Retinopathy of prematurity

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ORPHA:90050OMIM:133780H35.1
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1FDA treatments20Active trials54Specialists8Treatment centers

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ℹ
UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Also known as:

ROPRetrolental fibroplasia

Clinical phenotype terms— hover any for plain English:

Abnormal retinal vascular morphologyHP:0008046Retinopathy of prematurityHP:0500049Abnormal macular morphologyHP:0001103Retinal arteriolar tortuosityHP:0001136Vitreous hemorrhageHP:0007902Tractional retinal detachmentHP:0007917
Orphanet ↗OMIM ↗NORD ↗

FDA & Trial Timeline

10 events
Apr 2026EYLEA HD: New indication approved
FDAcompleted
Oct 2025Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm Infants

IWK Health Centre — PHASE1, PHASE2

TrialNOT YET RECRUITING
Oct 2025Safety, PK and PD of FLQ-101 in Premature Neonates

FELIQS INC. — PHASE1

TrialNOT YET RECRUITING
Mar 2025Use of Intranasal Midazolam to Reduce Stress and Procedural Pain in Premature Infants During Routine ROP Examination.

Polish Mother Memorial Hospital Research Institute — PHASE1

TrialNOT YET RECRUITING
Feb 2025Point-of-Care Ophthalmic Diagnostic Imaging of Retinopathy of Prematurity

Vanderbilt University Medical Center

TrialRECRUITING
Jan 2025Pain and Comfort in the Examination of Retinopathy of Prematurity

Ataturk University — NA

TrialENROLLING BY INVITATION
Dec 2024A Multicenter and Prospective Study of Screening Retinopathy of Prematurity in China

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

TrialNOT YET RECRUITING
Nov 2024Efficacy and Safety of Low-dose Conbercept for Retinopathy of Prematurity Therapy

Wang Yusheng — NA

TrialRECRUITING
Nov 2024Long-term Ophthalmic Outcomes in Ex-premature Infants

Erasmus Medical Center

TrialNOT YET RECRUITING
Oct 2024Imaging Retinal Vasculature in Infant Eyes

Duke University

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

1 available

Eylea

aflibercept· Regeneron Pharmaceuticals, Inc.Orphan Drug

treatment of retinopathy of prematurity (ROP)

View Details →FDA Label ↗

Clinical Trials

20 recruitingView all trials with filters →
Phase 31 trial
Intranasal Dexmedetomidine for Pain Management During Screening for Retinopathy of Prematurity
Phase 3
Actively Recruiting
· Sites: Be’er Ya‘aqov, Center
View on ClinicalTrials.gov ↗I'm interested →
Phase 22 trials
Bevacizumab Treatment For Type 1 ROP
Phase 2
Active
PI: David K Wallace, MD, MPH (Vanderbilt University) · Sites: Little Rock, Arkansas; Irvine, California +24 more
View on ClinicalTrials.gov ↗I'm interested →
Oral Propranolol for Prevention of Threshold Retinopathy of Prematurity
Phase 2
Actively Recruiting
PI: Dirk Bassler, M.D. (University of Zurich) · Sites: Tübingen, Baden-Wurttemberg; Zurich, Canton of Zurich +1 more
View on ClinicalTrials.gov ↗I'm interested →
Phase 11 trial
Pharmacokinetics and Safety of Dexamethasone Eye Drops in Preterm Infants
Phase 1
Actively Recruiting
PI: Hanna Maria Öhnell, PhD (Ophthalmology, dep. of clinical sciences Lund, Lun) · Sites: Lund, Skåne County; Gothenburg, Västra Götaland County
View on ClinicalTrials.gov ↗I'm interested →
N/A5 trials
Efficacy and Safety of Low-dose Conbercept for Retinopathy of Prematurity Therapy
N/A
Actively Recruiting
PI: Wang · Sites: Xi'an, Shaanxi; Xi'an, Shaanxi +1 more
View on ClinicalTrials.gov ↗I'm interested →
Retinal Microanatomy in Retinopathy of Prematurity (BabySTEPS2)
N/A
Actively Recruiting
PI: Cynthia A Toth, MD (Duke University Eye Center) · Sites: Durham, North Carolina; Philadelphia, Pennsylvania
View on ClinicalTrials.gov ↗I'm interested →
Validation of i-ROP DL to Detect More Than Mild ROP
N/A
Active
PI: John P Campbell, MD/MPH (Oregon Health and Science University) · Sites: Portland, Oregon · Age: 20–80 yrs
View on ClinicalTrials.gov ↗I'm interested →
Pain and Comfort in the Examination of Retinopathy of Prematurity
N/A
Enrolling by Invitation
· Sites: Erzurum, Yakutiye
View on ClinicalTrials.gov ↗I'm interested →
The Effect of Two Non-Pharmacological Methods on Pain During Retinopathy Examination
N/A
Actively Recruiting
PI: Hatice Bal Yılmaz, Prof. Dr. (Ege University) · Sites: Izmir, Menemen
View on ClinicalTrials.gov ↗I'm interested →
Other10 trials
Clinical and Genetic Analysis of ROP
Actively Recruiting
PI: John P Campbell, M.D. (Oregon Health and Science University) · Sites: Palo Alto, California; Chicago, Illinois +3 more · Age: 0–1 yrs
View on ClinicalTrials.gov ↗I'm interested →
Point-of-Care Ophthalmic Diagnostic Imaging of Retinopathy of Prematurity
Actively Recruiting
· Sites: Nashville, Tennessee
View on ClinicalTrials.gov ↗I'm interested →
Evaluation of the Frequency, Risk Factors, and Outcomes of ROP in Infants with a BW >1500 Grs or GA ≥33 Wks in Turkey.
Actively Recruiting
PI: Esin Koç, MD (Gazi University) · Sites: Ankara
View on ClinicalTrials.gov ↗I'm interested →
Study of the Involvement of Fatty Acids in Retinopathy of Prematurity: Relationship Between Retinopathy of Prematurity and the Rate of Expression of Transplacental Fatty Acid Receptors.
Actively Recruiting
· Sites: Dijon · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Smartphone Screening for Eye Diseases
Enrolling by Invitation
PI: Yannis Paulus, MD (University of Michigan)
View on ClinicalTrials.gov ↗I'm interested →
Imaging Retinal Vasculature in Infant Eyes
Actively Recruiting
PI: Xi Chen, MD (Duke University) · Sites: Durham, North Carolina; Philadelphia, Pennsylvania
View on ClinicalTrials.gov ↗I'm interested →
Extension Study to Evaluate the Long-Term Outcomes of Pediatric Patients Who Received Treatment for Retinopathy of Prematurity in the VGFTe-ROP-1920 Study (Acronym: Butterfleye Next)
Active
PI: Clinical Trial Management (Regeneron Pharmaceuticals) · Sites: La Jolla, California; Loma Linda, California +28 more · Age: 0–5 yrs
View on ClinicalTrials.gov ↗I'm interested →
A Study to Collect Data on the Use of Eylea in Babies Born Too Early Who Have a Condition of the Eye Where Blood Vessels Grow Abnormally in the Retina (Retinopathy of Prematurity)
Actively Recruiting
· Sites: Multiple Locations · Age: 0–2 yrs
View on ClinicalTrials.gov ↗I'm interested →
European Disease Registry on Retinopathy of Prematurity (ROP)
Actively Recruiting
PI: Andreas Stahl, Professor (Department of Ophthalmology, University Medicine G) · Sites: Salzburg; Plovdiv +57 more
View on ClinicalTrials.gov ↗I'm interested →
An Observational Study to Collect Data on How Aflibercept (Eylea) Given Using a Paediatric Dosing Device is Used in Preterm Babies With Retinopathy of Prematurity in the United Kingdom (UK)
Actively Recruiting
· Sites: Multiple Locations · Age: 0–1 yrs
View on ClinicalTrials.gov ↗I'm interested →

Specialists

Showing 25 of 54View all specialists →
AM
Ahmet Y Bas, MD
Specialist
PI on 2 active trials
JM
Janet Berrington, MD
Specialist
PI on 1 active trial
DM
Dale L. Phelps, MD
ROCHESTER, NY
Specialist
PI on 2 active trials
MM
Maria Martínez-Castellanos, MD
Specialist
PI on 1 active trial
JP
Jacob V Aranda, MD, PhD
DETROIT, MI
Specialist
PI on 2 active trials
NM
Nooran Abdelkader, MD
Specialist
PI on 1 active trial
AD
Annegret Dahlmann-Noor
Specialist
PI on 1 active trial
LM
Luca Filippi, M.D.
Specialist
PI on 1 active trial
MM
Mitsuru Arima, MD,PhD
Specialist
PI on 1 active trial
RM
Roland Joseph D Tan, MD
Specialist
PI on 1 active trial
EM
Esin Koç, MD
Specialist
PI on 1 active trial
SM
Sezin Unal, MD
Specialist
PI on 2 active trials
OB
Ozgul Bulut
Specialist
PI on 1 active trial
MM
Mehmet Yalaz, Prof, MD
Specialist
PI on 1 active trial
İM
İlke Mungan Akın, Prof, MD
Specialist
PI on 1 active trial1 Retinopathy of prematurity publication
SM
Saadet Arsan, Prof, MD
Specialist
PI on 1 active trial
İP
İbrahim M Hirfanoğlu, MD, PhD
Specialist
PI on 1 active trial
HP
Hakon Bergseng, PhD
Specialist
PI on 2 active trials
HM
Hülya Bilgen, Prof, MD
Specialist
PI on 1 active trial
BM
Betül Acunaş, Prof, MD
Specialist
PI on 1 active trial
XM
Xi Chen, MD
Specialist
PI on 1 active trial
SM
Sule Yigit, Prof, MD
Specialist
PI on 1 active trial
GM
Gary M Chan, MD
Specialist
PI on 3 active trials
SM
Sezin Unal, Prof, MD
Specialist
PI on 1 active trial
SB
Serdar Beken
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program ↗

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Retinopathy of prematurity.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Retinopathy of prematurity

Disease timeline:

New recruiting trial: Efficacy and Safety of Low-dose Conbercept for Retinopathy of Prematurity Therapy

A new clinical trial is recruiting patients for Retinopathy of prematurity

New recruiting trial: Clinical and Genetic Analysis of ROP

A new clinical trial is recruiting patients for Retinopathy of prematurity

New recruiting trial: Oral Propranolol for Prevention of Threshold Retinopathy of Prematurity

A new clinical trial is recruiting patients for Retinopathy of prematurity

New recruiting trial: European Disease Registry on Retinopathy of Prematurity (ROP)

A new clinical trial is recruiting patients for Retinopathy of prematurity

New recruiting trial: Pharmacokinetics and Safety of Dexamethasone Eye Drops in Preterm Infants

A new clinical trial is recruiting patients for Retinopathy of prematurity

New recruiting trial: Point-of-Care Ophthalmic Diagnostic Imaging of Retinopathy of Prematurity

A new clinical trial is recruiting patients for Retinopathy of prematurity

New recruiting trial: Retinal Microanatomy in Retinopathy of Prematurity (BabySTEPS2)

A new clinical trial is recruiting patients for Retinopathy of prematurity

New recruiting trial: Study of the Involvement of Fatty Acids in Retinopathy of Prematurity: Relationship Between Retinopathy of Prematurity and the Rate of Expression of Transplacental Fatty Acid Receptors.

A new clinical trial is recruiting patients for Retinopathy of prematurity

New recruiting trial: Antiangiogenic Therapy With Bevacizumab in Retinopathy of Prematurity. Structural Outcome

A new clinical trial is recruiting patients for Retinopathy of prematurity

New recruiting trial: Intranasal Dexmedetomidine for Pain Management During Screening for Retinopathy of Prematurity

A new clinical trial is recruiting patients for Retinopathy of prematurity

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Retinopathy of prematurity

Are there clinical trials for Retinopathy of prematurity?

Yes — 20 recruiting clinical trials are currently listed for Retinopathy of prematurity on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Retinopathy of prematurity?

25 specialists and care centers treating Retinopathy of prematurity are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.