Rare disease news

FDA approvals, research breakthroughs, clinical trials, and advocacy updates

Curated and summarized by AI for patients and caregivers

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443 articles from the last 90 days

NewsRSS5 days ago

A novel helped me process heavy questions I face as an ALS caregiver

An ALS caregiver shares how reading a novel about a woman with cancer helped her process difficult emotions and questions she faces while caring for her husband who has had ALS for 16 years. The article explores how literature can be a meaningful tool for caregivers dealing with serious illness in their families. It highlights the emotional and psychological challenges that come with long-term caregiving.

WHY IT MATTERSALS caregivers often experience isolation and emotional burden — this article validates that seeking emotional support through creative outlets like reading is an important part of managing caregiver wellbeing.
Good to knowamyotrophic lateral sclerosisRead →
AdvocacyRSS5 days ago

Collaboration aims to improve design of FSHD clinical trials

Three organizations that work with facioscapulohumeral muscular dystrophy (FSHD) patients are joining together to make clinical trials better. FSHD is a rare muscle disease that causes weakness in the face, shoulders, and upper arms. This partnership wants to improve how these trials are designed so they can test new treatments more effectively.

WHY IT MATTERSBetter-designed clinical trials mean faster progress toward treatments for FSHD, and patient input through the FSHD Society ensures trials are structured in ways that actually work for people living with the disease.
Good to knowFacioscapulohumeral muscular dystrophyRead →
ResearchRSS5 days ago

Study links protein, fat regulator to nerve cell damage in ALS

Scientists discovered that a protein called UBQLN2 helps nerve cells manage both proteins and fats. When UBQLN2 doesn't work properly — especially in controlling fats — it may cause nerve cells to die in ALS, a disease that weakens muscles over time. This discovery suggests doctors might be able to help nerve cells stay healthier by fixing how fats are controlled.

WHY IT MATTERSUnderstanding how fat regulation breaks down in ALS nerve cells could lead to new treatments that target this specific problem, potentially slowing or stopping nerve cell damage in people living with ALS.
Good to knowamyotrophic lateral sclerosisRead →
NewsRSS5 days ago

We must each find our own way as we learn to live with ALS

A person living with ALS is sharing their experience about staying active and maintaining muscle strength. They were unsure whether to write about this topic because they worried people might misunderstand their message. The author emphasizes that everyone with ALS may need to find their own approach to managing the disease.

WHY IT MATTERSThis personal perspective helps ALS patients understand that maintaining mobility is individual—what works for one person may not work for another, so they shouldn't feel pressured to follow someone else's exact approach.
Good to knowAmyotrophic Lateral SclerosisRead →
NewsRSS5 days ago

Delivering an ALS diagnosis

A doctor named Richard Lewis shares his approach to telling patients they have ALS (a disease that affects nerve cells that control muscles). The article focuses on how he explains the diagnosis, talks about things that are uncertain, and helps patients and families cope with the news.

WHY IT MATTERSLearning how doctors communicate an ALS diagnosis can help patients and families understand what to expect when receiving their own diagnosis and how to have better conversations with their care team.
Good to knowAmyotrophic Lateral SclerosisRead →
ResearchRSS5 days ago

Exposure to pesticide HCB may raise risk of ALS, new study finds

A new study from Denmark found that people with higher levels of HCB (a pesticide that was banned in many countries) in their blood may have a higher risk of developing ALS, a disease that affects nerve cells and causes muscle weakness. HCB was used as a pesticide in the past but is no longer allowed in many places because it can be harmful to health. This research suggests that exposure to this old pollutant might be connected to ALS risk.

WHY IT MATTERSIf you have ALS or a family history of it, understanding environmental risk factors like HCB exposure could help you and your doctor identify potential causes and discuss ways to reduce exposure to similar pollutants.
💬 Ask your doctoramyotrophic lateral sclerosisRead →
NewsRSS5 days ago

Seeing ‘Les Misérables’ reminds me of the arc of my own life with DMD

A person living with Duchenne muscular dystrophy (DMD) attended a performance of Les Misérables and reflected on how the musical's themes of second chances and perseverance mirror their own life journey with this progressive muscle disease. The article connects the emotional arc of the musical to personal experiences of living with a rare genetic condition. This is a personal perspective piece rather than medical news.

WHY IT MATTERSFor people with DMD, reading personal narratives from others living with the same condition can provide emotional support and help them feel less alone in their disease journey.
Good to knowDuchenne muscular dystrophyRead →
NewsRSS5 days ago

Understanding pseudobulbar affect in ALS

Pseudobulbar affect (PBA) is a condition where people with ALS have sudden, uncontrollable crying or laughing that doesn't match what they're actually feeling. A doctor named Richard Lewis explains what causes PBA, what it looks like, and shares a specific question he uses to ask patients about it—because many people don't mention this symptom unless directly asked.

WHY IT MATTERSMany ALS patients experience PBA but don't report it to their doctors, so learning the screening question could help you get diagnosed and treated for this treatable symptom that affects quality of life.
💬 Ask your doctorAmyotrophic Lateral SclerosisPseudobulbar AffectRead →
Clinical trialRSS5 days ago

FDA clears trial testing Mesoblast cell therapy in kids with DMD

The FDA has approved a clinical trial for a new cell therapy called remestemcel-L-rknd made by Mesoblast. The therapy will be tested in children ages 5-9 who have Duchenne muscular dystrophy (DMD), a serious muscle disease. About 76 children will participate in the trial and receive either the therapy or a placebo while continuing their regular DMD treatments.

WHY IT MATTERSThis trial represents a new treatment approach for DMD in young children who are still in a critical window for muscle development, offering families a potential alternative or complement to existing therapies.
You can act on thisDuchenne muscular dystrophyRead →
AdvocacyRSS5 days ago

To me, a wheelchair is a symbol of improved function, not disability

A person with a muscular dystrophy explains how using a wheelchair has improved their quality of life and ability to participate in daily activities. Rather than viewing the wheelchair as a symbol of disability, they see it as a tool that gives them more independence and function. The article challenges common misconceptions about wheelchairs and disability.

WHY IT MATTERSThis perspective piece helps patients with muscular dystrophy and other mobility conditions understand that mobility aids like wheelchairs can expand independence rather than limit it, which may help reduce stigma and encourage earlier adoption of helpful devices.
Good to knowMuscular DystrophyRead →
AdvocacyRSS5 days ago

Navigating disability benefits for muscular dystrophy

When muscular dystrophy makes it hard to work, you may qualify for disability benefits that provide money and health insurance. This article explains how to navigate the process of getting these public benefits so you don't lose financial stability. Understanding your options can help you manage living with MD while keeping some independence.

WHY IT MATTERSPeople with muscular dystrophy who can no longer work need to know how to access disability benefits and medical coverage to avoid financial hardship during disease progression.
💬 Ask your doctorMuscular DystrophyRead →
AdvocacyRSS5 days ago

I won’t apologize for having 3 children with Duchenne MD

A mother of seven children shares her story about having three sons with Duchenne muscular dystrophy, a serious genetic muscle disease. She discusses her decision to have children despite knowing the genetic risks and explains why she doesn't regret her family planning choices. The article focuses on her perspective as both a caregiver and parent navigating life with this condition.

WHY IT MATTERSThis personal narrative highlights the lived experience and decision-making process for families with Duchenne muscular dystrophy, offering perspective on genetic counseling, family planning, and the emotional aspects of raising multiple children with the same rare disease.
Good to knowDuchenne muscular dystrophyRead →
ResearchRSS5 days ago

AI may help hemophilia patients detect joint bleeding at home

Researchers developed an artificial intelligence tool that can accurately detect bleeding inside joints in adults with hemophilia by analyzing ultrasound images. This technology could eventually allow patients to get ultrasound scans at home instead of traveling to a hospital or clinic. Early detection of joint bleeding is important because it helps prevent long-term damage to the joints.

WHY IT MATTERSHemophilia patients currently must travel to medical facilities for ultrasound imaging to detect joint bleeds; this AI tool could enable home-based monitoring, reducing travel burden and potentially catching bleeding episodes earlier.
👁 Watch this spaceHemophilia AHemophilia BRead →
NewsRSS5 days ago

On learning to master the art of sleep, one shut-eye at a time

This is a personal essay about someone's lifelong struggle with sleep, published on a hemophilia news website. The author describes how they've always found sleep difficult and treated it as optional, especially during high school. The article appears to be about learning better sleep habits, though the full content is cut off.

WHY IT MATTERSPeople with hemophilia often experience sleep disruption due to pain from joint bleeds and other complications, making sleep management strategies particularly relevant to this community.
Good to knowhemophiliaRead →
NewsRSS5 days ago

Ironing out low ferritin levels after surgery for SMAS

A patient with Superior Mesenteric Artery Syndrome (SMAS) who had surgery is experiencing low iron levels (low ferritin), which is causing severe fatigue, brain fog, restless legs at night, and poor sleep. The article discusses how iron deficiency after SMAS surgery can make recovery harder and affect quality of life.

WHY IT MATTERSPatients recovering from SMAS surgery need to know that low ferritin levels are a treatable complication that directly causes the exhaustion and cognitive problems they may be experiencing post-operatively.
💬 Ask your doctorSuperior Mesenteric Artery SyndromeRead →
ResearchRSS5 days ago

Early nerve-muscle connection flaws set stage for SMA damage

Scientists studied how spinal muscular atrophy (SMA) damages the connections between nerves and muscles. They found that in people with SMA, these nerve-muscle connections don't develop properly right after birth, making them weak and unable to work well before nerve cells start dying. This early problem may be an important part of how SMA causes muscle weakness.

WHY IT MATTERSUnderstanding that nerve-muscle connection problems happen early in SMA—before nerve cell loss—could lead to new treatments that target this early stage rather than only treating later damage.
Good to knowSpinal Muscular Atrophy (SMA)Read →
NewsRSS5 days ago

Tips for finding friends and growing your friendship caregiving team

An adult with SMA (spinal muscular atrophy) who lives independently shares insights about how they built a caregiving team of over 20 volunteer friends instead of relying on paid professional caregivers. The article discusses strategies for finding and organizing friends to help with daily care needs, challenging the assumption that people with serious disabilities must use traditional caregiving services.

WHY IT MATTERSFor adults with SMA seeking independence, learning practical strategies to recruit and coordinate volunteer caregivers from your social network can make living on your own financially and socially sustainable.
Good to knowspinal muscular atrophyRead →
NewsRSS5 days ago

My recent overnight sleep study was uncomfortable, but necessary

The author shares their personal experience undergoing an overnight sleep study, comparing it to a previous study from 2002. They describe feeling nervous about the procedure but acknowledge that despite being uncomfortable, the study was necessary for their health. The article appears to be a patient perspective piece about the importance of sleep studies for diagnosis.

WHY IT MATTERSSleep studies are often critical diagnostic tools for patients with rare diseases like SMA (spinal muscular atrophy) that can affect breathing and sleep quality, making this firsthand account relevant to others considering or preparing for the same procedure.
Good to knowspinal muscular atrophyRead →
ResearchRSS5 days ago

Antipsychotic drug may help treat SMA symptoms, research shows

Scientists found that haloperidol, a medication normally used to treat psychiatric conditions, may help treat spinal muscular atrophy (SMA) by increasing levels of a protein called SMN that is missing or low in SMA patients. In laboratory tests with mouse cells and human patient cells, haloperidol helped nerve cells survive longer, reduced harmful inflammation, and improved movement. This suggests haloperidol could potentially be used alongside or instead of current SMA treatments.

WHY IT MATTERSIf haloperidol proves effective in human trials, SMA patients could potentially benefit from a medication that already exists and is FDA-approved, potentially offering a faster path to treatment than developing entirely new drugs.
💬 Ask your doctorspinal muscular atrophyRead →
NewsRSS5 days ago

The transition to adult healthcare brings both fear and gratitude

A patient shares their experience moving from pediatric (children's) doctors to adult healthcare providers. The article describes the mixed feelings of relief and worry that come with this major life transition, using a waiting room scene to explore how gratitude and fear can happen at the same time.

WHY IT MATTERSTransitioning from pediatric to adult care is a critical moment for patients with rare diseases like SMA, where continuity of specialized treatment and emotional support can directly affect health outcomes and quality of life.
Good to knowSpinal Muscular AtrophyRead →
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