Reactive arthritis

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ORPHA:29207M02.3
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1Active trials17Specialists8Treatment centers

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Reactive arthritis (also known as Reiter's syndrome or Reiter's disease) is a type of inflammatory arthritis that develops as a reaction to an infection somewhere else in the body. The infection usually starts in the gut, urinary tract, or genitals, and then the immune system — while trying to fight off the infection — mistakenly attacks the joints, eyes, and sometimes the skin. The joints most often affected are the knees, ankles, and feet, but other joints can be involved too. The main symptoms include joint pain and swelling, eye inflammation (called conjunctivitis or uveitis), and sometimes painful urination or skin rashes. Not everyone gets all three of these symptoms. The condition most commonly appears in young adults, especially men between the ages of 20 and 40, though anyone can develop it. Most people with reactive arthritis recover fully within a few months to a year. However, some people develop a long-lasting or recurring form of the disease. Treatment focuses on relieving symptoms using anti-inflammatory medicines, antibiotics (if an active infection is still present), and physical therapy. There is no cure, but most people do very well with proper care.

Also known as:

Key symptoms:

Joint pain, swelling, and stiffness — especially in the knees, ankles, and feetRed, painful, or irritated eyes (conjunctivitis or uveitis)Painful or burning urinationSkin rashes, especially on the palms or soles of the feetMouth sores or ulcersSwollen fingers or toes that look like sausages (dactylitis)Heel pain or pain in the bottom of the foot (enthesitis)Low back pain or buttock painFatigue and general feeling of being unwellDischarge from the penis or vaginaNail changes such as thickening or pitting

Clinical phenotype terms (36)— hover any for plain English
UrethritisHP:0500006Dystrophic fingernailsHP:0008391Recurrent aphthous stomatitisHP:0011107EnthesitisHP:0100686Cartilage destructionHP:0100773IritisHP:0001101Inflammation of the large intestineHP:0002037
Inheritance

Multifactorial

Caused by a mix of several genes and environmental factors

Age of Onset

Adult

Begins in adulthood (age 18 or older)

Orphanet ↗NORD ↗

FDA & Trial Timeline

2 events
Jun 2025Efficacy Test of Curcuminoid Standardized Turmeric Capsules to Improving Inflammatory Biomarkers in Osteoarthritis Genu

Gadjah Mada University — PHASE2, PHASE3

TrialENROLLING BY INVITATION
Apr 2022Testing of an Educational Tool for Patients With Melanoma and Pre-Existing Autoimmune Disease Who Are Candidates for Immune Checkpoint Inhibitors

M.D. Anderson Cancer Center

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Reactive arthritis.

1 clinical trialare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

1 recruitingView all trials with filters →
Other1 trial
Testing of an Educational Tool for Patients With Melanoma and Pre-Existing Autoimmune Disease Who Are Candidates for Immune Checkpoint Inhibitors
Actively Recruiting
PI: Angeles Lopez-Olivo (M.D. Anderson Cancer Center) · Sites: Houston, Texas · Age: 1899 yrs

Specialists

17 foundView all specialists →
AA
Abhishek Abhishek
CORNING, CA
Specialist
PI on 2 active trials
AL
Angeles Lopez-Olivo
Specialist
PI on 1 active trial
JM
John D. Carter, MD
Specialist
PI on 1 active trial
MM
Marjatta Leirisalo-Repo, MD
Specialist
PI on 1 active trial
MM
Monique Hinchcliff, MD
NORTH HAVEN, CT
Specialist
PI on 2 active trials
DP
Dénes Páll, MD, PhD
Specialist
PI on 1 active trial
RM
Ramiro Gutierrez, MD
EL PASO, TX
Specialist
PI on 1 active trial
FM
Fabienne COURY-LUCAS, MD
Specialist
PI on 1 active trial
MP
Margaret Lee, PhD
Specialist
PI on 1 active trial
RL
Rana El-Dash, Assistant Lecturer
Specialist
PI on 1 active trial
LP
Lamia El-Wakeel, Professor of Clinical Pharmacy
Specialist
PI on 1 active trial
MP
Megan L Fitzgerald, PhD
Delafield, Wisconsin
Specialist

Rare Disease Specialist

PI on 1 active trial
SP
Sarah Zaki, Professor of Clinical Pharmacy
RED BANK, NJ
Specialist
PI on 1 active trial
SP
Selim Nalbant, Prof
Specialist
PI on 1 active trial
KM
Karen H Costenbader, MD, MPH
BOSTON, MA
Specialist
PI on 1 active trial
JS
Joachim Sieper
Specialist
PI on 2 active trials

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Reactive arthritis.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Reactive arthritis

Disease timeline:

New recruiting trial: Efficacy and Safety of Resveratrol in Patients With Rheumatoid Arthritis.

A new clinical trial is recruiting patients for Reactive arthritis

New recruiting trial: Testing of an Educational Tool for Patients With Melanoma and Pre-Existing Autoimmune Disease Who Are Candidates for Immune Checkpoint Inhibitors

A new clinical trial is recruiting patients for Reactive arthritis

New trial: Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research

Phase NA trial recruiting.

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.What infection likely triggered my reactive arthritis, and do I still need treatment for it?,Should I be tested for HLA-B27, and what would a positive result mean for my long-term outlook?,How long should I expect my symptoms to last, and what are the signs that it is becoming chronic?,What medications are best for my joint pain, and what are the risks of long-term use?,Do I need to see an eye doctor, and how often should my eyes be checked?,Are there lifestyle changes or exercises that can help prevent flares or joint damage?,What should I do if my symptoms come back after I recover?

Common questions about Reactive arthritis

What is Reactive arthritis?

Reactive arthritis (also known as Reiter's syndrome or Reiter's disease) is a type of inflammatory arthritis that develops as a reaction to an infection somewhere else in the body. The infection usually starts in the gut, urinary tract, or genitals, and then the immune system — while trying to fight off the infection — mistakenly attacks the joints, eyes, and sometimes the skin. The joints most often affected are the knees, ankles, and feet, but other joints can be involved too. The main symptoms include joint pain and swelling, eye inflammation (called conjunctivitis or uveitis), and sometim

How is Reactive arthritis inherited?

Reactive arthritis follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does Reactive arthritis typically begin?

Typical onset of Reactive arthritis is adult. Age of onset can vary across affected individuals.

Are there clinical trials for Reactive arthritis?

Yes — 1 recruiting clinical trial is currently listed for Reactive arthritis on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Reactive arthritis?

17 specialists and care centers treating Reactive arthritis are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.