Overview
Reactive arthritis (also known as Reiter's syndrome or Reiter's disease) is a type of inflammatory arthritis that develops as a reaction to an infection somewhere else in the body. The infection usually starts in the gut, urinary tract, or genitals, and then the immune system — while trying to fight off the infection — mistakenly attacks the joints, eyes, and sometimes the skin. The joints most often affected are the knees, ankles, and feet, but other joints can be involved too. The main symptoms include joint pain and swelling, eye inflammation (called conjunctivitis or uveitis), and sometimes painful urination or skin rashes. Not everyone gets all three of these symptoms. The condition most commonly appears in young adults, especially men between the ages of 20 and 40, though anyone can develop it. Most people with reactive arthritis recover fully within a few months to a year. However, some people develop a long-lasting or recurring form of the disease. Treatment focuses on relieving symptoms using anti-inflammatory medicines, antibiotics (if an active infection is still present), and physical therapy. There is no cure, but most people do very well with proper care.
Also known as:
Key symptoms:
Joint pain, swelling, and stiffness — especially in the knees, ankles, and feetRed, painful, or irritated eyes (conjunctivitis or uveitis)Painful or burning urinationSkin rashes, especially on the palms or soles of the feetMouth sores or ulcersSwollen fingers or toes that look like sausages (dactylitis)Heel pain or pain in the bottom of the foot (enthesitis)Low back pain or buttock painFatigue and general feeling of being unwellDischarge from the penis or vaginaNail changes such as thickening or pitting
Clinical phenotype terms (36)— hover any for plain English
Multifactorial
Caused by a mix of several genes and environmental factors
Adult
Begins in adulthood (age 18 or older)
FDA & Trial Timeline
2 eventsGadjah Mada University — PHASE2, PHASE3
M.D. Anderson Cancer Center
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Reactive arthritis.
1 clinical trialare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Rare Disease Specialist
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Reactive arthritis.
Community
No community posts yet. Be the first to share your experience with Reactive arthritis.
Start the conversation →Latest news about Reactive arthritis
Disease timeline:
New recruiting trial: Efficacy and Safety of Resveratrol in Patients With Rheumatoid Arthritis.
A new clinical trial is recruiting patients for Reactive arthritis
New recruiting trial: Testing of an Educational Tool for Patients With Melanoma and Pre-Existing Autoimmune Disease Who Are Candidates for Immune Checkpoint Inhibitors
A new clinical trial is recruiting patients for Reactive arthritis
New trial: Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
Phase NA trial recruiting.
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What infection likely triggered my reactive arthritis, and do I still need treatment for it?,Should I be tested for HLA-B27, and what would a positive result mean for my long-term outlook?,How long should I expect my symptoms to last, and what are the signs that it is becoming chronic?,What medications are best for my joint pain, and what are the risks of long-term use?,Do I need to see an eye doctor, and how often should my eyes be checked?,Are there lifestyle changes or exercises that can help prevent flares or joint damage?,What should I do if my symptoms come back after I recover?
Common questions about Reactive arthritis
What is Reactive arthritis?
Reactive arthritis (also known as Reiter's syndrome or Reiter's disease) is a type of inflammatory arthritis that develops as a reaction to an infection somewhere else in the body. The infection usually starts in the gut, urinary tract, or genitals, and then the immune system — while trying to fight off the infection — mistakenly attacks the joints, eyes, and sometimes the skin. The joints most often affected are the knees, ankles, and feet, but other joints can be involved too. The main symptoms include joint pain and swelling, eye inflammation (called conjunctivitis or uveitis), and sometim
How is Reactive arthritis inherited?
Reactive arthritis follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Reactive arthritis typically begin?
Typical onset of Reactive arthritis is adult. Age of onset can vary across affected individuals.
Are there clinical trials for Reactive arthritis?
Yes — 1 recruiting clinical trial is currently listed for Reactive arthritis on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Reactive arthritis?
17 specialists and care centers treating Reactive arthritis are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.