FDA-Approved Treatments

Drugs with orphan designation or indications for rare diseases — 955 total

Treatment data is sourced from FDA drug labels, DailyMed, and openFDA.
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Drug information is sourced from FDA labels and prescribing information. Always verify current prescribing information with your pharmacist or prescriber before starting, stopping, or changing any medication.

Orphan

Azithromycin Dihydrate

AZITHROMYCIN DIHYDRATE

PD-Rx Pharmaceuticals, Inc.

1 INDICATIONS AND USAGE Azithromycin is a macrolide antibacterial drug indicated for the treatment of patients with mild to moderate infections caused

Erythrocyte galactose epimerase deficiencyView details →
Orphan

Cayston

aztreonam

Gilead Sciences, Inc.

1 INDICATIONS AND USAGE CAYSTON ® is indicated to improve respiratory symptoms in cystic fibrosis (CF) patients with Pseudomonas aeruginosa . Safety a

Congenital insensitivity to pain-hyperhidrosis-absence of cutaneous sensory innervationPneumonia caused by Pseudomonas aeruginosa infection
View details →
Orphan

Lioresal Intrathecal

baclofen

Medtronic, Inc.

INDICATIONS AND USAGE Baclofen tablets, USP are useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, part

Multiple sclerosis variantView details →
Orphan

Colazal

Balsalazide disodium

Salix Pharmaceuticals, Inc.

1 INDICATIONS AND USAGE Balsalazide disodium capsules are indicated for the treatment of mildly to moderately active ulcerative colitis in patients 5

NON RARE IN EUROPE: Ulcerative colitis
View details →
Orphan⚠️ Black Box

Simulect

Basiliximab

Novartis Pharmaceuticals Corporation

INDICATIONS AND USAGE Simulect ® (basiliximab) is indicated for the prophylaxis of acute organ rejection in patients receiving renal transplantation w

Gyrate atrophy of choroid and retinaView details →
Orphan⚠️ Black Box

SIRTURO

bedaquiline

Janssen Research & Development, LLC

1 INDICATIONS AND USAGE SIRTURO is a diarylquinoline antimycobacterial drug indicated as part of combination therapy in the treatment of adult and ped

Testicular teratomaPulmonary non-tuberculous mycobacterial infection
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Orphan⚠️ Black Box

BLENREP

belantamab mafodotin-blmf

GlaxoSmithKline Intellectual Property Development Ltd.

1 INDICATIONS AND USAGE BLENREP is indicated in combination with bortezomib and dexamethasone for the treatment of adult patients with relapsed or ref

Multiple myeloma
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Orphan⚠️ Black Box

Nulojix

belatacept

Bristol-Myers Squibb Company

1 INDICATIONS AND USAGE • NULOJIX is a selective T cell costimulation blocker indicated for prophylaxis of organ rejection in adult patients receiving

MiT family translocation renal cell carcinomaView details →
Orphan

Beleodaq

Belinostat

Acrotech Biopharma LLC

1 INDICATIONS AND USAGE Beleodaq is indicated for the treatment of adult patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). This

Primary cutaneous peripheral T-cell lymphoma not otherwise specified
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Orphan

Rezurock

belumosudil

Kadmon Pharmaceuticals, LLC

1 INDICATIONS AND USAGE REZUROCK is indicated for the treatment of adult and pediatric patients 12 years and older with chronic graft-versus-host dise

Chronic graft versus host disease
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Orphan⚠️ Black Box

Welireg

BELZUTIFAN

Merck Sharp & Dohme LLC

1 INDICATIONS AND USAGE WELIREG is a hypoxia-inducible factor inhibitor indicated: von Hippel-Lindau (VHL) disease for treatment of adult patients wit

Von Hippel-Lindau disease
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Orphan

Bendeka

bendamustine for 50 ml admixture

Eagle Pharmaceuticals, Inc.

1 INDICATIONS AND USAGE BENDEKA injection is an alkylating drug indicated for treatment of patients with: Chronic lymphocytic leukemia (CLL). Efficacy

T-cell prolymphocytic leukemiaIndolent B-cell non-Hodgkin lymphomaB-cell chronic lymphocytic leukemia
View details →
Orphan

Treanda

Bendamustine hydrochloride

Cephalon, Inc.

1 INDICATIONS AND USAGE TREANDA is an alkylating drug indicated for treatment of patients with: Chronic lymphocytic leukemia (CLL). Efficacy relative

T-cell prolymphocytic leukemiaIndolent B-cell non-Hodgkin lymphomaB-cell chronic lymphocytic leukemia
View details →
Orphan

Fasenra

benralizumab

AstraZeneca Pharmaceuticals LP

1 INDICATIONS AND USAGE FASENRA is an interleukin-5 receptor alpha-directed cytolytic monoclonal antibody (IgG1, kappa) indicated for: • add-on mainte

Eosinophilic granulomatosis with polyangiitisEosinophilic fasciitis
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Orphan

Ucephan

Benzoate and phenylacetate

ImmunexImmunex

OBSOLETE: Non-pore-loop channelopathy due to Cl- channel skeletal muscle Clc1 anomaly
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Orphan

Ammonul

benzoate/phenylacetate

Medicis Pharmaceutical Corp.

Adjunctive therapy in the treatment of acute hyperammonemia and associated encephalopathy in patients with deficiencies in enzymes of the urea cycle.

Acute encephalopathy with biphasic seizures and late reduced diffusionView details →
Orphan

Survanta intratracheal suspension

Beractant

Ross Laboratories

INDICATIONS AND USAGE SURVANTA is indicated for prevention and treatment (“rescue”) of Respiratory Distress Syndrome (RDS) (hyaline membrane disease)

Infant acute respiratory distress syndrome
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Orphan

Orladeyo

berotralstat

BioCryst Pharmaceuticals, Inc.

1 INDICATIONS AND USAGE ORLADEYO ® is indicated for prophylaxis to prevent attacks of hereditary angioedema (HAE) in adults and pediatric patients 2 y

Hereditary angioedema
View details →
Orphan

Orladeyo

BEROTRALSTAT HYDROCHLORIDE

BioCryst Pharmaceuticals, Inc.

1 INDICATIONS AND USAGE ORLADEYO ® is indicated for prophylaxis to prevent attacks of hereditary angioedema (HAE) in adults and pediatric patients 2 y

Hereditary angioedema
View details →
Orphan

Cystadane

BETAINE

Recordati Rare Diseases

1 INDICATIONS AND USAGE CYSTADANE ® is indicated for the treatment of homocystinuria to decrease elevated homocysteine blood concentrations in pediatr

HomocystinuriaNeurodegeneration due to 3-hydroxyisobutyryl-CoA hydrolase deficiencyHomocystinuria due to cystathionine beta-synthase deficiencyHomocystinuria due to methylene tetrahydrofolate reductase deficiency
View details →
Orphan

Betaine Anhydrous

BETAINE ANHYDROUS

Eton Pharmaceuticals, Inc.

1. INDICATIONS AND USAGE Betaine Anhydrous for Oral Solution is indicated for the treatment of homocystinuria to decrease elevated homocysteine blood

HomocystinuriaHomocystinuria due to cystathionine beta-synthase deficiencyHomocystinuria due to methylene tetrahydrofolate reductase deficiency
View details →
Orphan

Betaloan Suik

BETAMETHASONE SODIUM PHOSPHATE AND BETAMETHASONE ACETATE

Advanced Rx Pharmacy of Tennessee, LLC

INDICATIONS AND USAGE When oral therapy is not feasible, the intramuscular use of Betamethasone Sodium Phosphate and Betamethasone Acetate Injectable

View details →
Orphan⚠️ Black Box

Marbeta 25 Kit

BETAMETHASONE SODIUM PHOSPHATE AND BETAMETHASONE ACETATE, BUPIVACAINE HYDROCHLORIDE, POVIDINE IODINE

Asclemed USA, Inc.

1 INDICATIONS AND USAGE Bupivacaine Hydrochloride Injection is indicated in adults for the production of local or regional anesthesia or analgesia for

View details →
Orphan

Zynteglo

BETIBEGLOGENE AUTOTEMCEL

Genetix Biotherapeutics Inc.

1 INDICATIONS AND USAGE ZYNTEGLO is indicated for the treatment of adult and pediatric patients with β-thalassemia who require regular red blood cell

Thalassemia
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Orphan

Avastin

bevacizumab

Genentech, Inc.

1 INDICATIONS AND USAGE Avastin is a vascular endothelial growth factor inhibitor indicated for the treatment of: Metastatic colorectal cancer, in com

Malignant tumor of fallopian tubesHereditary nonpolyposis colon cancerNON RARE IN EUROPE: Non-small cell lung cancerPrimary peritoneal carcinoma
View details →
Orphan⚠️ Black Box

Targretin

Bexarotene

Eisai, Inc.

1 INDICATIONS AND USAGE TARGRETIN ® (bexarotene) Capsules are indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in

Primary cutaneous T-cell lymphoma
View details →
Orphan

Normocarb HF

bicarbonate infusate

Dialysis Solutions, Inc.

Use as a replacement solution in Continuous Renal Replacement Therapy (CRRT) to replace water and to correct electrolytes and acid-base imbalances in

Late-onset retinal degenerationCongenital sucrase-isomaltase deficiencyErythrocyte galactose epimerase deficiency
View details →
Orphan⚠️ Black Box

Biktarvy

bictegravir, emtricitabine, and tenofovir alafenamide

Gilead Sciences, Inc.

1 INDICATIONS AND USAGE BIKTARVY is indicated as a complete regimen for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adul

Combined immunodeficiency-multiple intestinal atresiaZika virus disease
View details →
Orphan

Filsuvez

BIRCH TRITERPENES

Chiesi USA, Inc.

1 INDICATIONS AND USAGE FILSUVEZ is indicated for the treatment of wounds associated with dystrophic and junctional epidermolysis bullosa (EB) in adul

Junctional epidermolysis bullosaDystrophic epidermolysis bullosa
View details →
Orphan⚠️ Black Box

Blenoxane

Bleomycin sulfate

Bristol-Myers Squibb Pharmaceutical Research Institute

INDICATIONS AND USAGE Bleomycin for Injection, USP should be considered a palliative treatment. It has been shown to be useful in the management of th

Malignant peritoneal mesotheliomaEmbryonal carcinomaNon-Hodgkin lymphomaSquamous cell carcinoma of head and neckTesticular teratomaSquamous cell carcinoma of the cervix uteriSquamous cell carcinoma of the penis
View details →
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