Waldenström Macroglobulinemia

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At a Glance

Live from database

Regulatory Watchboard

10 events
Mar 2026ABBV-383 for the Treatment of Relapsed Refractory Waldenström Macroglobulinemia

Mayo Clinic — PHASE1, PHASE2

TrialNOT YET RECRUITING
Feb 2026Phenotypic and Functional Study of Bone Marrow Mesenchymal Stem Cells in Waldenström Macroglobulinemia

Centre Hospitalier Universitaire, Amiens — NA

TrialRECRUITING
Dec 2025A Phase II Clinical Study of Zanubrutinib Combined With Four Cycles of CD20 Monoclonal Antibody and Reduced-Dose Bendamustine in the Treatment of Untreated Waldenström Macroglobulinemia

Institute of Hematology & Blood Diseases Hospital, China — PHASE2

TrialNOT YET RECRUITING
Dec 2025Study Evaluating the Efficacy and Tolerance of a Zanubrutinib and BGB-11417 Combination in Patients Previously Treated for Waldenström Macroglobulinemia

French Innovative Leukemia Organisation — PHASE2

TrialNOT YET RECRUITING
Nov 2025A Phase 2 Study to Evaluate the Safety and Efficacy of Pacritinib in Relapsed or Refractory Waldenström Macroglobulinemia

Shayna Sarosiek, MD — PHASE2

TrialRECRUITING
Oct 2025A Study to Evaluate the Efficacy and Safety of Zanubrutinib in Chinese Adults With Treatment-Naive Waldenström Macroglobulinemia

BeiGene — PHASE4

TrialRECRUITING
Sep 2025Ibrutinib Followed by BR (Bendamustine and Rituximab) as a Time-Limited Therapy for Waldenström Macroglobulinemia

Institute of Hematology & Blood Diseases Hospital, China — PHASE1

TrialNOT YET RECRUITING
Oct 2023A Study to Investigate Efficacy and Safety of BCL2 Inhibitor Sonrotoclax as Monotherapy and in Combination With Zanubrutinib in Adults With Waldenström Macroglobulinemia

BeOne Medicines — PHASE2

TrialACTIVE NOT RECRUITING
Jun 2023Study to Evaluate Adverse Events, Change in Disease Activity, and How Oral ABBV-101 Moves Through the Body in Adult Participants With B-Cell Malignancies

AbbVie — PHASE1

TrialACTIVE NOT RECRUITING
May 2023Pirtobrutinib and Venetoclax in Waldenström Macroglobulinemia

Dana-Farber Cancer Institute — PHASE2

TrialRECRUITING

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

1 program

FINANCIAL LANDSCAPE SUMMARY

1

Total programs

1

Open now

1

Travel grants

Travel Grants1

PAN Foundation Waldenström Macroglobulinemia Disease Fund

PAN Foundation

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Approved Treatments

2 FDA-approved

BRUKINSA

(zanubrutinib)Orphan drugstandard

BeOne Medicines USA, Inc.

Kinase Inhibitor [EPC]

12.1 Mechanism of Action Zanubrutinib is a small-molecule inhibitor of Bruton's tyrosine kinase (BTK). Zanubrutinib forms a covalent bond with a cyste...

FDA label ↗

IMBRUVICA

(ibrutinib)Orphan drugstandard

Pharmacyclics, LLC

Kinase Inhibitor [EPC]

12.1 Mechanism of Action Ibrutinib is a small-molecule inhibitor of Bruton’s tyrosine kinase (BTK). Ibrutinib forms a covalent bond with a cysteine re...

FDA label ↗

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Clinical Trial Landscape

9 active trials
1Phase 4
4Phase 2
3N/A
1Unknown
9Total recruiting
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Recent News & Research

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Specialist Network

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