

8 events
Apr 2026Rechallenge With a Low Pathogenicity Avian H10N7 Influenza Virus in Healthy Human Volunteers Previously Challenged With H10N7 Influenza

National Institute of Allergy and Infectious Diseases (NIAID) — PHASE1

TrialENROLLING BY INVITATION
Mar 2026A Study of mRNA-1018-H5 Pandemic Influenza Vaccine in Healthy Adults

ModernaTX, Inc. — PHASE3

TrialRECRUITING
Nov 2025Pandemic Influenza Vaccine in Organ Transplantation (PIVOT Trial)

University Health Network, Toronto — PHASE3

TrialRECRUITING
Oct 2025Immunogenicity and Safety of 2 Doses of Avian Influenza A (H5N1) Vaccine Administered 3 vs. 8 Weeks Apart

Canadian Immunization Research Network — PHASE4

TrialACTIVE NOT RECRUITING
Sep 2025A Phase I/II Study on Safety AND Immunogenicity of AZD4117 and AZD5315 Vaccines (PANDA)

AstraZeneca — PHASE1, PHASE2

TrialACTIVE NOT RECRUITING
Sep 2025Safety and Immunogenicity of the Monovalent Influenza Vaccine A (H5N8) (Inactivated, Fragmented and Adjuvanted) in Adults and Older Adults

Butantan Institute — PHASE1, PHASE2

TrialRECRUITING
Jun 2025A Study to Evaluate the Safety and Immunogenicity of Two Doses of a Novel H5 Central Antigen mRNA-LNP in Healthy Adults

National Institute of Allergy and Infectious Diseases (NIAID) — PHASE1

TrialACTIVE NOT RECRUITING
May 2025H5N1 Milk Detection Study

Emory University — NA

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Avian influenza.

6 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

6 recruitingView all trials with filters →
Phase 32 trials
A Study of mRNA-1018-H5 Pandemic Influenza Vaccine in Healthy Adults
Phase 3
Actively Recruiting
· Sites: San Bernardino, California; Savannah, Georgia +34 more · Age: 1899 yrs
Pandemic Influenza Vaccine in Organ Transplantation (PIVOT Trial)
Phase 3
Actively Recruiting
· Sites: Toronto, Ontario · Age: 1899 yrs
Phase 41 trial
Immunogenicity and Safety of 2 Doses of Avian Influenza A (H5N1) Vaccine Administered 3 vs. 8 Weeks Apart
Phase 4
Active
PI: Joanne M Langley (CIRN, Canadian Center for Vaccinology, Dalhousie U) · Sites: Vancouver, British Columbia; Halifax, Nova Scotia +2 more · Age: 1859 yrs
Phase 11 trial
A Study to Evaluate the Safety and Immunogenicity of Two Doses of a Novel H5 Central Antigen mRNA-LNP in Healthy Adults
Phase 1
Active
· Sites: Durham, North Carolina; Nashville, Tennessee +1 more · Age: 1849 yrs
N/A1 trial
H5N1 Milk Detection Study
N/A
Actively Recruiting
PI: Daniel Graciaa, MD, MPH, MSc (Emory University) · Sites: Atlanta, Georgia · Age: 1864 yrs

Specialists

Showing 25 of 56View all specialists →
BI
Baxter Bio Science Investigator
Specialist
PI on 2 active trials1 Avian influenza publication
GM
Gerald Aichinger, MD
Specialist
PI on 1 active trial1 Avian influenza publication
RM
Ruth A. Karron, MD
BALTIMORE, MD
Specialist
PI on 4 active trials
DM
Daniel Graciaa, MD, MPH, MSc
ATLANTA, GA
Specialist
PI on 1 active trial
LM
Le Hoang San, MD
Specialist
PI on 1 active trial1 Avian influenza publication
JP
John S Tsang, Ph.D.
LODI, CA
Specialist
PI on 1 active trial
NM
Nadine Rouphael, MD
ATLANTA, GA
Specialist
PI on 6 active trials
TM
Tran Tinh Hien, MD
Specialist
PI on 1 active trial
MM
Matthew J Memoli, M.D.
BETHESDA, MD
Specialist
PI on 6 active trials
JM
John Treanor, MD
ROCHESTER, NY
Specialist
PI on 5 active trials
TM
Tawee Chotpitayasunohdh, MD
Specialist
PI on 1 active trial
KM
Kawsar Talaat, MD
BALTIMORE, MD
Specialist
PI on 7 active trials
EM
Eric Sheldon, MD
NORTHAMPTON, MA
Specialist
PI on 3 active trials
YH
Yupaporn Wattanagoon, DTM & H
Specialist
PI on 1 active trial1 Avian influenza publication
FM
Franco Piazza, MD, MPH
Specialist
PI on 6 active trials
DP
D. Nigel Thomas, Ph.D.
COLUMBUS, OH
Specialist
PI on 1 active trial
DS
Drug Information Services
Specialist
PI on 3 active trials5 Avian influenza publications
DM
Dora Mathiasz, MD
Specialist
PI on 1 active trial
JM
Justin Ortiz, MD, MS
Specialist
PI on 2 active trials
PM
Philip Leese, MD
OVERLAND PARK, KS
Specialist
PI on 2 active trials
CM
Chih-Jen Chang, MD
Specialist
PI on 1 active trial
SD
Shan-Chwen Chang, Dr.
Specialist
PI on 1 active trial
ZC
Ze Chen
Specialist
PI on 1 active trial
DT
David Taylor
Specialist
PI on 1 active trial
DM
Don Guterwill, BS, MT
Specialist
PI on 2 active trials

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Avian influenza.

Search all travel grants →NORD Financial Assistance ↗

Community

Open Avian influenzaForum →

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Latest news about Avian influenza

Disease timeline:

New recruiting trial: H5N1 Milk Detection Study

A new clinical trial is recruiting patients for Avian influenza

New recruiting trial: Safety and Immunogenicity of the Monovalent Influenza Vaccine A (H5N8) (Inactivated, Fragmented and Adjuvanted) in Adults and Older Adults

A new clinical trial is recruiting patients for Avian influenza

New recruiting trial: Pandemic Influenza Vaccine in Organ Transplantation (PIVOT Trial)

A new clinical trial is recruiting patients for Avian influenza

New recruiting trial: A Study of mRNA-1018-H5 Pandemic Influenza Vaccine in Healthy Adults

A new clinical trial is recruiting patients for Avian influenza

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.What specific strain of avian influenza do I have, and what does that mean for my outlook?,How soon should I start antiviral treatment, and which medication is best for my case?,What warning signs should I watch for that would mean I need to go to the emergency room?,Can my family members or close contacts catch this from me, and should they take preventive medication?,How long will I need to be isolated, and when is it safe to be around others again?,Will I have any lasting effects on my lungs or other organs after recovery?,Should I be vaccinated against seasonal influenza, and is there a bird flu vaccine available for me?

Common questions about Avian influenza

What is Avian influenza?

Avian influenza, commonly known as bird flu, is an infectious disease caused by influenza viruses that normally spread among birds but can sometimes infect humans. The most well-known strains that affect people include H5N1, H7N9, and H5N6, though other subtypes have also caused human infections. When the virus crosses from birds to humans, it can cause a wide range of illness, from mild eye infections and flu-like symptoms to severe pneumonia, acute respiratory distress syndrome (ARDS), organ failure, and even death. The disease primarily affects the lungs and respiratory system. After an in

How is Avian influenza inherited?

Avian influenza follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

Are there clinical trials for Avian influenza?

Yes — 6 recruiting clinical trials are currently listed for Avian influenza on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Avian influenza?

25 specialists and care centers treating Avian influenza are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.