Precursor T-cell acute lymphoblastic leukemia

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At a Glance

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Regulatory Watchboard

10 events
Aug 2026A Phase 1 Study Of FLAG Chemotherapy In Combination With Lisaftoclax And Pelcitoclax In Patients With Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia

M.D. Anderson Cancer Center — PHASE1

TrialNOT YET RECRUITING
Mar 2026Efficacy and Safety of CD7 CAR-T in Newly Diagnosed High-Risk T-LBL/ALL

Institute of Hematology & Blood Diseases Hospital, China — EARLY_PHASE1

TrialNOT YET RECRUITING
Jul 2025A Multicenter, Open-Label, Non-Randomized, Single-Arm Clinical Study of Nanobody CD5-CAR T Cell Therapy for Refractory/Relapsed T Lymphocyte Malignancies

Beijing GoBroad Hospital — PHASE1, PHASE2

TrialRECRUITING
Jul 2025The Safety and Efficacy of VGO-Cs01p in Patients With CD7-positive Relapsed/Refractory Acute T-lymphoblastic Leukemia

Shanghai Jiao Tong University School of Medicine — EARLY_PHASE1

TrialNOT YET RECRUITING
Oct 2024Isatuximab in Adult Patients With Cytologic or Molecular Relapsed/Refractory CD38 Positive T-cell Acute Lymphoblastic Leukemia

Goethe University — PHASE2

TrialRECRUITING
Apr 2024Comparing the Efficacy of VHAG and Traditional Chemotherapy Regimens in Newly Diagnosed ETP-ALL

First Affiliated Hospital of Zhejiang University — PHASE3

TrialRECRUITING
Mar 2024

Iclusig: FDA approved

treatment of adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) in combination with chemotherapy

FDAcompleted
Jan 2024Efficacy, Safety, and Pharmacokinetics of ThisCART19A Combined With Olverembatinib in Patients With Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.

The First Affiliated Hospital of Soochow University — EARLY_PHASE1

TrialACTIVE NOT RECRUITING
Dec 2019Response to Chimeric Antigen Receptor (CAR)-T Cells Therapy in Patients With Hematologic Malignancies Depending on Tumor Characteristics

Assistance Publique - Hôpitaux de Paris

TrialNOT YET RECRUITING
Sep 2018

COPIKTRA: FDA approved

Treatment of adult patients with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) after at least two prior therapies

FDAcompleted

Data from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Financial Assistance

8 programs

FINANCIAL LANDSCAPE SUMMARY

8

Total programs

8

Open now

2

Copay cards

Copay Assistance2

Kymriah (tisagenlecleucel)

Novartis Pharmaceuticals Corporation

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Vumon for injection

Bristol-Myers Squibb Pharmaceutical Research Institute

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Patient Assistance Programs6

Arranon

Novartis Pharmaceuticals Corp.

OpenContact for detailsApply ↗

Clolar

Genzyme Corporation

OpenContact for details

Iclusig

Takeda Pharmaceuticals U.S.A., Inc.

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Blincyto

Amgen, Inc.

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TECARTUS�

Kite Pharma, Inc.

OpenContact for details

Aucatzyl

Autolus Incorporated, US subsidiary of Autolus Limited

OpenContact for details

View all support programs on disease page →

Approved Treatments

8 FDA-approved

Iclusig

(ponatinib)Orphan drug

Takeda Pharmaceuticals U.S.A., Inc.

12.1 Mechanism of Action Ponatinib is a kinase inhibitor. Ponatinib inhibited the in vitro tyrosine kinase activity of ABL and T315I mutant ABL with I...

Approved Mar 2024FDA label ↗

COPIKTRA

(duvelisib)Orphan drug

Secura Bio, Inc.

12.1 Mechanism of Action Duvelisib is an inhibitor of PI3K with inhibitory activity predominantly against PI3K-δ and PI3K-γ isoforms expressed in norm...

Approved Sep 2018FDA label ↗

Kymriah (tisagenlecleucel)

((tisagenlecleucel) Autologous T Cells transduced with lentiviral vector containing a chimeric antigen receptor directed against CD19)Orphan drug

Novartis Pharmaceuticals Corporation

Approved Aug 2017

Vumon for injection

(Teniposide)Orphan drug

Bristol-Myers Squibb Pharmaceutical Research Institute

Approved Jul 1992

TECARTUS�

(brexucabtagene autoleucel)Orphan drugstandard

Kite Pharma, Inc.

12.1 Mechanism of Action TECARTUS, a CD19-directed genetically modified autologous T cell immunotherapy, binds to CD19-expressing cancer cells and nor...

FDA label ↗

Marqibo

(vinCRIStine sulfate LIPOSOME injection)Orphan drugstandard

Acrotech Biopharma LLC

Kymriah

(tisagenlecleucel)Orphan drugstandard

Novartis Pharmaceuticals Corporation

CD19-directed Chimeric Antigen Receptor [EPC]

12.1 Mechanism of Action KYMRIAH is a CD19-directed genetically modified autologous T cell immunotherapy which involves reprogramming a patient’s own ...

FDA label ↗

Blincyto

(blinatumomab)Orphan drugstandard

Amgen, Inc.

12.1 Mechanism of Action Blinatumomab is a bispecific CD19-directed CD3 T-cell engager that binds to CD19 expressed on the surface of cells of B-linea...

FDA label ↗

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Clinical Trial Landscape

2 active trials
1Phase 2
1PHASE1, PHASE2
2Total recruiting
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