Overview
Pseudomonas aeruginosa pneumonia is a serious lung infection caused by a bacterium called Pseudomonas aeruginosa. This germ is found widely in the environment — in soil, water, and even in hospitals — and it is known for being very hard to treat because it can resist many common antibiotics. While healthy people rarely get this infection, it can be life-threatening for people who are already sick, have weakened immune systems, or are on breathing machines (ventilators) in intensive care units. When Pseudomonas infects the lungs, it causes inflammation and fluid buildup that makes it very hard to breathe. The infection can spread quickly and damage lung tissue. People with conditions like cystic fibrosis, chronic obstructive pulmonary disease (COPD), HIV, cancer, or those who have had organ transplants are at much higher risk. Patients in hospitals — especially those on ventilators — are also very vulnerable. This type of hospital-acquired pneumonia is sometimes called ventilator-associated pneumonia (VAP). Symptoms include high fever, chills, a bad cough with thick or greenish mucus, chest pain, and serious difficulty breathing. Treatment requires strong antibiotics, often given through an IV, and sometimes combinations of drugs are needed because the bacteria can become resistant. Early diagnosis and fast treatment are critical to improving outcomes.
Key symptoms:
High fever and chillsSevere cough with thick, green, yellow, or bloody mucusShortness of breath or difficulty breathingChest pain, especially when breathing deeply or coughingRapid breathing or rapid heart rateLow oxygen levels in the bloodExtreme tiredness and weaknessConfusion or disorientation, especially in older adultsBluish tint to lips or fingertips (a sign of low oxygen)Loss of appetite and weight loss in prolonged illness
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
2 eventsUniversity of Ulm
TOBI: FDA approved
Management of cystic fibrosis patients with P.aeruginosa.
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
1 availableCayston
indicated to improve respiratory symptoms in cystic fibrosis (CF) patients with Pseudomonas aeruginosa
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Financial Resources
3 resourcesTOBRAMYCIN
Eli Lilly
Pseudomonas Pneumonia
TOBI
Mylan Specialty LP
TOBI — Contact Mylan Specialty LP
Travel Grants
No travel grants are currently matched to Pneumonia caused by Pseudomonas aeruginosa infection.
Community
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Start the conversation →Latest news about Pneumonia caused by Pseudomonas aeruginosa infection
Disease timeline:
New recruiting trial: Monocyte Profiles in Critically Ill Patients With Pseudomonas Aeruginosa Sepsis
A new clinical trial is recruiting patients for Pneumonia caused by Pseudomonas aeruginosa infection
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Which antibiotic is being used to treat this infection, and how do we know it will work against this specific strain?,How long will treatment last, and will it be given in the hospital or can it be continued at home?,Is this a drug-resistant strain, and what does that mean for my treatment options?,What can we do to prevent this infection from coming back?,Are there any long-term effects on my lungs that I should watch for after recovery?,Should other family members or close contacts take any precautions?,If I have an underlying condition like cystic fibrosis or a weakened immune system, how does that change my treatment plan?
Common questions about Pneumonia caused by Pseudomonas aeruginosa infection
What is Pneumonia caused by Pseudomonas aeruginosa infection?
Pseudomonas aeruginosa pneumonia is a serious lung infection caused by a bacterium called Pseudomonas aeruginosa. This germ is found widely in the environment — in soil, water, and even in hospitals — and it is known for being very hard to treat because it can resist many common antibiotics. While healthy people rarely get this infection, it can be life-threatening for people who are already sick, have weakened immune systems, or are on breathing machines (ventilators) in intensive care units. When Pseudomonas infects the lungs, it causes inflammation and fluid buildup that makes it very hard
Are there clinical trials for Pneumonia caused by Pseudomonas aeruginosa infection?
Yes — 1 recruiting clinical trial is currently listed for Pneumonia caused by Pseudomonas aeruginosa infection on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Pneumonia caused by Pseudomonas aeruginosa infection?
5 specialists and care centers treating Pneumonia caused by Pseudomonas aeruginosa infection are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.
What treatment and support options exist for Pneumonia caused by Pseudomonas aeruginosa infection?
2 patient support programs are currently tracked on UniteRare for Pneumonia caused by Pseudomonas aeruginosa infection. See the treatments and support programs sections for copay assistance, eligibility, and contact details.