Clinical trials for Sickle cell disease
100 recruiting or active trials synced from ClinicalTrials.gov.
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Clinical trial records are synced from ClinicalTrials.gov through automated extraction.
Report missing data- RECRUITINGPhase 4NCT06979492Prophylactic Transfusion In Pregnant in Women With Sickle Cell DiseaseEmory University · PI: Ross Fasano, MD
- RECRUITINGNCT07392216Functional Ovarian Reserve in Sickle Cell DiseaseSt. Jude Children's Research Hospital · PI: Christine Yu, MD
- RECRUITINGN/ANCT07246265Morphine Clearance and Glomerular Filtration in Sickle Cell Patients in Crisis in Intensive CareUniversity Hospital, Tours
- ENROLLING BY INVITATIONPhase 2NCT07401823Open-Label Extension Study to Pioneer Study 6058-SCD-101Fulcrum Therapeutics
- RECRUITINGPHASE1, PHASE2NCT07432867Efficacy Safety Study of Gene Therapy for Sickle Cell DiseaseSCD Using Autologous CD34+ Cells Transduced ex Vivo, Carrying a Corrected Globin Gene and a Silencing RNA.Assistance Publique - Hôpitaux de Paris · PI: Elisa MAGRIN, PhD
- RECRUITINGN/ANCT07222475Writing Relaxing Beats in Adolescents Who Have Sickle Cell DiseaseMayo Clinic · PI: C. Robert Bennett, PhD
- RECRUITINGPhase 2NCT07224360Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)CSL Behring · PI: Study Director
- RECRUITINGPhase 3NCT07247188Study of a Single Dose of a 21-valent Pneumococcal Conjugate Vaccine in Children and Adolescents With Sickle Cell DiseaseSanofi · PI: Clinical Sciences & Operations Study Director
- RECRUITINGN/ANCT06919224Delivering Patient-Facing Evidence-Based Guidelines Through mHealth to Adults With Sickle Cell DiseaseOhio State University · PI: Robert M Cronin, MD, MS
- RECRUITINGPhase 1NCT07187973A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)Disc Medicine, Inc
- RECRUITINGPhase 1NCT07431398Single-dose Pharmacokinetics of Pociredir in Participants With Sickle Cell DiseaseFulcrum Therapeutics
- RECRUITINGPhase 1NCT07226219Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell DiseaseSt. Jude Children's Research Hospital · PI: Andrew Heitzer, PhD
- RECRUITINGPhase 2NCT07023666Early Screening and Treatment of Heart Complication in Sickle Cell DiseaseInova Health Care Services · PI: Sheinei Alan, MD
- RECRUITINGN/ANCT06725550Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0Indiana University
- RECRUITINGN/ANCT06619197Exploratory Study on Global Reflexology in Sickle Cell DiseaseHospices Civils de Lyon · PI: COLLOT SOPHIE
- RECRUITINGPhase 4NCT06665997Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell DiseaseUniversity of Pennsylvania · PI: Andrea Roe, MD MPH
- RECRUITINGN/ANCT06880679Ultrasound Acute Chest Syndrome Sickle Cell DiseaseIndiana University · PI: Seethal Jacob, MD
- RECRUITINGPhase 2NCT05519111Cannabinoids for the Reduction of Inflammation and Sickle Cell Related PainIcahn School of Medicine at Mount Sinai · PI: Susanna Curtis
- RECRUITINGN/ANCT06853158MULTIsite Feasibility of MUSIc Therapy to Address Quality Of Life in Sickle Cell DiseaseUniversity of California, Irvine · PI: Jeffery A Dusek, PhD
- RECRUITINGNCT06887907Phenotypic and Transcriptomic Description of Megakaryocytes in Sickle Cell PatientUniversity Hospital, Toulouse · PI: Pierre COUGOUL, MD
- RECRUITINGPhase 3NCT06612268A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell DiseaseNovo Nordisk A/S · PI: Clinical Transparency (dept. 2834)
- RECRUITINGN/ANCT06650813Adapting the FACETS Program to Sickle Cell DiseaseVersailles Hospital · PI: Marie-Claire GAY, Pr
- RECRUITINGPhase 2NCT06635902Intravenous L-Citrulline for Vaso-occlusive Pain Episode in Sickle Cell DiseaseSuvankar Majumdar · PI: Suvankar Majumdar, MD
- RECRUITINGN/ANCT05383911Empowering Adolescents and Young Adults With Sickle Cell Disease as Partners in Treatment Decision Making (EMPOWER-AYA)Nemours Children's Clinic
- RECRUITINGPhase 1NCT06442761SCD Stem Cell Mobilization and Apheresis Using MotixafortideSt. Jude Children's Research Hospital · PI: Alexis Leonard, MD
- RECRUITINGN/ANCT06184126Virtual Reality Devices as an Adjunct to Usual Care for Patients With Sickle Cell Disease Experiencing Vaso-Occlusive CrisesUniversity of Maryland, Baltimore · PI: R. Gentry Wilklerson, MD
- RECRUITINGPhase 3NCT06439082A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)Novartis Pharmaceuticals
- RECRUITINGN/ANCT07001631Effect of EMDR for Reduction of Pain Interference in Children With Sickle Cell DiseaseAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · PI: Karin Fijnvandraat, prof. dr.
- RECRUITINGPHASE1, PHASE2NCT04774536Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients with Severe Sickle Cell DiseaseMark Walters, MD · PI: Mark Walters, MD
- RECRUITINGNCT06477289Peripheral Arterial Tonometry and Neurocognition in Sickle Cell DiseaseSt. Jude Children's Research Hospital · PI: Andrew Heitzer, Phd
- RECRUITINGN/ANCT06773715Virtual Reality As Adjunct Therapy for Vaso-Occlusive PainLouisiana State University Health Sciences Center in New Orleans
- ENROLLING BY INVITATIONN/ANCT06300723Clinical Study of BRL-101 in Severe SCDBioray Laboratories · PI: Yongrong Lai, phD
- RECRUITINGN/ANCT06139510Predictors of Pain in Sickle Cell DiseaseDuke University · PI: Martha Kenney, MD
- RECRUITINGN/ANCT06264700Applying Directly Observed Therapy to Hydroxyurea to Realize EffectivenessNationwide Children's Hospital · PI: Susan Creary, MD, MSc
- RECRUITINGNCT06497153Lung Ultrasound in Pediatric Acute Chest SyndromeAssistance Publique - Hôpitaux de Paris · PI: Aurélie HAYOTTE, MD
- RECRUITINGNCT07000747Molecular and Cellular Basis of Severe Forms of Dengue in Sickle Cell PatientsCentre Hospitalier Universitaire de la Guadeloupe · PI: Maryse Etienne-Julan, MD PhD
- ENROLLING BY INVITATIONNCT06363760A Long-Term Follow-Up Study of Participants With Sickle Cell Disease or Transfusion Dependent β-Thalassemia Who Received EDIT-301Editas Medicine, Inc.
- RECRUITINGEarly Phase 1NCT06313398Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin LabelingNational Heart, Lung, and Blood Institute (NHLBI) · PI: John F Tisdale, M.D.
- ACTIVE NOT RECRUITINGPhase 1NCT06155500Long-term Follow-up (LTFU) of Patients Treated With Genome-edited Autologous Hematopoietic Stem and Progenitor Cells (HSPC)Novartis Pharmaceuticals · PI: Novartis Pharmaceuticals
- RECRUITINGN/ANCT06035939SMYLS Multi-site TrialMedical University of South Carolina
- RECRUITINGPhase 2NCT06358638Sickle Cell Disease Transplant Using a Nonmyeloablative Approach for Patients With Anti-donor Red Cell AntibodyChildren's National Research Institute · PI: Robert Nickel, MD
- ACTIVE NOT RECRUITINGPhase 2NCT05725902Study of the Effect of Etavopivat on Cerebral Hemodynamic Response in Children With Sickle Cell DiseaseNovo Nordisk A/S · PI: Clinical Transparency dept. 2834
- RECRUITINGN/ANCT06511453Acupressure in Patients With Sickle Cell DiseaseIndiana University
- ACTIVE NOT RECRUITINGPHASE1, PHASE2NCT06145282Non-myeloablative Haploidentical HCT Study for Patients With Sickle Cell Disease, Including Compromised Organ FunctionNational Heart, Lung, and Blood Institute (NHLBI) · PI: Courtney F Joseph, M.D.
- ACTIVE NOT RECRUITINGN/ANCT06074198Sickle Cell Children's Exercise Study (SuCCESs)University of Maryland, Baltimore
- ACTIVE NOT RECRUITINGPhase 2NCT06023199Assessing Physical Function in Sickle Cell Patients Taking VoxelotorInova Health Care Services · PI: Sheinei Alan
- RECRUITINGPhase 2NCT05953584A Phase 2 Open-label Study to Evaluate the Activity of Etavopivat on Transcranial Doppler Velocities in Pediatric Patients With Sickle Cell Disease Who Are at Increased Risk for Primary StrokeForma Therapeutics, Inc. · PI: Clinical Transparency (dept. 2834)
- RECRUITINGPhase 4NCT05730205Effects of the Contraceptive Implant in Women With Sickle Cell DiseaseUniversity of Pennsylvania
- RECRUITINGNCT06385886Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell DiseaseRTI International · PI: Julie Kanter, MD
- RECRUITINGNCT05810181Gene Therapy Communication: Use of a Needs Assessment to Drive Decision-AIDS for Gene Therapy for Rare Diseases (GENETX)St. Jude Children's Research Hospital · PI: Liza-Marie Johnson, MD, MPH, MSB
- RECRUITINGPhase 2NCT05640271Tocilizumab for Acute Chest SyndromeUniversity of Chicago · PI: Austin Wesevich, MD
- ACTIVE NOT RECRUITINGN/ANCT05789355Effect of NUV001 Supplementation in Patients Suffering From Sickle Cell Disease (SCD)LGD · PI: Laurent LAGANIER
- RECRUITINGPhase 3NCT05392894RElated Haplo-DonoR Haematopoietic stEm Cell Transplantation for Adults With Severe Sickle Cell DiseaseKing's College Hospital NHS Trust · PI: Ann-Marie Murtagh
- RECRUITINGPhase 2NCT05736419A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT)Memorial Sloan Kettering Cancer Center · PI: Maria Cancio, MD
- RECRUITINGNCT05748717Arterial Function Parameters and Transcranial Doppler Velocity in Paediatric Patients With Sickle Cell DiseaseThe University of The West Indies
- RECRUITINGPhase 2NCT06198712A Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients With Sickle Cell DiseaseForma Therapeutics, Inc. · PI: Clinical Transparency (dept. 2834)
- ACTIVE NOT RECRUITINGN/ANCT05292781CHOICES3: Sickle Cell Disease Parenting CHOICESUniversity of Florida · PI: Diana Wilkie, PhD
- ACTIVE NOT RECRUITINGN/ANCT05780775Lipid Balance in Adult Sickle Cell PatientsCentre Hospitalier Universitaire de la Guadeloupe · PI: Marie-Laure LALANNE-MISTRIH
- RECRUITINGPhase 1NCT04925492PET Imaging of Vaso-Occlusive Crisis (VOC) in SCDEnrico Novelli · PI: Enrico Novelli, MD, MS
- ACTIVE NOT RECRUITINGNCT06794281Synthetic Generation of Hematological Data Over Federated Computing Frameworks: SCD Use CaseHospital Universitari Vall d'Hebron Research Institute
- RECRUITINGNCT05799118Study of the Role of Genetic Modifiers in HemoglobinopathiesCyprus Institute of Neurology and Genetics · PI: Petros Kountouris, PhD
- ACTIVE NOT RECRUITINGPHASE1, PHASE2NCT05456880BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell DiseaseBeam Therapeutics Inc.
- ACTIVE NOT RECRUITINGPhase 1NCT05384756TMLI and Alemtuzumab for Treatment of Sickle Cell DiseaseCity of Hope Medical Center · PI: Anna Pawlowska
- RECRUITINGNCT05153967Cooperative Assessment of Late Effects for SCD Curative TherapiesVanderbilt University Medical Center · PI: Michael R DeBaun, MD, MPH
- ACTIVE NOT RECRUITINGPhase 2NCT05353647A Gene Transfer Study Inducing Fetal Hemoglobin in Sickle Cell Disease (GRASP, BMT CTN 2001)David Williams · PI: David Williams
- RECRUITINGPhase 2NCT05336201Cognitive Remediation Intervention to Prepare for Transition of CareUniversity of Alabama at Birmingham
- ACTIVE NOT RECRUITINGEarly Phase 1NCT05662098Alternative Dosing And Prevention of Transfusions (ADAPT)Children's Hospital Medical Center, Cincinnati · PI: Russell Ware, MD, PhD
- RECRUITINGNCT05170412Dietary Intake and Dietary Behaviors in Adults With Sickle Cell DiseaseNational Institutes of Health Clinical Center (CC) · PI: Nicole M Farmer, M.D.
- ACTIVE NOT RECRUITINGNCT05143021Sickle Cell Disease Obstetric Multi-Disciplinary Care ProgrammeVanderbilt University Medical Center · PI: Leshana St. Jean, PhD
- ACTIVE NOT RECRUITINGPhase 2NCT05031780A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)Agios Pharmaceuticals, Inc.
- RECRUITINGN/ANCT05210114Cutaneous Hydration Assessment in SCDEnrico Novelli · PI: Enrico Novelli, MD
- RECRUITINGNCT06213402RADeep Multicenter European Epidemiological Platform for Patients Diagnosed With Rare Anemia Disorders (RADs)Hospital Universitari Vall d'Hebron Research Institute · PI: María del Mar Manú Pereira, PhD
- RECRUITINGPhase 2NCT05012631Losartan for Diffuse Myocardial Fibrosis in Sickle Cell DiseaseChildren's Hospital Medical Center, Cincinnati
- ACTIVE NOT RECRUITINGN/ANCT05045820Integrative Medicine in Pain Management in Sickle Cell DiseaseIndiana University
- ACTIVE NOT RECRUITINGPHASE1, PHASE2NCT04853576A Study Evaluating the Safety and Efficacy of EDIT-301 in Participants With Severe Sickle Cell Disease (RUBY)Editas Medicine, Inc.
- RECRUITINGN/ANCT04484272A Stress and Pain Self-management m-Health App for Adult Outpatients With Sickle Cell DiseaseUniversity of Florida · PI: Miriam O. Ezenwa
- ACTIVE NOT RECRUITINGN/ANCT04691323The Longitudinal Relationship of HU Adherence to HRQOL, Barriers to Adherence and Habit in SCD.Ann & Robert H Lurie Children's Hospital of Chicago · PI: Sherif M. Badawy, MD, MS
- RECRUITINGNCT04416178Sickle Cell Disease and the Genomic and Gene Therapy Needs of StakeholdersSt. Jude Children's Research Hospital · PI: Liza M. Johnson, MD, MPH, MSB
- ACTIVE NOT RECRUITINGPHASE1, PHASE2NCT04610866Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of MitapivatNational Heart, Lung, and Blood Institute (NHLBI) · PI: Swee Lay Thein, M.D.
- ENROLLING BY INVITATIONNCT04628585Long-term Follow-up of Subjects with Sickle Cell Disease Treated with Ex Vivo Gene TherapyGenetix Biotherapeutics Inc. · PI: Anjulika Chawla, MD
- RECRUITINGN/ANCT04688411An mHealth Strategy to Improve Medication Adherence in Adolescents With Sickle Cell DiseaseAnn & Robert H Lurie Children's Hospital of Chicago · PI: Sherif M. Badawy, MD, MS
- ACTIVE NOT RECRUITINGNCT04707235ESCORT-HU Extension: European Sickle Cell Disease Cohort - Hydroxyurea - Extension StudyTheravia · PI: Mariane de Montalembert, MD, PhD
- RECRUITINGN/ANCT03976180High-flow Oxygen for Vaso-occlusive Pain CrisisAssistance Publique - Hôpitaux de Paris · PI: Armand Mekontso
- ACTIVE NOT RECRUITINGPhase 3NCT04084080Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE)University of Pittsburgh · PI: Mark Gladwin, MD
- ACTIVE NOT RECRUITINGPhase 3NCT04293185A Study Evaluating Gene Therapy With BB305 Lentiviral Vector in Sickle Cell DiseaseGenetix Biotherapeutics Inc. · PI: Anjulika Chawla, MD, FAAP
- RECRUITINGPhase 1NCT04055818A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell DiseaseEpiDestiny, Inc. · PI: Robert Molokie
- ACTIVE NOT RECRUITINGPhase 2NCT04018937Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell TransplantationEmory University · PI: Ann Haight, MD
- ACTIVE NOT RECRUITINGPhase 1NCT03249831A Blood Stem Cell Transplant for Sickle Cell DiseaseCity of Hope Medical Center · PI: Joseph Rosenthal, MD
- RECRUITINGNCT05376046Study of Erythrocyte Parameters and Hypercoagulability in Sickle Cell Disease (SCD-TGA)BILLOIR
- RECRUITINGPhase 2NCT03587272Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell DiseaseRobert Nickel · PI: Robert Nickel, MD
- ACTIVE NOT RECRUITINGPhase 1NCT03282656Gene Transfer for Sickle Cell DiseaseDavid Williams · PI: Erica Esrick, MD
- RECRUITINGN/ANCT03353584Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell DiseaseSt. Jude Children's Research Hospital · PI: Michael Frett, MD
- RECRUITINGPhase 2NCT02675959Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell DiseaseNew York Medical College · PI: Mitchell Cairo, MD
- ACTIVE NOT RECRUITINGPhase 1NCT03077542Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell DiseaseNational Heart, Lung, and Blood Institute (NHLBI) · PI: Courtney F Joseph, M.D.
- RECRUITINGPhase 2NCT03121001Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell DiseaseUniversity of Illinois at Chicago · PI: Damiano Rondelli, MD
- RECRUITINGPHASE1, PHASE2NCT03128996Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant DisordersWashington University School of Medicine · PI: Shalini Shenoy, MD
- RECRUITINGNCT03327428Sickle-cell Disease Registry of the GPOHUniversity Hospital Heidelberg · PI: Joachim Kunz, Dr.
- ACTIVE NOT RECRUITINGNCT02785848Identifying Barriers and Strategies to Support Self-efficacy for Medication Adherence With Text MessagingVanderbilt University · PI: Robert Cronin, MD, MS
- ACTIVE NOT RECRUITINGNCT02922296Glucose Metabolism in Sickle Cell DiseaseUniversity of Illinois at Chicago · PI: Victor Gordeuk, MD
- ACTIVE NOT RECRUITINGNCT02306993Sickle Cell Hemoglobinopathies and Bone HealthUConn Health · PI: Biree Andemariam, MD