Overview
Bronchial malformation is a rare congenital condition in which the bronchi — the airways that carry air from the windpipe (trachea) into the lungs — do not develop normally before birth. This abnormal development can affect the shape, size, number, or branching pattern of the bronchial tubes. Because the airways are not formed correctly, air may not flow properly into parts of the lung, which can lead to breathing difficulties, recurrent lung infections, and other respiratory problems. The severity of bronchial malformation varies widely. Some people may have mild forms that cause few or no symptoms and are discovered incidentally on imaging studies done for other reasons. Others, particularly newborns and infants, may experience significant breathing problems that require medical attention soon after birth. Symptoms can include wheezing, chronic cough, repeated pneumonia or bronchitis, and difficulty breathing during exercise or at rest. Treatment depends on the type and severity of the malformation. Mild cases may only need monitoring and management of respiratory infections. More significant malformations may require surgical correction, such as removal of the affected portion of the lung (lobectomy) or reconstruction of the airway. Supportive care, including respiratory therapy and antibiotics for infections, plays an important role. Early diagnosis and appropriate management can significantly improve outcomes and quality of life.
Key symptoms:
Wheezing or noisy breathingChronic or recurrent coughRepeated lung infections such as pneumonia or bronchitisDifficulty breathing or shortness of breathBreathing problems at birth or in infancyStridor (a high-pitched sound when breathing in)Poor feeding in infants due to breathing difficultyBluish skin color (cyanosis) in severe casesReduced exercise toleranceAbnormal chest sounds heard by a doctorCollapse of part of the lung (atelectasis)
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
10 eventsCandid Therapeutics — PHASE1
SinoMab BioScience Ltd — PHASE1
National Institute of Allergy and Infectious Diseases (NIAID)
Biokosmes Srl — NA
National Institute of Allergy and Infectious Diseases (NIAID)
University of Michigan — NA
Hawler Medical University — NA
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Bronchial malformation.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for Bronchial malformation at this time.
New trials open frequently. Follow this disease to get notified.
Rare Disease Specialist
Rare Disease Specialist
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Bronchial malformation.
Community
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Start the conversation →Latest news about Bronchial malformation
Disease timeline:
New recruiting trial: Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions
A new clinical trial is recruiting patients for Bronchial malformation
New recruiting trial: Bioresorbable Airway Splint Pivotal Clinical Trial
A new clinical trial is recruiting patients for Bronchial malformation
New recruiting trial: Post-Marketing Clinical Follow-Up Trial to Evaluate the Performance and Safety of the Medical Device 047 TD Dermatitis Cream in Adults and Children With Atopic and Contact Dermatitis Symptoms Confirmed by Clinical Parameters
A new clinical trial is recruiting patients for Bronchial malformation
New recruiting trial: Effect of CPAP on 6-Minute Walk Test Outcomes in Patients With ECAC
A new clinical trial is recruiting patients for Bronchial malformation
New recruiting trial: Xenon-129 and Inert Fluorinated Gas Lung MRI: Study of Healthy Volunteers and Participants With Pulmonary Disease
A new clinical trial is recruiting patients for Bronchial malformation
New recruiting trial: A Double-Blind, Active-Controlled, Multiple-Ascending Dose Study of Aerosolized RSP-1502 in Subjects With CF and Chronic PA Lung Infection
A new clinical trial is recruiting patients for Bronchial malformation
New recruiting trial: Detection of Genetic Markers of Lung Cancer
A new clinical trial is recruiting patients for Bronchial malformation
New recruiting trial: NIS to Examine the Effectiveness of TDC in Patients With Metastatic Non-squamous NSCLC and High-risk Genetic Alterations
A new clinical trial is recruiting patients for Bronchial malformation
New recruiting trial: Effect of Ultrasound-guided Erector Spinae Plane Block on Postoperative Pain and Sleep Quality of Infants With Congenital Pulmonary Cystic Disease After Thoracoscopic Surgery
A new clinical trial is recruiting patients for Bronchial malformation
New recruiting trial: A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine
A new clinical trial is recruiting patients for Bronchial malformation
Caregiver Resources
NORD Caregiver Resources
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Mental Health Support
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Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What type of bronchial malformation does my child (or do I) have, and how severe is it?,Will this condition require surgery, or can it be managed without an operation?,How often should we have follow-up imaging or lung function tests?,What signs of a respiratory infection should prompt me to seek urgent care?,Are there any activity restrictions I should be aware of?,Could this condition be associated with any other health problems?,What is the long-term outlook for lung function and overall health?
Common questions about Bronchial malformation
What is Bronchial malformation?
Bronchial malformation is a rare congenital condition in which the bronchi — the airways that carry air from the windpipe (trachea) into the lungs — do not develop normally before birth. This abnormal development can affect the shape, size, number, or branching pattern of the bronchial tubes. Because the airways are not formed correctly, air may not flow properly into parts of the lung, which can lead to breathing difficulties, recurrent lung infections, and other respiratory problems. The severity of bronchial malformation varies widely. Some people may have mild forms that cause few or no s
Which specialists treat Bronchial malformation?
13 specialists and care centers treating Bronchial malformation are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.