Overview
Chikungunya is an infectious disease caused by the chikungunya virus, which is spread to people through the bite of infected mosquitoes, mainly Aedes aegypti and Aedes albopictus. The name comes from a word in the Kimakonde language meaning "to become contorted," referring to the stooped posture people develop from severe joint pain. The disease typically begins suddenly with high fever and intense joint pain, usually affecting the hands, wrists, ankles, and feet on both sides of the body. Other common symptoms include headache, muscle pain, joint swelling, and a skin rash. Most people start feeling sick 4 to 8 days after being bitten by an infected mosquito. While chikungunya is rarely fatal, the joint pain can be extremely severe and debilitating, sometimes lasting for weeks, months, or even years after the initial infection. This chronic joint pain is one of the most challenging aspects of the disease and can significantly affect quality of life. Newborns infected around the time of birth and older adults with other health conditions are at higher risk for severe disease. There is currently no specific antiviral treatment for chikungunya. Care focuses on relieving symptoms with rest, fluids, and pain medications such as acetaminophen. In late 2023, the FDA approved the first chikungunya vaccine, Ixchiq (VLA1553), for adults aged 18 and older who are at increased risk of exposure. This was a major milestone in prevention. Research continues into antiviral therapies and additional vaccines.
Key symptoms:
High fever (often above 102°F/39°C)Severe joint pain, especially in hands, wrists, ankles, and feetJoint swellingMuscle painHeadacheSkin rash (often appearing a few days after fever)Fatigue and weaknessNauseaBack painEye pain or sensitivity to lightChronic joint pain lasting months or yearsJoint stiffness, especially in the morningLoss of appetiteSwollen lymph nodes
Clinical phenotype terms (50)— hover any for plain English
Sporadic
Usually appears on its own, not inherited from a parent
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
10 eventsGylden Pharma Ltd — EARLY_PHASE1
Bavarian Nordic — PHASE3
Centre Hospitalier Universitaire de la Réunion — NA
Butantan Institute — PHASE3
Valneva Austria GmbH
Valneva Austria GmbH
Valneva Austria GmbH
Hospital Israelita Albert Einstein
Jiangsu Kanion Pharmaceutical Co., Ltd — NA
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Chikungunya.
12 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Chikungunya.
Community
No community posts yet. Be the first to share your experience with Chikungunya.
Start the conversation →Latest news about Chikungunya
Disease timeline:
New recruiting trial: Real-World Study on Chinese Medicine for Treating Chikungunya Fever
A new clinical trial is recruiting patients for Chikungunya
New recruiting trial: Virological and Immunological Determinants of Arbovirus Infection in New Caledonia
A new clinical trial is recruiting patients for Chikungunya
New recruiting trial: A Safety and Immunogenicity Study of CHIKV VLP Vaccine in Children.
A new clinical trial is recruiting patients for Chikungunya
New recruiting trial: Genetic Evolution of Arboviruses in New Caledonia Between 1995 and 2024 and Impact of Wolbachia
A new clinical trial is recruiting patients for Chikungunya
New recruiting trial: Real-world Effectiveness, Safety and Immunogenicity of Chikungunya Vaccination in Populations at Risk of Severe or Complicated Forms: Prospective Study in La Réunion
A new clinical trial is recruiting patients for Chikungunya
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.How can I tell if my symptoms are from chikungunya and not dengue or Zika?,What pain medications are safe for me to take right now?,How long should I expect my joint pain to last, and what are the chances it becomes chronic?,What can I do to prevent spreading the virus to my family members?,Should I see a rheumatologist if my joint pain continues after the fever goes away?,Are there any warning signs I should watch for that would require emergency care?,Is the chikungunya vaccine recommended for me or my family members for future protection?
Common questions about Chikungunya
What is Chikungunya?
Chikungunya is an infectious disease caused by the chikungunya virus, which is spread to people through the bite of infected mosquitoes, mainly Aedes aegypti and Aedes albopictus. The name comes from a word in the Kimakonde language meaning "to become contorted," referring to the stooped posture people develop from severe joint pain. The disease typically begins suddenly with high fever and intense joint pain, usually affecting the hands, wrists, ankles, and feet on both sides of the body. Other common symptoms include headache, muscle pain, joint swelling, and a skin rash. Most people start f
How is Chikungunya inherited?
Chikungunya follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
Are there clinical trials for Chikungunya?
Yes — 12 recruiting clinical trials are currently listed for Chikungunya on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Chikungunya?
25 specialists and care centers treating Chikungunya are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.