Hereditary palmoplantar keratoderma

Last reviewed March 21, 2026

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ORPHA:79357

Who is this for?

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1Active trials 8Specialists 8Treatment centers

Where are you in your journey?

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.

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Overview

Also known as:

Hereditary PPK Hereditary keratosis palmoplantaris Hereditary palmoplantar hyperkeratosis

Orphanet ↗NORD ↗

FDA & Trial Timeline

1 event

Oct 2024Study to Evaluate the Safety and Efficacy of Tapinarof in Adults With Palmoplantar Keratoderma

Indiana University — PHASE2

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Hereditary palmoplantar keratoderma.

1 clinical trialare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

1 recruitingView all trials with filters →

Phase 21 trial

Study to Evaluate the Safety and Efficacy of Tapinarof in Adults With Palmoplantar Keratoderma

Phase 2

Actively Recruiting

PI: David Rosmarin, MD (Dermatology) · Sites: Indianapolis, Indiana · Age: 18–99 yrs

Specialists

8 foundView all specialists →

DM

David Rosmarin, MD

BELMONT, MA

Specialist

Body integrity dysphoria Chronic cutaneous lupus erythematosus Hypopigmentation of the skin

PI on 4 active trials

Active trials Directions Travel grants

AP

Antoni Gostynski, MD, PhD

Maastricht, Limburg

Specialist

Rare Disease Specialist

Ectodermal dysplasia syndrome Genetic hypopigmentation of the skin Gorlin syndrome+3 more

PI on 2 active trials

Active trials Directions Travel grants

CB

Christine BODEMER

Bobigny

Specialist

Rare Disease Specialist

Benign peripheral nerve sheath tumor Bullous pemphigoid Ectodermal dysplasia syndrome+12 more

PI on 2 active trials

Active trials Directions Travel grants

JP

Johanna H Hagman, M.D, PhD

Specialist

Diffuse palmoplantar keratoderma Epidermolytic palmoplantar keratoderma

PI on 1 active trial

Active trials Directions Travel grants

MM

Mark Darling, MSc, MChD

FORT COLLINS, CO

Specialist

Diffuse palmoplantar keratoderma Epidermolytic palmoplantar keratoderma Genetic head and neck malformation

PI on 1 active trial

Active trials Directions Travel grants

SP

Simon W Young, DDS, MD, PhD

Specialist

Diffuse palmoplantar keratoderma Epidermolytic palmoplantar keratoderma

PI on 1 active trial

Active trials Directions Travel grants

KM

Konika P Schallen, MD

JACKSONVILLE, FL

Specialist

Diffuse palmoplantar keratoderma Epidermolytic palmoplantar keratoderma

PI on 1 active trial

Active trials Directions Travel grants

RM

Ronnie Aronson, MD

STAMFORD, CT

Specialist

Chronic bilirubin encephalopathy Diffuse palmoplantar keratoderma Epidermolytic palmoplantar keratoderma+2 more

PI on 2 active trials

Active trials Directions Travel grants

Treatment Centers

8 centers

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

UCLA Rare Disease Day Program ↗

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Hereditary palmoplantar keratoderma.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Hereditary palmoplantar keratoderma

Disease timeline:

New recruiting trial: Study to Evaluate the Safety and Efficacy of Tapinarof in Adults With Palmoplantar Keratoderma

A new clinical trial is recruiting patients for Hereditary palmoplantar keratoderma

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Hereditary palmoplantar keratoderma

Are there clinical trials for Hereditary palmoplantar keratoderma?

Yes — 1 recruiting clinical trial is currently listed for Hereditary palmoplantar keratoderma on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Hereditary palmoplantar keratoderma?

8 specialists and care centers treating Hereditary palmoplantar keratoderma are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.