Overview
Tick-borne encephalitis (TBE) is a viral infection of the brain and surrounding tissues caused by the tick-borne encephalitis virus (TBEV). It is spread mainly through the bite of infected ticks, particularly the Ixodes species. In some cases, people can also get it by drinking unpasteurized milk from infected animals like goats or cows. The virus attacks the central nervous system, which includes the brain and spinal cord, causing inflammation that can lead to serious neurological problems. The illness often happens in two stages. The first stage feels like a typical flu, with fever, headache, muscle aches, and tiredness. Many people recover at this point. However, in about one-third of cases, the illness moves into a second, more serious stage where the virus reaches the brain. This can cause encephalitis (brain inflammation), meningitis (inflammation of the membranes around the brain), or both. Symptoms in this stage include severe headache, high fever, confusion, difficulty with balance and coordination, and in serious cases, paralysis or seizures. There is no specific antiviral drug to treat TBE once someone is infected. Treatment focuses on managing symptoms and supporting the body through the illness, often in a hospital setting. The good news is that a safe and effective vaccine exists to prevent TBE, and it is widely recommended for people living in or traveling to high-risk areas. Most people recover, but some are left with lasting neurological effects. TBE is also sometimes called Central European encephalitis or Russian spring-summer encephalitis, depending on the virus subtype.
Also known as:
Key symptoms:
FeverSevere headacheMuscle aches and painsExtreme tiredness and fatigueNausea and vomitingStiff neckConfusion or disorientationDifficulty with balance and coordinationSensitivity to lightSeizuresWeakness or paralysis of limbsDifficulty speaking or swallowingMemory and concentration problemsTremors or involuntary movementsLoss of consciousness in severe cases
Clinical phenotype terms (50)— hover any for plain English
Sporadic
Usually appears on its own, not inherited from a parent
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
4 eventsRiphah International University — NA
W.L.Gore & Associates — NA
W.L.Gore & Associates — NA
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Tick-borne encephalitis.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for Tick-borne encephalitis at this time.
New trials open frequently. Follow this disease to get notified.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Tick-borne encephalitis.
Community
No community posts yet. Be the first to share your experience with Tick-borne encephalitis.
Start the conversation →Latest news about Tick-borne encephalitis
Disease timeline:
New recruiting trial: TBE Zone 2 PMS in Japan
A new clinical trial is recruiting patients for Tick-borne encephalitis
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What stage of TBE do I have, and how severe is my infection based on my test results?,What symptoms should prompt me to go to the emergency room immediately?,How long is my recovery likely to take, and what does rehabilitation look like for me?,Are there any lasting neurological effects I should watch for, and how will they be monitored?,Should my family members or travel companions be vaccinated, and which vaccine is recommended?,Are there any clinical trials or new treatments for TBE that I might be eligible for?,What support services are available to help me return to work or school after recovery?
Common questions about Tick-borne encephalitis
What is Tick-borne encephalitis?
Tick-borne encephalitis (TBE) is a viral infection of the brain and surrounding tissues caused by the tick-borne encephalitis virus (TBEV). It is spread mainly through the bite of infected ticks, particularly the Ixodes species. In some cases, people can also get it by drinking unpasteurized milk from infected animals like goats or cows. The virus attacks the central nervous system, which includes the brain and spinal cord, causing inflammation that can lead to serious neurological problems. The illness often happens in two stages. The first stage feels like a typical flu, with fever, headach
How is Tick-borne encephalitis inherited?
Tick-borne encephalitis follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
Which specialists treat Tick-borne encephalitis?
25 specialists and care centers treating Tick-borne encephalitis are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.