What is NON RARE IN EUROPE: Gender dysphoria?
Gender dysphoria is a condition where a person experiences significant distress because their gender identity — their inner sense of being male, female, or another gender — does not match the sex they were assigned at birth. It is not classified as a rare disease in Europe, but it is listed in some health databases for tracking purposes. People with gender dysphoria may feel deeply uncomfortable with their body, particularly physical features associated with their birth sex, such as chest, voice, or body hair. This discomfort can cause anxiety, depression, social withdrawal, and difficulty functioning in daily life. Gender dysphoria can appear in childhood, adolescence, or adulthood. In children, it may show up as a strong preference for clothing, toys, or activities typically associated with another gender, or a persistent wish to be a different gender. In teens and adults, the distress often centers on physical characteristics and how others perceive them. Treatment is individualized and may include psychological support, social transition (living as one's identified gender), hormone therapy, and in some cases gender-affirming surgeries. Mental health support is an important part of care at every stage. The goal of treatment is to reduce distress and help the person live comfortably in alignment with their gender identity. Many people who receive appropriate care report significant improvements in quality of life and mental health.
Key symptoms:
Strong feeling that your gender does not match the sex you were assigned at birthDiscomfort or distress about your body, especially sex-related physical featuresStrong desire to have the physical characteristics of another genderStrong desire to be treated as another genderAnxietyDepressionSocial withdrawal or isolationLow self-esteemDifficulty concentrating at school or workDiscomfort with expected social roles based on birth sexDistress when referred to by birth name or pronouns that don't match gender identity
- Inheritance
- Multifactorial
- Caused by a mix of several genes and environmental factors
- Age of Onset
- Variable
- Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
6 eventsMedical University Innsbruck
University Hospitals Cleveland Medical Center
IRCCS Azienda Ospedaliero-Universitaria di Bologna — NA
Cedars-Sinai Medical Center — PHASE3
Data is compiled from FDA regulatory filings and ClinicalTrials.gov, then processed through automated extraction; event classifications and dates may occasionally be misclassified. Verify against the linked FDA filing or trial record before clinical decisions. Updated periodically.
Treatments
Source: openFDA + DailyMed · NDA / BLA labels with structured indications · refreshed weekly
No FDA-approved treatments are currently listed for NON RARE IN EUROPE: Gender dysphoria.
6 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Source: ClinicalTrials.gov · synced daily · phases, status, and PI names normalized at ingest
Specialists
View all specialists →Source: NPI Registry + PubMed · trial PI roles cross-referenced with ClinicalTrials.gov · ranked by match score (publications + PI activity + community signal)
No specialists are currently listed for NON RARE IN EUROPE: Gender dysphoria.
Treatment Centers
8 centersSource: NORD Rare Disease Centers + NIH Undiagnosed Diseases Network (UDN) · centers verified active within last 12 months
Children's Hospital Colorado Rare Disease Program ↗
Children's Hospital Colorado
📍 Aurora, CO
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDBoston Children's Hospital Rare Disease Program ↗
Boston Children's Hospital
📍 Boston, MA
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
🏨 Children'sAnn & Robert H. Lurie Children's Hospital Genetics ↗
Lurie Children's Hospital
📍 Chicago, IL
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDCincinnati Children's Hospital Medical Center ↗
Cincinnati Children's
📍 Cincinnati, OH
👤 Boston Children's Hospital Rare Disease Program
🏨 Children'sNationwide Children's Hospital Rare Disease Center ↗
Nationwide Children's Hospital
📍 Columbus, OH
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
Travel Grants
No travel grants are currently matched to NON RARE IN EUROPE: Gender dysphoria.
Community
No community posts yet. Be the first to share your experience with NON RARE IN EUROPE: Gender dysphoria.
Start the conversation →Latest news about NON RARE IN EUROPE: Gender dysphoria
Source: PubMed + NIH RePORTER + openFDA + clinical-journal RSS · last 30 days · disease-tagged at ingest by AI extraction with human QC
No recent news articles for NON RARE IN EUROPE: Gender dysphoria.
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What are the treatment options available for my age group, and what does each involve?,What are the expected benefits and potential risks of hormone therapy?,How long will it take before I notice changes from treatment?,What mental health support do you recommend alongside medical treatment?,Are there support groups or community resources you can connect me with?,What monitoring or follow-up appointments will be needed during treatment?,How will treatment affect my fertility, and what options exist for fertility preservation?
Common questions about NON RARE IN EUROPE: Gender dysphoria
What is NON RARE IN EUROPE: Gender dysphoria?
Gender dysphoria is a condition where a person experiences significant distress because their gender identity — their inner sense of being male, female, or another gender — does not match the sex they were assigned at birth. It is not classified as a rare disease in Europe, but it is listed in some health databases for tracking purposes. People with gender dysphoria may feel deeply uncomfortable with their body, particularly physical features associated with their birth sex, such as chest, voice, or body hair. This discomfort can cause anxiety, depression, social withdrawal, and difficulty fun
How is NON RARE IN EUROPE: Gender dysphoria inherited?
NON RARE IN EUROPE: Gender dysphoria follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
Are there clinical trials for NON RARE IN EUROPE: Gender dysphoria?
Yes — 6 recruiting clinical trials are currently listed for NON RARE IN EUROPE: Gender dysphoria on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Conditions related to NON RARE IN EUROPE: Gender dysphoria
Other rare diseases that share clinical features, genetic basis, or diagnostic-code family with NON RARE IN EUROPE: Gender dysphoria. These are starting points for further reading, not a substitute for a clinician's assessment.
Frequently asked questions about NON RARE IN EUROPE: Gender dysphoria
Auto-generated from canonical disease facts (Orphanet, OMIM, ClinicalTrials.gov, openFDA, NPPES). Not a substitute for clinical guidance.
What is NON RARE IN EUROPE: Gender dysphoria?
NON RARE IN EUROPE: Gender dysphoria is a rare disease catalogued in international rare-disease ontologies (Orphanet ORPHA:459690). It is typically inherited as multifactorial. Age of onset is generally variable. For verified primary sources, see the UniteRare NON RARE IN EUROPE: Gender dysphoria page.
How is NON RARE IN EUROPE: Gender dysphoria inherited?
NON RARE IN EUROPE: Gender dysphoria follows multifactorial inheritance. Genetic counseling is recommended for affected families to understand recurrence risk in offspring and the likelihood of unaffected siblings being carriers. Variants in the underlying gene(s) may be identified via clinical genetic testing.
Are there FDA-approved treatments for NON RARE IN EUROPE: Gender dysphoria?
Approved treatments for NON RARE IN EUROPE: Gender dysphoria are tracked from openFDA and DailyMed primary sources. Many rare diseases have no specific FDA-approved therapy; for those, supportive care and management of complications form the basis of clinical care. Orphan-drug-designation status is noted where applicable.
Are there clinical trials recruiting for NON RARE IN EUROPE: Gender dysphoria?
UniteRare currently lists 6 clinical trials relevant to NON RARE IN EUROPE: Gender dysphoria sourced from ClinicalTrials.gov. Each trial entry includes recruitment status, eligibility criteria summary, principal-investigator information, and study locations. Patients should discuss eligibility with their healthcare provider before enrolling.
How do I find a specialist for NON RARE IN EUROPE: Gender dysphoria?
Verified NON RARE IN EUROPE: Gender dysphoria specialists are identified through ClinicalTrials.gov principal-investigator records, peer-reviewed publication authorship (via PubMed), and the NPPES NPI registry. NORD-designated Centers of Excellence and NIH-affiliated rare-disease clinics are also tracked. UniteRare's specialist directory is updated continuously as new evidence becomes available.
See full NON RARE IN EUROPE: Gender dysphoria page for complete clinical details, sources, and verified-specialist listings.
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