Precursor T-cell acute lymphoblastic leukemia

Last reviewed

🖨 Print for my doctorAdvocacy Hub →
ORPHA:99861C91.0
Who is this for?
Show terms as
15FDA treatments2Active trials17Specialists8Treatment centers7Financial resources

Where are you in your journey?

UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
Report missing data

Overview

Also known as:

Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events
Aug 2026A Phase 1 Study Of FLAG Chemotherapy In Combination With Lisaftoclax And Pelcitoclax In Patients With Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia

M.D. Anderson Cancer Center — PHASE1

TrialNOT YET RECRUITING
Mar 2026Efficacy and Safety of CD7 CAR-T in Newly Diagnosed High-Risk T-LBL/ALL

Institute of Hematology & Blood Diseases Hospital, China — EARLY_PHASE1

TrialNOT YET RECRUITING
Jul 2025A Multicenter, Open-Label, Non-Randomized, Single-Arm Clinical Study of Nanobody CD5-CAR T Cell Therapy for Refractory/Relapsed T Lymphocyte Malignancies

Beijing GoBroad Hospital — PHASE1, PHASE2

TrialRECRUITING
Jul 2025The Safety and Efficacy of VGO-Cs01p in Patients With CD7-positive Relapsed/Refractory Acute T-lymphoblastic Leukemia

Shanghai Jiao Tong University School of Medicine — EARLY_PHASE1

TrialNOT YET RECRUITING
Oct 2024Isatuximab in Adult Patients With Cytologic or Molecular Relapsed/Refractory CD38 Positive T-cell Acute Lymphoblastic Leukemia

Goethe University — PHASE2

TrialRECRUITING
Apr 2024Comparing the Efficacy of VHAG and Traditional Chemotherapy Regimens in Newly Diagnosed ETP-ALL

First Affiliated Hospital of Zhejiang University — PHASE3

TrialRECRUITING
Mar 2024

Iclusig: FDA approved

treatment of adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) in combination with chemotherapy

FDAcompleted
Jan 2024Efficacy, Safety, and Pharmacokinetics of ThisCART19A Combined With Olverembatinib in Patients With Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.

The First Affiliated Hospital of Soochow University — EARLY_PHASE1

TrialACTIVE NOT RECRUITING
Dec 2019Response to Chimeric Antigen Receptor (CAR)-T Cells Therapy in Patients With Hematologic Malignancies Depending on Tumor Characteristics

Assistance Publique - Hôpitaux de Paris

TrialNOT YET RECRUITING
Sep 2018

COPIKTRA: FDA approved

Treatment of adult patients with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) after at least two prior therapies

FDAcompleted

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

15 available

Imatinib Mesylate

IMATINIB· Mylan Institutional Inc

Adult patients with relapsed or refractory Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL).

Blincyto

blinatumomab· Amgen, Inc.■ Boxed Warning
BLINCYTO is indicated for the treatment of CD19-positive B-cell precursor acute lymphoblastic leukemia (ALL) in first or second complete remission with minimal residual disease (MRD) greater than or e

BLINCYTO is indicated for the treatment of CD19-positive B-cell precursor acute lymphoblastic leukemia (ALL) in first or second complete remission with minimal residual disease (MRD) greater than or equal to 0.1% in adult and pediatric patients one month and older.

Besponsa

inotuzumab ozogamicin· Wyeth Pharmaceuticals, LLC■ Boxed WarningOrphan DrugAccelerated Approval

BESPONSA is indicated for the treatment of relapsed or refractory CD22-positive B-cell precursor acute lymphoblastic leukemia (ALL) in adult and pediatric patients 1 year and older

Clolar

clofarabine· Genzyme Corporation

Clofarabine injection is indicated for the treatment of pediatric patients 1 to 21 years old with relapsed or refractory acute lymphoblastic leukemia after at least two prior regimens.

Arranon

nelarabine· Novartis Pharmaceuticals Corp.■ Boxed Warning
indicated for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) in adult and pediatric patients age 1 year and older whose disease has not responded to or has relapsed following treatment w

indicated for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) in adult and pediatric patients age 1 year and older whose disease has not responded to or has relapsed following treatment with at least 2 chemotherapy regimens

Imkeldi

IMATINIB ORAL· Shorla Oncology Inc.,

Adult patients with relapsed or refractory Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL).

Imatinib Mesylate

IMATINIB MESYLATE· Apotex Corp

Adult patients with relapsed or refractory Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL)

Aucatzyl

obecabtagene autoleucel· Autolus Incorporated, US subsidiary of Autolus Limited■ Boxed Warning

AUCATZYL is indicated for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL)

TECARTUS�

brexucabtagene autoleucel· Kite Pharma, Inc.■ Boxed Warning

Adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL)

Marqibo

vinCRIStine sulfate LIPOSOME injection· Acrotech Biopharma LLC
Treatment of adult patients with Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL) in second or greater relapse or whose disease has progressed following two or more anti-leuke

Treatment of adult patients with Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL) in second or greater relapse or whose disease has progressed following two or more anti-leukemia therapies

Kymriah

tisagenlecleucel· Novartis Pharmaceuticals Corporation■ Boxed Warning

KYMRIAH is indicated for treatment of patients up to 25 years of age with B-cell precursor acute lymphoblastic leukemia (ALL) that is refractory or in second or later relapse.

Iclusig

ponatinib· Takeda Pharmaceuticals U.S.A., Inc.■ Boxed WarningOrphan Drug

treatment of adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) in combination with chemotherapy

COPIKTRA

duvelisib· Secura Bio, Inc.■ Boxed WarningOrphan Drug

Treatment of adult patients with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) after at least two prior therapies

Kymriah (tisagenlecleucel)

(tisagenlecleucel) Autologous T Cells transduced with lentiviral vector containing a chimeric antigen receptor directed against CD19· Novartis Pharmaceuticals CorporationOrphan Drug

Treatment of patients up to 25 years of age with B-cell precursor acute lymphoblastic leukemia (ALL) that is refractory or in second or later relapse

Vumon for injection

Teniposide· Bristol-Myers Squibb Pharmaceutical Research InstituteOrphan Drug

Induction therapy in patients with refractory childhood acute lymphoblastic leukemia when used in combination with other approved anticancer agents.

Clinical Trials

2 recruitingView all trials with filters →
Phase 21 trial
Isatuximab in Adult Patients With Cytologic or Molecular Relapsed/Refractory CD38 Positive T-cell Acute Lymphoblastic Leukemia
Phase 2
Actively Recruiting
PI: Nicola Goekbuget, MD (Department of Medicine, Hematology and Oncology, G) · Sites: Augsburg; Berlin +12 more · Age: 1899 yrs

Specialists

17 foundView all specialists →
PM
Paolo Caimi, MD
CLEVELAND, OH
Specialist
PI on 5 active trials
TM
Thomas G. Martin, MD
Specialist
PI on 4 active trials
RM
Robert Lowsky, MD
STANFORD, CA
Specialist
PI on 2 active trials
FG
Francis Giles
SAN ANTONIO, TX
Specialist
PI on 4 active trials
AK
Anne Kuan
SAN ANTONIO, TX
Specialist
PI on 1 active trial
NM
Nirali N Shah, M.D.
Specialist
PI on 7 active trials
SK
Shaji Kumar
Anchorage, Alaska
Specialist

Rare Disease Specialist

PI on 7 active trials
PM
Pamela Lee, MD
Specialist
PI on 1 active trial
MM
Minoti Hiremath, MD
Specialist
PI on 2 active trials
WD
Weili Zhao, Dr
Specialist
PI on 1 active trial
YF
Ying Feng
BRONX, NY
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Financial Resources

7 resources
Blincyto(blinatumomab)Amgen, Inc.
Arranon(nelarabine)Novartis Pharmaceuticals Corp.
Kymriah(tisagenlecleucel)Novartis Pharmaceuticals Corporation
Iclusig(ponatinib)Takeda Pharmaceuticals U.S.A., Inc.
COPIKTRA(duvelisib)Secura Bio, Inc.
Kymriah (tisagenlecleucel)((tisagenlecleucel) Autologous T Cells transduced with lentiviral vector containing a chimeric antigen receptor directed against CD19)Novartis Pharmaceuticals Corporation
Vumon for injection(Teniposide)Bristol-Myers Squibb Pharmaceutical Research Institute

Travel Grants

No travel grants are currently matched to Precursor T-cell acute lymphoblastic leukemia.

Search all travel grants →NORD Financial Assistance ↗

Community

Open Precursor T-cell acute lymphoblastic leukemiaForum →

No community posts yet. Be the first to share your experience with Precursor T-cell acute lymphoblastic leukemia.

Start the conversation →

Latest news about Precursor T-cell acute lymphoblastic leukemia

1 articles
Clinical trialUNITERAREApr 3, 2026
New Recruiting Trial: Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin (DA-EPOCH) With or Without Rituximab Plus Recombinant Erwinia Asparaginase (JZP458) for the Treatment of Newly Diagnosed Ph Negative B-Acute Lymphoblastic Leukemia or T Acute Lymphoblastic Leukemia
Researchers are looking for patients with a type of blood cancer called acute lymphoblastic leukemia (ALL) to test a new treatment combination. The study will t
See all news about Precursor T-cell acute lymphoblastic leukemia

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Precursor T-cell acute lymphoblastic leukemia

Are there clinical trials for Precursor T-cell acute lymphoblastic leukemia?

Yes — 2 recruiting clinical trials are currently listed for Precursor T-cell acute lymphoblastic leukemia on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Precursor T-cell acute lymphoblastic leukemia?

17 specialists and care centers treating Precursor T-cell acute lymphoblastic leukemia are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.

What treatment and support options exist for Precursor T-cell acute lymphoblastic leukemia?

8 patient support programs are currently tracked on UniteRare for Precursor T-cell acute lymphoblastic leukemia. See the treatments and support programs sections for copay assistance, eligibility, and contact details.