Waldenström Macroglobulinemia

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Who is this for?
Show terms as
2FDA treatments9Active trials24Specialists8Treatment centers1Financial resources

Where are you in your journey?

UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Waldenström Macroglobulinemia is treated with 1 medication in our database, including BRUKINSA. 1 of these has manufacturer assistance programs available to help reduce out-of-pocket costs. Medications are manufactured by BeiGene. Patients and caregivers can find copay cards, patient assistance programs, and travel grants for Waldenström Macroglobulinemia treatment below.

Inheritance

Multifactorial

Caused by a mix of several genes and environmental factors

Age of Onset

Late onset

Begins later in life, typically after age 50

NORD ↗

FDA & Trial Timeline

10 events
Mar 2026ABBV-383 for the Treatment of Relapsed Refractory Waldenström Macroglobulinemia

Mayo Clinic — PHASE1, PHASE2

TrialNOT YET RECRUITING
Feb 2026Phenotypic and Functional Study of Bone Marrow Mesenchymal Stem Cells in Waldenström Macroglobulinemia

Centre Hospitalier Universitaire, Amiens — NA

TrialRECRUITING
Dec 2025A Phase II Clinical Study of Zanubrutinib Combined With Four Cycles of CD20 Monoclonal Antibody and Reduced-Dose Bendamustine in the Treatment of Untreated Waldenström Macroglobulinemia

Institute of Hematology & Blood Diseases Hospital, China — PHASE2

TrialNOT YET RECRUITING
Dec 2025Study Evaluating the Efficacy and Tolerance of a Zanubrutinib and BGB-11417 Combination in Patients Previously Treated for Waldenström Macroglobulinemia

French Innovative Leukemia Organisation — PHASE2

TrialNOT YET RECRUITING
Nov 2025A Phase 2 Study to Evaluate the Safety and Efficacy of Pacritinib in Relapsed or Refractory Waldenström Macroglobulinemia

Shayna Sarosiek, MD — PHASE2

TrialRECRUITING
Oct 2025A Study to Evaluate the Efficacy and Safety of Zanubrutinib in Chinese Adults With Treatment-Naive Waldenström Macroglobulinemia

BeiGene — PHASE4

TrialRECRUITING
Sep 2025Ibrutinib Followed by BR (Bendamustine and Rituximab) as a Time-Limited Therapy for Waldenström Macroglobulinemia

Institute of Hematology & Blood Diseases Hospital, China — PHASE1

TrialNOT YET RECRUITING
Oct 2023A Study to Investigate Efficacy and Safety of BCL2 Inhibitor Sonrotoclax as Monotherapy and in Combination With Zanubrutinib in Adults With Waldenström Macroglobulinemia

BeOne Medicines — PHASE2

TrialACTIVE NOT RECRUITING
Jun 2023Study to Evaluate Adverse Events, Change in Disease Activity, and How Oral ABBV-101 Moves Through the Body in Adult Participants With B-Cell Malignancies

AbbVie — PHASE1

TrialACTIVE NOT RECRUITING
May 2023Pirtobrutinib and Venetoclax in Waldenström Macroglobulinemia

Dana-Farber Cancer Institute — PHASE2

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

2 available

BRUKINSA

zanubrutinib· BeOne Medicines USA, Inc.

BRUKINSA is indicated for the treatment of adult patients with Waldenström's macroglobulinemia (WM).

IMBRUVICA

ibrutinib· Pharmacyclics, LLC

IMBRUVICA is indicated for the treatment of adult patients with Waldenström's macroglobulinemia (WM).

Clinical Trials

9 recruitingView all trials with filters →
Phase 41 trial
A Study to Evaluate the Efficacy and Safety of Zanubrutinib in Chinese Adults With Treatment-Naive Waldenström Macroglobulinemia
Phase 4
Actively Recruiting
PI: Study Director (BeiGene) · Sites: Beijing, Beijing Municipality; Guangzhou, Guangdong +6 more · Age: 1899 yrs
Phase 24 trials
An Open-label, Phase 2 Study of ACP-196 in Subjects With Waldenström Macroglobulinemia
Phase 2
Active
PI: AstraZeneca Clinical study Information Center (1-877-240-9479 information.center@astrazeneca.com) · Sites: Santa Barbara, California; Aurora, Colorado +36 more · Age: 1899 yrs
A Study to Investigate Efficacy and Safety of BCL2 Inhibitor Sonrotoclax as Monotherapy and in Combination With Zanubrutinib in Adults With Waldenström Macroglobulinemia
Phase 2
Active
PI: Study Director (BeOne Medicines) · Sites: Duarte, California; Denver, Colorado +70 more · Age: 1899 yrs
A Phase 2 Study to Evaluate the Safety and Efficacy of Pacritinib in Relapsed or Refractory Waldenström Macroglobulinemia
Phase 2
Actively Recruiting
PI: Shayna Sarosiek, MD (Dana-Farber Cancer Institute) · Sites: Boston, Massachusetts · Age: 1899 yrs
Pirtobrutinib and Venetoclax in Waldenström Macroglobulinemia
Phase 2
Actively Recruiting
PI: Jorge Castillo, MD (Dana-Farber Cancer Institute) · Sites: Boston, Massachusetts; Boston, Massachusetts · Age: 1899 yrs
N/A3 trials
Prognostic Value of Circulating Tumoral DNA After the First 6 Months of Treatment in Patients With Waldenström Macroglobulinemia
N/A
Actively Recruiting
· Sites: Amiens · Age: 1899 yrs
Phenotypic and Functional Study of Bone Marrow Mesenchymal Stem Cells in Waldenström Macroglobulinemia
N/A
Actively Recruiting
· Sites: Amiens · Age: 1899 yrs
Clinical Study of the Hyperviscosity Syndrome in Waldenström Macroglobulinemia
N/A
Actively Recruiting
· Sites: Amiens · Age: 1899 yrs
Other1 trial
Observational Study Evaluating the Efficacy and Safety of Zanubrutinib in Participants With Waldenström Macroglobulinemia
Actively Recruiting
PI: Study Director (BeiGene) · Sites: Huntsville, Alabama; Mobile, Alabama +6 more · Age: 1899 yrs

Specialists

24 foundView all specialists →
JM
Jorge J Castillo, MD
Specialist
PI on 3 active trials
SS
Shayna Sarosiek
BOSTON, MA
Specialist
9 Waldenström Macroglobulinemia publications
RO
Roger G Owen
CHRISTINSBURG, VA
Specialist
3 Waldenström Macroglobulinemia publications
JT
Judith Trotman
LUTZ, FL
Specialist
3 Waldenström Macroglobulinemia publications
CT
Constantine S Tam
CANOGA PARK, CA
Specialist
3 Waldenström Macroglobulinemia publications
JP
Jonas Paludo
ROCHESTER, MN
Specialist
3 Waldenström Macroglobulinemia publications
ZH
Zachary R Hunter
Specialist
3 Waldenström Macroglobulinemia publications
PK
Prashant Kapoor
ROCHESTER, MN
Specialist
3 Waldenström Macroglobulinemia publications
JC
Jorge J Castillo
Specialist
13 Waldenström Macroglobulinemia publications
ST
Steven P Treon
COPPERHILL, TN
Specialist
8 Waldenström Macroglobulinemia publications
CB
Christian Buske
Specialist
4 Waldenström Macroglobulinemia publications
MG
Morie A Gertz
ROCHESTER, MN
Specialist
3 Waldenström Macroglobulinemia publications
SK
Shaji Kumar
Anchorage, Alaska
Specialist

Rare Disease Specialist

PI on 7 active trials
OP
Oliver W. Press, MD, PhD
SAN LUIS OBISPO, CA
Specialist
PI on 4 active trials
HA
Heather Allewelt
ORLANDO, FL
Specialist
3 Waldenström Macroglobulinemia publications
WC
Wai Y Chan
Specialist
3 Waldenström Macroglobulinemia publications
AT
Alessandra Tedeschi
Specialist
3 Waldenström Macroglobulinemia publications
AC
Aileen Cohen
PALO ALTO, CA
Specialist
3 Waldenström Macroglobulinemia publications
LS
Lode Swinnen
BALTIMORE, MD
Specialist
PI on 1 active trial
DS
David Scadden
BOSTON, MA
Specialist
PI on 1 active trial
RB
Rainer Brachmann
Specialist
PI on 1 active trial
MG
Morie Gertz
ROCHESTER, MN
Specialist
PI on 1 active trial
SB
Seema Bhat
COLUMBUS, OH
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

1 grants

PAN Foundation Waldenström Macroglobulinemia Disease Fund

PAN Foundation

Apply ↗

Community

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Latest news about Waldenström Macroglobulinemia

Disease timeline:

New recruiting trial: Loncastuximab Tesirine in WM

A new clinical trial is recruiting patients for Waldenström Macroglobulinemia

New recruiting trial: Spanish Registry of Patients With IgM Monoclonal Gammopathies

A new clinical trial is recruiting patients for Waldenström Macroglobulinemia

New recruiting trial: Pirtobrutinib and Venetoclax in Waldenström Macroglobulinemia

A new clinical trial is recruiting patients for Waldenström Macroglobulinemia

New recruiting trial: Phenotypic and Functional Study of Bone Marrow Mesenchymal Stem Cells in Waldenström Macroglobulinemia

A new clinical trial is recruiting patients for Waldenström Macroglobulinemia

New recruiting trial: Prognostic Value of Circulating Tumoral DNA After the First 6 Months of Treatment in Patients With Waldenström Macroglobulinemia

A new clinical trial is recruiting patients for Waldenström Macroglobulinemia

New recruiting trial: Clinical Study of the Hyperviscosity Syndrome in Waldenström Macroglobulinemia

A new clinical trial is recruiting patients for Waldenström Macroglobulinemia

New recruiting trial: Zanubrutinib, Bendamustine, Rituximab Prev. Untreated WM

A new clinical trial is recruiting patients for Waldenström Macroglobulinemia

New recruiting trial: A Phase 2 Study to Evaluate the Safety and Efficacy of Pacritinib in Relapsed or Refractory Waldenström Macroglobulinemia

A new clinical trial is recruiting patients for Waldenström Macroglobulinemia

New recruiting trial: Observational Study Evaluating the Efficacy and Safety of Zanubrutinib in Participants With Waldenström Macroglobulinemia

A new clinical trial is recruiting patients for Waldenström Macroglobulinemia

New recruiting trial: A Study to Evaluate the Efficacy and Safety of Zanubrutinib in Chinese Adults With Treatment-Naive Waldenström Macroglobulinemia

A new clinical trial is recruiting patients for Waldenström Macroglobulinemia

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Waldenström Macroglobulinemia

What is Waldenström Macroglobulinemia?

Waldenström Macroglobulinemia is treated with 1 medication in our database, including BRUKINSA. 1 of these has manufacturer assistance programs available to help reduce out-of-pocket costs. Medications are manufactured by BeiGene. Patients and caregivers can find copay cards, patient assistance programs, and travel grants for Waldenström Macroglobulinemia treatment below.

How is Waldenström Macroglobulinemia inherited?

Waldenström Macroglobulinemia follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does Waldenström Macroglobulinemia typically begin?

Typical onset of Waldenström Macroglobulinemia is late onset. Age of onset can vary across affected individuals.

Are there clinical trials for Waldenström Macroglobulinemia?

Yes — 9 recruiting clinical trials are currently listed for Waldenström Macroglobulinemia on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Waldenström Macroglobulinemia?

24 specialists and care centers treating Waldenström Macroglobulinemia are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.

What treatment and support options exist for Waldenström Macroglobulinemia?

1 FDA-approved treatment are currently tracked on UniteRare for Waldenström Macroglobulinemia. See the treatments and support programs sections for copay assistance, eligibility, and contact details.